The shared genetic risk factors between Tourette syndrome and obsessive-compulsive disorder
Tourette syndrome (TS) and obsessive-compulsive disorder (OCD) are two neuropsychiatric disorders that frequently co-occur. Previous evidence suggests a shared genetic diathesis underlying the comorbidity of TS and OCD. This review aims to comprehensively summarize the current literature on the genetic factors linked with TS and its comorbidities, with a focus on OCD. Family studies, linkage analysis, cytogenetic studies, and genome-wide association studies (GWAS) have played a pivotal role in identifying common and rare genetic variants connected with TS and OCD. Although the genetic framework of TS and OCD is complex and...
Source: Frontiers in Neurology - October 13, 2023 Category: Neurology Source Type: research
Tourette-like syndrome secondary to Kleefstra syndrome 1 with a de novo microdeletion in the EHMT1 gene
Gills de la Tourette syndrome (TS) is a childhood-onset neurodevelopmental disorder manifested by motor and vocal tics. Kleefstra syndrome 1 (KS1), a rare genetic disorder, is caused by haploinsufficiency of the (Source: BMC Neurology)
Source: BMC Neurology - October 10, 2023 Category: Neurology Authors: Mengyue Niu, Yanjing Li, Shikun Zhan, Bomin Sun, Jun Liu and Yiwen Wu Tags: Case Report Source Type: research
Primary complex motor stereotypies are associated with de novo damaging DNA coding mutations that identify < i > KDM5B < /i > as a risk gene
In this study, we perform whole-exome DNA sequencing in 129 parent-child trios with pCMS and 853 control trios (118 cases and 750 controls after quality control). We report an increased rate of de novo predicted-damaging DNA coding variants in pCMS versus controls, identifyingKDM5B as a high-confidence risk gene and estimating 184 genes conferring risk. Genes harboring de novo damaging variants in pCMS probands show significant overlap with those in Tourette syndrome, ASD, and those in ASD probands with high versus low stereotypy scores. An exploratory analysis of these pCMS gene expression patterns finds clustering within...
Source: PLoS One - October 3, 2023 Category: Biomedical Science Authors: Thomas V. Fernandez Source Type: research
Inhibitory Control in Children With Tourette ’s Disorder Is Impaired in Everyday Life But Intact During a Stop Signal Task
This study aims to: 1) investigate the specific association between TD and IC, assessed with a laboratory-based measure as well as a parent- and teacher-reported questionnaire; and 2) increase the understanding of the effect of comorbid ADHD. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2023 Category: Psychiatry Authors: Melanie Ritter, Signe Allerup Vangkilde, Katrine Maigaard, Kerstin Jessica Plessen, Anne Katrine Pagsberg, Julie Hagstr øm Source Type: research
5.42 Pediatric OCD, ADHD, and Tourette's Disorder: Relationship to Medical Disorders
This study aims to characterize the complex triad phenotype of pediatric OCD+TD+ADHD in relation to medical disorders. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2023 Category: Psychiatry Authors: S Shamtej Singh Rana, Marco A. Grados Source Type: research
8.6 fears, tears, and tics: impact and interactions
Although world literature reports that ADHD and OCD are the most common psychiatric disorders that co-occur with persistent tic disorders and Tourette ’s disorder (TD), anxiety disorders are highly prevalent, begin early in life, and may have a significant role in later psychosocial outcome. However, their role and impact has not been as widely investigated. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2023 Category: Psychiatry Authors: Barbara J. Coffey Source Type: research
55.3 Evolving Nonstandard Tic Treatment Approaches
Tourette ’s disorder is a childhood-onset, neuropsychiatric disorder with a prevalence of approximately 1%. For decades, behavioral and pharmacological approaches have remained the same for Tourette’s disorder. Comprehensive behavioral intervention for tics (CBIT), the gold-standard behavioral treatment, can be very effective, yet it is often very challenging to find a well-trained treater. Our stronger pharmacological treatment options (ie, antipsychotics) can help reduce tics, but they are not infrequently associated with intolerable side effects. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2023 Category: Psychiatry Authors: Erica Greenberg Source Type: research
55.2 Evolving Concepts in Distinguishing Tics From Nontics in Tourette's Disorder
In Tourette ’s disorder, it is common to see multiple co-occurring conditions. Some of these, including disruptive behavior disorders (eg, ADHD and intermittent explosive episodes) and mood lability/behavioral disinhibition, have been long-established in Tourette’s disorder and are believed to be associated with dysregulated frontal-striatal brain circuitry. Although each condition typically has distinct phenomenology, it can at times be difficult to distinguish between tics, impulsive behavior, and aggressive behavior, and between mood lability vs formal mood disorders. (Source: Journal of the American Academy of Chil...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2023 Category: Psychiatry Authors: Cathy L. Budman Source Type: research
55.1 Evolving Understanding of Female and Young Adult Profile in Tourette's Disorder
Tourette ’s disorder is prototypically thought to onset in young childhood and to disproportionately affect males over females. Previous studies suggest that tic symptoms improve in later adolescence and adulthood. Data on the phenomenology and impact of Tourette’s disorder in females and young adults is scant. This presentation will highlight the clinical presentations and research on Tourette’s disorder in females and young adults. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2023 Category: Psychiatry Authors: Shannon Bennett Source Type: research
Evolving Topics in Tourette's Disorder
Chronic tic disorders (CTD), including Tourette ’s disorder (TD), are childhood-onset neuropsychiatric disorders characterized by tics. Although our gold-standard treatment approaches have remained similar for the last 2 decades, our knowledge base continues to evolve. Areas of increased understanding include the association between natal sex a nd one’s TD symptom profile, how one’s clinical profile changes with age, the differences between “Tourettic” tics and functional tic-like behaviors, how the implicated neurocircuitry associates with various disruptive behavioral symptoms, and new nonpharmacological approa...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2023 Category: Psychiatry Authors: Erica Greenberg, Barbara J. Coffey Tags: Clinical Perspectives 55 Source Type: research
52.2 Involving Parents and Caregivers in Treatment, Education, and Advocacy for Tourette's Disorder and Related Conditions
Tic disorders, and common co-occurring conditions such as ADHD and anxiety, onset most often in childhood, requiring participation from parents in the treatment process. In fact, evidence exists for the effective treatment of ADHD and anxiety in youth by engaging parents only in a behavioral treatment process without actively including the child. Preliminary evidence suggests that this may be a useful approach for young children with tic disorders as well. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2023 Category: Psychiatry Authors: Shannon Bennett Source Type: research
Review on pharmacological effects of gastrodin
Arch Pharm Res. 2023 Sep 25. doi: 10.1007/s12272-023-01463-0. Online ahead of print.ABSTRACTGastrodia elata Blume is a well-known traditional Chinese medicine that is mainly used to treat diseases related to the nervous system, such as stroke, epilepsy, and headache. Gastrodin is the main bioactive component of Gastrodia elata Blume, and studies have shown that it has extensive pharmacological activity. This narrative review aims to systematically review relevant studies on the pharmacological effects of gastrodin to provide researchers with the latest and most useful information. Studies have shown that gastrodin has prom...
Source: Archives of Pharmacal Research - September 25, 2023 Category: Drugs & Pharmacology Authors: Guirong Xiao Rong Tang Nan Yang Yanhua Chen Source Type: research
Cerebrospinal fluid findings in patients with obsessive-compulsive disorder, Tourette syndrome, and PANDAS: A systematic literature review
CONCLUSIONS: This systematic review of available CSF data shows that too few studies are currently available for conclusions with good evidence. The existing data indicates glutamate alterations in OCD and possible immunological abnormalities in OCD and TS. More CSF studies avoiding sources of bias are needed.PMID:37748568 | DOI:10.1016/j.bbi.2023.09.016 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 25, 2023 Category: Neurology Authors: Benjamin Pankratz Bernd Feige Kimon Runge Karl Bechter Miriam A Schiele Katharina Domschke Harald Pr üss Ludger Tebartz van Elst Kathrin Nickel Dominique Endres Source Type: research
Review on pharmacological effects of gastrodin
Arch Pharm Res. 2023 Sep 25. doi: 10.1007/s12272-023-01463-0. Online ahead of print.ABSTRACTGastrodia elata Blume is a well-known traditional Chinese medicine that is mainly used to treat diseases related to the nervous system, such as stroke, epilepsy, and headache. Gastrodin is the main bioactive component of Gastrodia elata Blume, and studies have shown that it has extensive pharmacological activity. This narrative review aims to systematically review relevant studies on the pharmacological effects of gastrodin to provide researchers with the latest and most useful information. Studies have shown that gastrodin has prom...
Source: Archives of Pharmacal Research - September 25, 2023 Category: Drugs & Pharmacology Authors: Guirong Xiao Rong Tang Nan Yang Yanhua Chen Source Type: research
Cerebrospinal fluid findings in patients with obsessive-compulsive disorder, Tourette syndrome, and PANDAS: A systematic literature review
CONCLUSIONS: This systematic review of available CSF data shows that too few studies are currently available for conclusions with good evidence. The existing data indicates glutamate alterations in OCD and possible immunological abnormalities in OCD and TS. More CSF studies avoiding sources of bias are needed.PMID:37748568 | DOI:10.1016/j.bbi.2023.09.016 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - September 25, 2023 Category: Neurology Authors: Benjamin Pankratz Bernd Feige Kimon Runge Karl Bechter Miriam A Schiele Katharina Domschke Harald Pr üss Ludger Tebartz van Elst Kathrin Nickel Dominique Endres Source Type: research
