Ulcerative Colitis Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Ginseng polysaccharides ameliorate ulcerative colitis via regulating gut microbiota and tryptophan metabolism
In this study, we demonstrated that ginseng polysaccharides (GPs) could alleviate the development of dextran sulfate sodium (DSS)-induced UC as reflected by the ameliorated pathological lesions in the colon. GPs strikingly suppressed the expression levels of multiple inflammatory cytokines, as well as significantly inhibited the infiltration of inflammatory cells. Microbiota-dependent investigations by virtue of 16S rRNA gene sequencing, antibiotic treatment and fecal microbiota transplantation illustrated that GPs treatment prominently restored intestinal microbial balance predominantly through modulating the relative abu...
Source: International Journal of Biological Macromolecules - March 23, 2024 Category: Biochemistry Authors: Li Wan Cheng Qian Chunmei Yang Sainan Peng Guanglu Dong Peng Cheng Gangfan Zong Hongkuan Han Mingyue Shao Guanwen Gong Zhengming Deng Huafeng Pan Haifeng Wang Xinxin Liu Gang Wang Yin Lu Yang Zhao Zhiwei Jiang Source Type: research

Additional Data in Expanded Patient Populations and New Indications Support the Practice of Biosimilar-to-Biosimilar Switching
AbstractAs of 31 December, 2023, 31 observational studies have been published, including a total of 6081 patients who underwent a switch from one biosimilar to another biosimilar of the same reference biologic. Most studies evaluated infliximab, while a smaller number evaluated adalimumab, rituximab or etanercept. Indications studied now include sarcoidosis, as well as the indications previously reported of rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis/ankylosing spondylitis and inflammatory bowel disease (Crohn ’s disease and ulcerative colitis). This updated data set includes eight additional studi...
Source: BioDrugs - March 23, 2024 Category: Drugs & Pharmacology Source Type: research

Exploring the therapeutic potential of Anastatica hierochuntica essential oil in DSS-induced colitis
AbstractThe aim of this investigation was to explore the protective impacts and mechanisms ofAnastatica hierochuntica essential oil (EOAH) against dextran sulfate sodium (DSS)-induced experimental colitis in mice.EOAH demonstrated a reduction in DSS-induced body weight decline, disease activity index (DAI), colon length reduction, colonic tissue damage, and myeloperoxidase (MPO) activity. The essential oil significantly mitigated the production of pro-inflammatory agents including TNF- α, IL-1β, and IL-12. Further analysis revealed that EOAH’s anti-inflammatory effects involved the regulation of NF-κB and PPARγ pathw...
Source: Inflammopharmacology - March 23, 2024 Category: Drugs & Pharmacology Source Type: research

Constituents of stable commensal microbiota imply diverse colonic epithelial cell reactivity in patients with ulcerative colitis
ConclusionThis study reveals that a substantial part of the gut microbiota remains stable throughout progression of UC. Functional experiments suggest that members of core microbiota –Escherichia coli andPhocaeicola vulgatus – potentially differentially regulate the expression of tight junction gene in the colonic epithelium of UC patients and healthy individuals. (Source: Gut Pathogens)
Source: Gut Pathogens - March 23, 2024 Category: Microbiology Source Type: research

Investigating the association between the tissue expression of miRNA ‐101, JAK2/STAT3 with TNF‐α, IL‐6, IL‐1β, and IL‐10 cytokines in the ulcerative colitis patients
ConclusionThis study provides evidence of increased miRNA-101 expression in UC tissue, suggesting a potential correlation between miRNA-101 and IL-6 expression and their involvement in the JAK2-STAT3 pathway. The study confirms alterations in UC patients' pro-inflammatory cytokines and anti-inflammatory IL-10. However, further investigations are needed to understand the exact role of miRNA-101 in UC pathogenesis fully. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 22, 2024 Category: Allergy & Immunology Authors: Qazaleh Voshagh, Amir Anoshiravani, Amin Karimpour, Golnaz Goodarzi, Sadra Samavarchi Tehrani, Ozra Tabatabaei ‐Malazy, Ghodratollah Panahi Tags: ORIGINAL ARTICLE Source Type: research

Innovate therapeutic targets for autoimmune diseases: insights from proteome-wide mendelian randomization and Bayesian colocalization
CONCLUSIONS: Our integrated study identified 12 potential therapeutic targets for ADs and provided novel insights into future drug development for ADs.PMID:38515381 | DOI:10.1080/08916934.2024.2330392 (Source: Autoimmunity)
Source: Autoimmunity - March 22, 2024 Category: Allergy & Immunology Authors: Qiubai Jin Feihong Ren Ping Song Source Type: research

Fraxin Ameliorates Ulcerative Colitis by Modulating Oxidative Stress, Inflammation and TLR4/NF- κB and MAPK Signaling Pathways
CONCLUSION: Taken together, Fraxin ameliorates UC by regulating oxidative stress, inflammation, and TLR4/NF-κB and MAPK pathways, and Fraxin may be a new treatment for UC. Our findings suggest that Fraxin could offer a novel therapeutic approach for UC, targeting oxidative stress and key inflammatory pathways.PMID:38518135 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: Wenkai Sun Li Hang Liping Chen Yun Qu Yingchun Zhang Zhiwei Miao Xiaoyu Wang Source Type: research