Post-transplant recurrence of steroid resistant nephrotic syndrome in children: the Italian experience.
CONCLUSIONS: Absence of a causative mutation represents the major risk factor for post-transplant recurrence in children with SRNS, while transplant can be curative in genetic SRNS. A prolonged time spent on dialysis before transplantation has no protective effect on the risk of relapse and should not be encouraged. Retransplantation represents a second chance after graft loss for recurrence. PMID: 31617157 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - October 15, 2019 Category: Urology & Nephrology Authors: Morello W, Puvinathan S, Puccio G, Ghiggeri GM, Dello Strologo L, Peruzzi L, Murer L, Cioni M, Guzzo I, Cocchi E, Benetti E, Testa S, Ghio L, Caridi G, Cardillo M, Torelli R, Montini G Tags: J Nephrol Source Type: research

Proteomic profiling of peritoneal dialysis effluent-derived extracellular vesicles: a longitudinal study.
CONCLUSIONS: PDE-EV proteome show alterations much earlier than PET monitoring, thus unveiling the potential of PDE-EV proteins as feasible biomarkers of PM alteration in PD patients. PMID: 31617158 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - October 15, 2019 Category: Urology & Nephrology Authors: Carreras-Planella L, Soler-Majoral J, Rubio-Esteve C, Morón-Font M, Franquesa M, Bonal J, Troya-Saborido MI, Borràs FE Tags: J Nephrol Source Type: research

Acute kidney injury as an independent predictor of infection and malignancy: the NARA-AKI cohort study.
CONCLUSIONS: AKI was significantly associated with hospitalization for infection and development of malignancy during long-term follow-up. Those with AKI might be in persistent immunosuppressed state. PMID: 31617159 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - October 15, 2019 Category: Urology & Nephrology Authors: Tagawa M, Nishimoto M, Kokubu M, Matsui M, Eriguchi M, Samejima KI, Akai Y, Tsuruya K Tags: J Nephrol Source Type: research

Aortic stiffness and central systolic pressure are associated with ambulatory orthostatic BP fall in chronic kidney disease.
Abstract OBJECTIVE: Orthostatic hypotension (OH) has a significant association with cardiovascular disease. OH becomes more common in older age, as does arterial stiffness, shown to be independently associated with impaired baroreflex sensitivity and OH. Measurement of arterial compliance and central blood pressures are increasingly important, with evidence that central BP more closely correlates to end-organ damage and mortality than peripheral measurements. Patients with chronic kidney disease (CKD) are high risk for cardiovascular events, which can be predicted through measures of arterial compliance. We hypoth...
Source: Journal of Nephrology - October 9, 2019 Category: Urology & Nephrology Authors: Kirkham FA, Rankin P, Parekh N, Holt SG, Rajkumar C Tags: J Nephrol Source Type: research

Treatment of metabolic acidosis with sodium bicarbonate delays progression of chronic kidney disease: the UBI Study.
Abstract BACKGROUND: Metabolic acidosis is associated with accelerated progression of chronic kidney disease (CKD). Whether treatment of metabolic acidosis with sodium bicarbonate improves kidney and patient survival in CKD is unclear. METHODS: We conducted a randomized (ratio 1:1). open-label, controlled trial (NCT number: NCT01640119. www.clinicaltrials.gov ) to determine the effect in patients with CKD stage 3-5 of treatment of metabolic acidosis with sodium bicarbonate (SB) on creatinine doubling (primary endpoint), all-cause mortality and time to renal replacement therapy compared to standard care (SC) o...
Source: Journal of Nephrology - October 9, 2019 Category: Urology & Nephrology Authors: Di Iorio BR, Bellasi A, Raphael KL, Santoro D, Aucella F, Garofano L, Ceccarelli M, Di Lullo L, Capolongo G, Di Iorio M, Guastaferro P, Capasso G, UBI Study Group Tags: J Nephrol Source Type: research

Associations between preoperative continuation of renin-angiotensin system inhibitor and cardiac surgery-associated acute kidney injury: a propensity score-matching analysis.
CONCLUSION: Preoperative use of RAS inhibitor was associated with less AKI development and severity, and higher renal recovery. Although more risk reduction of AKI development was shown in low-risk group by our prediction model, continued use of RAS inhibitor before cardiac surgery could provide protective effect in all patients. PMID: 31595420 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - October 8, 2019 Category: Urology & Nephrology Authors: Chou YH, Huang TM, Wu VC, Chen WS, Wang CH, Chou NK, Chiang WC, Chu TS, Lin SL, National Taiwan University Study Group on Acute Renal Failure (NSARF) Tags: J Nephrol Source Type: research

Anemia and clinical outcomes in patients with non-dialysis dependent or dialysis dependent severe chronic kidney disease: a Danish population-based study.
en RW Abstract BACKGROUND: Routine clinical evidence is limited on clinical outcomes associated with anemia in patients with severe chronic kidney disease (CKD). METHODS: We linked population-based medical databases to identify individuals with severe CKD (eGFR 
Source: Journal of Nephrology - October 5, 2019 Category: Urology & Nephrology Authors: Toft G, Heide-Jørgensen U, van Haalen H, James G, Hedman K, Birn H, Christiansen CF, Thomsen RW Tags: J Nephrol Source Type: research

Making urinary extracellular vesicles a clinically tractable source of biomarkers for inherited tubulopathies using a small volume precipitation method: proof of concept.
Abstract Biomarkers of inherited tubulopathies would be useful for clarifying diagnoses in patients where genetic screening is not readily available or where disease-attributable mutations are not found. Urinary extracellular vesicles (uEVs) obtained by ultracentrifugation can be used as a source of biomarkers for inherited tubulopathies such as Gitelman Syndrome (GS), however, ultracentrifugation requires costly equipment and is thus not usually accessible. In contrast, precipitation methods can extract uEVs using standard laboratory centrifuges, thus making uEVs extracted by this method clinically tractable as a...
Source: Journal of Nephrology - October 4, 2019 Category: Urology & Nephrology Authors: Williams TL, Bastos C, Faria N, Karet Frankl FE Tags: J Nephrol Source Type: research

UK renal transplant outcomes in low and high BMI recipients: the need for a national policy.
Abstract INTRODUCTION: We assessed the effect of recipient body mass index (BMI) on the outcomes of renal transplantation and the management of obese patients with end-stage renal disease across the UK. METHODS: We analyzed data of 25539 adult renal transplants (2007-2016) from the UK Transplant Registry. Patients were divided in BMI groups [underweight: 
Source: Journal of Nephrology - October 3, 2019 Category: Urology & Nephrology Authors: Kostakis ID, Kassimatis T, Bianchi V, Paraskeva P, Flach C, Callaghan C, Phillips BL, Karydis N, Kessaris N, Calder F, Loukopoulos I Tags: J Nephrol Source Type: research

Nephronophthisis type I, left ventricular non-compaction cardiomyopathy and reduced cilia motility-atypical manifestations of one disease.
This report points to a variety of clinical manifestations of ciliopathy and aims to understand the individual relationships. PMID: 31583536 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - October 3, 2019 Category: Urology & Nephrology Authors: Brndiarova M, Antonyova M, Dedinska I, Havlicekova Z, Jesenak M Tags: J Nephrol Source Type: research

Diabetic kidney disease: new clinical and therapeutic issues. Joint position statement of the Italian Diabetes Society and the Italian Society of Nephrology on "The natural history of diabetic kidney disease and treatment of hyperglycemia in patients with type 2 diabetes and impaired renal function".
CONCLUSIONS: The heterogeneity in the clinical presentation and course of DKD has important implications for the diagnosis, prognosis, and possibly treatment of this complication. The therapeutic options for patients with type 2 diabetes and impaired renal function have substantially increased, thus allowing a better management of these individuals. PMID: 31576500 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - October 2, 2019 Category: Urology & Nephrology Authors: Pugliese G, Penno G, Natali A, Barutta F, Di Paolo S, Reboldi G, Gesualdo L, De Nicola L, Italian Diabetes Society and the Italian Society of Nephrology Tags: J Nephrol Source Type: research

Distribution and association of cancer with mortality in end-stage renal disease patients receiving dialysis.
CONCLUSIONS: In our real-world multi-morbid dialysis cohort of 119 cancer patients, baseline cancer history did not prove to be an independent risk factor for all-cause mortality in the first 5 years of follow-up, suggesting the need for a case-by-case approach in provision of RRT options, including transplantation. PMID: 31555974 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - September 25, 2019 Category: Urology & Nephrology Authors: Chinnadurai R, Flanagan E, Kalra PA Tags: J Nephrol Source Type: research

Single needle hemodialysis: is the past the future?
Abstract Whereas the usual way to gain access to the vascular bed for hemodialysis is by inserting two needles, an alternative option based on the introduction of only one needle has been available for several decades. Although single needle hemodialysis gradually lost popularity in the early nineties of last century, this option now seems to make a come-back, with the current change in patient mix towards more elderly and cardio-vascular disease and the appearance of more flexible hardware. Single needle hemodialysis offers several advantages, such as the possibility to puncture small or maturing access systems, ...
Source: Journal of Nephrology - September 19, 2019 Category: Urology & Nephrology Authors: Vanholder R Tags: J Nephrol Source Type: research

Ethics of publication, between forgery, retraction and protecting freedom: an ENJOY score for authors and editors.
PMID: 31531824 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - September 17, 2019 Category: Urology & Nephrology Authors: Piccoli GB Tags: J Nephrol Source Type: research

Correction to: When kidneys and lungs suffer together.
Abstract Given names of all the authors have been interchanged with family names. PMID: 31529293 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - September 16, 2019 Category: Urology & Nephrology Authors: Sorino C, Scichilone N, Pedone C, Negri S, Visca D, Spanevello A Tags: J Nephrol Source Type: research

Videodialysis: a pilot experience of telecare for assisted peritoneal dialysis.
CONCLUSIONS: VD-Assisted PD is a reliable, safe system which requires no technological know-how and it is easy to use when self-care is not possible due to physical, cognitive or psychological barriers. PMID: 31529294 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - September 16, 2019 Category: Urology & Nephrology Authors: Viglino G, Neri L, Barbieri S, Tortone C Tags: J Nephrol Source Type: research

Hypophosphatemia in critically ill patients with acute kidney injury on renal replacement therapies.
Abstract Hypophosphatemia is a common but often underestimated electrolyte derangement among intensive care unit (ICU) patients. Low phosphate levels can lead to cellular dysfunction with potentially relevant clinical manifestations (e.g., muscle weakness, respiratory failure, lethargy, confusion, arrhythmias). In critically ill patients with severe acute kidney injury (AKI) renal replacement therapies (RRTs) represent a well-known risk factor for hypophosphatemia, especially if the most intensive and prolonged modalities of RRT, such as continuous RRT or prolonged intermittent RRT, are used. Currently, no evidenc...
Source: Journal of Nephrology - September 12, 2019 Category: Urology & Nephrology Authors: Pistolesi V, Zeppilli L, Fiaccadori E, Regolisti G, Tritapepe L, Morabito S Tags: J Nephrol Source Type: research

Impact of point-of-care creatinine monitoring on early detection of acute kidney injury in critical illness.
Abstract PURPOSE: To assess the utility and accuracy of creatinine measurement using point-of-care (POC) blood gas analysis compared to standard laboratory assay and to assess the effectiveness of frequent creatinine monitoring using POC blood gas analysis with respect to early detection of acute kidney injury (AKI). METHODS: We performed a single center retrospective observational study in 398 patients admitted to the intensive care unit. We investigated the clinical concordance of creatinine values measured by POC blood gas analysis (Cr-BG) compared to those measured by laboratory assay (Cr-lab). We compare...
Source: Journal of Nephrology - September 11, 2019 Category: Urology & Nephrology Authors: Takaori K, Uchino S, Takinami M Tags: J Nephrol Source Type: research

Comparison of sodium removal in peritoneal dialysis patients treated by continuous ambulatory and automated peritoneal dialysis.
Abstract BACKGROUND: Optimal fluid balance for peritoneal dialysis (PD) patients requires both water and sodium removal. Previous studies have variously reported that continuous ambulatory peritoneal dialysis (CAPD) removes more or equivalent amounts of sodium than automated PD (APD) cyclers. We therefore wished to determine peritoneal dialysate losses with different PD treatments. METHODS: Peritoneal and urinary sodium losses were measured in 24-h collections of urine and PD effluent in patients attending for their first assessment of peritoneal membrane function. We adjusted fluid and sodium losses for CAPD...
Source: Journal of Nephrology - September 9, 2019 Category: Urology & Nephrology Authors: Maharjan SRS, Davenport A Tags: J Nephrol Source Type: research

Does the renal expression of Toll-like receptors play a role in patients with IgA nephropathy?
Abstract The onset of IgA nephropathy (IgAN), characterized by glomerular deposition of IgA-containing immune complexes, is often associated with synpharyngitic hematuria. Innate immune responses mediated by Toll-like receptors (TLR) may play a role in IgAN onset and/or progression. Here, we assessed the expression of TLR 4, 7, 8, and 9 in renal-biopsy specimens from patients with IgAN, with different degree of proteinuria and eGFR, compared with normal-kidney and disease-control tissues (ANCA-associated vasculitis). Renal-biopsy specimens from 34 patients with IgAN and 7 patients with ANCA-associated vasculitis w...
Source: Journal of Nephrology - September 5, 2019 Category: Urology & Nephrology Authors: Ciferska H, Honsova E, Lodererova A, Hruskova Z, Neprasova M, Vachek J, Suchanek M, Zima T, Coppo R, Tesar V, Novak J, Maixnerova D Tags: J Nephrol Source Type: research

Kidney transplantation in ANCA-associated vasculitis.
k U Abstract The kidney is commonly affected in patients with ANCA-associated vasculitis (AAV), causing end-stage renal disease (ESRD) in 20-40% of cases. Kidney transplantation is the treatment of choice for eligible patients with ESRD due to AAV. This review provides a summary of patient and graft outcome after kidney transplantation in AAV patients, the risk of relapse and the optimal time of transplantation. We also address the rare event of de novo ANCA-associated vasculitis after kidney transplantation and the treatment options. PMID: 31471816 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - August 30, 2019 Category: Urology & Nephrology Authors: Sagmeister MS, Grigorescu M, Schönermarck U Tags: J Nephrol Source Type: research

Calciphylaxis: a conundrum for patients and nephrologists?
PMID: 31471817 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - August 30, 2019 Category: Urology & Nephrology Authors: Pasquali M, De Martini N, Mazzaferro S Tags: J Nephrol Source Type: research

Pre-implantation kidney biopsy: value of the expertise in determining histological score and comparison with the whole organ on a series of discarded kidneys.
CONCLUSIONS: Our data suggests that the creation of a pool of specialist pathologists would improve organ utilization. Moreover, biopsies are not representative of the whole organ. As the Remuzzi score on biopsy is a major reasons for discard, a quota of transplantable kidneys may be erroneously discarded. Refinement in Remuzzi cut-offs based on expert reporting and recognition of sampling error of biopsies in correlation with clinical outcome data should be undertaken. PMID: 31471818 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - August 30, 2019 Category: Urology & Nephrology Authors: Girolami I, Gambaro G, Ghimenton C, Beccari S, Caliò A, Brunelli M, Novelli L, Boggi U, Campani D, Zaza G, Boschiero L, López JI, Martignoni G, D'Errico A, Segev D, Neil D, Eccher A Tags: J Nephrol Source Type: research

Correction to: Role of anemia and proteinuria in the development of subsequent renal function deterioration in a general population with preserved glomerular filtration rate: a community-based cohort study.
Abstract After the online first publication of their research, the authors realized they made several mistakes in the data conversion process from the original data of health check-up at the Center for Preventive Medicine at The University of Tokyo Hospital to the datasheet which was used for the statistical analysis by SPSS. Particularly, the prevalence of hypertension, diabetes mellitus, and hypercholesterolemia was not appropriately analyzed. Therefore, the authors re-analyzed the data according to the corrected database. PMID: 31429048 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - August 19, 2019 Category: Urology & Nephrology Authors: Kiriyama H, Kaneko H, Itoh H, Yoshida Y, Nakanishi K, Mizuno Y, Daimon M, Morita H, Yatomi Y, Komuro I Tags: J Nephrol Source Type: research

Factors associated with systolic hypertension in peritoneal dialysis patients.
Abstract BACKGROUND: Hypertension is common in peritoneal dialysis (PD) patients and associated with adverse outcomes. Besides solute clearance, PD convective clearance is used to control extracellular water (ECW) volume and sodium balance. Previous studies have reported on hypertension in PD patients treated with continuous ambulatory peritoneal dialysis (CAPD) using hypertonic glucose dialysates. However, increasing numbers of PD patients are now treated with automated peritoneal dialysis (APD) and icodextrin dialysates. As such, we wished to explore factors associated with systolic blood pressure (SBP) in a mod...
Source: Journal of Nephrology - August 10, 2019 Category: Urology & Nephrology Authors: Vongsanim S, Davenport A Tags: J Nephrol Source Type: research

Improvement in wound healing, pain, and quality of life after 12 weeks of SNF472 treatment: a phase 2 open-label study of patients with calciphylaxis.
te; J Abstract BACKGROUND: Calciphylaxis in end-stage renal disease is characterized by painful necrotic skin ulcers and high mortality. There are no approved therapies. SNF472, an intravenous formulation of myo-inositol hexaphosphate, inhibits the formation and growth of hydroxyapatite crystals, the final common pathway in the pathogenesis of vascular calcification. METHODS: In this open-label, single-arm study, calciphylaxis patients on thrice-weekly hemodialysis and standard care, received intravenous SNF472 3 times per week for 12 weeks. The primary endpoint was wound healing assessed using the quant...
Source: Journal of Nephrology - August 10, 2019 Category: Urology & Nephrology Authors: Brandenburg VM, Sinha S, Torregrosa JV, Garg R, Miller S, Canals AZ, Bahr D, Joubert PH, Salcedo C, Carroll KJ, Gold A, Perelló J Tags: J Nephrol Source Type: research

The present and future of transplant organ shortage: some potential remedies.
Abstract Transplantation remains the modality of choice for patients with end stage renal disease (ESRD). However, while there has been a steady rise in the number of patients with ESRD the supply of donors (combine living and deceased) has fallen far behind the need, resulting in an increasing number of qualified patients remaining on the wait-list, and thousands being removed from the list every year because of death or becoming too sick for transplantation. This has also fed to transplant tourism around the world. Several countries have implemented a variety of policies to overcome their organ shortage that are...
Source: Journal of Nephrology - August 9, 2019 Category: Urology & Nephrology Authors: Bastani B Tags: J Nephrol Source Type: research

What volume to choose to assess online Kt/V?
CONCLUSIONS: V_ID can be considered the reference method to estimate the modelled V and then the first choice to assess Kt/V. V_SPEEDY is a valuable alternative to V_ID. V_KTV can be utilized in the daily practice, taking also into account its simple way of calculation. VW is not advisable because it leads to underestimation of Kt/V by about 20%. PMID: 31392658 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - August 7, 2019 Category: Urology & Nephrology Authors: Casino FG, Mancini E, Santarsia G, Mostacci SD, D'Elia F, Di Carlo M, Iannuzzella F, Rossi L, Vernaglione L, Grimaldi D, Rapanà R, Basile C Tags: J Nephrol Source Type: research

The regulation effect of WNT-RAS signaling in hypothalamic paraventricular nucleus on renal fibrosis.
CONCLUSION: These data suggest that the central WNT-RAS signaling plays a significant role in the development and progression of CKD. PMID: 31392659 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - August 7, 2019 Category: Urology & Nephrology Authors: Zhou G, Li J, Zeng T, Yang P, Li A Tags: J Nephrol Source Type: research

Predictive value of circulating coagulation related microRNAs expressions for major adverse cardiac and cerebral event risk in patients undergoing continuous ambulatory peritoneal dialysis: a cohort study.
CONCLUSION: Circulating miR-92a-3p, miR-126-5p, miR-652-3p and miR-423-5p exhibit potential to serve as novel biomarkers for MACCE risk in patients undergoing CAPD. PMID: 31359371 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - July 29, 2019 Category: Urology & Nephrology Authors: Wang Y, Liu C, Wei W, Chen W Tags: J Nephrol Source Type: research

Decline in serum uric acid predicts higher risk for mortality in peritoneal dialysis patients-a propensity score analysis.
Abstract BACKGROUND: The level of serum uric acid (SUA) in treatment follow-up is associated with mortality in peritoneal dialysis (PD) patients, but it remains unknown if the longitudinal change in SUA affects mortality. METHODS: 309 PD patients who were not using UA-lowering agents were enrolled. The longitudinal change in SUA was estimated by comparing the values between the run-in and follow-up periods. Based the calculated values, the patients were divided into SUA decliner and SUA non-decliner. A propensity score (PS) was calculated using the parameters measured in run-in period. After PS matching, the ...
Source: Journal of Nephrology - July 18, 2019 Category: Urology & Nephrology Authors: Chang W, Uchida S, Qi P, Zhang W, Wang X, Liu Y, Han Y, Li J, Xu H, Hao J Tags: J Nephrol Source Type: research

Atrial fibrillation and chronic kidney disease conundrum: an update.
Abstract Atrial fibrillation (AF) is the most common cardiac arrhythmia and it is frequently encountered in chronic kidney disease (CKD) subjects. CKD patients are already at high risk for cardiovascular (CV) complications and the addition of AF further aggravates the prognosis. Data is missing regarding on how to best approach CKD patients with AF, due to lack of randomized controlled trials (RCTs). AF and CKD have a double edged-sword relationship. On one hand, there are kidney-specific mechanisms which can alter cardiac structure and predispose to AF, and on the other hand the development of AF itself can accel...
Source: Journal of Nephrology - July 18, 2019 Category: Urology & Nephrology Authors: Tapoi L, Ureche C, Sascau R, Badarau S, Covic A Tags: J Nephrol Source Type: research

Chronic kidney disease in preeclamptic patients: not found unless searched for-Is a nephrology evaluation useful after an episode of preeclampsia?
CONCLUSIONS: Within the limits of a single-center study, our data quantify CKD as common in PE women and suggest the presence of a "CKD phenotype" characterised by preterm delivery and adequate growth, implying that CKD is compatible with good placental function up to the last phase of pregnancy. PMID: 31317437 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - July 17, 2019 Category: Urology & Nephrology Authors: Filali Khattabi Z, Biolcati M, Fois A, Chatrenet A, Laroche D, Attini R, Cheve MT, Piccoli GB Tags: J Nephrol Source Type: research

A simple risk score for prediction of sepsis associated-acute kidney injury in critically ill patients.
Abstract BACKGROUND: Sepsis is common and frequently fatal condition in critically ill patients and is a major cause of acute kidney injury (AKI). In this retrospective study, we sought to develop a comprehensive risk score model of sepsis associated-AKI (SA-AKI). METHODS: A total of 2617 patients were randomly assigned to a development (1554 patients) and a validation group (777 patients). The risk score model for SA-AKI was developed with multivariate regression analysis in development group and the model was further evaluated on validation group. RESULTS: We identified 16 independent predictors of SA-...
Source: Journal of Nephrology - July 16, 2019 Category: Urology & Nephrology Authors: Zhou J, Bai Y, Wang X, Yang J, Fu P, Cai D, Yang L Tags: J Nephrol Source Type: research

Update on ANCA-associated vasculitis: from biomarkers to therapy.
Abstract ANCA-associated vasculitis (AAV) are the prototype of a disease characterised by the presence of a biomarker; ANCA positivity in fact is recorded in 90% of cases of GPA and MPA. The role of ANCA in the management of AAV ranges from diagnostic to prognostic purposes with also therapeutic implications. Changes in clinical practice with the increased use of rituximab have drawn attention to B-cells as a biomarker able to contribute to patient management. Cytokines and other circulating factors, although still at a research stage, may represent future biomarkers of interest or even therapeutic options. From t...
Source: Journal of Nephrology - July 12, 2019 Category: Urology & Nephrology Authors: Tedesco M, Gallieni M, Pellegata F, Cozzolino M, Alberici F Tags: J Nephrol Source Type: research

MALDI imaging in Fabry nephropathy: a multicenter study.
CONCLUSIONS: The present study demonstrated the feasible application of MALDI-MSI in the analysis of FN FFPE renal biopsies, allowing the detection of putative signatures for phenotypic distinction and demonstrating genetic classification capabilities. PMID: 31292888 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - July 10, 2019 Category: Urology & Nephrology Authors: L'Imperio V, Smith A, Pisani A, D'Armiento M, Scollo V, Casano S, Sinico RA, Nebuloni M, Tosoni A, Pieruzzi F, Magni F, Pagni F Tags: J Nephrol Source Type: research

Risk factors of cardiac surgery-associated acute kidney injury: development and validation of a perioperative predictive nomogram.
CONCLUSION: The novel predictive nomogram achieved a good preoperative prediction of CSA-AKI within the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Though the model, the risk of an individual patient with "subclinical AKI" undergoing cardiac surgery could be determined earlier and such application was helpful for timely intervention in order to improve patient's prognosis. PMID: 31243735 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - June 26, 2019 Category: Urology & Nephrology Authors: Guan C, Li C, Xu L, Zhen L, Zhang Y, Zhao L, Zhou B, Che L, Wang Y, Xu Y Tags: J Nephrol Source Type: research

Homocysteine and chronic kidney disease: an ongoing narrative.
PMID: 31228166 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - June 21, 2019 Category: Urology & Nephrology Authors: Perna AF, Ingrosso D Tags: J Nephrol Source Type: research

Differential methylation pattern of xenobiotic metabolizing genes and susceptibility to Balkan endemic nephropathy, in a cohort of Romanian patients.
Abstract A severe, chronic and irreversible kidney disease affecting discrete rural populations in the Balkan Peninsula countries, Balkan endemic nephropathy (BEN) has been a scientific puzzle for more than half a century. Many environmental and other factors have been suggested as the primary cause and recent significant findings have linked BEN to aristolochic acids, phytotoxins derived from the plant Aristolochia clematitis, found in high density in the endemic areas. However, given that the incidence of BEN is less than 10% in affected villages, and it tends to have a family aggregation, as yet unidentified ge...
Source: Journal of Nephrology - June 20, 2019 Category: Urology & Nephrology Authors: Ivan A, Lam D, Cristea MI, Telea A, Gruia AT, Oprean C, Margineanu F, Bojin FM, Saffery R, Paunescu V, Tatu CA Tags: J Nephrol Source Type: research

Evaluation of inactive Matrix-Gla-Protein (MGP) as a biomarker for incident and recurrent kidney stones.
Abstract BACKGROUND: Matrix-Gla-protein (MGP) is an inhibitor of vascular calcification. Its dephosphorylated and uncarboxylated inactive form, dpucMGP, is a marker of vitamin K status and of cardio-vascular outcomes in chronic kidney disease. We hypothesized that higher serum dpucMGP would be a biomarker of kidney stone disease. METHODS: We measured serum dpucMGP in incident symptomatic kidney stone-formers and non-stone formers at a baseline visit. Symptomatic stone recurrence was assessed in the stones formers over a 5-year period. The association of dpucMGP with incident or recurrent kidney stones was ass...
Source: Journal of Nephrology - June 20, 2019 Category: Urology & Nephrology Authors: Castiglione V, Pottel H, Lieske JC, Lukas P, Cavalier E, Delanaye P, Rule AD Tags: J Nephrol Source Type: research

Extracellular resistance is sensitive to tissue sodium status; implications for bioimpedance-derived fluid volume parameters in chronic kidney disease.
Abstract Multifrequency bioimpedance spectroscopy (BIS) is an established method for assessing fluid status in chronic kidney disease (CKD). However, the technique is lacking in predictive value and accuracy. BIS algorithms assume constant tissue resistivity, which may vary with changing tissue ionic sodium concentration (Na+). This may introduce significant inaccuracies to BIS outputs. To investigate this, we used 23Na magnetic resonance imaging (MRI) to measure Na+ in muscle and subcutaneous tissues of 10 healthy controls (HC) and 20 patients with CKD 5 (not on dialysis). The extracellular (Re) and intracellular...
Source: Journal of Nephrology - June 18, 2019 Category: Urology & Nephrology Authors: Mitsides N, McHugh D, Swiecicka A, Mitra R, Brenchley P, Parker GJM, Mitra S Tags: J Nephrol Source Type: research

The relationship between the concentration of plasma homocysteine and chronic kidney disease: a cross sectional study of a large cohort.
Abstract BACKGROUND: High concentrations of homocysteine are considered a risk factor for developing atherosclerosis and coronary artery disease. The aim of this study was to assess the concentrations of homocysteine in subjects with chronic kidney disease (CKD). METHODS: Data were collected from medical records of individuals examined at a screening center in Israel between the years 2000-2014. Cross sectional analysis was carried out on 17,010 subjects; 67% were men. RESULTS: Significant differences were observed between four quartiles of homocysteine concentrations and estimated glomerular filtration ...
Source: Journal of Nephrology - June 5, 2019 Category: Urology & Nephrology Authors: Cohen E, Margalit I, Shochat T, Goldberg E, Krause I Tags: J Nephrol Source Type: research

Stone composition and vascular calcifications in patients with nephrolithiasis.
In conclusion, we demonstrated a significant direct association of AAC and the amount of calcium phosphate was found, suggesting an increased cardiovascular risk. Our study suggests that some subtypes of kidney stone disease deserve a closer cardiovascular risk assessment. PMID: 31165423 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - June 4, 2019 Category: Urology & Nephrology Authors: Ferraro PM, Marano R, Primiano A, Gervasoni J, Bargagli M, Rovere G, Bassi PF, Gambaro G Tags: J Nephrol Source Type: research

Management of hyperkalemia in patients with kidney disease: a position paper endorsed by the Italian Society of Nephrology.
Abstract Hyperkalemia (HK) is the most common electrolyte disturbance observed in patients with kidney disease, particularly in those in whom diabetes and heart failure are present or are on treatment with renin-angiotensin-aldosterone system inhibitors (RAASIs). HK is recognised as a major risk of potentially life threatening cardiac arrhythmic complications. When an acute reduction of renal function manifests, both in patients with chronic kidney disease (CKD) and in those with previously normal renal function, HK is the main indication for the execution of urgent medical treatment and the recourse to extracorpo...
Source: Journal of Nephrology - May 22, 2019 Category: Urology & Nephrology Authors: Bianchi S, Aucella F, De Nicola L, Genovesi S, Paoletti E, Regolisti G Tags: J Nephrol Source Type: research

Furosemide as a functional marker of acute kidney injury in ICU patients: a new role for an old drug.
Abstract New pharmacokinetics insight suggests that the furosemide pharmacology occurring in ICU patients with AKI is similar, but not equal to that described in chronic stable renal patients. Even if the diuretic response to furosemide is expressed by a steep dose-response curve positively correlated with renal function, pharmacodynamic limitations occur when creatinine clearance is 
Source: Journal of Nephrology - May 14, 2019 Category: Urology & Nephrology Authors: Mariano F, Mella A, Vincenti M, Biancone L Tags: J Nephrol Source Type: research

Transitional care program to facilitate recovery following severe acute kidney injury.
We examined outcomes following ATCP implementation in adults with AKI-RRT from a tertiary institution (versus pre-ATCP controls), including mortality, cumulative hospital days, and renal function over one year; RRT and haemodialysis catheter days in initial 90 days. RESULTS: We studied 89 patients with age 62 ( ± 15) years. 47% had septic AKI, 20% cardiorenal syndrome, and 29% had baseline eGFR 
Source: Journal of Nephrology - May 14, 2019 Category: Urology & Nephrology Authors: Hong WZ, Haroon S, Lau T, Hui SH, Ma V, Goh JX, Chua HR Tags: J Nephrol Source Type: research

The role of uric acid in mineral bone disorders in chronic kidney disease.
Abstract Increasing survival in the chronic kidney disease (CKD) population exposes the bone to the cumulative detrimental sequelae of CKD, now defined physiologically and histopathologically as chronic kidney disease mineral bone disorder (CKD-BMD). This disorder is increasingly recognized as a "nontraditional" driver of morbidity and mortality and presents an opportunity to improve CKD outcomes via research. However, recent advances in the literature on this topic have not yet been collected into a single review. Therefore, this report aims to discuss the disordered renal-bone axis in CKD-BMD, molecula...
Source: Journal of Nephrology - April 27, 2019 Category: Urology & Nephrology Authors: Afsar B, Sag AA, Oztosun C, Kuwabara M, Cozzolino M, Covic A, Kanbay M Tags: J Nephrol Source Type: research

Everolimus in kidney transplant recipients at high cardiovascular risk: a narrative review.
Abstract Kidney transplant recipients (KTRs) are at increased risk of cardiovascular (CV) morbidity and mortality, and side effects induced by immunosuppressive therapy may be a major contributor to this risk, together with traditional CV risk factors. Many strategies have been considered in order to reduce CV risk in KTRs, such as steroid and/or calcineurin inhibitor (CNI) minimization, but current data are inconclusive. The introduction of mammalian target of rapamycin (mTOR) inhibitors, the cornerstone of CNI minimization, in the immunosuppressive protocol may reduce both the incidence and severity of CNI-assoc...
Source: Journal of Nephrology - April 27, 2019 Category: Urology & Nephrology Authors: Paoletti E, Citterio F, Corsini A, Potena L, Rigotti P, Sandrini S, Bussalino E, Stallone G, ENTROPIA Project Tags: J Nephrol Source Type: research

Morphological evaluation of sympathetic renal innervation in patients with autosomal dominant polycystic kidney disease.
In conclusion, our study better clarifies the effect of sympathetic hyperactivity in the progression of polycystic disease. PMID: 31025246 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - April 25, 2019 Category: Urology & Nephrology Authors: Rovella V, Scimeca M, Giannini E, D'Ercole A, Giacobbi E, Noce A, D'Urso G, Anselmo A, Bove P, Santeusanio G, Bonanno E, Casasco M, Mauriello S, Di Daniele N, Mauriello A, Anemona L Tags: J Nephrol Source Type: research

Prognostic value of high-sensitive cardiac troponin I in asymptomatic chronic hemodialysis patients.
ve; P Abstract INTRODUCTION: Increased levels of cardiac troponins (cTn) are a hallmark of acute myocardial infarction (AMI), along with symptoms and electrocardiographic (ECG) changes. Stably elevated cTn concentrations are frequently observed in asymptomatic patients with chronic kidney disease (CKD) and/or on hemodialysis (HD); the meaning of this elevation, as assessed by conventional techniques, remains unclear. Aim of our study was to evaluate the clinical significance of cTnI levels in asymptomatic HD patients by employing a newer high-sensitive cTnI (hs-cTnI) assay. METHODS: We enrolled 49 patients un...
Source: Journal of Nephrology - April 24, 2019 Category: Urology & Nephrology Authors: Maresca B, Manzione A, Moioli A, Salerno G, Cardelli P, Punzo G, Barberi S, Menè P Tags: J Nephrol Source Type: research