Apixaban in bridge to transplant and destination LVAD ‐ rationale and study design: the ApixiVAD trial
ConclusionsA positive outcome in the ApixiVAD study would provide the basis for future, larger, pivotal anticoagulation trials in LVAD patients. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 23, 2024 Category: Cardiology Authors: Bruno Schnegg,
Ricardo Deveza,
Christopher Hayward Tags: Study Design Source Type: research
Cardiopulmonary Resuscitation Outcomes and Trainee Perception of Code Status Discussions in Patients with Cirrhosis
ConclusionsWe identified significant trainee uncertainty about outcomes in patients with cirrhosis. These deficits improved after an educational intervention and gave providers more confidence in holding informed code status conversations with patients with cirrhosis, a population that faces barriers to adequate code discussions. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 23, 2024 Category: Gastroenterology Source Type: research
Improvement in right heart function following kidney transplantation in esrd patients: insights from speckle tracking echocardiography analysis
This study aimed to evaluate the effects of KTx on the right heart chambers in ESRD patients. 57 adult KTx candidates were enrolled in this prospective longitudinal study, while 49 of them were included in the final assessment. Patients underwent a comprehensive cardiac assessment, including conventional echocardiography, speckle tracking echocardiography, and three-dimensional heart modeling both before and after surgery. Echocardiographic assessments showed significant increases in right ventricular (RV) ejection fraction, RV fractional area change (RVFAC), tricuspid annular plain systolic excursion, RV fractional shorte...
Source: The International Journal of Cardiovascular Imaging - April 23, 2024 Category: Radiology Source Type: research
Toupet fundoplication to prevent progression of scleroderma-associated interstitial lung damage: a study protocol
ConclusionsThe expected reduction of reflux burden in SSc patients selected for Toupet fundoplication may improve GERD symptoms/complications, pulmonary function, and quality of life, and may be associated with a reduced risk for lung transplant. (Source: European Surgery)
Source: European Surgery - April 22, 2024 Category: Surgery Source Type: research
Spectrum of chronic lung allograft dysfunction pathology in human lung transplantation
Long-term survival after lung transplantation (LTx) remains limited by Chronic Lung Allograft Dysfunction (CLAD), which includes two main phenotypes: bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS), with possible overlap. We aimed to detail and quantify pathological features of these CLAD sub-types. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 22, 2024 Category: Transplant Surgery Authors: Benjamin Renaud-Picard, Gregory Berra, David Hwang, Ella Huszti, Ei Miyamoto, Gerald J Berry, Prodipto Pal, Stephen Juvet, Shaf Keshavjee, Tereza Martinu Tags: Original Clinical Science Source Type: research
Evolving Applications of Echocardiography in the Evaluation of Left Atrial and Right Ventricular Strain
AbstractPurpose of ReviewSpeckle-tracking echocardiography (STE) can assess myocardial motion in non-LV chambers —including assessment of left atrial (LA) and right ventricular (RV) strain. This review seeks to highlight the diagnostic, prognostic, and clinical significance of these parameters in heart failure, atrial fibrillation (AF), diastolic dysfunction, pulmonary hypertension (PH), tricuspid regurgitat ion, and heart transplant recipients.Recent FindingsImpaired LA strain reflects worse LV diastolic function in individuals with and without HF, and this is associated with decreased exercise capacity. Initiating trea...
Source: Current Cardiology Reports - April 22, 2024 Category: Cardiology Source Type: research
Role of nutritional therapy on dietary habits and glycemic control in insulin-treated kidney transplant patients with diabetes
To evaluate the effect of nutritional therapy on glycemic compensation and key cardio-renal risk markers in patients with diabetes and kidney transplant, on insulin treatment by Multiple Daily Injection (MDI) or Continuous Subcutaneous Insulin Infusion (CSII). (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 22, 2024 Category: Endocrinology Authors: G. Clemente, N. Della Pia, A. Bramanti, L. Cerbara, G. Russo, P. De Rosa, V. Marotta, A. Tortora, M. Riccio, M. Vitale Source Type: research
CD8+ T cell-mediated rejection of allogenic human induced pluripotent stem cell-derived cardiomyocyte sheets in human PBMC-transferred NOG MHC double knockout mice
Transplantation of human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) has emerged as a promising therapy to treat end-stage heart failure. However, immunogenicity of hiPS-CMs in transplanted patients has not been fully elucidated. Thus, in vivo models are required to estimate immune responses against hiPS-CMs in transplant recipients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 22, 2024 Category: Transplant Surgery Authors: Ryu Matsumoto, Yin Enzhi, Kazuyoshi Takeda, Kodai Morimoto, Kyoko Yogo, Masaki Harada, Koji Tokushige, Yui Maehara, Saori Hirota, Yuko Kojima, Mamoru Ito, Nagako Sougawa, Shigeru Miyagawa, Yoshiki Sawa, Ko Okumura, Koichiro Uchida Tags: Original Translational Science Source Type: research
Fetal Echocardiographic Evaluation of Tricuspid Valve and Right Ventricular Function Including Global Longitudinal Strain in Hypoplastic Left Heart Syndrome and Association with Postnatal Outcomes
AbstractDespite significant advancements in the care of patients with hypoplastic left heart syndrome (HLHS) morbidity and mortality remain high. Postnatal right ventricular dysfunction and tricuspid regurgitation (TR) are associated with worse outcomes in HLHS. We aim to determine if right ventricle functional parameters and TR on fetal echocardiogram are associated with postnatal outcomes in HLHS patients. Retrospective review was performed on all fetuses with HLHS from 2014 to 2022 at our institution. Initial and follow up fetal echocardiogram measurements of right ventricular myocardial performance index (MPI), fractio...
Source: Mammalian Genome - April 22, 2024 Category: Genetics & Stem Cells Source Type: research
Risk factors and prediction score for new ‐onset diabetes mellitus after liver transplantation
ConclusionsAge at the time of transplantation, preoperative IFG, postoperative FPG, and length of hospital stay were independent predictive factors of NODALT. The use of a simple risk prediction score can identify the patients who have the highest risk of NODALT and interventions may start early. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 20, 2024 Category: Endocrinology Authors: Ruiping Bai,
Rui An,
Siyu Chen,
Wenkang Ding,
Mengwen Xue,
Ge Zhao,
Qingyong Ma,
Xin Shen Tags: Original Article Source Type: research
Feasibility of an animal model for long-term mechanical circulatory support with Impella 5.5 implanted through carotid artery access in sheep
This study aimed to evaluate the feasibility of an animal model for long-term support with Impella 5.5 implanted through carotid artery access in sheep.Impella 5.5 was implanted in four sheep through the proximal region of the left carotid artery without a thoracotomy, and myocardial injuries were induced by coronary microembolization. Support by Impella 5.5 was maintained for 4 weeks, and the animals were observed. The position of Impella 5.5 and cardiac function was evaluated using cardiac computer tomography at 2 and 4 weeks after implantation.All four animals completed the 4-week study without major complications. The ...
Source: Journal of Artificial Organs - April 20, 2024 Category: Transplant Surgery Source Type: research
Use of a donor kidney with known autosomal dominant polycystic kidney disease in a highly sensitised paediatric recipient
We report the use of an autosomal-dominant polycystic kidney disease (ADPKD) donor kidney in a paediatric recipient. A 14-year-old boy on haemodialysis for 4 years following loss of a first kidney transplant, highly sensitised, and with limited vascular options for ongoing dialysis access, was offered a deceased brain death donor transplant from a mid-30s donor with known ADPKD but normal kidney function and negligible proteinuria. After extensive discussion with the patient and family, discussing all alternative options and review of available literature, the kidney was accepted and implanted. Graft function was immediate...
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Optimizing Palliative Medicine Support for Liver Transplant Candidates
1. Participants will be able to identify how a quality approach can be successfully used to improve access to palliative medicine for liver transplant candidates.2. Participants will be able to define methods which can be employed to improve collaboration between teams and alleviate quality gaps among unique patient populations. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Richard Guthrie, Rolland Dickson, David M H Chascsa, Matthew Martin, Beth Perry, Sue Weinhold, Kathleen Minner Source Type: research
Development and validation of a novel nomogram model for predicting delayed graft function in deceased donor kidney transplantation based on pre-transplant biopsies
Delayed graft function (DGF) is an important complication after kidney transplantation surgery. The present study aimed to develop and validate a nomogram for preoperative prediction of DGF on the basis of cli... (Source: BMC Nephrology)
Source: BMC Nephrology - April 19, 2024 Category: Urology & Nephrology Authors: Meihe Li, Xiaojun Hu, Yang Li, Guozhen Chen, Chen-guang Ding, Xiaohui Tian, Puxun Tian, Heli Xiang, Xiaoming Pan, Xiaoming Ding, Wujun Xue, Jin Zheng and Chenguang Ding Tags: Research Source Type: research
Trends, Outcomes, and Evaluation of the Older Living Kidney Donor
AbstractPurpose of ReviewWe aim to review trends, donor and recipient outcomes, and considerations in the evaluation of older living kidney donors (LD).Recent FindingsOlder donors comprise a small but growing proportion of LDs. Aging is associated with nephrosclerosis, nephron loss, and a physiologic decline in kidney function. Importantly, living donor outcomes are favorable, with older LDs having similar mortality to age-matched healthy older non-donors, a lower lifetime risk of ESKD than younger LDs, and preserved quality of life. Allograft survival of LDKT from older LDs is also acceptable, and recipient survival is be...
Source: Current Transplantation Reports - April 19, 2024 Category: Transplant Surgery Source Type: research
