Impaired kidney function: supporting the safe use of medicines for patients
This article provides an overview of the effects of impaired kidney function on pharmacokinetics and the importance of accurate drug dose adjustments for patients with related conditions. It also discusses various aspects of medicines use in patients with AKI, the pharmacological management of patients with CKD and the use of immunosuppressive therapy in patients who have had a kidney transplant. The authors consider the role of the nurse in ensuring safe medicines use for patients with impaired kidney function throughout the article.PMID:38646689 | DOI:10.7748/ns.2024.e12075 (Source: Nursing Standard)
Source: Nursing Standard - April 22, 2024 Category: Nursing Authors: Kathrine Parker Janette Chu Source Type: research
Comparison of skin cancer risk between renal transplant recipients and patients with glomerular diseases in rural Queensland
CONCLUSION: In patients with a high risk of NMSC, reducing skin cancer risk should be considered in conjunction with the optimisation of treatment.PMID:38646861 | DOI:10.1111/ajr.13081 (Source: The Australian Journal of Rural Health)
Source: The Australian Journal of Rural Health - April 22, 2024 Category: Rural Health Authors: Zaw Thet Alfred King-Yin Lam Shu-Kay Ng Soe Yu Aung Thin Han Dwarakanathan Ranganathan Stephanie Newsham Jennifer Borg Christine Pepito Tien K Khoo Source Type: research
Impaired kidney function: supporting the safe use of medicines for patients
This article provides an overview of the effects of impaired kidney function on pharmacokinetics and the importance of accurate drug dose adjustments for patients with related conditions. It also discusses various aspects of medicines use in patients with AKI, the pharmacological management of patients with CKD and the use of immunosuppressive therapy in patients who have had a kidney transplant. The authors consider the role of the nurse in ensuring safe medicines use for patients with impaired kidney function throughout the article.PMID:38646689 | DOI:10.7748/ns.2024.e12075 (Source: Nursing Standard)
Source: Nursing Standard - April 22, 2024 Category: Nursing Authors: Kathrine Parker Janette Chu Source Type: research
From the Clinical to the Bench: Exploring the Insulin Modulation Effects of Tacrolimus and Belatacept
This study investigates whether the observed effects on PTD stem solely from CNI withdrawal or if belatacept influences PTD independently. The study assessed the impact of tacrolimus and belatacept on insulin secretion in MIN6 cells (a beta cell line) and rat islets. Tacrolimus and belatacept were administered to the cells and islets, followed by assessments of cell viability and insulin secretion. Tacrolimus impaired insulin secretion without affecting cell viability, while belatacept showed no detrimental effects on either parameter. These findings support clinical observations of improved HbA1c upon switching from tacro...
Source: Cell Transplantation - April 22, 2024 Category: Cytology Authors: Quentin Perrier C écile Cottet-Rouselle Marine de-Beaumont Johan Noble Sandrine Lablanche Source Type: research
Comparison of skin cancer risk between renal transplant recipients and patients with glomerular diseases in rural Queensland
CONCLUSION: In patients with a high risk of NMSC, reducing skin cancer risk should be considered in conjunction with the optimisation of treatment.PMID:38646861 | DOI:10.1111/ajr.13081 (Source: The Australian Journal of Rural Health)
Source: The Australian Journal of Rural Health - April 22, 2024 Category: Rural Health Authors: Zaw Thet Alfred King-Yin Lam Shu-Kay Ng Soe Yu Aung Thin Han Dwarakanathan Ranganathan Stephanie Newsham Jennifer Borg Christine Pepito Tien K Khoo Source Type: research
Drug-drug interaction between tacrolimus and caspofungin in Chinese kidney transplant patients with different < em > CYP3A5 < /em > genotypes
CONCLUSION: Co-administration of caspofungin reduced tacrolimus blood levels and elevated the required daily dose of tacrolimus. In CYP3A5 non-expressers, co-administration of caspofungin had a significant effect on tacrolimus C0/D values. An approximate 10% increase in the weight-adjusted daily dose of tacrolimus in CYP3A5 non-expressers is recommended to ensure the safety of tacrolimus administration.PMID:38646424 | PMC:PMC11027596 | DOI:10.1177/20420986241243165 (Source: Adv Data)
Source: Adv Data - April 22, 2024 Category: Epidemiology Authors: Yundi Zhang Bowen Shen Yue Li Huiying Zong Xiaoming Zhang Xiaohong Cao Fengxi Liu Yan Li Source Type: research
Impaired kidney function: supporting the safe use of medicines for patients
This article provides an overview of the effects of impaired kidney function on pharmacokinetics and the importance of accurate drug dose adjustments for patients with related conditions. It also discusses various aspects of medicines use in patients with AKI, the pharmacological management of patients with CKD and the use of immunosuppressive therapy in patients who have had a kidney transplant. The authors consider the role of the nurse in ensuring safe medicines use for patients with impaired kidney function throughout the article.PMID:38646689 | DOI:10.7748/ns.2024.e12075 (Source: Nursing Standard)
Source: Nursing Standard - April 22, 2024 Category: Nursing Authors: Kathrine Parker Janette Chu Source Type: research
Toupet fundoplication to prevent progression of scleroderma-associated interstitial lung damage: a study protocol
ConclusionsThe expected reduction of reflux burden in SSc patients selected for Toupet fundoplication may improve GERD symptoms/complications, pulmonary function, and quality of life, and may be associated with a reduced risk for lung transplant. (Source: European Surgery)
Source: European Surgery - April 22, 2024 Category: Surgery Source Type: research
Spectrum of chronic lung allograft dysfunction pathology in human lung transplantation
Long-term survival after lung transplantation (LTx) remains limited by Chronic Lung Allograft Dysfunction (CLAD), which includes two main phenotypes: bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS), with possible overlap. We aimed to detail and quantify pathological features of these CLAD sub-types. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 22, 2024 Category: Transplant Surgery Authors: Benjamin Renaud-Picard, Gregory Berra, David Hwang, Ella Huszti, Ei Miyamoto, Gerald J Berry, Prodipto Pal, Stephen Juvet, Shaf Keshavjee, Tereza Martinu Tags: Original Clinical Science Source Type: research
Evolving Applications of Echocardiography in the Evaluation of Left Atrial and Right Ventricular Strain
AbstractPurpose of ReviewSpeckle-tracking echocardiography (STE) can assess myocardial motion in non-LV chambers —including assessment of left atrial (LA) and right ventricular (RV) strain. This review seeks to highlight the diagnostic, prognostic, and clinical significance of these parameters in heart failure, atrial fibrillation (AF), diastolic dysfunction, pulmonary hypertension (PH), tricuspid regurgitat ion, and heart transplant recipients.Recent FindingsImpaired LA strain reflects worse LV diastolic function in individuals with and without HF, and this is associated with decreased exercise capacity. Initiating trea...
Source: Current Cardiology Reports - April 22, 2024 Category: Cardiology Source Type: research
Role of nutritional therapy on dietary habits and glycemic control in insulin-treated kidney transplant patients with diabetes
To evaluate the effect of nutritional therapy on glycemic compensation and key cardio-renal risk markers in patients with diabetes and kidney transplant, on insulin treatment by Multiple Daily Injection (MDI) or Continuous Subcutaneous Insulin Infusion (CSII). (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 22, 2024 Category: Endocrinology Authors: G. Clemente, N. Della Pia, A. Bramanti, L. Cerbara, G. Russo, P. De Rosa, V. Marotta, A. Tortora, M. Riccio, M. Vitale Source Type: research
CD8+ T cell-mediated rejection of allogenic human induced pluripotent stem cell-derived cardiomyocyte sheets in human PBMC-transferred NOG MHC double knockout mice
Transplantation of human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) has emerged as a promising therapy to treat end-stage heart failure. However, immunogenicity of hiPS-CMs in transplanted patients has not been fully elucidated. Thus, in vivo models are required to estimate immune responses against hiPS-CMs in transplant recipients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 22, 2024 Category: Transplant Surgery Authors: Ryu Matsumoto, Yin Enzhi, Kazuyoshi Takeda, Kodai Morimoto, Kyoko Yogo, Masaki Harada, Koji Tokushige, Yui Maehara, Saori Hirota, Yuko Kojima, Mamoru Ito, Nagako Sougawa, Shigeru Miyagawa, Yoshiki Sawa, Ko Okumura, Koichiro Uchida Tags: Original Translational Science Source Type: research
Fetal Echocardiographic Evaluation of Tricuspid Valve and Right Ventricular Function Including Global Longitudinal Strain in Hypoplastic Left Heart Syndrome and Association with Postnatal Outcomes
AbstractDespite significant advancements in the care of patients with hypoplastic left heart syndrome (HLHS) morbidity and mortality remain high. Postnatal right ventricular dysfunction and tricuspid regurgitation (TR) are associated with worse outcomes in HLHS. We aim to determine if right ventricle functional parameters and TR on fetal echocardiogram are associated with postnatal outcomes in HLHS patients. Retrospective review was performed on all fetuses with HLHS from 2014 to 2022 at our institution. Initial and follow up fetal echocardiogram measurements of right ventricular myocardial performance index (MPI), fractio...
Source: Mammalian Genome - April 22, 2024 Category: Genetics & Stem Cells Source Type: research
Donor Lung Preservation at 10 °C: Clinical and Logistical Impact
CONCLUSIONS: Preservation at 10°C may represent a safe and feasible strategy to intentionally prolong the CIT. In our center, extending the CIT at 10°C may allow for semi-elective LTx and improve logistics with similar outcomes compared to the current standard preservation on ice.PMID:38644153 | DOI:10.1016/j.arbres.2024.03.021 (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - April 21, 2024 Category: Respiratory Medicine Authors: Mariana Gil Barturen Rosal ía Laporta Hernández Antonio Romero Berrocal Marina P érez Redondo Natalia G ómez Lozano Javier Mart ín López Ana Royuela Vicente Alejandra Romero Rom án Lucas Hoyos Mej ía Silvana Crowley Carrasco David G ómez de Anton Source Type: research
Donor Lung Preservation at 10 °C: Clinical and Logistical Impact
CONCLUSIONS: Preservation at 10°C may represent a safe and feasible strategy to intentionally prolong the CIT. In our center, extending the CIT at 10°C may allow for semi-elective LTx and improve logistics with similar outcomes compared to the current standard preservation on ice.PMID:38644153 | DOI:10.1016/j.arbres.2024.03.021 (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - April 21, 2024 Category: Respiratory Medicine Authors: Mariana Gil Barturen Rosal ía Laporta Hernández Antonio Romero Berrocal Marina P érez Redondo Natalia G ómez Lozano Javier Mart ín López Ana Royuela Vicente Alejandra Romero Rom án Lucas Hoyos Mej ía Silvana Crowley Carrasco David G ómez de Anton Source Type: research
