The future of Diabetic Kidney Disease management: reducing the unmet need.
Abstract Patients with type 2 diabetes run a high risk for progressive renal function loss. Many interventions have been tested to reduce the risk, but we are nowadays still confronted with a high unmet need. To improve on this unmet need, we will have to change the current strategies in drug discovery, clinical trials and clinical practice. Target finding and the search for new interventions has to change to include more individual mechanistic approaches. Drugs will be selected on basis of finding the "individual" mechanism of renal function loss by looking at renal tissue biopsies or new biomarkers in ...
Source: Journal of Nephrology - August 4, 2020 Category: Urology & Nephrology Authors: de Zeeuw D Tags: J Nephrol Source Type: research

From the patient's side. On life, death, and taxes: reflections on cancer and kidney transplantation.
PMID: 32749581 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - August 4, 2020 Category: Urology & Nephrology Authors: Horton DL Tags: J Nephrol Source Type: research

Influence of bowel habits on gut-derived toxins in peritoneal dialysis patients.
Abstract BACKGROUND: Gut-derived uremic toxins have been associated with adverse outcomes in chronic kidney disease (CKD). Alterations in bowel habits, including constipation, seem to play an additional role in uremic toxicity. The aim of this study is to investigate the association of bowel habits with gut-derived uremic toxins and intestinal permeability in patients on automated peritoneal dialysis (APD). METHODS: This cross-sectional study enrolled 58 APD patients (age 52.5 ± 15.1 years; dialysis vintage 14.1 (6.0-36.5) months). Constipation was defined according to the ...
Source: Journal of Nephrology - August 1, 2020 Category: Urology & Nephrology Authors: Pereira NBF, Ramos CI, de Andrade LS, Teixeira RR, Nakao LS, Rodrigues SD, de Lima JD, Dalboni MA, Cuppari L Tags: J Nephrol Source Type: research

Kidney and cardiovascular protection with SGLT2 inhibitors: lessons from cardiovascular outcome trials and CREDENCE.
Abstract The burden of diabetic kidney disease is rising rapidly worldwide, and new therapies are of vital importance to reduce the risk of kidney failure and major cardiovascular events. Of the newer glucose-lowering agents, sodium-glucose co-transporter 2 (SGLT2) inhibitors have shown exciting potential in preventing these adverse events. The results of several large cardiovascular outcome trials, a single dedicated kidney outcome trial and a dedicated heart failure trial, demonstrate substantial clinical benefits for several different SGLT2 inhibitors. Emerging evidence raises the possibility that these benefit...
Source: Journal of Nephrology - July 28, 2020 Category: Urology & Nephrology Authors: O'Hara DV, Neuen BL, Jardine MJ Tags: J Nephrol Source Type: research

Lessons for the clinical nephrologist: a rare case of unfused renal ectopia.
Abstract Right crossed inferior unfused renal ectopia is a rare developmental anomaly in which both kidneys are located on the left side of the body. It's the result of a halt in migration of kidneys to their normal location during the embryonic period and in ureteral bud faulty that migrates to the opposite side and induces the metanephric blastema on the wrong side. In this article, we aim to review embryology and complete description of renal ectopia anatomy and describe a rare case of right crossed unfused inferior renal ectopia with a left lower kidney artery originated directly from an abdominal aortic aneur...
Source: Journal of Nephrology - July 28, 2020 Category: Urology & Nephrology Authors: Bernard C, Leboffe M, Garcia J, Steinmetz E, Cheynel N Tags: J Nephrol Source Type: research

Types of M protein and clinicopathological profiles in patients with monoclonal gammopathy of renal significance.
CONCLUSION: The clinicopathological features were distinct in patients with different types of M protein. Integration of the types of M protein and renal pathologic findings may shed light on individual management of patients with MGRS. PMID: 32725498 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - July 28, 2020 Category: Urology & Nephrology Authors: Liang D, Liu J, Liang S, Xu F, Cheng Z, Huang X, Zeng C, Liu Z Tags: J Nephrol Source Type: research

Attention to detail: not simple bed wetting-Hinman-Allen syndrome.
PMID: 32720135 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - July 27, 2020 Category: Urology & Nephrology Authors: Mannemuddhu SS, Bayne CE, Tufan Pekkucuksen N, Shoemaker LR Tags: J Nephrol Source Type: research

Lessons for the clinical nephrologist: dietary management of adult-onset type II citrullinemia in chronic kidney disease: a nutritional dilemma.
PMID: 32720136 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - July 27, 2020 Category: Urology & Nephrology Authors: Weng HL, Yang FJ, Chien YH, Chen PR, Lin ZX, Lee NC, Hwu WL Tags: J Nephrol Source Type: research

Patients' and healthcare personnel expectations for SARS-CoV-2 screening in dialysis unit during the Covid-19 pandemic.
PMID: 32720137 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - July 27, 2020 Category: Urology & Nephrology Authors: Przedlacki J, Wojtaszek E, Żebrowski P, Mieczkowski M, Głogowski T, Pyrża M, Ołdakowska-Jedynak U Tags: J Nephrol Source Type: research

Use of proton pump inhibitors in dialysis patients: a double-edged sword?
Abstract Large cohort-based studies have shown that proton pump inhibitors (PPIs) are linked to rare but multiple and varied secondary events when used in the general population. Although clinicians accept the negative effects of PPIs on renal function, there is a lack of available data regarding the potential consequences of their use by dialysis patients in whom the risk of gastrointestinal bleeding is quite high. This review aims to highlight the risks and benefits of PPIs use in dialysis patients. To summarize, the benefit on the reduction of high digestive bleeding seems certain, but without any beneficial im...
Source: Journal of Nephrology - July 24, 2020 Category: Urology & Nephrology Authors: Desbuissons G, Mercadal L Tags: J Nephrol Source Type: research

Detoxification of bilirubin and bile acids with intermittent coupled plasmafiltration and adsorption in liver failure (HERCOLE study).
CONCLUSIONS: CPFA resulted to be effective in liver detoxification. Thus, it may be considered as a "bridge technique" both to the liver transplant and to the recovery of the basal liver function. PMID: 32710265 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - July 24, 2020 Category: Urology & Nephrology Authors: Donati G, Angeletti A, Gasperoni L, Piscaglia F, Croci Chiocchini AL, Scrivo A, Natali T, Ullo I, Guglielmo C, Simoni P, Mancini R, Bolondi L, La Manna G Tags: J Nephrol Source Type: research

COVID-19 and the kidney: what we think we know so far and what we don't.
Abstract The novel coronavirus disease infection (COVID-19) outbreak that was declared a global pandemic in March 2020 had led to an internationally variable but concerning incidence of COVID-associated acute kidney injury (AKI), with prevalence reported as high as 46% in large cohorts of hospitalized patients. Variability in AKI may be explained by differences in traditional risk factors for AKI, heterogeneity among patient cohorts, and differences in racial and ethnic groups. Further, AKI requiring kidney replacement therapies (KRT) has been associated with increased mortality. Proposed mechanisms of kidney inju...
Source: Journal of Nephrology - July 20, 2020 Category: Urology & Nephrology Authors: Farouk SS, Fiaccadori E, Cravedi P, Campbell KN Tags: J Nephrol Source Type: research

Digital pathology for the routine diagnosis of renal diseases: a standard model.
Abstract Whole-slide imaging and virtual microscopy are useful tools implemented in the routine pathology workflow in the last 10 years, allowing primary diagnosis or second-opinions (telepathology) and demonstrating a substantial role in multidisciplinary meetings and education. The regulatory approval of this technology led to the progressive digitalization of routine pathological practice. Previous experiences on renal biopsies stressed the need to create integrate networks to share cases for diagnostic and research purposes. In the current paper, we described a virtual lab studying the routine renal biops...
Source: Journal of Nephrology - July 18, 2020 Category: Urology & Nephrology Authors: L'Imperio V, Brambilla V, Cazzaniga G, Ferrario F, Nebuloni M, Pagni F Tags: J Nephrol Source Type: research

Membranous nephropathy: setting the bar for hypothesis-driven, selective therapies in nephrology.
PMID: 32683657 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - July 18, 2020 Category: Urology & Nephrology Authors: Angeletti A, Leventhal JS, Cravedi P Tags: J Nephrol Source Type: research

Hand function assessment in peritoneal dialysis patient: a pilot study.
CONCLUSION: The evaluation of hand function of PD patients is feasible in daily practice using the Jebsen, Purdue Pegboard, pinch and Jamar tests and may support choosing the appropriate utilization of assisted PD. PMID: 32681469 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - July 17, 2020 Category: Urology & Nephrology Authors: Beaumier M, Ruet A, Boyer A, Lanot A, Guillouet S, Lobbedez T, Béchade C Tags: J Nephrol Source Type: research

Blood pressure reduction and RAAS inhibition in diabetic kidney disease: therapeutic potentials and limitations.
This article reviews the current literature and discusses potentials and limitation of targeting the RAAS in order to provide the greatest renal protection in DKD. PMID: 32681470 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - July 17, 2020 Category: Urology & Nephrology Authors: Leoncini G, Viazzi F, De Cosmo S, Russo G, Fioretto P, Pontremoli R Tags: J Nephrol Source Type: research

Correction to: Kidney health for everyone everywhere: from prevention to detection and equitable access to care.
Abstract The copyright of the article has been incorrectly published. PMID: 32677027 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - July 16, 2020 Category: Urology & Nephrology Authors: Li PK, Garcia-Garcia G, Lui SF, Andreoli S, Fung WW, Hradsky A, Kumaraswami L, Liakopoulos V, Rakhimova Z, Saadi G, Strani L, Ulasi I, Kalantar-Zadeh K, World Kidney Day Steering Committee Tags: J Nephrol Source Type: research

Nomenclature for kidney function and disease: executive summary and glossary from a Kidney Disease: Improving Global Outcomes (KDIGO) consensus conference.
PMID: 32677028 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - July 16, 2020 Category: Urology & Nephrology Authors: Levey AS, Eckardt KU, Dorman NM, Christiansen SL, Cheung M, Jadoul M, Winkelmayer WC Tags: J Nephrol Source Type: research

Correction to: Outcomes on safety and efficacy of left atrial appendage occlusion in end stage renal disease patients undergoing dialysis.
P, Galli F, Rebora P, Valsecchi M, Mazzone P Abstract The original article can be found online. PMID: 32661734 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - July 13, 2020 Category: Urology & Nephrology Authors: Genovesi S, Porcu L, Slaviero G, Casu G, Bertoli S, Sagone A, Buskermolen M, Pieruzzi F, Rovaris G, Montoli A, Oreglia J, Piccaluga E, Molon G, Gaggiotti M, Ettori F, Gaspardone A, Palumbo R, Viazzi F, Breschi M, Gallieni M, Contaldo G, D'Angelo G, Merell Tags: J Nephrol Source Type: research

Iliac crest bone biopsy by interventional radiologists to improve access to bone biopsy in chronic kidney disease populations: technical note and a case series.
CONCLUSIONS: We believe this approach will increase the access to iliac crest biopsy for diagnosing bone disease in CKD population. Studies are now needed to evaluate whether CKD patients will benefit from anti-osteoporotic therapy based on the results of iliac crest biopsy. PMID: 32656748 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - July 12, 2020 Category: Urology & Nephrology Authors: Lavigne F, Desbiens LC, Garneau G, Côté F, Mac-Way F Tags: J Nephrol Source Type: research

Increased circulating Cathepsin-K levels reflect PTH control in chronic hemodialysis patients.
In this study, we tested the hypothesis of an association between Cathepsin-K, uremic-MBD and circulating PTH levels in a cohort of chronic HD patients. METHODS: We measured Cathepsin-K in 85 stable chronic HD patients and dialysis vintage> 6 months by a commercially available ELISA kit and we collected routine clinical parameters, including intact PTH. Patients were further stratified according to their "on- target" or "off-target" PTH status. RESULTS: Cathepsin-K levels were significantly higher in HD patients than in healthy controls (p 
Source: Journal of Nephrology - July 12, 2020 Category: Urology & Nephrology Authors: Bolignano D, Greco M, Arcidiacono V, Tripolino O, Vita C, Provenzano M, Donato C, Chiarella S, Fuiano G, De Sarro G, Russo E, Andreucci M, Foti DP, Coppolino G Tags: J Nephrol Source Type: research

Renal structure in type 2 diabetes: facts and misconceptions.
Abstract The clinical manifestations of diabetic nephropathy are similar in type 1 and type 2 diabetes, while the renal lesions may differ. Indeed, diabetic glomerulopathy is the predominant renal lesion in type 1 diabetes, although also tubular, interstitial and arteriolar lesions are present in the advanced stages of renal disease. In contrast, in type 2 diabetes renal lesions are heterogeneous, and a substantial number of type 2 diabetic patients with diabetic kidney disease have mild or absent glomerulopathy with tubulointerstitial and/or arteriolar abnormalities. In addition, a high prevalence of non-diabetic...
Source: Journal of Nephrology - July 12, 2020 Category: Urology & Nephrology Authors: Di Vincenzo A, Bettini S, Russo L, Mazzocut S, Mauer M, Fioretto P Tags: J Nephrol Source Type: research

Peritoneal dialysis: the ideal bridge from conservative therapy to kidney transplant.
CONCLUSION: PD is a practical and noninferior form of renal replacement that serves as an ideal bridge from conservative therapy to kidney transplantation. PMID: 32654095 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - July 11, 2020 Category: Urology & Nephrology Authors: Tang SCW, Lai KN Tags: J Nephrol Source Type: research

Uric acid and risk of diabetic kidney disease.
Abstract Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease (ESKD) in the Western world. Better control of glycemia and blood pressure, including renin-angiotensin system blockade (RASB), appear to have slowed DKD progression rate but have been unable to substantially decrease the annual incidence of new cases of DKD related ESKD. Thus, new treatment targets are needed. Higher levels of serum uric acid (SUA) have been associated with increased risk and progression of DKD in persons with types 1 (T1D) and 2 (T2D) diabetes and of chronic kidney disease (CKD) in general. This review presen...
Source: Journal of Nephrology - July 10, 2020 Category: Urology & Nephrology Authors: Mauer M, Doria A Tags: J Nephrol Source Type: research

AKI: an increasingly recognized risk factor for CKD development and progression.
Abstract Acute kidney injury (AKI) is an increasing health burden with high morbidity and mortality rates worldwide. AKI is a risk factor for chronic kidney disease (CKD) development and progression to end stage renal disease (ESRD). Rapid action is required to find treatment options for AKI, plus to anticipate the development of CKD and other complications. Therefore, it is essential to understand the pathophysiology of AKI to CKD transition. Over the last several years, research has revealed maladaptive repair to be an interplay of cell death, endothelial dysfunction, tubular epithelial cell senescence, inflamma...
Source: Journal of Nephrology - July 10, 2020 Category: Urology & Nephrology Authors: Kurzhagen JT, Dellepiane S, Cantaluppi V, Rabb H Tags: J Nephrol Source Type: research

The impact of the superficial cuff position on the exit site and tunnel infections in CAPD patients.
CONCLUSIONS: Positioning the superficial cuff subcutaneously at least 4 cm internal to the exit-site might prevent the bacterial cuff colonization and reduce ESIs, tunnel infections and peritonitis. PMID: 32648207 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - July 9, 2020 Category: Urology & Nephrology Authors: Nardelli L, Scalamogna A, Messa P Tags: J Nephrol Source Type: research

Novel loss of function variants in FRAS1 AND FREM2 underlie renal agenesis in consanguineous families.
CONCLUSION: We describe consanguineous families with clinical features of antenatal oligohydramnios and bilateral renal agenesis, in whom we have identified novel pathogenic variants in FRAS1 and FREM2. These finding highlights the association between mutations in FRAS1 and FREM2 and antenatal/perinatal death. PMID: 32643034 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - July 8, 2020 Category: Urology & Nephrology Authors: Al-Hamed MH, Sayer JA, Alsahan N, Tulbah M, Kurdi W, Ambusaidi Q, Ali W, Imtiaz F Tags: J Nephrol Source Type: research

Exposure to novel coronavirus in patients on renal replacement therapy during the exponential phase of COVID-19 pandemic: survey of the Italian Society of Nephrology.
Abstract BACKGROUND: Between February and April 2020, Italy experienced an overwhelming growth of the COVID-19 pandemic. Little is known, at the country level, where and how patients on renal replacement therapy (RRT) have been mostly affected. METHODS: Survey of the network of Nephrology centers using a simplified 17 items electronic questionnaire designed by Italian Society of Nephrology COVID-19 Research Group. We used spatial epidemiology and geographical information systems to map SARS-CoV-2 spread among RRT patients in Italy. RESULTS: On April 9th 2020, all nephrology centers (n = 454...
Source: Journal of Nephrology - July 3, 2020 Category: Urology & Nephrology Authors: Quintaliani G, Reboldi G, Di Napoli A, Nordio M, Limido A, Aucella F, Messa P, Brunori G, Italian Society of Nephrology COVID-19 Research Group Tags: J Nephrol Source Type: research

Research, friendship, the joy of writing and the editorship of Journal of Nephrology.
PMID: 32613527 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - July 1, 2020 Category: Urology & Nephrology Authors: Gambaro G, Piccoli GB Tags: J Nephrol Source Type: research

The relationship between intra-parenchymal renal resistive index variation and renal functional reserve in healthy subjects.
We examined data from a group of 47 healthy subjects undergoing protein loading and IRRIV testing. The correlation between IRRIV and renal functional reserve was tested using Pearson correlation analysis. Concordance between presence of renal functional reserve (i.e. a value of renal functional reserve ≥ 15 ml/min/1.73 m2) and IRRIV was evaluated using logistic regression analysis. RESULTS: We found a significant correlation between IRRIV and renal functional reserve (Pearson correlation coefficient = 0.83 [95% confidence interval (CI) 0.71-0.90; p 
Source: Journal of Nephrology - June 29, 2020 Category: Urology & Nephrology Authors: Samoni S, Villa G, De Rosa S, Neri M, Tofani L, Husain-Syed F, De Cal M, Nalesso F, Meola M, Ronco C Tags: J Nephrol Source Type: research

Impact of renal function on admission in COVID-19 patients: an analysis of the international HOPE COVID-19 (Health Outcome Predictive Evaluation for COVID 19) Registry.
The objective was to evaluate the association between kidney failure severity on admission with the mortality of patients with SARS-CoV-2 infection. Patients were categorized in 3 groups according to the estimated glomerular filtration rate on admission (eGFR > 60 mL/min/1.73 m2, eGFR 30-60 mL/min/1.73 m2 and eGFR 
Source: Journal of Nephrology - June 29, 2020 Category: Urology & Nephrology Authors: Uribarri A, Núñez-Gil IJ, Aparisi A, Becerra-Muñoz VM, Feltes G, Trabattoni D, Fernández-Rozas I, Viana-Llamas MC, Pepe M, Cerrato E, Capel-Astrua T, Romero R, Castro-Mejía AF, El-Battrawy I, López-País J, D'Ascenzo F, Fabregat-Andres O, Bardají A Tags: J Nephrol Source Type: research

Efficacy of low or standard rituximab-based protocols and comparison to Ponticelli's regimen in membranous nephropathy.
Abstract BACKGROUND: Patients (pts) with primary Membranous nephropathy (MN) have an autoimmune disease caused by autoantibodies against podocyte antigens and 60-80% of them have antibodies directed against the M-type phospholipase A2 receptor (PLA2R). Immunosuppressive treatment is recommended in high-medium risk pts. Recently the use of rituximab (RTX), has emerged as an important therapeutic option in pts with primary MN. The appropriate cumulative dose of RTX in PMN pts is still uncertain, and favorable outcomes even with low-dose of RTX has been described. We compared efficacy and safety of 3 different treatm...
Source: Journal of Nephrology - June 27, 2020 Category: Urology & Nephrology Authors: Fenoglio R, Baldovino S, Sciascia S, De Simone E, Del Vecchio G, Ferro M, Quattrocchio G, Naretto C, Roccatello D Tags: J Nephrol Source Type: research

Recurrent antibody-mediated rejection in renal allograft: physician's dilemma.
We present a case of 47-year-old with end-stage renal disease due to presumed lupus status post deceased donor renal transplantation. The patient developed recurrent (a total of five) antibody-mediated rejections (donor-specific antibody and C4d staining negative) spanning within a year of transplant despite the standard of care therapies. The present case draws attention to the importance of non-HLA antibodies in antibody-mediated rejection and diagnostic tools we can rely on when the histology is inconclusive and the role of new immunological agents. PMID: 32557204 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - June 18, 2020 Category: Urology & Nephrology Authors: Kotla SK, Tanriover B Tags: J Nephrol Source Type: research

Clinicopathological characteristics and outcome of patients with fibrillary glomerulonephritis: DNAJB9 is a valuable histologic marker.
CONCLUSIONS: Extraglomerular deposits in the FGN were common. Monotypic FGN was found in young patients with a favorable renal outcome. PMID: 32557205 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - June 18, 2020 Category: Urology & Nephrology Authors: Liang S, Chen D, Liang D, Xu F, Zhang M, Yang F, Zhu X, Li P, Zeng C Tags: J Nephrol Source Type: research

Smile! (Life will be better).
PMID: 32557242 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - June 17, 2020 Category: Urology & Nephrology Authors: Esposito V, Sileno G, Abati S, Colucci M, Torreggiani M, Grosjean F, Esposito C Tags: J Nephrol Source Type: research

Renal disorders in rheumatologic diseases: the spectrum is changing (part 2. Arthridides).
Abstract This review is devoted to rheumatologic diseases mainly characterized by different types of arthritis. They may involve also different organs, including the kidney, but renal disease is more frequently caused by the nephrotoxicity of drugs to relieve pain or to interfere with the pathophysiology of the underlying disease. Rheumatoid arthritis is the prototype of arthropathies. This autoimmune disease mainly attacks joints, tendons and ligaments but can also involve internal organs including the kidney. Psoriatic arthritis is a complex disease in which psoriasis, a chronic inflammatory disease, is associat...
Source: Journal of Nephrology - June 16, 2020 Category: Urology & Nephrology Authors: Ponticelli C, Doria A, Moroni G Tags: J Nephrol Source Type: research

The COVID-19 infection in dialysis: are home-based renal replacement therapies a way to improve patient management?
PMID: 32542561 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - June 15, 2020 Category: Urology & Nephrology Authors: Cozzolino M, Piccoli GB, Ikizler TA, Ronco C Tags: J Nephrol Source Type: research

Outcomes on safety and efficacy of left atrial appendage occlusion in end stage renal disease patients undergoing dialysis.
CONCLUSIONS: The study could open the way to a non-pharmacological option for thromboembolic protection in dialysis patients with AF and high bleeding risk. PMID: 32535831 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - June 13, 2020 Category: Urology & Nephrology Authors: Genovesi S, Porcu L, Slaviero G, Casu G, Bertoli S, Sagone A, Buskermolen M, Pieruzzi F, Rovaris G, Montoli A, Oreglia J, Piccaluga E, Molon G, Gaggiotti M, Ettori F, Gaspardone A, Palumbo R, Viazzi F, Breschi M, Gallieni M, Contaldo G, D'Angelo G, Merell Tags: J Nephrol Source Type: research

Histological changes of a kidney in a recipient who received an allograft from a patient with Fabry disease.
PMID: 32535832 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - June 13, 2020 Category: Urology & Nephrology Authors: Fujii H, Kono K, Hara S, Ishimura T, Nishi S Tags: J Nephrol Source Type: research

Donor-transmitted cancer in kidney transplant recipients: a systematic review.
Abstract The transmission of cancer from a donor organ is a rare event but has important consequences. Aim of this systematic review was to summarize all the published evidence on cancer transmission in kidney recipients. We reviewed published case reports and series describing the outcome of recipients with donor-transmitted cancer until August 2019. A total of 128 papers were included, representing 234 recipients. The most common transmitted cancers were lymphoma (n = 48, 20.5%), renal cancer (42, 17.9%), melanoma (40, 17.1%), non-small cell lung cancer (n = 13, 5.6%), neuroendocrine ...
Source: Journal of Nephrology - June 13, 2020 Category: Urology & Nephrology Authors: Eccher A, Girolami I, Motter JD, Marletta S, Gambaro G, Momo REN, Nacchia F, Donato P, Boschiero L, Boggi U, Lombardini L, Cardillo M, D'Errico A, Neil D, Segev DL, Zaza G Tags: J Nephrol Source Type: research

Everolimus for BKV nephropathy in kidney transplant recipients: a prospective, controlled study.
In conclusion an Everolimus-based immunosuppressive protocol with minimization of Calcineurin inhibitors and antimetabolite discontinuation effectively treated BKVN in kidney transplant recipients. PMID: 32533451 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - June 12, 2020 Category: Urology & Nephrology Authors: Bussalino E, Marsano L, Parodi A, Russo R, Massarino F, Ravera M, Gaggero G, Fontana I, Garibotto G, Zaza G, Stallone G, Paoletti E Tags: J Nephrol Source Type: research

A sticky, palpable area of the perinephric adipose tissue at organ donor procurement: highlights on the diagnostic challenge and transplant management.
PMID: 32529558 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - June 11, 2020 Category: Urology & Nephrology Authors: Novelli L, Mescoli C, Malvi D, Girolami I, Eccher A Tags: J Nephrol Source Type: research

Renal disorders in rheumatologic diseases: the spectrum is changing (Part 1: connective tissue diseases).
Abstract The kidney is frequently involved by autoimmune rheumatic diseases. The renal manifestations may be variable, ranging from asymptomatic proteinuria and microscopic haematuria to nephrotic syndrome and rapidly progressive glomerulonephritis or vasculitis. In a number of cases the kidney involvement is related to the treatment of the original disease and may represent a major cause of morbidity and mortality. Thus, it is important for nephrologists and rheumatologists to remember that dysfunction of the kidney may be part of the primary systemic disorder or consequence of its pharmacotherapy. In the first p...
Source: Journal of Nephrology - June 11, 2020 Category: Urology & Nephrology Authors: Ponticelli C, Doria A, Moroni G Tags: J Nephrol Source Type: research

Lessons for the clinical nephrologist: Thyroid-Cardio-Renal Syndrome-a rare association.
PMID: 32524522 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - June 11, 2020 Category: Urology & Nephrology Authors: Salcedo Betancourt JD, Carias Martinez KG, Venkat V, Soberon D, Ladino MA Tags: J Nephrol Source Type: research

Identical twins with idiopathic membranous nephropathy.
Abstract The pathogenesis of idiopathic membranous nephropathy is associated with autoantibodies, most often against the phospholipase A2 receptor (PLA2R) and with genetic factors, especially those involving human leukocyte antigen (HLA) genes. Idiopathic membranous nephropathy is not a typical inherited Mendelian disorder. Reports of idiopathic membranous nephropathy in twins are rare. Herein, we report on two twin sisters diagnosed with PLA2R-associated idiopathic membranous nephropathy. We identified the HLA-DRB1*0301, HLA-DRB1*1501, and HLA-DQB1*0602 alleles in the twin sisters, which were reported as independ...
Source: Journal of Nephrology - June 10, 2020 Category: Urology & Nephrology Authors: Tao T, Wang J, Lei S, Hu Z Tags: J Nephrol Source Type: research

Effect of water composition and timing of ingestion on urinary lithogenic profile in healthy volunteers: a randomized crossover trial.
This study examines the effect of two different waters [calcium-bicarbonate water (CBW) and oligomineral water (OW)] consumed at different times during the day on urine composition in a group of healthy volunteers. In a cross-over randomized trial, 12 healthy volunteers were assigned to a different sequence of four combined interventions (1 L of water consumed during fasting and 1 L of water consumed with meals): CBW/OW; OW/CBW; CBW/CBW; OW/OW. Participants were instructed to follow the same diet and to avoid smoking, caffeine and other beverages during the day of intervention, and to collect their urine every 2 h dur...
Source: Journal of Nephrology - June 8, 2020 Category: Urology & Nephrology Authors: Ferraro PM, Baccaro R, Baroni S, D'Alessandri L, Carpenito C, Di Daniele N, Urbani A, Gambaro G Tags: J Nephrol Source Type: research

Plant-based diets, insulin sensitivity and inflammation in elderly men with chronic kidney disease.
uevas A, Carrero JJ Abstract BACKGROUND: In persons with CKD, adherence to plant-based diets is associated with lower risk of CKD progression and death, but underlying mechanisms are poorly characterized. We here explore associations between adherence to plant-based diets and measures of insulin sensitivity and inflammation in men with CKD stages 3-5. METHODS: Cross-sectional study including 418 men free from diabetes, aged 70-71 years and with cystatin-C estimated glomerular filtration rate (eGFR)
Source: Journal of Nephrology - June 8, 2020 Category: Urology & Nephrology Authors: González-Ortiz A, Xu H, Avesani CM, Lindholm B, Cederholm T, Risérus U, Ärnlöv J, Espinosa-Cuevas A, Carrero JJ Tags: J Nephrol Source Type: research

Neonatal thrombotic microangiopathy secondary to factor I variant with Hirschsprung disease.
We describe herein an early-term infant who underwent hemicolectomy at 4 days of age due to intestinal perforation. Following surgery, the patient had recurrent bouts of vomiting and abdominal distention, together with acute kidney injury, non-immune hemolytic anemia, and severe thrombocytopenia. Low complement levels raised the possibility of complement-mediated neonatal TMA. Finally, genetic tests identified a heterozygous mutation in the complement factor I gene. Anti-C5 monoclonal antibody therapy led to complete cessation of the hematological and renal manifestations, but symptoms of intestinal obstruction recurr...
Source: Journal of Nephrology - June 8, 2020 Category: Urology & Nephrology Authors: Nitzan-Luques A, Slae M, Zugayar D, Dixon BP, Meir K, Volovelsky O Tags: J Nephrol Source Type: research

Long-term renal survival and undetected risk factors of IgA nephropathy in Chinese children-a retrospective 1243 cases analysis from single centre experience.
Abstract BACKGROUND: The long-term renal outcome for IgA nephropathy (IgAN) in large cohorts of children remains unclear. IgAN is a progressive disease, to explore novel biomarkers is necessary for predicting the disease activity and progression of IgAN. In addition, there is a hot debate on when to treat with immunosuppression in children. We aimed to confirm the long-term renal survival, find some undetected risk factors and investigate when to treat with immunosuppression can benefit for renal outcome in Chinese children. METHODS: 1243 Children with IgAN were enrolled and a follow-up of at least 1 yea...
Source: Journal of Nephrology - June 7, 2020 Category: Urology & Nephrology Authors: Wu H, Fang X, Xia Z, Gao C, Peng Y, Li X, Zhang P, Kuang Q, Wang R, Wang M Tags: J Nephrol Source Type: research

The interesting picture: simultaneous occurrence of myeloma cast nephropathy, light chain deposition disease and light chain proximal tubulopathy in a patient with multiple myeloma.
PMID: 32506206 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - June 6, 2020 Category: Urology & Nephrology Authors: Lin ZS, Yu XJ, Wang SX, Zhou FD, Zhao MH Tags: J Nephrol Source Type: research