Correlation Between Serum and Fecal Biomarkers and Patient-Reported Outcomes in Patients with Crohn ’s Disease and Ulcerative Colitis
ConclusionPROs correlate with CRP and FCP; however, disease location and phenotype impact their ability to distinguish symptom severity. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 5, 2024 Category: Gastroenterology Source Type: research
Protective effects of sinomenine against dextran sulfate sodium-induced ulcerative colitis in rats via alteration of HO-1/Nrf2 and inflammatory pathway
ConclusionThe results clearly indicate that sinomenine demonstrated a protective effect against DSS-induced inflammation, potentially through the modulation of inflammatory pathways and gut microbiota. (Source: Inflammopharmacology)
Source: Inflammopharmacology - April 4, 2024 Category: Drugs & Pharmacology Source Type: research
Rapid Endoscopic Diagnosis of Benign Ulcerative Colorectal Diseases with an Artificial Intelligence Contextual Framework
Benign ulcerative colorectal diseases (UCDs) such as ulcerative colitis (UC), Crohn ’s disease (CD), ischemic colitis (IC) and intestinal tuberculosis (ITB) share similar phenotypes with different etiologies and treatment strategies. To accurately diagnose closely-related diseases like UCDs, we hypothesize that contextual learning is critical in enhancing the ability of the artif icial intelligence models to differentiate the subtle differences in lesions amidst the vastly divergent spatial contexts. (Source: Gastroenterology)
Source: Gastroenterology - April 4, 2024 Category: Gastroenterology Authors: Xiaobei Luo, Jiahao Wang, Chuanchuan Tan, Qi Dou, Zelong Han, Zhenjiang Wang, Farah Tasnim, Xiyu Wang, Qiang Zhan, Xiang Li, Qunyan Zhou, Jianbin Cheng, Fabiao Liao, Hon Chi Yip, Jiayi Jiang, Robby T. Tan, Side Liu, Hanry Yu Tags: Clinical - Alimentary Tract Source Type: research
Rosa laevigata Polysaccharides Ameliorate Dextran Sulfate Sodium-induced Ulcerative Colitis of Beagles through Regulating Gut Microbiota
In conclusion, our study has provided that RLP effectively alleviated colitis by preserving the intestinal barrier and regulating the gut microbiota composition.PMID:38567653 | DOI:10.1002/cbdv.202302102 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - April 3, 2024 Category: Biochemistry Authors: Song Peng Xuanqi Lu Fangzhu Lin Ningning Mao Lin Yu Tianyu Zhu Jing He Yang Yang Zhenguang Liu Deyun Wang Source Type: research
Rosa laevigata Polysaccharides Ameliorate Dextran Sulfate Sodium-induced Ulcerative Colitis of Beagles through Regulating Gut Microbiota
In conclusion, our study has provided that RLP effectively alleviated colitis by preserving the intestinal barrier and regulating the gut microbiota composition.PMID:38567653 | DOI:10.1002/cbdv.202302102 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - April 3, 2024 Category: Biochemistry Authors: Song Peng Xuanqi Lu Fangzhu Lin Ningning Mao Lin Yu Tianyu Zhu Jing He Yang Yang Zhenguang Liu Deyun Wang Source Type: research
Effectiveness and safety of adalimumab biosimilar in patients with inflammatory bowel disease
CONCLUSIONS: Between originator adalimumab and biosimilar-start cohorts, no differences were observed, between originator adalimumab and switch cohorts, no significant differences were found either, and with the pre- and post-switch to biosimilar comparison, 2 of the 9 patients experienced AEs after the switch. The biosimilar showed a favorable safety profile (one patient with a serious adverse effect (rash) with biosimilar discontinued treatment) and no significant changes to clinical or biochemical parameters were observed after the switch.PMID:38570210 | DOI:10.1016/j.farma.2024.01.002 (Source: Farmacia Hospitalaria)
Source: Farmacia Hospitalaria - April 3, 2024 Category: Drugs & Pharmacology Authors: Jaime E Poquet-Jornet In és Ibáñez-Sala Teresa Garrigues-Pelufo Adri án Munilla-Das Antonio Valdivia-P érez Francisco Javier Carrera-Hueso Source Type: research
Advancements of Macrophages Involvement in Pathological Progression of Colitis-Associated Colorectal Cancer and Associated Pharmacological Interventions
AbstractIntestinal macrophages play crucial roles in both intestinal inflammation and immune homeostasis. They can adopt two distinct phenotypes, primarily determined by environmental cues. These phenotypes encompass the classically activated pro-inflammatory M1 phenotype, as well as the alternatively activated anti-inflammatory M2 phenotype. In regular conditions, intestinal macrophages serve to shield the gut from inflammatory harm. However, when a combination of genetic and environmental elements influences the polarization of these macrophages, it can result in an M1/M2 macrophage activation imbalance, subsequently lea...
Source: Chinese Journal of Integrative Medicine - April 3, 2024 Category: Internal Medicine Source Type: research
Shared genetic basis and causality between schizophrenia and inflammatory bowel disease: evidence from a comprehensive genetic analysis
CONCLUSIONS: We confirmed a shared genetic basis, pleiotropic loci/genes, and causal relationship between SCZ and IBD, providing novel insights into the biological mechanism and therapeutic targets underlying these two disorders.PMID:38563283 | DOI:10.1017/S0033291724000771 (Source: Psychological Medicine)
Source: Psychological Medicine - April 2, 2024 Category: Psychiatry Authors: Jing Wang Guang-Yu Luo Tian Tian Yu-Qiang Zhao Shi-Yin Meng Jun-Hua Wu Wen-Xiu Han Bin Deng Jing Ni Source Type: research
Advancements of Macrophages Involvement in Pathological Progression of Colitis-Associated Colorectal Cancer and Associated Pharmacological Interventions
Chin J Integr Med. 2024 Apr 3. doi: 10.1007/s11655-024-4101-1. Online ahead of print.ABSTRACTIntestinal macrophages play crucial roles in both intestinal inflammation and immune homeostasis. They can adopt two distinct phenotypes, primarily determined by environmental cues. These phenotypes encompass the classically activated pro-inflammatory M1 phenotype, as well as the alternatively activated anti-inflammatory M2 phenotype. In regular conditions, intestinal macrophages serve to shield the gut from inflammatory harm. However, when a combination of genetic and environmental elements influences the polarization of these mac...
Source: Cancer Control - April 2, 2024 Category: Cancer & Oncology Authors: Jun-Yu Ke Jin-Bin Song Long Li Zhen-Fan He Zhuo-Jian Huang Zheng-Lin Liu Gui-Rong Chen Hai-Yan Wang Su-Ru Wen Heng-Li Zhou Hui-Lin Ma Qun Du Yong-Qiang Wu Yan-Wu Li Xin-Lin Chen Source Type: research
Shared genetic basis and causality between schizophrenia and inflammatory bowel disease: evidence from a comprehensive genetic analysis
CONCLUSIONS: We confirmed a shared genetic basis, pleiotropic loci/genes, and causal relationship between SCZ and IBD, providing novel insights into the biological mechanism and therapeutic targets underlying these two disorders.PMID:38563283 | DOI:10.1017/S0033291724000771 (Source: Psychological Medicine)
Source: Psychological Medicine - April 2, 2024 Category: Psychiatry Authors: Jing Wang Guang-Yu Luo Tian Tian Yu-Qiang Zhao Shi-Yin Meng Jun-Hua Wu Wen-Xiu Han Bin Deng Jing Ni Source Type: research
Integrative analysis with microbial modelling and machine learning uncovers potential alleviators for ulcerative colitis
Volume 16, Issue 1, January-December 2024 . (Source: Gut Microbes)
Source: Gut Microbes - April 2, 2024 Category: Microbiology Authors: Jinlin ZhuJialin YinJing ChenMingyi HuWenwei LuHongchao WangHao ZhangWei Chena State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Chinab School of Food Science and Technology, Jiangnan University, Wuxi, Chinac International Joi Source Type: research
Suppression of Inflammation in Ulcerative Colitis Rats by Avocado and Pomegranate
Pomegranate seed oil (PSO) and avocado seed oil (ASO) are natural polyphenols with established anti-inflammatory activity. (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - April 2, 2024 Category: Nutrition Authors: Nahla E. El-Ashmawy, Eman G. Khedr, Enas A. El-Zamarany, Sarah M. Ahmed Tags: Original article Source Type: research
Tissue-specific reprogramming leads to angiogenic neutrophil specialization and tumor vascularization in colorectal cancer
Neutrophil (PMN) tissue accumulation is an established feature of ulcerative colitis (UC) lesions and colorectal cancer (CRC). To assess the PMN phenotypic and functional diversification during the transition from inflammatory ulceration to CRC we analyzed the transcriptomic landscape of blood and tissue PMNs. Transcriptional programs effectively separated PMNs based on their proximity to peripheral blood, inflamed colon, and tumors. In silico pathway overrepresentation analysis, protein-network mapping, gene signature identification, and gene-ontology scoring revealed unique enrichment of angiogenic and vasculature develo...
Source: Journal of Clinical Investigation - April 1, 2024 Category: Biomedical Science Authors: Triet M. Bui, Lenore K. Yalom, Edward Ning, Jessica M. Urbanczyk, Xingsheng Ren, Caroline J. Herrnreiter, Jackson A. Disario, Brian Wray, Matthew J. Schipma, Yuri S. Velichko, David P. Sullivan, Kouki Abe, Shannon M. Lauberth, Guang-Yu Yang, Parambir S. D Source Type: research
Automated Spatial Omics Landscape Analysis Approach Reveals Novel Tissue Architectures in Ulcerative Colitis
Res Sq [Preprint]. 2024 Mar 11:rs.3.rs-3965505. doi: 10.21203/rs.3.rs-3965505/v1.ABSTRACTThe utility of spatial omics in leveraging cellular interactions in normal and diseased states for precision medicine is hampered by a lack of strategies for matching disease states with spatial heterogeneity-guided cellular annotations. Here we use a spatial context-dependent approach that matches spatial pattern detection to cell annotation. Using this approach in existing datasets from ulcerative colitis patient colonic biopsies, we identified architectural complexities and associated difficult-to-detect rare cell types in ulcerativ...
Source: Cell Research - April 1, 2024 Category: Cytology Authors: Stephan Rogalla Derek Holman Samuel Rubin Mariusz Ferenc Elizabeth Holman Alexander Koron Robel Daniel Brigid Boland Garry Nolan John Chang Source Type: research
