The basics of onco-nephrology in the renal clinic.
Abstract Onconephrology is a rapidly evolving subspecialty that covers all areas of renal involvement in cancer patients. The complexity of the field may benefit from well-defined multidisciplinary management by a dedicated team. Patients with cancer frequently suffer from concurrent chronic kidney disease (CKD), with a prevalence ranging from 12% to 53% at the time of cancer diagnosis. Taking into account the incidence of cancer and the prevalence of CKD in the Italian population, we estimate that about 44,000 patients suffered from both diseases in 2020. Since there is an increasing necessity to address the need...
Source: Journal of Nephrology - November 26, 2020 Category: Urology & Nephrology Authors: Cosmai L, Porta C, Foramitti M, Rizzo M, Gallieni M Tags: J Nephrol Source Type: research

The end-of-the year 2020 issue: on disasters and challenges, research and the power of love.
PMID: 33242212 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - November 26, 2020 Category: Urology & Nephrology Authors: Piccoli GB Tags: J Nephrol Source Type: research

Clinical exome sequencing is a powerful tool in the diagnostic flow of monogenic kidney diseases: an Italian experience.
CONCLUSIONS: These results underline the importance of clinical exome sequencing as a versatile and highly useful, non-invasive tool for genetic diagnosis of kidney diseases. Identifying patients who can benefit from targeted therapies, and improving the management of organ transplantation are further expected applications. PMID: 33226606 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - November 23, 2020 Category: Urology & Nephrology Authors: Vaisitti T, Sorbini M, Callegari M, Kalantari S, Bracciamà V, Arruga F, Vanzino SB, Rendine S, Togliatto G, Giachino D, Pelle A, Cocchi E, Benvenuta C, Baldovino S, Rollino C, Fenoglio R, Sciascia S, Tamagnone M, Vitale C, Calabrese G, Biancone L, Bussol Tags: J Nephrol Source Type: research

Nephrology consultation and kidney failure in people with stage 4 chronic kidney disease: a population-based cohort study.
Abstract BACKGROUND: Guidelines recommend referral for nephrology consultation for people with severe chronic kidney disease (CKD) to improve care and renal outcomes, yet the advocated benefits of nephrology referral on CKD progression in this patient population are unclear. METHODS: We linked laboratory and administrative data in Alberta, Canada to identify adults with stage 4 CKD between 2002 and 2014 (follow-up end on March 31, 2017). We studied the association between time-varying receipt of outpatient nephrology consultation and kidney failure (the earlier of renal replacement initiation or eGFR 
Source: Journal of Nephrology - November 19, 2020 Category: Urology & Nephrology Authors: Liu P, Quinn RR, Cortese G, Mahsin M, James MT, Ronksley PE, Quan H, Manns B, Hemmelgarn BR, Tonelli M, Ravani P Tags: J Nephrol Source Type: research

Tens of thousands of organ donor families and recipients have communicated with each other and, in the great majority of cases, the results have been positive for both sides.
PMID: 33201511 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - November 17, 2020 Category: Urology & Nephrology Authors: Green R Tags: J Nephrol Source Type: research

Surgical versus percutaneous catheter placement for peritoneal dialysis: an updated systematic review and meta-analysis.
CONCLUSION: Overall, the quality of published literature on the field of peritoneal dialysis catheter placement is poor, with a small percentage of studies being randomized clinical trials. Percutaneous peritoneal dialysis catheter placement is a safe procedure and may result in fewer complications, such as tunnel/exit-site infections, and catheter migration, compared to surgical placement. PROTOCOL REGISTRATION: PROSPERO CRD42020154951. PMID: 33197001 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - November 16, 2020 Category: Urology & Nephrology Authors: Esagian SM, Sideris GA, Bishawi M, Ziogas IA, Lehrich RW, Middleton JP, Suhocki PV, Pappas TN, Economopoulos KP Tags: J Nephrol Source Type: research

Lesson for the clinical nephrologist: Kidney transplant, COVID-19 and pregnancy.
PMID: 33180315 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - November 12, 2020 Category: Urology & Nephrology Authors: Gleeson S, Noori M, Lightstone L, Webster P Tags: J Nephrol Source Type: research

Home hemodialysis during the COVID-19 epidemic: comment on the French experience from the viewpoint of a French home hemodialysis care network.
PMID: 33175342 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - November 11, 2020 Category: Urology & Nephrology Authors: Michel PA, Piccoli GB, Couchoud C, Fessi H Tags: J Nephrol Source Type: research

The effect of protein-enriched snacks on serum albumin concentration in non-selected haemodialysis patients.
Abstract OBJECTIVE: Serum albumin level is not only one of the protein-energy wasting criteria but also a powerful marker of mortality in patients on haemodialysis (HD) treatment. The study aimed to assess the effect of a protein-enriched snack given during HD treatment on serum albumin level. DESIGN AND METHODS: This prospective, single-centre, observational, non-randomized 16-month study was sub-divided into four 4-month periods. Patients on hemodialysis for more than three months and receiving a regular standard snack (8.8 g of protein) during the HD session were included and assigned during four...
Source: Journal of Nephrology - November 2, 2020 Category: Urology & Nephrology Authors: Deleaval P, Guillaume J, Bernollin AL, Lorriaux C, Hurot JM, Major B, Mehdi M, Chazot C Tags: J Nephrol Source Type: research

Diagnostic accuracy of anti-phospholipase A2 receptor (PLA2R) antibodies in idiopathic membranous nephropathy: an Italian experience.
CONCLUSION: Depending on the clinical use (early diagnosis or as a support to confirm clinical diagnosis), nephrologists may take advantage of this evidence by choosing the most convenient cut-off. However, renal biopsy remains mandatory for the definitive diagnosis of iMN and for the assessment of disease severity. PMID: 33123964 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - October 29, 2020 Category: Urology & Nephrology Authors: Porcelli B, Guarnieri A, Ferretti F, Garosi G, Terzuoli L, Cinci F, Tabucchi A, Tampoia M, Abbracciavento L, Villani C, Deleonardi G, Grondona AG, Mazzolini M, La Manna G, Santostefano M, Infantino M, Manfredi M, Spatoliatore G, Rosati A, Somma C, Bizzaro Tags: J Nephrol Source Type: research

Renal infarction in COVID-19 patient.
PMID: 33119839 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - October 29, 2020 Category: Urology & Nephrology Authors: Ammous A, Ghaffar MA, El-Charabaty E, El-Sayegh S Tags: J Nephrol Source Type: research

An unusual case of multiple bilateral kidney tumors.
et A PMID: 33113122 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - October 28, 2020 Category: Urology & Nephrology Authors: Hamroun A, Lenain R, Provôt F, Maanaoui M, Lionet A Tags: J Nephrol Source Type: research

Cancer post kidney transplant: the question of risk.
PMID: 33108603 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - October 27, 2020 Category: Urology & Nephrology Authors: Irish GL, Coates PT, Clayton PA Tags: J Nephrol Source Type: research

The lacking equation that estimates the protein catabolic rate in patients on once-weekly haemodialysis.
CONCLUSIONS: The equation here introduced allows a simple and accurate estimate of PCRn in patients on once-weekly HD regimen. The availability of the nomogram relating C0 to PCRn and Kru/V could be a further step to make safer and safer the once-weekly HD regimen. The following equation was established by means of the multiple regression analysis [Formula: see text] where PCRn is the normalized protein catabolic rate (PCRn), C0 is pre-dialysis blood urea nitrogen concentration (BUN), eKt/V is the equilibrated Kt/V, Kru is the residual renal urea clearance and V is the post-dialysis urea distribution volume. A nomogram rel...
Source: Journal of Nephrology - October 27, 2020 Category: Urology & Nephrology Authors: Casino FG, Mostacci SD, Sabato A, Montemurro M, Procida C, Saracino A, Santarsia G, Basile C Tags: J Nephrol Source Type: research

A challenging case of pneumo-renal syndrome (Nephrology Zebras).
PMID: 33098522 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - October 24, 2020 Category: Urology & Nephrology Authors: Hamroun A, Fages V, Julien B, Lenain R, Frimat M Tags: J Nephrol Source Type: research

Association of obesity and muscle mass with risk of albuminuria in renal transplant recipients.
CONCLUSIONS: These associations, which have not previously been reported, suggest, but do not prove, that an imbalance between metabolic demand and nephron mass may be responsible for increased albuminuria in the renal transplant population. PMID: 33098523 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - October 24, 2020 Category: Urology & Nephrology Authors: Zingerman B, Erman A, Mashraki T, Chagnac A, Rozen-Zvi B, Rahamimov R Tags: J Nephrol Source Type: research

Large potassium shifts during dialysis enhance cardiac repolarization instability.
CONCLUSIONS: We provide evidence that large potassium shifts during HD enhance sympathetic activity-associated repolarization instability. This could facilitate the occurrence of malignant arrhythmias, and PRD measurements might serve as a non-invasive monitoring tool in HD patients in future. PMID: 33058038 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - October 15, 2020 Category: Urology & Nephrology Authors: Schüttler D, Schönermarck U, Wenner F, Toepfer M, Rizas KD, Bauer A, Brunner S, Hamm W Tags: J Nephrol Source Type: research

Correction to: Is metformin associated with acute kidney injury? A case-control study of patients with type 2 diabetes admitted with acute infection.
Abstract While typesetting the article the title has been incorrectly published. PMID: 33058039 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - October 15, 2020 Category: Urology & Nephrology Authors: Schytz PA, Nissen AB, Hommel K, Schou M, Nelveg-Kristensen KE, Torp-Pedersen C, Gislason GH, Gerds TA, Carlson N Tags: J Nephrol Source Type: research

Socioeconomic dependency and kidney transplantation accessibility and outcomes: a nationwide observational cohort study in South Korea.
CONCLUSION: Disparities in kidney transplantation accessibility were present in South Korea according to socioeconomic dependency; these differences may have an impact on prognosis. PMID: 33048288 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - October 13, 2020 Category: Urology & Nephrology Authors: Park S, Park J, Kim M, Kim JE, Yu MY, Kim K, Park M, Kim YC, Kim DK, Joo KW, Kim YS, Lee H Tags: J Nephrol Source Type: research

Implementation of a frailty screening programme and Geriatric Assessment Service in a nephrology centre: a quality improvement project.
CONCLUSIONS: This quality improvement project details an approach to the implementation of a frailty screening programme and GA service within a nephrology centre. Patients living with frailty and CKD at risk of adverse outcomes can be identified using the CFS. Furthermore, a GA can be used to identify problems and implement a person-centred management plan that aims to improve outcomes for this vulnerable group of patients. PMID: 33040293 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - October 10, 2020 Category: Urology & Nephrology Authors: Nixon AC, Brown J, Brotherton A, Harrison M, Todd J, Brannigan D, Ashcroft Q, So B, Pendleton N, Ebah L, Mitra S, Dhaygude AP, Brady ME Tags: J Nephrol Source Type: research

In this issue: Journal of Nephrology, October 2020: diabetic kidney disease and more.
PMID: 33037598 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - October 9, 2020 Category: Urology & Nephrology Authors: Piccoli GB Tags: J Nephrol Source Type: research

The impact of COVID-19 pandemic on patients with ANCA associated vasculitis.
CONCLUSION: The incidence of COVID-19 in patients with AAV appears to be similar to that of the general population. For a patient population that requires active clinical surveillance, there is significant disruption in care as a result of the pandemic. Reduction of immunosuppression may not be indicated, and the risk of relapse likely far outweighs the risk of COVID-19. PMID: 33034038 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - October 8, 2020 Category: Urology & Nephrology Authors: Kant S, Morris A, Ravi S, Floyd L, Gapud E, Antichos B, Dhaygude A, Seo P, Geetha D Tags: J Nephrol Source Type: research

Successful treatment of PLA2R1-antibody positive membranous nephropathy with ocrelizumab.
Abstract Membranous nephropathy (MN) is a common cause of nephrotic syndrome in adults. The disease is induced by antibodies, which are directed against the podocyte protein phospholipase A2 receptor 1 (PLA2R1-ab) in 80% of cases. B cell depleting treatments, most notably rituximab, a chimeric CD20-antibody, are often effective for treatment of MN. However, in 35-40% of patients rituximab fails to induce remission of disease and relapses after rituximab-induced remission are frequent. Therefore, alternative treatment options are necessary. Over the past years optimized antibodies targeting CD20 were designed to ov...
Source: Journal of Nephrology - October 7, 2020 Category: Urology & Nephrology Authors: Schmidt T, Schulze M, Harendza S, Hoxha E Tags: J Nephrol Source Type: research

Kidney disease and all-cause mortality in patients with COVID-19 hospitalized in Genoa, Northern Italy.
Abstract BACKGROUND: The prevalence of kidney involvement during SARS-CoV-2 infection has been reported to be high. Nevertheless, data are lacking about the determinants of acute kidney injury (AKI) and the combined effect of chronic kidney disease (CKD) and AKI in COVID-19 patients. METHODS: We collected data on patient demographics, comorbidities, chronic medications, vital signs, baseline laboratory test results and in-hospital treatment in patients with COVID-19 consecutively admitted to our Institution. Chronic kidney disease was defined as eGFR 
Source: Journal of Nephrology - October 6, 2020 Category: Urology & Nephrology Authors: Russo E, Esposito P, Taramasso L, Magnasco L, Saio M, Briano F, Russo C, Dettori S, Vena A, Di Biagio A, Garibotto G, Bassetti M, Viazzi F, GECOVID working group Tags: J Nephrol Source Type: research

Prevention of hypomagnesemia in critically ill patients with acute kidney injury on continuous kidney replacement therapy: the role of early supplementation and close monitoring.
Abstract Hypomagnesemia is a common electrolyte disorder in critically ill patients and is associated with increased morbidity and mortality risk. Many clinical conditions may contribute to hypomagnesemia through different pathogenetic mechanisms. In patients with acute kidney injury (AKI) the need for continuous or prolonged intermittent kidney replacement therapy (CKRT and PIKRT, respectively) may further add to other causes of hypomagnesemia, especially when regional citrate anticoagulation (RCA) is used. The basic principle of RCA is chelation of ionized calcium by citrate within the extracorporeal circuit, th...
Source: Journal of Nephrology - September 30, 2020 Category: Urology & Nephrology Authors: Di Mario F, Regolisti G, Greco P, Maccari C, Superchi E, Morabito S, Pistolesi V, Fiaccadori E Tags: J Nephrol Source Type: research

A case-control study of patients with type 2 diabetes admitted with acute infection.
CONCLUSIONS: In patients with type 2 diabetes hospitalized with acute infection, metformin was not independently associated with AKI, since other antidiabetics were also significantly associated, indicating confounding by indication. PMID: 33001414 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - September 30, 2020 Category: Urology & Nephrology Authors: Schytz PA, Nissen AB, Hommel K, Schou M, Nelveg-Kristensen KE, Torp-Pedersen C, Gislason GH, Gerds TA, Carlson N Tags: J Nephrol Source Type: research

Treatment of COVID-19 atypical pneumonia by early Tocilizumab administration in "non-critically-ill" patients on hemodialysis.
Treatment of COVID-19 atypical pneumonia by early Tocilizumab administration in "non-critically-ill" patients on hemodialysis. J Nephrol. 2020 Sep 30;: Authors: Castellano G, Infante B, Mercuri S, Forcella M, Cox SN, Serviddio G, Gesualdo L, Stallone G PMID: 32997331 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - September 29, 2020 Category: Urology & Nephrology Authors: Castellano G, Infante B, Mercuri S, Forcella M, Cox SN, Serviddio G, Gesualdo L, Stallone G Tags: J Nephrol Source Type: research

Feasibility of computed tomography-based assessment of skeletal muscle mass in hemodialysis patients.
Abstract BACKGROUND: Sarcopenia is a major health issue especially in patients on maintenance hemodialysis. Low skeletal muscle mass is included in the diagnostic criteria for sarcopenia. The skeletal muscle mass is usually evaluated by modalities such as bioimpedance analysis (BIA) or dual-energy X-ray absorptiometry, however the assessment of skeletal muscle mass using computed tomography (CT) images has not been established. The purpose of the study was to investigate the feasibility of the assessment of skeletal muscle mass using CT images in hemodialysis patients. METHODS: Skeletal muscle mass index (SMI...
Source: Journal of Nephrology - September 28, 2020 Category: Urology & Nephrology Authors: Takata T, Motoe A, Tanida K, Taniguchi S, Ida A, Yamada K, Hamada S, Ogawa M, Yamamoto M, Mae Y, Iyama T, Taniguchi M, Nakaoka A, Isomoto H Tags: J Nephrol Source Type: research

COVID-19 and acute kidney injury in pediatric subjects: is there a place for eculizumab treatment?
PMID: 32996110 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - September 28, 2020 Category: Urology & Nephrology Authors: Trimarchi H, Coppo R Tags: J Nephrol Source Type: research

Close encounters of the peritoneal kind: case series and literature review of uroperitoneum. Lessons for the clinical nephrologist.
PMID: 32986200 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - September 27, 2020 Category: Urology & Nephrology Authors: Kant S, Menez S, Hanouneh M, Fine DM Tags: J Nephrol Source Type: research

Eculizumab treatment for renal failure in a pediatric patient with COVID-19.
We present a pediatric case of COVID-19 and renal failure due to thombotic microangiopathy, successfully treated with eculizumab. PMID: 32981025 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - September 25, 2020 Category: Urology & Nephrology Authors: Mahajan R, Lipton M, Broglie L, Jain NG, Uy NS Tags: J Nephrol Source Type: research

Effect of ultrafiltration profiling on outcomes among maintenance hemodialysis patients: a pilot randomized crossover trial.
CONCLUSIONS: Ultrafiltration (UF) profiling did not reduce the odds of treatment-related cardiac stress but did reduce the odds of light-headedness and post-dialysis hypervolemia. TRIAL REGISTRATION: Clinicaltrials.gov identifier: NCT03301740 (registered October 4, 2017). PMID: 32975783 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - September 24, 2020 Category: Urology & Nephrology Authors: Flythe JE, Tugman MJ, Narendra JH, Assimon MM, Li Q, Wang Y, Brunelli SM, Hinderliter AL Tags: J Nephrol Source Type: research

Handling immune-suppressive therapies during SARS-CoV-2 pandemic: insights from pediatric datasets.
PMID: 32970281 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - September 23, 2020 Category: Urology & Nephrology Authors: Angeletti A, Cravedi P, Ghiggeri GM Tags: J Nephrol Source Type: research

Totally tubular, dude: rethinking DKD pathogenesis in the wake of SGLT2i data.
PMID: 32965657 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - September 22, 2020 Category: Urology & Nephrology Authors: Yu SM, Leventhal JS, Cravedi P Tags: J Nephrol Source Type: research

Marble brain disease: a rare cause of renal tubular acidosis.
PMID: 32960441 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - September 21, 2020 Category: Urology & Nephrology Authors: Hamroun A, Maanaoui M, Lenain R, Lionet A Tags: J Nephrol Source Type: research

Pregnancy after pancreas-kidney transplantation.
Abstract A combined kidney and pancreas transplant is a therapeutic option for patients with type 1 diabetes and end-stage renal disease. After successful transplantation, fertility is rapidly restored, allowing women of childbearing age to have spontaneous pregnancies and men to father pregnancies. These pregnancies are at increased risk for maternal and neonatal adverse outcomes due to immunosuppressive therapy, comorbidities, previous type 1 diabetes and previous transplant surgery, although the majority ends with the birth of a live and healthy offspring. Hypertension, miscarriages, diabetes, infections, graft...
Source: Journal of Nephrology - September 20, 2020 Category: Urology & Nephrology Authors: Caretto A, Caldara R, Castiglioni MT, Scavini M, Secchi A Tags: J Nephrol Source Type: research

Two unusual cases of Gitelman's syndrome with a complex inheritance: how the phenotype can help interpret the genotype: lesson for the clinical nephrologist.
ani F PMID: 32926342 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - September 13, 2020 Category: Urology & Nephrology Authors: Calò LA, Palazzo V, Salviati L, Anglani F Tags: J Nephrol Source Type: research

Practice patterns of kidney stone management across European and non-European centers: an in-depth investigation from the European Renal Stone Network (ERSN).
CONCLUSIONS: Our survey highlights the potential for the creation of a network of centers that could share information in a common database for observational research and for enrollment of patients in interventional trials. PMID: 32918723 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - September 11, 2020 Category: Urology & Nephrology Authors: Ferraro PM, Unwin R, Bonny O, Gambaro G Tags: J Nephrol Source Type: research

Evaluation of left atrial remodeling in kidney transplant patients using cardiac magnetic resonance imaging.
CONCLUSIONS: LA volumes and function as measured by CMR did not change significantly over 12 months post-KT. There were significant associations between LA and LV remodeling, NT-proBNP and sBP, suggesting common underlying pathophysiological mechanisms. PMID: 32910428 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - September 9, 2020 Category: Urology & Nephrology Authors: Huang F, Connelly PW, Prasad GVR, Nash MM, Gunaratnam L, Deva DP, Lok CE, Yuan W, Wald RM, Shalmon T, Wald R, Connelly KA, Yan AT Tags: J Nephrol Source Type: research

Diabetic kidney disease: the onset of a new era?
PMID: 32902772 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - September 8, 2020 Category: Urology & Nephrology Authors: Fioretto P Tags: J Nephrol Source Type: research

Lessons for the clinical nephrologist: recurrence of nephrotic syndrome induced by SARS-CoV-2.
We describe the first case of nephrotic syndrome in the context of COVID-19 in a renal transplant recipient. A 35 year old male patient received a kidney allograft for primary focal segmental glomerulosclerosis (FSGS). Three months posttransplant a recurrence of podocytopathy was successfully managed by plasma exchange, ivIG, and a conversion from tacrolimus to belatacept (initial proteinuria> 6 g/l decreased to 169 mg/l). Six weeks later he was tested positive for SARS-CoV-2 and developed a second increase of proteinuria (5.6 g/l). Renal allograft biopsy revealed diffuse podocyte effacement and was positive for SARS-Co...
Source: Journal of Nephrology - September 4, 2020 Category: Urology & Nephrology Authors: Doevelaar AAN, Hölzer B, Seibert FS, Bauer F, Stervbo U, Rohn BJ, Zgoura P, Schenker P, Vonbrunn E, Amann K, Viebahn R, Babel N, Westhoff TH Tags: J Nephrol Source Type: research

The effect of diabetes during pregnancy on fetal renal parenchymal growth.
CONCLUSIONS/INTERPRETATION: Our study provides unique data on how diabetes during pregnancy influences fetal kidney growth. Appropriate management of diabetic pregnancies may mitigate some of the adverse effects on the fetal kidneys. Increasing degrees of hyperglycaemia, as seen sometimes in pregestational diabetes, may affect nephrogenesis; however larger studies are needed. PMID: 32889637 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - September 4, 2020 Category: Urology & Nephrology Authors: Brennan S, Kandasamy Y, Rudd DM, Schneider ME, Jones RE, Watson DL Tags: J Nephrol Source Type: research

Clinical physiology of the kidney, electrolytes and lithiasis. The "old" meets the "new".
Clinical physiology of the kidney, electrolytes and lithiasis. The "old" meets the "new". J Nephrol. 2020 Sep 04;: Authors: Ferraro PM, Fuster DG PMID: 32886324 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - September 3, 2020 Category: Urology & Nephrology Authors: Ferraro PM, Fuster DG Tags: J Nephrol Source Type: research

Supporting physicians in the management of metabolic alterations in adult kidney transplant recipients: a comment on the joint position statement of the Italian Society of Nephrology (SIN), the Italian Society for Organ Transplantation (SITO) and the Italian Diabetes Society (SID).
PMID: 32876937 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - September 1, 2020 Category: Urology & Nephrology Authors: Conte C, Maggiore U, Cappelli G, Ietto G, Lai Q, Salis P, Marchetti P, Piemonti L, Secchi A, Capocasale E, Caldara R Tags: J Nephrol Source Type: research

Outbreak of chronic renal failure: will this be a delayed heritage of COVID-19?
PMID: 32876938 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - September 1, 2020 Category: Urology & Nephrology Authors: Khoshdel-Rad N, Zahmatkesh E, Shpichka A, Timashev P, Vosough M Tags: J Nephrol Source Type: research

Ex vivo confocal microscopy performs real-time assessment of renal biopsy in non-neoplastic diseases.
CONCLUSION: The ease and speed of grayscale and fluorescence image acquisition, together with the quality of the H&E-like digitally stained images obtained with this approach, suggest that this technique shows promise for use in clinical nephrology and renal transplantation. PMID: 32876939 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - September 1, 2020 Category: Urology & Nephrology Authors: Villarreal JZ, Pérez-Anker J, Puig S, Pellacani G, Solé M, Malvehy J, Quintana LF, García-Herrera A Tags: J Nephrol Source Type: research

Sarcopenia in chronic kidney disease: what have we learned so far?
Abstract The term sarcopenia was first introduced in 1988 by Irwin Rosenberg to define a condition of muscle loss that occurs in the elderly. Since then, a broader definition comprising not only loss of muscle mass, but also loss of muscle strength and low physical performance due to ageing or other conditions, was developed and published in consensus papers from geriatric societies. Sarcopenia was proposed to be diagnosed based on operational criteria using two components of muscle abnormalities, low muscle mass and low muscle function. This brought awareness of an important nutritional derangement with adverse o...
Source: Journal of Nephrology - September 1, 2020 Category: Urology & Nephrology Authors: Sabatino A, Cuppari L, Stenvinkel P, Lindholm B, Avesani CM Tags: J Nephrol Source Type: research

Acute pyelonephritis in children and the risk of end-stage kidney disease.
CONCLUSION: History of pyelonephritis was associated with significantly increased risk of treated ESKD, particularly when associated with kidney scarring or reduced baseline kidney function. PMID: 32875542 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - August 31, 2020 Category: Urology & Nephrology Authors: Pleniceanu O, Twig G, Tzur D, Sherman G, Afek A, Erlich T, Keinan-Boker L, Skorecki K, Vivante A, Calderon-Margalit R Tags: J Nephrol Source Type: research

Lessons for the clinical nephrologist: an uncommon cause of pulmonary-renal syndrome.
We report the case of a 24-year-old man presenting with diffuse alveolar hemorrhage as well as a nephritic syndrome associating kidney failure, moderate hypertension, hematuria and selective glomerular proteinuria. The initial high suspicion of anti-glomerular basement membrane (GBM) disease or ANCA-associated vasculitis justified intravenous pulse-corticotherapy in association with plasma exchange. Renal biopsy was remarkable for an IgA nephropathy, lesions of active thrombotic microangiopathy (TMA) and a positive staining for complement factor C4d. Because anti-GBM and ANCA antibodies returned negative, plasma exchange w...
Source: Journal of Nephrology - August 31, 2020 Category: Urology & Nephrology Authors: Binet Q, Aydin S, Lengele JP, Cambier JF Tags: J Nephrol Source Type: research

SGLT2 inhibitors, sodium and off-target effects: an overview.
Abstract Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a relatively new class of antidiabetic drugs that in addition to emerging as an effective antihyperglycemic treatment have been shown to improve, in several trials, both renal and cardiovascular outcomes. In consideration of the renal site of action and the associated osmotic diuresis, a negative sodium balance has been postulated during SGLT2i administration. Actually, sodium and water depletion may contribute to some positive actions of SGLT2i but evidence is far from being conclusive and the real physiologic effects of SGLT2i on sodium remain large...
Source: Journal of Nephrology - August 31, 2020 Category: Urology & Nephrology Authors: De Pascalis A, Cianciolo G, Capelli I, Brunori G, La Manna G Tags: J Nephrol Source Type: research