Drug-drug interaction between tacrolimus and caspofungin in Chinese kidney transplant patients with different < em > CYP3A5 < /em > genotypes

CONCLUSION: Co-administration of caspofungin reduced tacrolimus blood levels and elevated the required daily dose of tacrolimus. In CYP3A5 non-expressers, co-administration of caspofungin had a significant effect on tacrolimus C0/D values. An approximate 10% increase in the weight-adjusted daily dose of tacrolimus in CYP3A5 non-expressers is recommended to ensure the safety of tacrolimus administration.PMID:38646424 | PMC:PMC11027596 | DOI:10.1177/20420986241243165
Source: Adv Data - Category: Epidemiology Authors: Source Type: research