Pregnancy in dystonia or Tourette ’s patients treated with DBS. Four new cases and a review of the literature
Background: Deep Brain Stimulation (DBS) has been demonstrated to improve quality of life in patients with refractory dystonia and Tourette ’s syndrome (TS). Because of the young age at onset of these disorders, and the marked benefit from DBS, pregnancy in patients who have received DBS is becoming a more frequent clinical occurrence, although clear management guidelines are lacking. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: R. Mehanna, A. Tarakad, L.Y. Taneff, E. Furr Stimming Source Type: research
Abnormal H3K4 enzyme catalytic activity and neuronal morphology caused by ASH1L mutations in individuals with Tourette syndrome
In this study, we validated five pathogenicASH1L rare variants and observed symptoms in patients with simple tics and behavioral comorbidities. Mutations near the catalytic domain of TS patients cause mental state abnormalities and disruptASH1L function by destabilizing its spatial conformation, leading to decreased activity of catalytic H3K4, thereby affecting the neurite growth. We need to conduct larger-scale studies on TS patients and perform additional neurological evaluations on mature neurons. We first reported the effects ofASH1L mutations in TS patients, including phenotypic heterogeneity, protein function, and ne...
Source: European Child and Adolescent Psychiatry - April 18, 2024 Category: Psychiatry Source Type: research
Supporting neurodivergent nursing students in their practice placements
This article details the strengths that neurodivergent students can bring to nursing, as well as some of the challenges they may experience in practice settings. It outlines how practice assessors and supervisors can develop neuro-inclusive learning environments where neurodivergent students can thrive, as well as how to support them if they are not meeting their required proficiencies. The authors also discuss how appropriate reasonable adjustments can be implemented by using a collaborative approach with students.PMID:38616773 | DOI:10.7748/ns.2024.e12262 (Source: Nursing Standard)
Source: Nursing Standard - April 15, 2024 Category: Nursing Authors: Rachael Major Chloe Jackson Jade Wareham Jessica Pidcock Source Type: research
Supporting neurodivergent nursing students in their practice placements
This article details the strengths that neurodivergent students can bring to nursing, as well as some of the challenges they may experience in practice settings. It outlines how practice assessors and supervisors can develop neuro-inclusive learning environments where neurodivergent students can thrive, as well as how to support them if they are not meeting their required proficiencies. The authors also discuss how appropriate reasonable adjustments can be implemented by using a collaborative approach with students.PMID:38616773 | DOI:10.7748/ns.2024.e12262 (Source: Nursing Standard)
Source: Nursing Standard - April 15, 2024 Category: Nursing Authors: Rachael Major Chloe Jackson Jade Wareham Jessica Pidcock Source Type: research
Agreement between self-, mother and father proxy-reports on health-related quality of life in adolescents with Tourette syndrome
This study aimed to investigate agreement and discrepancies between parent proxy- and adolescent self-reports on assessments of adolescents ’ health-related quality of life (HRQoL), and the role that individual factors may play in parent-adolescent agreement, in a sample of adolescents with Tourette syndrome (TS) compared to a control group of healthy adolescents. Adolescents aged 12–18 years diagnosed with TS were recruited with t heir parents from primary and secondary referral centres. Adolescent healthy controls were matched for gender and age. Adolescents and each of their parents completed a set of questionnaire...
Source: European Child and Adolescent Psychiatry - April 13, 2024 Category: Psychiatry Source Type: research
Streptococcal Serology in Children With Stuttering
Conclusion: The higher serum antistreptococcal antibody amounts in CWS suggest that an increased autoimmune response against GAHBS may be the etiology of childhood stuttering. It has been suggested that CWS should be examined for autoimmune reactions, especially to GAHBS.PMID:38591779 | DOI:10.1177/01455613241244946 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - April 9, 2024 Category: ENT & OMF Authors: Tulin Fidan Serkan Ceyhan Vural Fidan Source Type: research
