Genes, Vol. 15, Pages 497: Association of CYP3A4-392A/G, CYP3A5-6986A/G, and ABCB1-3435C/T Polymorphisms with Tacrolimus Dose, Serum Concentration, and Biochemical Parameters in Mexican Patients with Kidney Transplant

Conclusion: The findings of this study of the Mexican population showed that CYP3A5-6986 A/G GG genotype is associated with a four-fold increase in the likelihood of encountering a TAC concentration of more than 15 ng/dL. The co-occurrence of the CYP3A5-6986GG genotype and the use of drugs that increase TAC concentration correlates with a nine-fold increased risk of experiencing a TAC at a level above 15 ng/mL. Therefore, these patients have an increased susceptibility to TAC-associated toxicity.

Source: Genes - April 16, 2024 Category: Genetics & Stem Cells Authors: Edith Viridiana Alatorre-Moreno Ana Miriam Salda ña-Cruz Edsa úl Emilio Pérez-Guerrero Mar ía Cristina Morán-Moguel Betsab é Contreras-Haro David Alejandro L ópez-de La Mora Ingrid Patricia D ávalos-Rodríguez Alejandro Mar ín-Medina Alicia River Tags: Article Source Type: research