Automated Spatial Omics Landscape Analysis Approach Reveals Novel Tissue Architectures in Ulcerative Colitis

Res Sq [Preprint]. 2024 Mar 11:rs.3.rs-3965505. doi: 10.21203/rs.3.rs-3965505/v1.ABSTRACTThe utility of spatial omics in leveraging cellular interactions in normal and diseased states for precision medicine is hampered by a lack of strategies for matching disease states with spatial heterogeneity-guided cellular annotations. Here we use a spatial context-dependent approach that matches spatial pattern detection to cell annotation. Using this approach in existing datasets from ulcerative colitis patient colonic biopsies, we identified architectural complexities and associated difficult-to-detect rare cell types in ulcerative colitis germinal-center B cell follicles. Our approach deepens our understanding of health and disease pathogenesis, illustrates a strategy for automating nested architecture detection for highly multiplexed spatial biology data, and informs precision diagnosis and therapeutic strategies.PMID:38559236 | PMC:PMC10980100 | DOI:10.21203/rs.3.rs-3965505/v1
Source: Cell Research - Category: Cytology Authors: Source Type: research