Tissue-specific reprogramming leads to angiogenic neutrophil specialization and tumor vascularization in colorectal cancer
Neutrophil (PMN) tissue accumulation is an established feature of ulcerative colitis (UC) lesions and colorectal cancer (CRC). To assess the PMN phenotypic and functional diversification during the transition from inflammatory ulceration to CRC we analyzed the transcriptomic landscape of blood and tissue PMNs. Transcriptional programs effectively separated PMNs based on their proximity to peripheral blood, inflamed colon, and tumors. In silico pathway overrepresentation analysis, protein-network mapping, gene signature identification, and gene-ontology scoring revealed unique enrichment of angiogenic and vasculature develo...
Source: Journal of Clinical Investigation - April 1, 2024 Category: Biomedical Science Authors: Triet M. Bui, Lenore K. Yalom, Edward Ning, Jessica M. Urbanczyk, Xingsheng Ren, Caroline J. Herrnreiter, Jackson A. Disario, Brian Wray, Matthew J. Schipma, Yuri S. Velichko, David P. Sullivan, Kouki Abe, Shannon M. Lauberth, Guang-Yu Yang, Parambir S. D Source Type: research
Automated Spatial Omics Landscape Analysis Approach Reveals Novel Tissue Architectures in Ulcerative Colitis
Res Sq [Preprint]. 2024 Mar 11:rs.3.rs-3965505. doi: 10.21203/rs.3.rs-3965505/v1.ABSTRACTThe utility of spatial omics in leveraging cellular interactions in normal and diseased states for precision medicine is hampered by a lack of strategies for matching disease states with spatial heterogeneity-guided cellular annotations. Here we use a spatial context-dependent approach that matches spatial pattern detection to cell annotation. Using this approach in existing datasets from ulcerative colitis patient colonic biopsies, we identified architectural complexities and associated difficult-to-detect rare cell types in ulcerativ...
Source: Cell Research - April 1, 2024 Category: Cytology Authors: Stephan Rogalla Derek Holman Samuel Rubin Mariusz Ferenc Elizabeth Holman Alexander Koron Robel Daniel Brigid Boland Garry Nolan John Chang Source Type: research
Impact of cytomegalovirus on outcomes in acute severe ulcerative colitis: a retrospective observational study
CONCLUSION: CMV positivity was associated with worse outcomes of need for rescue therapy, hospital stay and readmissions. Antiviral therapy was not found to reduce the risk of colectomy but did extend the time to colectomy. Further prospective studies will be required to more clearly determine its benefit in patients with concomitant CMV and ASUC.PMID:38560721 | PMC:PMC10981253 | DOI:10.1177/20406223241233203 (Source: Adv Data)
Source: Adv Data - April 1, 2024 Category: Epidemiology Authors: Dazhong Huang Michael Rennie Alicia Krasovec Shyam Nagubandi Sichang Liu Edward Ge Barinder Khehra Michael Au Shobini Sivagnanam Vu Kwan Claudia Rogge Nikola Mitrev Viraj Kariyawasam Source Type: research
Systematic review of metabolomic alterations in ulcerative colitis: unveiling key metabolic signatures and pathways
CONCLUSION: This study elucidates key metabolic characteristics in UC, offering insights into molecular mechanisms and biomarker discovery for the disease. Future research could focus on validating these findings and exploring their clinical applications.PMID:38560428 | PMC:PMC10981261 | DOI:10.1177/17562848241239580 (Source: Adv Data)
Source: Adv Data - April 1, 2024 Category: Epidemiology Authors: Meiling Liu Siyi Guo Liang Wang Source Type: research
Robotic-assisted reoperative ileal pouch –anal anastomosis: robotic pouch excision and pouch revision
ConclusionRobotic reoperative pouch surgery in highly selected patients is technically feasible with acceptable outcomes. (Source: Techniques in Coloproctology)
Source: Techniques in Coloproctology - April 1, 2024 Category: Surgery Source Type: research
Polysaccharides from an edible mushroom, Hericium erinaceus, alleviate ulcerative colitis in mice by inhibiting the NLRP3 inflammasomes and reestablish intestinal homeostasis
This study aimed to assess the effects of polysaccharides extracted from Hericium erinaceus fruiting bodies (HEFPs) on the inflammatory response to oxidative stress in a mouse model of ulcerative colitis (UC) induced by ingestion of dextran sodium sulfate. The results indicated reduced oxidative damage in the HEFPs groups, as evidenced by significantly decreased malondialdehyde levels and significantly increased levels of the antioxidant enzymes superoxide dismutase and catalase in colon homogenates, compared with those in the Model Control (MC) group. Additionally, compared with the levels in the MC group, the levels of t...
Source: International Journal of Biological Macromolecules - March 31, 2024 Category: Biochemistry Authors: Hao Li Jiaxin Feng Chang Liu Shuting Hou Junlong Meng Jing-Yu Liu Sun Zilong Ming-Chang Chang Source Type: research
Polysaccharides from an edible mushroom, Hericium erinaceus, alleviate ulcerative colitis in mice by inhibiting the NLRP3 inflammasomes and reestablish intestinal homeostasis
This study aimed to assess the effects of polysaccharides extracted from Hericium erinaceus fruiting bodies (HEFPs) on the inflammatory response to oxidative stress in a mouse model of ulcerative colitis (UC) induced by ingestion of dextran sodium sulfate. The results indicated reduced oxidative damage in the HEFPs groups, as evidenced by significantly decreased malondialdehyde levels and significantly increased levels of the antioxidant enzymes superoxide dismutase and catalase in colon homogenates, compared with those in the Model Control (MC) group. Additionally, compared with the levels in the MC group, the levels of t...
Source: International Journal of Biological Macromolecules - March 31, 2024 Category: Biochemistry Authors: Hao Li Jiaxin Feng Chang Liu Shuting Hou Junlong Meng Jing-Yu Liu Sun Zilong Ming-Chang Chang Source Type: research
Modelling Treatment Sequences in Immunology: Optimizing Patient Outcomes
CONCLUSIONS: Prescribing more efficacious treatments earlier provides a greater opportunity to improve patient outcomes and minimizes treatment failures.PMID:38554238 | DOI:10.1007/s12325-023-02766-w (Source: Adv Data)
Source: Adv Data - March 30, 2024 Category: Epidemiology Authors: Rose J Hart Fareen Hassan Sarah Alulis Karl W Patterson Jennifer Norma Barthelmes Jennifer H Boer Dawn Lee Source Type: research
Characterization of Th17 tissue-resident memory cells in non-inflamed intestinal tissue of Crohn's disease patients
J Autoimmun. 2024 Mar 29;145:103206. doi: 10.1016/j.jaut.2024.103206. Online ahead of print.ABSTRACTCrohn's disease (CD) is a chronic inflammatory disorder affecting the bowel wall. Tissue-resident memory T (Trm) cells are implicated in CD, yet their characteristics remain unclear. We aimed to investigate the transcriptional profiles and functional characteristics of Trm cells in the small bowel of CD and their interactions with immune cells. Seven patients with CD and four with ulcerative colitis as controls were included. Single-cell RNA sequencing and paired T cell receptor sequencing assessed T cell subsets and transcr...
Source: Journal of Autoimmunity - March 30, 2024 Category: Allergy & Immunology Authors: Yoonho Lee Jiwon Baek Sojung Park Yongjae Kim Sung Wook Hwang Jong Lyul Lee Sang Hyoung Park Jihun Kim Suk-Kyun Yang Buhm Han Mi-Na Kweon Kyuyoung Song Yong Sik Yoon Byong Duk Ye Ho-Su Lee Source Type: research
Modelling Treatment Sequences in Immunology: Optimizing Patient Outcomes
CONCLUSIONS: Prescribing more efficacious treatments earlier provides a greater opportunity to improve patient outcomes and minimizes treatment failures.PMID:38554238 | DOI:10.1007/s12325-023-02766-w (Source: Adv Data)
Source: Adv Data - March 30, 2024 Category: Epidemiology Authors: Rose J Hart Fareen Hassan Sarah Alulis Karl W Patterson Jennifer Norma Barthelmes Jennifer H Boer Dawn Lee Source Type: research
Characterization of Th17 tissue-resident memory cells in non-inflamed intestinal tissue of Crohn's disease patients
J Autoimmun. 2024 Mar 29;145:103206. doi: 10.1016/j.jaut.2024.103206. Online ahead of print.ABSTRACTCrohn's disease (CD) is a chronic inflammatory disorder affecting the bowel wall. Tissue-resident memory T (Trm) cells are implicated in CD, yet their characteristics remain unclear. We aimed to investigate the transcriptional profiles and functional characteristics of Trm cells in the small bowel of CD and their interactions with immune cells. Seven patients with CD and four with ulcerative colitis as controls were included. Single-cell RNA sequencing and paired T cell receptor sequencing assessed T cell subsets and transcr...
Source: Journal of Autoimmunity - March 30, 2024 Category: Allergy & Immunology Authors: Yoonho Lee Jiwon Baek Sojung Park Yongjae Kim Sung Wook Hwang Jong Lyul Lee Sang Hyoung Park Jihun Kim Suk-Kyun Yang Buhm Han Mi-Na Kweon Kyuyoung Song Yong Sik Yoon Byong Duk Ye Ho-Su Lee Source Type: research
Characterization of Th17 tissue-resident memory cells in non-inflamed intestinal tissue of Crohn's disease patients
J Autoimmun. 2024 Mar 29;145:103206. doi: 10.1016/j.jaut.2024.103206. Online ahead of print.ABSTRACTCrohn's disease (CD) is a chronic inflammatory disorder affecting the bowel wall. Tissue-resident memory T (Trm) cells are implicated in CD, yet their characteristics remain unclear. We aimed to investigate the transcriptional profiles and functional characteristics of Trm cells in the small bowel of CD and their interactions with immune cells. Seven patients with CD and four with ulcerative colitis as controls were included. Single-cell RNA sequencing and paired T cell receptor sequencing assessed T cell subsets and transcr...
Source: Journal of Autoimmunity - March 30, 2024 Category: Allergy & Immunology Authors: Yoonho Lee Jiwon Baek Sojung Park Yongjae Kim Sung Wook Hwang Jong Lyul Lee Sang Hyoung Park Jihun Kim Suk-Kyun Yang Buhm Han Mi-Na Kweon Kyuyoung Song Yong Sik Yoon Byong Duk Ye Ho-Su Lee Source Type: research
Characterization of Th17 tissue-resident memory cells in non-inflamed intestinal tissue of Crohn's disease patients
J Autoimmun. 2024 Mar 29;145:103206. doi: 10.1016/j.jaut.2024.103206. Online ahead of print.ABSTRACTCrohn's disease (CD) is a chronic inflammatory disorder affecting the bowel wall. Tissue-resident memory T (Trm) cells are implicated in CD, yet their characteristics remain unclear. We aimed to investigate the transcriptional profiles and functional characteristics of Trm cells in the small bowel of CD and their interactions with immune cells. Seven patients with CD and four with ulcerative colitis as controls were included. Single-cell RNA sequencing and paired T cell receptor sequencing assessed T cell subsets and transcr...
Source: Journal of Autoimmunity - March 30, 2024 Category: Allergy & Immunology Authors: Yoonho Lee Jiwon Baek Sojung Park Yongjae Kim Sung Wook Hwang Jong Lyul Lee Sang Hyoung Park Jihun Kim Suk-Kyun Yang Buhm Han Mi-Na Kweon Kyuyoung Song Yong Sik Yoon Byong Duk Ye Ho-Su Lee Source Type: research
Retracted: High-Fat Diet Promotes DSS-Induced Ulcerative Colitis by Downregulated FXR Expression through the TGFB Pathway
Biomed Res Int. 2024 Mar 20;2024:9836018. doi: 10.1155/2024/9836018. eCollection 2024.ABSTRACT[This retracts the article DOI: 10.1155/2020/3516128.].PMID:38550202 | PMC:PMC10977278 | DOI:10.1155/2024/9836018 (Source: Biomed Res)
Source: Biomed Res - March 29, 2024 Category: Research Authors: BioMed Research International Source Type: research
Retracted: High-Fat Diet Promotes DSS-Induced Ulcerative Colitis by Downregulated FXR Expression through the TGFB Pathway
Biomed Res Int. 2024 Mar 20;2024:9836018. doi: 10.1155/2024/9836018. eCollection 2024.ABSTRACT[This retracts the article DOI: 10.1155/2020/3516128.].PMID:38550202 | PMC:PMC10977278 | DOI:10.1155/2024/9836018 (Source: Biomed Res)
Source: Biomed Res - March 29, 2024 Category: Research Authors: BioMed Research International Source Type: research
