Early recovery of natural killer cells post T-cell depleted allogeneic stem cell transplantation using alemtuzumab "in the bag"
CONCLUSION: This study of ex vivo T-cell depleted SCT's demonstrates that NK cells recover quicker when compared to those receiving unfractionated grafts. These results may have implications for GvHD and the GvL effect which warrants further study.PMID:38641148 | DOI:10.1016/j.trim.2024.102045 (Source: Transplant Immunology)
Source: Transplant Immunology - April 19, 2024 Category: Transplant Surgery Authors: Glenda M Davison Jessica J Opie Saarah F G Davids Rygana Mohammed Nicolas Novitzky Source Type: research
Borderline rejection: To treat or not to treat?
CONCLUSION: Our preliminary study supports the indication for the treatment of acute borderline TCMR only in cases with biopsies confirmed by clinical indication.PMID:38641147 | DOI:10.1016/j.trim.2024.102047 (Source: Transplant Immunology)
Source: Transplant Immunology - April 19, 2024 Category: Transplant Surgery Authors: Alessandra Palmisano Marta D'Angelo Ilaria Gandolfini Marco Delsante Giovanni Maria Rossi Micaela Gentile Enrico Fiaccadori Paolo Cravedi Umberto Maggiore Source Type: research
Early recovery of natural killer cells post T-cell depleted allogeneic stem cell transplantation using alemtuzumab "in the bag"
CONCLUSION: This study of ex vivo T-cell depleted SCT's demonstrates that NK cells recover quicker when compared to those receiving unfractionated grafts. These results may have implications for GvHD and the GvL effect which warrants further study.PMID:38641148 | DOI:10.1016/j.trim.2024.102045 (Source: Transplant Immunology)
Source: Transplant Immunology - April 19, 2024 Category: Transplant Surgery Authors: Glenda M Davison Jessica J Opie Saarah F G Davids Rygana Mohammed Nicolas Novitzky Source Type: research
Beyond prevention: Unveiling the benefits of triple vaccination on COVID-19 severity and resource utilization in solid organ transplant recipients
CONCLUSION: In solid organ transplant recipients with COVID-19, triple vaccination, but not double vaccination, against SARS-CoV-2 was associated with significantly less hospital resource utilization, decreased disease severity, and fewer short-term complications. These real-world data from extensively matched controls support the protective effects of COVID-19 vaccination with boosters in this vulnerable population.PMID:38641149 | DOI:10.1016/j.trim.2024.102048 (Source: Transplant Immunology)
Source: Transplant Immunology - April 19, 2024 Category: Transplant Surgery Authors: Jared R Zhang John C Johnson Richard G Preble Muhammad Mujtaba A Scott Lea Heather L Stevenson Michael Kueht Source Type: research
Borderline rejection: To treat or not to treat?
CONCLUSION: Our preliminary study supports the indication for the treatment of acute borderline TCMR only in cases with biopsies confirmed by clinical indication.PMID:38641147 | DOI:10.1016/j.trim.2024.102047 (Source: Transplant Immunology)
Source: Transplant Immunology - April 19, 2024 Category: Transplant Surgery Authors: Alessandra Palmisano Marta D'Angelo Ilaria Gandolfini Marco Delsante Giovanni Maria Rossi Micaela Gentile Enrico Fiaccadori Paolo Cravedi Umberto Maggiore Source Type: research
De novo IgA nephropathy in a kidney transplant recipient after SARS-CoV-2 vaccination
Nefrologia (Engl Ed). 2024 Apr 18:S2013-2514(24)00070-1. doi: 10.1016/j.nefroe.2024.03.012. Online ahead of print.NO ABSTRACTPMID:38641488 | DOI:10.1016/j.nefroe.2024.03.012 (Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia)
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - April 19, 2024 Category: Urology & Nephrology Authors: M Alonso F Villanego Ó Segurado L A Vigara C Orellana T Garc ía A Mazuecos Source Type: research
Antiplatelet agent for the prevention of late hepatic vascular complications in living donor liver transplant dominant population
CONCLUSION: We recommend against antiplatelet therapy for more than 1 year in clinically stable LT recipients.PMID:38641537 | DOI:10.1016/j.asjsur.2024.04.002 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 19, 2024 Category: Surgery Authors: Deok-Gie Kim Sung Hwa Kim Jun Young Lee Jae Geun Lee Source Type: research
Early utilization of Ruxolitinib in acute graft-versus-Host Disease after liver transplant
Asian J Surg. 2024 Apr 18:S1015-9584(24)00655-9. doi: 10.1016/j.asjsur.2024.04.023. Online ahead of print.NO ABSTRACTPMID:38641533 | DOI:10.1016/j.asjsur.2024.04.023 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 19, 2024 Category: Surgery Authors: Siqi Qiu Xingjie Li Yongbing Qian Kang He Source Type: research
Optimizing Palliative Medicine Support for Liver Transplant Candidates
1. Participants will be able to identify how a quality approach can be successfully used to improve access to palliative medicine for liver transplant candidates.2. Participants will be able to define methods which can be employed to improve collaboration between teams and alleviate quality gaps among unique patient populations. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Richard Guthrie, Rolland Dickson, David M H Chascsa, Matthew Martin, Beth Perry, Sue Weinhold, Kathleen Minner Source Type: research
Development and validation of a novel nomogram model for predicting delayed graft function in deceased donor kidney transplantation based on pre-transplant biopsies
Delayed graft function (DGF) is an important complication after kidney transplantation surgery. The present study aimed to develop and validate a nomogram for preoperative prediction of DGF on the basis of cli... (Source: BMC Nephrology)
Source: BMC Nephrology - April 19, 2024 Category: Urology & Nephrology Authors: Meihe Li, Xiaojun Hu, Yang Li, Guozhen Chen, Chen-guang Ding, Xiaohui Tian, Puxun Tian, Heli Xiang, Xiaoming Pan, Xiaoming Ding, Wujun Xue, Jin Zheng and Chenguang Ding Tags: Research Source Type: research
Trends, Outcomes, and Evaluation of the Older Living Kidney Donor
AbstractPurpose of ReviewWe aim to review trends, donor and recipient outcomes, and considerations in the evaluation of older living kidney donors (LD).Recent FindingsOlder donors comprise a small but growing proportion of LDs. Aging is associated with nephrosclerosis, nephron loss, and a physiologic decline in kidney function. Importantly, living donor outcomes are favorable, with older LDs having similar mortality to age-matched healthy older non-donors, a lower lifetime risk of ESKD than younger LDs, and preserved quality of life. Allograft survival of LDKT from older LDs is also acceptable, and recipient survival is be...
Source: Current Transplantation Reports - April 19, 2024 Category: Transplant Surgery Source Type: research
The Role of Ultrasound in the Diagnosis and Treatment of Meniscal Injuries
AbstractPurpose of ReviewThis review evaluates the current understanding of the role of ultrasound in the diagnosis and treatment of meniscal disorders.Recent FindingsUltrasound (US) demonstrates similar sensitivity and specificity when compared to magnetic resonance imaging in the evaluation of meniscal injuries when compared to arthroscopy. Meniscal extrusion (ME) under US can be a reliable metric to evaluate for meniscal root tears in knees with and without osteoarthritis (OA). Sonographic ME is associated with development of OA in knees without OA. US following allograft meniscal transplant may be useful in predicting ...
Source: Current Reviews in Musculoskeletal Medicine - April 19, 2024 Category: Orthopaedics Source Type: research
Randomized clinical trial of non-antibiotic prophylaxis with d-Mannose plus Proanthocyanidins vs. Proanthocyanidins alone for urinary tract infections and asymptomatic bacteriuria in de novo kidney transplant recipients: The Manotras study
CONCLUSIONS: Non-antibiotic therapy is an unmet need to prevent UTI after kidney transplantation; however, the use of d-Mannose plus PAC does not seem capable to prevent it.PMID:38637262 | DOI:10.1016/j.nefroe.2024.02.011 (Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia)
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - April 18, 2024 Category: Urology & Nephrology Authors: Melissa Rau Adrian Santelli Sara Mart í Mar ía Isabel Díaz Nuria Sab é Mar ía Fiol Luis Riera Bego ña Etcheverry Sergi Codina Ana Coloma Anna Carreras-Salinas Carmen Ardanuy Josep M Cruzado Edoardo Melilli Source Type: research
The association of socioeconomic status on kidney transplant access and outcomes: a nationwide cohort study in Taiwan
CONCLUSION: A relevant disparity exists in accessing kidney transplantation in Taiwan, depending on individual and neighborhood socioeconomic status. However, results post transplantation were not different after five years. Improved access to waitlisting, education, and welfare support may reduce disparities.PMID:38635122 | DOI:10.1007/s40620-024-01928-5 (Source: Journal of Nephrology)
Source: Journal of Nephrology - April 18, 2024 Category: Urology & Nephrology Authors: Tung-Ling Chung Nai-Ching Chen Chun-Hao Yin Ching-Chih Lee Chien-Liang Chen Source Type: research
A Prognostic Survival Model Incorporating Patient-Reported Outcomes for Transplant-Ineligible Patients With Multiple Myeloma
Oncologist. 2024 Apr 18:oyae041. doi: 10.1093/oncolo/oyae041. Online ahead of print.ABSTRACTDeveloping prognostic tools specifically for patients themselves represents an important step in empowering patients to engage in shared decision-making. Incorporating patient-reported outcomes may improve the accuracy of these prognostic tools. We conducted a retrospective population-based study of transplant-ineligible (TIE) patients with multiple myeloma (MM) diagnosed between January 2007 and December 2018. A multivariable Cox regression model was developed to predict the risk of death within 1-year period from the index date. W...
Source: The Oncologist - April 18, 2024 Category: Cancer & Oncology Authors: Hira Mian Hsien Seow Amaris K Balitsky Matthew C Cheung Anastasia Gayowsky Jason Tay Tanya M Wildes Arleigh McCurdy Alissa Visram Irwindeep Sandhu Rinku Sutradhar Source Type: research
