Recent trends in the epidemiology and clinical outcomes of inflammatory bowel disease in South Korea, 2010-2018
CONCLUSION: The CD incidence has been stable since 2014, but that of UC has increased with a shift to a younger age at peak incidence between 2010 and 2018. IBD clinical outcomes improved over time, with increased use of immunomodulators and biologics.PMID:38577186 | PMC:PMC10989502 | DOI:10.3748/wjg.v30.i9.1154 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 5, 2024 Category: Gastroenterology Authors: Seulji Kim Hyun Jung Lee Seung Woo Lee Sanghyun Park Seong-Joon Koh Jong Pil Im Byeong Gwan Kim Kyung-Do Han Joo Sung Kim Source Type: research
Melanocortin 3,5 receptors immunohistochemical expression in colonic mucosa of inflammatory bowel disease patients: A matter of disease activity?
CONCLUSION: MC3R and MC5R are expressed in the colon of IBD patients. Furthermore, expression may differ according to disease endoscopic activity, with a higher degree of expression in the traits affected by disease activity in both CD and UC, suggesting a potential use of these receptors in IBD pharmacology.PMID:38577176 | PMC:PMC10989484 | DOI:10.3748/wjg.v30.i9.1132 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 5, 2024 Category: Gastroenterology Authors: Antonietta Gerarda Gravina Iacopo Panarese Maria Consiglia Trotta Michele D'Amico Raffaele Pellegrino Franca Ferraraccio Marilena Galdiero Roberto Alfano Paolo Grieco Alessandro Federico Source Type: research
Fibrosis in IBD: from pathogenesis to therapeutic targets
Background
Intestinal fibrosis resulting in stricture formation and obstruction in Crohn’s disease (CD) and increased wall stiffness leading to symptoms in ulcerative colitis (UC) is among the largest unmet needs in inflammatory bowel disease (IBD). Fibrosis is caused by a multifactorial and complex process involving immune and non-immune cells, their soluble mediators and exposure to luminal contents, such as microbiota and environmental factors. To date, no antifibrotic therapy is available. Some progress has been made in creating consensus definitions and measurements to quantify stricture morphology for clinical ...
Source: Gut - April 5, 2024 Category: Gastroenterology Authors: Rieder, F., Mukherjee, P. K., Massey, W. J., Wang, Y., Fiocchi, C. Tags: GUT Recent advances in clinical practice, Gut Source Type: research
Defining gene-lifestyle interactions in inflammatory bowel disease: progress towards understanding disease pathogenesis
Recently, Lopes et al quantified the effect of modifiable lifestyle factors in inflammatory bowel disease (IBD) prevention using population attributable risk, and reported that 42.9% of Crohn’s disease (CD) cases and 44.4% of ulcerative colitis (UC) cases could have been prevented by lifestyle interventions. This interesting result was based on 6 prospective cohorts including 3 US cohorts with 208 070 participants and 3 large European cohorts that were used for validation.1 Undoubtedly, this well-performed study illustrates the possible merits of lifestyle modification as a prevention strategy for IBD. However, we wo...
Source: Gut - April 5, 2024 Category: Gastroenterology Authors: Zhao, J., Chen, J., Sun, Y., Yuan, S., Wellens, J., Kalla, R., Theodoratou, E., Li, X., Satsangi, J. Tags: Gut PostScript Source Type: research
Correlation Between Serum and Fecal Biomarkers and Patient-Reported Outcomes in Patients with Crohn ’s Disease and Ulcerative Colitis
ConclusionPROs correlate with CRP and FCP; however, disease location and phenotype impact their ability to distinguish symptom severity. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 5, 2024 Category: Gastroenterology Source Type: research
Protective effects of sinomenine against dextran sulfate sodium-induced ulcerative colitis in rats via alteration of HO-1/Nrf2 and inflammatory pathway
ConclusionThe results clearly indicate that sinomenine demonstrated a protective effect against DSS-induced inflammation, potentially through the modulation of inflammatory pathways and gut microbiota. (Source: Inflammopharmacology)
Source: Inflammopharmacology - April 4, 2024 Category: Drugs & Pharmacology Source Type: research
Rapid Endoscopic Diagnosis of Benign Ulcerative Colorectal Diseases with an Artificial Intelligence Contextual Framework
Benign ulcerative colorectal diseases (UCDs) such as ulcerative colitis (UC), Crohn ’s disease (CD), ischemic colitis (IC) and intestinal tuberculosis (ITB) share similar phenotypes with different etiologies and treatment strategies. To accurately diagnose closely-related diseases like UCDs, we hypothesize that contextual learning is critical in enhancing the ability of the artif icial intelligence models to differentiate the subtle differences in lesions amidst the vastly divergent spatial contexts. (Source: Gastroenterology)
Source: Gastroenterology - April 4, 2024 Category: Gastroenterology Authors: Xiaobei Luo, Jiahao Wang, Chuanchuan Tan, Qi Dou, Zelong Han, Zhenjiang Wang, Farah Tasnim, Xiyu Wang, Qiang Zhan, Xiang Li, Qunyan Zhou, Jianbin Cheng, Fabiao Liao, Hon Chi Yip, Jiayi Jiang, Robby T. Tan, Side Liu, Hanry Yu Tags: Clinical - Alimentary Tract Source Type: research
Rosa laevigata Polysaccharides Ameliorate Dextran Sulfate Sodium-induced Ulcerative Colitis of Beagles through Regulating Gut Microbiota
In conclusion, our study has provided that RLP effectively alleviated colitis by preserving the intestinal barrier and regulating the gut microbiota composition.PMID:38567653 | DOI:10.1002/cbdv.202302102 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - April 3, 2024 Category: Biochemistry Authors: Song Peng Xuanqi Lu Fangzhu Lin Ningning Mao Lin Yu Tianyu Zhu Jing He Yang Yang Zhenguang Liu Deyun Wang Source Type: research
Rosa laevigata Polysaccharides Ameliorate Dextran Sulfate Sodium-induced Ulcerative Colitis of Beagles through Regulating Gut Microbiota
In conclusion, our study has provided that RLP effectively alleviated colitis by preserving the intestinal barrier and regulating the gut microbiota composition.PMID:38567653 | DOI:10.1002/cbdv.202302102 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - April 3, 2024 Category: Biochemistry Authors: Song Peng Xuanqi Lu Fangzhu Lin Ningning Mao Lin Yu Tianyu Zhu Jing He Yang Yang Zhenguang Liu Deyun Wang Source Type: research
Effectiveness and safety of adalimumab biosimilar in patients with inflammatory bowel disease
CONCLUSIONS: Between originator adalimumab and biosimilar-start cohorts, no differences were observed, between originator adalimumab and switch cohorts, no significant differences were found either, and with the pre- and post-switch to biosimilar comparison, 2 of the 9 patients experienced AEs after the switch. The biosimilar showed a favorable safety profile (one patient with a serious adverse effect (rash) with biosimilar discontinued treatment) and no significant changes to clinical or biochemical parameters were observed after the switch.PMID:38570210 | DOI:10.1016/j.farma.2024.01.002 (Source: Farmacia Hospitalaria)
Source: Farmacia Hospitalaria - April 3, 2024 Category: Drugs & Pharmacology Authors: Jaime E Poquet-Jornet In és Ibáñez-Sala Teresa Garrigues-Pelufo Adri án Munilla-Das Antonio Valdivia-P érez Francisco Javier Carrera-Hueso Source Type: research
Advancements of Macrophages Involvement in Pathological Progression of Colitis-Associated Colorectal Cancer and Associated Pharmacological Interventions
AbstractIntestinal macrophages play crucial roles in both intestinal inflammation and immune homeostasis. They can adopt two distinct phenotypes, primarily determined by environmental cues. These phenotypes encompass the classically activated pro-inflammatory M1 phenotype, as well as the alternatively activated anti-inflammatory M2 phenotype. In regular conditions, intestinal macrophages serve to shield the gut from inflammatory harm. However, when a combination of genetic and environmental elements influences the polarization of these macrophages, it can result in an M1/M2 macrophage activation imbalance, subsequently lea...
Source: Chinese Journal of Integrative Medicine - April 3, 2024 Category: Internal Medicine Source Type: research
Shared genetic basis and causality between schizophrenia and inflammatory bowel disease: evidence from a comprehensive genetic analysis
CONCLUSIONS: We confirmed a shared genetic basis, pleiotropic loci/genes, and causal relationship between SCZ and IBD, providing novel insights into the biological mechanism and therapeutic targets underlying these two disorders.PMID:38563283 | DOI:10.1017/S0033291724000771 (Source: Psychological Medicine)
Source: Psychological Medicine - April 2, 2024 Category: Psychiatry Authors: Jing Wang Guang-Yu Luo Tian Tian Yu-Qiang Zhao Shi-Yin Meng Jun-Hua Wu Wen-Xiu Han Bin Deng Jing Ni Source Type: research
Advancements of Macrophages Involvement in Pathological Progression of Colitis-Associated Colorectal Cancer and Associated Pharmacological Interventions
Chin J Integr Med. 2024 Apr 3. doi: 10.1007/s11655-024-4101-1. Online ahead of print.ABSTRACTIntestinal macrophages play crucial roles in both intestinal inflammation and immune homeostasis. They can adopt two distinct phenotypes, primarily determined by environmental cues. These phenotypes encompass the classically activated pro-inflammatory M1 phenotype, as well as the alternatively activated anti-inflammatory M2 phenotype. In regular conditions, intestinal macrophages serve to shield the gut from inflammatory harm. However, when a combination of genetic and environmental elements influences the polarization of these mac...
Source: Cancer Control - April 2, 2024 Category: Cancer & Oncology Authors: Jun-Yu Ke Jin-Bin Song Long Li Zhen-Fan He Zhuo-Jian Huang Zheng-Lin Liu Gui-Rong Chen Hai-Yan Wang Su-Ru Wen Heng-Li Zhou Hui-Lin Ma Qun Du Yong-Qiang Wu Yan-Wu Li Xin-Lin Chen Source Type: research
Shared genetic basis and causality between schizophrenia and inflammatory bowel disease: evidence from a comprehensive genetic analysis
CONCLUSIONS: We confirmed a shared genetic basis, pleiotropic loci/genes, and causal relationship between SCZ and IBD, providing novel insights into the biological mechanism and therapeutic targets underlying these two disorders.PMID:38563283 | DOI:10.1017/S0033291724000771 (Source: Psychological Medicine)
Source: Psychological Medicine - April 2, 2024 Category: Psychiatry Authors: Jing Wang Guang-Yu Luo Tian Tian Yu-Qiang Zhao Shi-Yin Meng Jun-Hua Wu Wen-Xiu Han Bin Deng Jing Ni Source Type: research
