Impact of renal replacement therapies on olfactory ability: results of a cross-sectional case control study
J Nephrol. 2021 Feb 24. doi: 10.1007/s40620-021-00983-6. Online ahead of print.ABSTRACTINTRODUCTION: Several studies have suggested that chronic kidney disease (CKD) may be associated with olfactory impairment. However, to date, the impact of renal replacement therapies has only been partly defined.METHODS: We tested the olfactory function of 235 participants [50 kidney transplant recipients (KT), 49 hemodialyzed patients (HD), 30 peritoneal dialysis patients (PD), 51 patients with CKD not on dialysis (ND-CKD) and 55 healthy subjects (HS)] by the Sniffin' Sticks test (Burghardt®, Wedel, Germany), including the sub-test...
Source: Journal of Nephrology - February 24, 2021 Category: Urology & Nephrology Authors: Valentina Iacono Gianmarco Lombardi Giancarlo Ottaviano Giovanni Gambaro Gianluigi Zaza Source Type: research

Correction to: Citrate high volume on-line hemodiafiltration modulates serum Interleukin-6 and Klotho levels: the multicenter randomized controlled study "Hephaestus"
J Nephrol. 2021 Feb 24. doi: 10.1007/s40620-021-01009-x. Online ahead of print.NO ABSTRACTPMID:33625693 | DOI:10.1007/s40620-021-01009-x (Source: Journal of Nephrology)
Source: Journal of Nephrology - February 24, 2021 Category: Urology & Nephrology Authors: Francesco Pizzarelli Vincenzo Cantaluppi Vincenzo Panichi Alessandro Toccafondi Giuseppe Ferro Serena Farruggio Elena Grossini Pietro Claudio Dattolo Vincenzo Miniello Massimiliano Migliori Cristina Grimaldi Aldo Casani Maurizio Borzumati Stefano Cusinato Source Type: research

Immune-mediated thrombotic thrombocytopenic purpura in childhood treated by caplacizumab, about 3 cases
We report our experience in three children who were treated successfully with caplacizumab.PMID:33616856 | DOI:10.1007/s40620-021-00992-5 (Source: Journal of Nephrology)
Source: Journal of Nephrology - February 22, 2021 Category: Urology & Nephrology Authors: Julie Boudali Benjamin Hallak Marie Haeck Anne-Laure Sellier-Leclerc Marc Ulrich Paul Coppo St éphanie Tellier Fran çois Provôt Source Type: research

Frequency of tooth brushing as a predictive factor for future kidney function decline
J Nephrol. 2021 Feb 22. doi: 10.1007/s40620-021-00987-2. Online ahead of print.ABSTRACTBACKGROUND: Tooth brushing is important for maintaining oral health and preventing periodontal diseases (PDs), which commonly arise in patients with chronic kidney disease (CKD). However, the association between tooth brushing frequency and kidney function decline remains unclear.METHODS: We conducted a retrospective longitudinal study at St Luke's International Hospital, Japan, and participants who underwent health examinations at the Centre for Preventive Medicine from 2005 to 2011 were included. Participants' tooth brushing frequencie...
Source: Journal of Nephrology - February 22, 2021 Category: Urology & Nephrology Authors: Keita Hirano Takuro Shimbo Yasuhiro Komatsu Daiki Kobayashi Source Type: research

Immune-mediated thrombotic thrombocytopenic purpura in childhood treated by caplacizumab, about 3 cases
We report our experience in three children who were treated successfully with caplacizumab.PMID:33616856 | DOI:10.1007/s40620-021-00992-5 (Source: Journal of Nephrology)
Source: Journal of Nephrology - February 22, 2021 Category: Urology & Nephrology Authors: Julie Boudali Benjamin Hallak Marie Haeck Anne-Laure Sellier-Leclerc Marc Ulrich Paul Coppo St éphanie Tellier Fran çois Provôt Source Type: research

Frequency of tooth brushing as a predictive factor for future kidney function decline
J Nephrol. 2021 Feb 22. doi: 10.1007/s40620-021-00987-2. Online ahead of print.ABSTRACTBACKGROUND: Tooth brushing is important for maintaining oral health and preventing periodontal diseases (PDs), which commonly arise in patients with chronic kidney disease (CKD). However, the association between tooth brushing frequency and kidney function decline remains unclear.METHODS: We conducted a retrospective longitudinal study at St Luke's International Hospital, Japan, and participants who underwent health examinations at the Centre for Preventive Medicine from 2005 to 2011 were included. Participants' tooth brushing frequencie...
Source: Journal of Nephrology - February 22, 2021 Category: Urology & Nephrology Authors: Keita Hirano Takuro Shimbo Yasuhiro Komatsu Daiki Kobayashi Source Type: research

Eculizumab use in a tertiary care nephrology center: data from the Vienna TMA cohort
CONCLUSIONS: In summary, eculizumab is the treatment of choice for cTMA patients that do not respond to plasma therapy. In patients with sTMA and C3G, the response rates to therapy are much lower and therefore, the decision to start therapy needs to be considered carefully.PMID:33599971 | DOI:10.1007/s40620-021-00981-8 (Source: Journal of Nephrology)
Source: Journal of Nephrology - February 18, 2021 Category: Urology & Nephrology Authors: Christof Aigner Martina Gaggl Gunar Stemer Michael Eder Georg B öhmig Renate Kain Zolt án Prohászka N óra Garam Dorottya Csuka Raute Sunder-Plassmann Leah Charlotte Piggott Natalja Haninger-Vacariu Alice Schmidt Gere Sunder-Plassmann Source Type: research

Presentation and outcome of chronic kidney disease in Italian and immigrant citizens: results from the Emilia-Romagna PIRP project
CONCLUSIONS: We found important differences between Italian and immigrant CKD patients, as well as among immigrant subgroups. First clinical encounters with nephrologists revealed that immigrants had varied patterns of clinical presentation and of nephropathy. During follow-up, immigrants showed faster kidney function decline which led to a higher risk of disease evolution and progression towards ESKD.PMID:33595822 | DOI:10.1007/s40620-021-00984-5 (Source: Journal of Nephrology)
Source: Journal of Nephrology - February 17, 2021 Category: Urology & Nephrology Authors: Dino Gibertoni Leonardo Mammana Giulia Gherardi Erica Baschieri Francesco Minora Antonio Santoro Source Type: research

Presentation and outcome of chronic kidney disease in Italian and immigrant citizens: results from the Emilia-Romagna PIRP project.
CONCLUSIONS: We found important differences between Italian and immigrant CKD patients, as well as among immigrant subgroups. First clinical encounters with nephrologists revealed that immigrants had varied patterns of clinical presentation and of nephropathy. During follow-up, immigrants showed faster kidney function decline which led to a higher risk of disease evolution and progression towards ESKD. PMID: 33595822 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - February 17, 2021 Category: Urology & Nephrology Authors: Gibertoni D, Mammana L, Gherardi G, Baschieri E, Minora F, Santoro A Tags: J Nephrol Source Type: research

Long-term safety and efficacy of hydroxychloroquine in patients with IgA nephropathy: a single-center experience.
Abstract BACKGROUND: Hydroxychloroquine (HCQ) has been used as a supportive therapy for IgA nephropathy (IgAN). We aimed to determine the long-term efficacy and safety of HCQ therapy in patients with IgAN. METHODS: A total of 180 patients with IgAN who had received HCQ therapy for at least 1 year were enrolled in this study. The changes in proteinuria and the estimated glomerular filtration rate (eGFR) were analyzed during the follow-up period. RESULTS: The level of proteinuria decreased from 1.69 [1.24, 2.30] to 1.01 [0.59, 1.74] g/day (- 37.58 [- 57.52, 8.24] %, P 
Source: Journal of Nephrology - February 16, 2021 Category: Urology & Nephrology Authors: Tang C, Lv JC, Shi SF, Chen YQ, Liu LJ, Zhang H Tags: J Nephrol Source Type: research

Dietary intake in adults on hemodialysis compared with guideline recommendations.
CONCLUSION: Patients on maintenance haemodialysis usually have a dietary intake which is inconsistent with current recommendations, especially for phosphate and potassium. PMID: 33591554 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - February 16, 2021 Category: Urology & Nephrology Authors: Saglimbene VM, Su G, Wong G, Natale P, Ruospo M, Palmer SC, Craig JC, Carrero JJ, Strippoli GFM Tags: J Nephrol Source Type: research

Association between serum phosphorus and mortality in NHANES 2003-2006: the effect of gender and renal function.
CONCLUSIONS: We demonstrated that the highest tercile of serum phosphorus is associated with increased all-cause mortality, irrespective of PTH, 25(OH)vitamin D or phosphorus intake. This association may differ by gender and renal function, but larger studies testing for effect modification are needed. PMID: 33580868 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - February 13, 2021 Category: Urology & Nephrology Authors: Mendonça L, Gonçalves F, Sampaio S, Castro-Chaves P, Pereira L Tags: J Nephrol Source Type: research

Hypertension and glomerular diseases: the importance of a holistic approach.
PMID: 33580456 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - February 12, 2021 Category: Urology & Nephrology Authors: Cravedi P, Leventhal JS, Piccoli GB Tags: J Nephrol Source Type: research

New predictive equations to estimate resting energy expenditure of non-dialysis dependent chronic kidney disease patients.
CONCLUSION: The equations showed acceptable accuracy for REE prediction making them a valuable tool to support practitioners to provide more reliable energy recommendations for this group of patients. PMID: 33575948 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - February 11, 2021 Category: Urology & Nephrology Authors: de Oliveira Fernandes T, Avesani CM, Aoike DT, Cuppari L Tags: J Nephrol Source Type: research

Renal thrombotic microangiopathy associated to worse renal prognosis in Lupus Nephritis.
The objective of this study was to evaluate the clinical and pathological aspects of patients with lupus and rTMA in kidney biopsy. METHODS: Analysis of medical reports and kidney biopsy of 253 patients with LN, between January 2012 and December 2018. RESULTS: Among our 253 patients, 43 (17%) showed acute or chronic TMA lesions on kidney histology This group had a significantly lower estimated glomerular filtration rate (eGFR) at the time of biopsy (24.1 vs. 64.15 ml/min/1.73m2, p 
Source: Journal of Nephrology - February 11, 2021 Category: Urology & Nephrology Authors: Strufaldi FL, Menezes Neves PDMM, Dias CB, Yu L, Woronik V, Cavalcante LB, Malheiros DMAC, Jorge LB Tags: J Nephrol Source Type: research

A brand new world: from cardiovascular diseases to aquaponics, focusing on challenges can bring new hope. An introduction to 2021 from Journal of Nephrology.
PMID: 33559849 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - February 9, 2021 Category: Urology & Nephrology Authors: Piccoli GB Tags: J Nephrol Source Type: research

Medication non-adherence in chronic kidney disease: a mixed-methods review and synthesis using the theoretical domains framework and the behavioural change wheel.
CONCLUSION: Medication non-adherence is common in adults with CKD, not on KRT and may lead to poor outcomes. Evidence synthesis using mixed study designs was crucial in identifying determinants of non-adherence, drawing on a parsimonious approach from behaviour science. PROSPERO REGISTRATION: CRD42020149983. PMID: 33559850 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - February 9, 2021 Category: Urology & Nephrology Authors: Tesfaye WH, Erku D, Mekonnen A, Tefera YG, Castelino R, Sud K, Thomas J, Obamiro K Tags: J Nephrol Source Type: research

Citrate high volume on-line hemodiafiltration modulates serum Interleukin-6 and Klotho levels: the multicenter randomized controlled study "Hephaestus".
CONCLUSIONS: Citrate buffer modulated IL-6, hsCRP and Klotho levels during high volume OL-HDF. These results are not attributable to differences in the dialysis schedule and may suggest a potential anti-inflammatory and anti-senescent effect of citrate even in dialysis patients with low grade inflammation. ClinicalTrials.gov identifier NCT02863016. PMID: 33559851 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - February 9, 2021 Category: Urology & Nephrology Authors: Pizzarelli F, Cantaluppi V, Panichi V, Toccafondi A, Ferro G, Farruggio S, Grossini E, Dattolo PC, Miniello V, Migliori M, Grimaldi C, Casani A, Borzumati M, Cusinato S, Capitanini A, Quercia A, Filiberti O, Dani L, Hephaestus study group Tags: J Nephrol Source Type: research

Body composition, adipokines, FGF23-Klotho and bone in kidney transplantation: Is there a link?
Abstract BACKGROUND: Kidney transplantation-associated mineral and bone disorder (KT-MBD) still represents a black box on the long-term due to scarce available data. We aimed to investigate the impact of non-classical bone regulating factors (body composition, adipokines, inflammatory markers, fibroblast growth factor 23-FGF23 and α-Klotho) in long-standing kidney transplant (KT) recipients compared to the general population. METHODS: Our cross-sectional study, enrolling 59 KT patients and age, sex and body mass index-matched healthy general population volunteers, assessed the predictive role of the bod...
Source: Journal of Nephrology - February 9, 2021 Category: Urology & Nephrology Authors: Matei A, Bilha SC, Constantinescu D, Pavel-Tanasa M, Cianga P, Covic A, Branisteanu DD Tags: J Nephrol Source Type: research

Tolvaptan-induced remission of primary palmar hyperhidrosis in a patient with ADPKD: a serendipitous finding.
Abstract A 37-year old man had suffered palmar hyperhidrosis since he was fifteen years old. In the last year, he has been treated with tolvaptan for autosomic polycystic kidney disease (ADPKD). The start of tolvaptan therapy was associated with a complete resolution of palmar hyperhidrosis and a sensation of relaxation. During the year on which the patient took tolvaptan, he had to suspend the drug twice. The suspension of tolvaptan was associated with the reappearance of palmar hyperhidrosis followed by sudden remission after the drug reintroduction. Palmar sweating also known as 'emotional sweating' is not rela...
Source: Journal of Nephrology - February 8, 2021 Category: Urology & Nephrology Authors: Cuka E, Vespa M, Joli G, Manunta P, Sciarrone Alibrandi TM Tags: J Nephrol Source Type: research

Feasibility and impact of carbon dioxide angiography on acute kidney injury following endovascular interventions in patients with peripheral artery disease and renal impairment.
CONCLUSION: CO2 is an applicable and safe alternative to iodinated contrast medium for endovascular revascularization in peripheral artery disease patients with concomitant CKD. Patients with CKD stage 4 or 5, being at highest risk for post-contrast AKI, should primarily be treated by CO2-guided endovascular revascularization. PMID: 33555574 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - February 8, 2021 Category: Urology & Nephrology Authors: Jakobi T, Meyborg M, Freisinger E, Gebauer K, Stella J, Engelbertz C, Reinecke H, Malyar NM Tags: J Nephrol Source Type: research

Systolic blood pressure and chronic kidney disease progression in patients with primary glomerular disease.
Abstract INTRODUCTION: Many current guidelines on optimal target blood pressure (BP) for chronic kidney disease (CKD) patients are largely based on studies in diabetic and hypertensive patients. However, there have been few studies in patients with glomerular diseases. METHODS: We retrospectively studied the longitudinal association between BP and CKD progression in 1,066 biopsy-proven patients diagnosed with primary glomerular diseases, including IgA nephropathy, membranous nephropathy (MN), and focal segmental glomerulosclerosis (FSGS), between 2005 and 2017. The main predictor was time-updated systoli...
Source: Journal of Nephrology - February 8, 2021 Category: Urology & Nephrology Authors: Kim HW, Park JT, Joo YS, Kang SC, Lee JY, Lee S, Chang TI, Kang EW, Ryu DR, Yoo TH, Chin HJ, Kang SW, Han SH, Korean GlomeruloNEphritis Study (KoGNET) Group Tags: J Nephrol Source Type: research

Lessons for the clinical nephrologist: acute kidney injury by a glyphosate-surfactant herbicide.
PMID: 33555576 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - February 8, 2021 Category: Urology & Nephrology Authors: Kimura T, Suzuki M, Yokoyama T, Kanetsuna Y, Tanemoto M Tags: J Nephrol Source Type: research

Osteitis fibrosa cystica von Recklinghausen.
PMID: 33555577 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - February 8, 2021 Category: Urology & Nephrology Authors: Maanaoui M, Hamroun A, Lebas C, Lenain R, Lionet A Tags: J Nephrol Source Type: research

Association between anemia and mortality in hemodialysis patients is modified by the presence of diabetes.
Abstract BACKGROUND: The prevalence and severity of anemia differ between diabetic and non-diabetic patients. We investigated whether the effect of hemoglobin (Hb) on patient outcome was affected by the presence or absence of diabetes among Japanese patients receiving chronic hemodialysis (HD). METHODS: We enrolled 149,308 patients from a nationwide dialysis registry in Japan at the end of 2012 (mean age, 67.6 ± 12.3 years; male, 61.7%; diabetes, 43.5%; median dialysis duration, 65 months) who underwent three HD sessions weekly. One-year all-cause and cardiovascular (CV) mortali...
Source: Journal of Nephrology - February 8, 2021 Category: Urology & Nephrology Authors: Maruyama Y, Kanda E, Kikuchi K, Abe M, Masakane I, Yokoo T, Nitta K Tags: J Nephrol Source Type: research

COVID-19-related collapsing glomerulopathy revealing a rare risk variant of APOL1: lessons for the clinical nephrologist.
PMID: 33548053 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - February 6, 2021 Category: Urology & Nephrology Authors: Laboux T, Gibier JB, Pottier N, Glowacki F, Hamroun A Tags: J Nephrol Source Type: research

Calciphylaxis in end-stage kidney disease: outcome data from the United Kingdom Calciphylaxis Study.
This study aimed to investigate the current management strategies and outcomes of patients enrolled in the United Kingdom Calciphylaxis study (UKCS). METHODS: The study was conducted on 89 patients registered in the UKCS since 2012. The initial analysis included a description of the baseline characteristics, management strategies and outcomes on follow-up until May 2020. Further analysis included a comparison of the mortality outcome of the UKCS patients who were receiving haemodialysis with a propensity score matched cohort of haemodialysis patients from the Chronic Renal Insufficiency Standards Implementation Study-...
Source: Journal of Nephrology - February 6, 2021 Category: Urology & Nephrology Authors: Chinnadurai R, Huckle A, Hegarty J, Kalra PA, Sinha S Tags: J Nephrol Source Type: research

Waves of infection and waves of communication: the importance of sharing in the era of Covid-19.
” PMID: 33534067 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - February 3, 2021 Category: Urology & Nephrology Authors: Mazzaferro S, Rocca AR, Bagordo D, “Consulta Primari di Nefrologia del Lazio” Tags: J Nephrol Source Type: research

COVID-19 in a dialysis center  in Milan from March to June 2020: understanding how to respond to the second wave of the pandemic.
COVID-19 in a dialysis center in Milan from March to June 2020: understanding how to respond to the second wave of the pandemic. J Nephrol. 2021 Feb 03;: Authors: Galassi A, Magagnoli L, Cozzolino M, COVID-19 Renal Working Group at ASST Santi Paolo & Carlo in Milan PMID: 33534068 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - February 3, 2021 Category: Urology & Nephrology Authors: Galassi A, Magagnoli L, Cozzolino M, COVID-19 Renal Working Group at ASST Santi Paolo & Carlo in Milan Tags: J Nephrol Source Type: research

Improving the "second generation Daugirdas equation" to estimate Kt/V on the once-weekly haemodialysis schedule.
CONCLUSION: A linear relationship was found between GFAC and Kru/V in patients on the 1HD/wk schedule. Such a relationship is able to improve the "second generation Daugirdas equation" for an accurate estimate of the single pool Kt/V in this setting. However, a simple replacement in the D2 equation of 0.008 with the mean observed GFAC (0.0035) could suffice in the clinical practice. PMID: 33515379 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - January 30, 2021 Category: Urology & Nephrology Authors: Casino FG, Deira J, Suárez MA, Aguilar J, Santarsia G, Basile C Tags: J Nephrol Source Type: research

Identifying prognostic risk factors for poor outcome following COVID-19 disease among in-centre haemodialysis patients: role of inflammation and frailty.
Abstract INTRODUCTION: The pandemic of coronavirus disease (COVID-19) has highly affected patients with comorbidities and frailty who cannot self-isolate, such as individuals undergoing haemodialysis. The aim of the study was to identify risk factors for mortality and hospitalisation, which may be useful in future disease spikes. METHODS: We collected data retrospectively from the electronic medical records of all patients receiving a diagnosis of COVID-19 between 11th March and 10th May 2020 undergoing maintenance haemodialysis at four satellite dialysis units from the Royal Free London NHS Foundation T...
Source: Journal of Nephrology - January 30, 2021 Category: Urology & Nephrology Authors: Hendra H, Vajgel G, Antonelou M, Neradova A, Manson B, Clark SG, Kostakis ID, Caplin B, Salama AD Tags: J Nephrol Source Type: research

Acute kidney injury and its outcomes in melioidosis.
This study aimed to assess the risk of acute kidney injury (AKI) and its outcomes in melioidosis. METHODS: A retrospective observational cohort study was performed. Case records of consecutive patients with culture-confirmed melioidosis, observed from January 1st, 2012 through December 31st, 2019 were analysed for demographics, presence of comorbidities, including chronic kidney disease (CKD), diabetes mellitus (DM), and presence of bacteraemia, sepsis, shock, AKI, and urinary abnormalities. The outcomes we studied were: mortality, need for hospitalisation in an intensive care unit (ICU), duration of hospitalization. ...
Source: Journal of Nephrology - January 30, 2021 Category: Urology & Nephrology Authors: Prabhu RA, Shaw T, Rao IR, Kalwaje Eshwara V, Nagaraju SP, Shenoy SV, Mukhopadhyay C Tags: J Nephrol Source Type: research

Reversible bone deformities in a severe case of uremic Leontiasis Ossea.
PMID: 33507522 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - January 28, 2021 Category: Urology & Nephrology Authors: Tassin C, Moscatelli L, Di Ascia L, Vacher-Coponat H, Gosset C Tags: J Nephrol Source Type: research

Towards optimizing use of PLA2R antibody testing in membranous nephropathy.
PMID: 33502725 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - January 27, 2021 Category: Urology & Nephrology Authors: Hogan JJ, Zee J, Beck LH Tags: J Nephrol Source Type: research

Sugar- and artificially-sweetened beverages and the risks of chronic kidney disease: a systematic review and dose-response meta-analysis.
Abstract BACKGROUND: Consumption of sugar or artificially-sweetened beverages (SASBs) has been linked to albuminuria, decline in kidney function, and risk of chronic kidney disease (CKD). However, the results are controversial. We therefore aim to evaluate the effects of sugar or artificially-sweetened beverage consumption on CKD risk. METHODS: Original observational studies reporting relative risks (RRs) with 95% confidence intervals (CIs) for the association between sugar or artificially-sweetened beverage consumption and impaired renal function or CKD risk in adults were identified using a systematic searc...
Source: Journal of Nephrology - January 27, 2021 Category: Urology & Nephrology Authors: Lo WC, Ou SH, Chou CL, Chen JS, Wu MY, Wu MS Tags: J Nephrol Source Type: research

A case of severe hypophosphatemia.
PMID: 33502727 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - January 27, 2021 Category: Urology & Nephrology Authors: Younis NK, Maktabi MAN, Jdiaa SS, Koubar SH Tags: J Nephrol Source Type: research

The role of pulse pressure in navigating the paradigm of chronic kidney disease progression in type 2 diabetes mellitus.
Abstract BACKGROUND AND AIMS: Arterial stiffness is a risk factor for chronic kidney disease progression (CKD). Pulse pressure is a surrogate marker of arterial stiffness. It is unclear if pulse pressure predicts CKD progression in type 2 diabetes mellitus. METHODS: This was prospective study involving 1494 patients with estimated glomerular filtration rate (eGFR) ≥ 15 ml/min/1.73 m2. Carotid-femoral pulse wave velocity was measured using applanation tonometry. Pulse pressure was calculated as difference between systolic and diastolic blood pressures. CKD progression was defined as worse...
Source: Journal of Nephrology - January 25, 2021 Category: Urology & Nephrology Authors: Low S, Moh A, Ang SF, Lim CL, Liu YL, Wang J, Ang K, Tang WE, Kwan PY, Lim Z, Subramaniam T, Sum CF, Lim SC Tags: J Nephrol Source Type: research

Protein-bound uremic toxin lowering strategies in chronic kidney disease: a  systematic review and meta-analysis.
CONCLUSIONS: The present meta-analysis demonstrated that prebiotics, synbiotics, and AST-120 can effectively reduce both serum indoxyl sulfate and p-cresyl sulfate in CKD patients when compared with placebo. Preservation of RRF was associated with lower serum indoxyl sulfate and p-cresyl sulfate levels. The effect of biotic supplements was detected only in dialysis patients. For non-dialysis CKD patients, the results were limited due to the small number of studies. Further studies are needed to determine the efficacy in these populations. PMID: 33484425 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - January 23, 2021 Category: Urology & Nephrology Authors: Takkavatakarn K, Wuttiputinun T, Phannajit J, Praditpornsilpa K, Eiam-Ong S, Susantitaphong P Tags: J Nephrol Source Type: research

Proteinuria in COVID-19: prevalence, characterization and prognostic role.
aye P Abstract BACKGROUND: Proteinuria has been commonly reported in patients with COVID-19. However, only dipstick tests have been frequently used thus far. Here, the quantification and characterization of proteinuria were investigated and their association with mortality was assessed. METHODS: This retrospective, observational, single center study included 153 patients, hospitalized with COVID-19 between March 28th and April 30th, 2020, in whom total proteinuria and urinary α1-microglobulin (a marker of tubular injury) were measured. Association with mortality was evaluated, with a follow-up...
Source: Journal of Nephrology - January 23, 2021 Category: Urology & Nephrology Authors: Huart J, Bouquegneau A, Lutteri L, Erpicum P, Grosch S, Résimont G, Wiesen P, Bovy C, Krzesinski JM, Thys M, Lambermont B, Misset B, Pottel H, Mariat C, Cavalier E, Burtey S, Jouret F, Delanaye P Tags: J Nephrol Source Type: research

Analysis of liver iron concentration in an elderly female undergoing hemodialysis with calcific uremic arteriolopathy does not support the role of iron overload in calciphylaxis: lesson for the clinical nephrologist.
hen Y PMID: 33484427 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - January 23, 2021 Category: Urology & Nephrology Authors: Rostoker G, Senet P, Lepeytre F, Griuncelli M, Loridon C, Rabaté C, Cohen Y Tags: J Nephrol Source Type: research

Immunosuppression-related neurological disorders in kidney transplantation.
lli C Abstract A large number of neurological disorders can affect renal transplant recipients, potentially leading to disabling or life-threatening complications. Prevention, early diagnosis and appropriate management of these conditions are critical to avoid irreversible lesions. A pivotal role in the pathogenesis of common post-transplant neurological disorders is played by immunosuppressive therapy. The most frequently administered regimen consists of triple immunosuppression, which comprises a calcineurin inhibitor (CNI), a purine synthesis inhibitor and glucocorticoids. Some of these immunosuppressive d...
Source: Journal of Nephrology - January 22, 2021 Category: Urology & Nephrology Authors: Faravelli I, Velardo D, Podestà MA, Ponticelli C Tags: J Nephrol Source Type: research

Insights on safety and efficacy of renal artery denervation for uncontrolled-resistant hypertension in a high risk population with chronic kidney disease: first Italian real-world experience.
Abstract AIMS: To evaluate the safety and efficacy of catheter-based radiofrequency renal sympathetic denervation (RSD) in a daily practice population of patients with uncontrolled resistant hypertension, on top of medical therapy. METHODS: Consecutive unselected patients with uncontrolled resistant hypertension undergoing RSD were enrolled. Office and ambulatory blood pressure (BP) measurements were collected at baseline and 3, 6 and 12 months after RSD. Efficacy was assessed even in patients with an estimated glomerular filtration rate (eGFR) below 45 mL/min/1.73 m2. Patients were defined as ...
Source: Journal of Nephrology - January 22, 2021 Category: Urology & Nephrology Authors: Marin F, Fezzi S, Gambaro A, Ederle F, Castaldi G, Widmann M, Gangemi C, Ferrero V, Pesarini G, Pighi M, Ribichini FL Tags: J Nephrol Source Type: research

A hemodialysis curriculum for nephrology fellows using a blended learning approach: best of both worlds?
Abstract A comprehensive, hands-on hemodialysis curriculum during nephrology training is necessary for effective learning and optimal patient care. Traditional instructive approaches are unable to fully meet the needs of the digitally inclined learner and are limited by time constraints and increasing clinical workload. Internet based learning (E-learning) is becoming increasingly popular in medical education and nephrology and gaining even greater relevance in the COVID era. However, it presents technical challenges and may create an environment of social isolation. A 'blended learning approach' combines E-learni...
Source: Journal of Nephrology - January 21, 2021 Category: Urology & Nephrology Authors: Krishnan N Tags: J Nephrol Source Type: research

The study of single cells in diabetic kidney disease.
Abstract In the past few years there has been a rapid expansion of interest in the study of single cells, especially through the new techniques that involve single-cell RNA sequencing (scRNA-seq). Recently, these techniques have provided new insights into kidney health and disease, including insights into diabetic kidney disease (DKD). However, despite the interest and the technological advances, the study of individual cells in DKD is not a new concept. Many clinicians and researchers who work within the DKD space may be familiar with experimental techniques that actually involve the study of individual cells, bu...
Source: Journal of Nephrology - January 21, 2021 Category: Urology & Nephrology Authors: Kaur H, Advani A Tags: J Nephrol Source Type: research

Spectrum of tubular dysfunction in Donnai-Barrow syndrome. Lessons for the clinical nephrologist.
PMID: 33471318 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - January 20, 2021 Category: Urology & Nephrology Authors: Aksenova M, Zaikova N, Lepaeva T Tags: J Nephrol Source Type: research

Haemoglobinuria for the early identification of aHUS relapse: data from the ItalKId-HUS Network.
CONCLUSION: Haemoglobinuria is a very sensitive and acceptably specific marker of aHUS relapse. This finding and its validation may have a positive impact on patients' quality of life and on the outcome of this life threatening disease via early diagnosis of relapse. PMID: 33459950 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - January 18, 2021 Category: Urology & Nephrology Authors: Brambilla M, Ardissino G, Paglialonga F, Testa S, Capone V, Montini G Tags: J Nephrol Source Type: research

Hyperuricaemia, gout and allopurinol in the CKD Queensland registry.
CONCLUSION: Hyperuricaemia seemed to be independently associated with faster CKD progression or renal death. This was not observed with gout or prescription of allopurinol. Furthermore, allopurinol was not associated with decreased incidence of cardiovascular events. These data suggest that hyperuricaemia is likely the effect and not the cause of CKD or CKD progression. PMID: 33439469 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - January 13, 2021 Category: Urology & Nephrology Authors: Jeyaruban A, Hoy W, Cameron A, Healy H, Wang Z, Zhang J, Mallett A Tags: J Nephrol Source Type: research

Hypocomplementemic urticarial vasculitis syndrome associated with rapidly progressive glomerulonephritis: lessons for the clinical nephrologist.
PMID: 33433859 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - January 12, 2021 Category: Urology & Nephrology Authors: Dominguez B, Vigo R Tags: J Nephrol Source Type: research

Atypical presentation of Dent disease in a patient with interstitial Xp11.22 deletion.
PMID: 33420968 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - January 9, 2021 Category: Urology & Nephrology Authors: Drovandi S, Servetti M, Angeletti A, Puliti A, Ronchetto P, Tassano E, Ghiggeri GM, Caridi G Tags: J Nephrol Source Type: research

Relationships between kidney dysfunction and left ventricular diastolic dysfunction: a hospital-based retrospective study.
Abstract BACKGROUND: Preclinical left ventricular diastolic dysfunction (LVDD) is a high-risk state for heart failure. Kidney dysfunction is a known risk factor for heart failure, but its association with asymptomatic LVDD is not well-known. METHODS: A hospital-based retrospective cohort study was conducted on patients who underwent echocardiogram between 2006 and 2016 to assess the association between baseline kidney function and LVDD on echocardiogram. E/e' ratio was defined as the ratio of peak velocity of early diastolic left ventricular inflow (E) to mitral annular velocity (e'). The primary outcome was ...
Source: Journal of Nephrology - January 5, 2021 Category: Urology & Nephrology Authors: Miyajima Y, Toyama T, Mori M, Nakade Y, Sato K, Yamamura Y, Ogura H, Yoneda-Nakagawa S, Oshima M, Miyagawa T, Usui S, Oe H, Kitajima S, Hara A, Iwata Y, Sakai N, Shimizu M, Sakai Y, Furuichi K, Wada T Tags: J Nephrol Source Type: research