Design, cohort profile and comparison of the KTD-Innov study: a prospective multidimensional biomarker validation study in kidney allograft rejection
AbstractThere is an unmet need for robust and clinically validated biomarkers of kidney allograft rejection. Here we present the KTD-Innov study (ClinicalTrials.gov, NCT03582436), an unselected deeply phenotyped cohort of kidney transplant recipients with a holistic approach to validate the clinical utility of precision diagnostic biomarkers. In 2018–2019, we prospectively enrolled consecutive adult patients who received a kidney allogr aft at seven French centers and followed them for a year. We performed multimodal phenotyping at follow-up visits, by collecting clinical, biological, immunological, and histological p...
Source: European Journal of Epidemiology - April 16, 2024 Category: Epidemiology Source Type: research
Genes, Vol. 15, Pages 497: Association of CYP3A4-392A/G, CYP3A5-6986A/G, and ABCB1-3435C/T Polymorphisms with Tacrolimus Dose, Serum Concentration, and Biochemical Parameters in Mexican Patients with Kidney Transplant
Conclusion: The findings of this study of the Mexican population showed that CYP3A5-6986 A/G GG genotype is associated with a four-fold increase in the likelihood of encountering a TAC concentration of more than 15 ng/dL. The co-occurrence of the CYP3A5-6986GG genotype and the use of drugs that increase TAC concentration correlates with a nine-fold increased risk of experiencing a TAC at a level above 15 ng/mL. Therefore, these patients have an increased susceptibility to TAC-associated toxicity. (Source: Genes)
Source: Genes - April 16, 2024 Category: Genetics & Stem Cells Authors: Edith Viridiana Alatorre-Moreno Ana Miriam Salda ña-Cruz Edsa úl Emilio Pérez-Guerrero Mar ía Cristina Morán-Moguel Betsab é Contreras-Haro David Alejandro L ópez-de La Mora Ingrid Patricia D ávalos-Rodríguez Alejandro Mar ín-Medina Alicia River Tags: Article Source Type: research
Outcomes of oncological intended thoracic surgery after lung transplantation
CONCLUSIONS: Incidence of lung cancer is increased after LT. Follow-up care allows early diagnosis with a comparably high share of operable tumor stage. Cancer as well as postoperative complications were more likely after single lung transplantation (SLT). Postoperative morbidity and mortality are higher in this scarce group of patients and hence, warrants a centered and experienced interdisciplinary approach.PMID:38617760 | PMC:PMC11009586 | DOI:10.21037/jtd-23-1669 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Armin Frille Johannes Broschewitz Isabella Bettine Metelmann Matthias Steinert Maximilian von Laffert Hubert Wirtz Alexandra Wald Sebastian Kraemer Source Type: research
Inquilinus limosus, an atypical Gram-negative rod from lung transplant recipients and cystic fibrosis patients
Ann Biol Clin (Paris). 2024 Apr 1;82(2):1-2. doi: 10.1684/abc.2024.1876. Online ahead of print.NO ABSTRACTPMID:38616576 | DOI:10.1684/abc.2024.1876 (Source: Annales de Biologie Clinique)
Source: Annales de Biologie Clinique - April 15, 2024 Category: Biochemistry Authors: Eric Farfour St éphane Corvec Thomas Guillard H élène Revillet Source Type: research
Outcomes of oncological intended thoracic surgery after lung transplantation
CONCLUSIONS: Incidence of lung cancer is increased after LT. Follow-up care allows early diagnosis with a comparably high share of operable tumor stage. Cancer as well as postoperative complications were more likely after single lung transplantation (SLT). Postoperative morbidity and mortality are higher in this scarce group of patients and hence, warrants a centered and experienced interdisciplinary approach.PMID:38617760 | PMC:PMC11009586 | DOI:10.21037/jtd-23-1669 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Armin Frille Johannes Broschewitz Isabella Bettine Metelmann Matthias Steinert Maximilian von Laffert Hubert Wirtz Alexandra Wald Sebastian Kraemer Source Type: research
Inquilinus limosus, an atypical Gram-negative rod from lung transplant recipients and cystic fibrosis patients
Ann Biol Clin (Paris). 2024 Apr 1;82(2):1-2. doi: 10.1684/abc.2024.1876. Online ahead of print.NO ABSTRACTPMID:38616576 | DOI:10.1684/abc.2024.1876 (Source: Annales de Biologie Clinique)
Source: Annales de Biologie Clinique - April 15, 2024 Category: Biochemistry Authors: Eric Farfour St éphane Corvec Thomas Guillard H élène Revillet Source Type: research
Do medical devices contribute to sustainability? The role of innovative polymers and device design
Int J Artif Organs. 2024 Apr 15:3913988241245013. doi: 10.1177/03913988241245013. Online ahead of print.ABSTRACTSustainability of a medical device has not yet become a major issue in public discussions compared to other topics with impact to material performance, clinical application, production economy and environmental pollution. Due to their unique properties, polymers (plastics) allow for multiple, flexible applications in medical device technology. Polymers are part of the majority of disposable and single use medical device and contribute with 3% to the worldwide production of plastics. The global medical polymer mar...
Source: The International Journal of Artificial Organs - April 15, 2024 Category: Transplant Surgery Authors: J örg Vienken Carlo Boccato Source Type: research
Outcomes of oncological intended thoracic surgery after lung transplantation
CONCLUSIONS: Incidence of lung cancer is increased after LT. Follow-up care allows early diagnosis with a comparably high share of operable tumor stage. Cancer as well as postoperative complications were more likely after single lung transplantation (SLT). Postoperative morbidity and mortality are higher in this scarce group of patients and hence, warrants a centered and experienced interdisciplinary approach.PMID:38617760 | PMC:PMC11009586 | DOI:10.21037/jtd-23-1669 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Armin Frille Johannes Broschewitz Isabella Bettine Metelmann Matthias Steinert Maximilian von Laffert Hubert Wirtz Alexandra Wald Sebastian Kraemer Source Type: research
