Video-based evaluation system for tic action in Tourette syndrome: modeling, detection, and evaluation
In this study, we proposed a tic action detection method using face video feature recognition for tic and control groups. Through facial ROI extraction, a 3D convolutional neural network was used to learn video feature representations, and multi-instance learning anomaly detection strategy was integrated to construct the tic action analysis and discrimination framework. We applied this tic recognition framework in our video dataset. The model evaluation results achieved average tic detection accuracy of 91.02%, precision of 77.07% and recall of 78.78%. And the tic score curve with postprocessing provided information of how...
Source: Health Information Science and Systems - August 28, 2023 Category: Information Technology Source Type: research
Images: Polysomnographic artifact in a patient with Tourette syndrome
Journal of Clinical Sleep Medicine, Ahead of Print. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - August 25, 2023 Category: Sleep Medicine Authors: Tejwant Bindra
David G. Ingram
Division of Pulmonary and Sleep Medicine, Children ’s Mercy Hospital Source Type: research
Factors associated with Tourette syndrome among adolescents in Taiwan: A cross-sectional correlational study
Adolescents with Tourette syndrome (TS) may suffer from learning difficulties (attention-deficit/hyperactivity disorder), challenges in interpersonal interactions (especially with peers), disruptions of daily routines (disruptive behavior disorders), and increased psychosocial stress, which can result in internalizing and externalizing behavioral problems, such as venting depression and stress through self-harm. The aim of this study was to investigate peer attachment in adolescents with TS and associated risk factors. (Source: Journal of Pediatric Nursing)
Source: Journal of Pediatric Nursing - August 5, 2023 Category: Nursing Authors: Che-Sheng Ho, Yi-Chang Chen, Mei-Yin Lee, Chen-Jung Chen, Huang-Ju Tsai Source Type: research
Immp2l knockdown in male mice increases stimulus-driven instrumental behaviour but does not alter goal-directed learning or neuron density in cortico-striatal circuits in a model of Tourette syndrome and autism spectrum disorder
Behav Brain Res. 2023 Aug 2:114610. doi: 10.1016/j.bbr.2023.114610. Online ahead of print.ABSTRACTCortico-striatal neurocircuits mediate goal-directed and habitual actions which are necessary for adaptive behaviour. It has recently been proposed that some of the core symptoms of autism spectrum disorder (ASD) and Gilles de la Tourette syndrome (GTS), such as tics and other repetitive behaviours, may emerge because of imbalances in these neurocircuits. We have recently developed a model of ASD and GTS by knocking down Immp2l, a mitochondrial gene frequently associated with these disorders. The current study sought to determ...
Source: Behavioural Brain Research - August 4, 2023 Category: Neurology Authors: Beatrice K Leung Sam Merlin Adam K Walker Adam J Lawther George Paxinos Valsamma Eapen Raymond Clarke Bernard W Balleine Teri M Furlong Source Type: research
Immp2l knockdown in male mice increases stimulus-driven instrumental behaviour but does not alter goal-directed learning or neuron density in cortico-striatal circuits in a model of Tourette syndrome and autism spectrum disorder
Behav Brain Res. 2023 Aug 2:114610. doi: 10.1016/j.bbr.2023.114610. Online ahead of print.ABSTRACTCortico-striatal neurocircuits mediate goal-directed and habitual actions which are necessary for adaptive behaviour. It has recently been proposed that some of the core symptoms of autism spectrum disorder (ASD) and Gilles de la Tourette syndrome (GTS), such as tics and other repetitive behaviours, may emerge because of imbalances in these neurocircuits. We have recently developed a model of ASD and GTS by knocking down Immp2l, a mitochondrial gene frequently associated with these disorders. The current study sought to determ...
Source: Brain Research - August 4, 2023 Category: Neurology Authors: Beatrice K Leung Sam Merlin Adam K Walker Adam J Lawther George Paxinos Valsamma Eapen Raymond Clarke Bernard W Balleine Teri M Furlong Source Type: research
Immp2l knockdown in male mice increases stimulus-driven instrumental behaviour but does not alter goal-directed learning or neuron density in cortico-striatal circuits in a model of Tourette syndrome and autism spectrum disorder
Behav Brain Res. 2023 Aug 2:114610. doi: 10.1016/j.bbr.2023.114610. Online ahead of print.ABSTRACTCortico-striatal neurocircuits mediate goal-directed and habitual actions which are necessary for adaptive behaviour. It has recently been proposed that some of the core symptoms of autism spectrum disorder (ASD) and Gilles de la Tourette syndrome (GTS), such as tics and other repetitive behaviours, may emerge because of imbalances in these neurocircuits. We have recently developed a model of ASD and GTS by knocking down Immp2l, a mitochondrial gene frequently associated with these disorders. The current study sought to determ...
Source: Behavioural Brain Research - August 4, 2023 Category: Neurology Authors: Beatrice K Leung Sam Merlin Adam K Walker Adam J Lawther George Paxinos Valsamma Eapen Raymond Clarke Bernard W Balleine Teri M Furlong Source Type: research
Immp2l knockdown in male mice increases stimulus-driven instrumental behaviour but does not alter goal-directed learning or neuron density in cortico-striatal circuits in a model of Tourette syndrome and autism spectrum disorder
Behav Brain Res. 2023 Aug 2:114610. doi: 10.1016/j.bbr.2023.114610. Online ahead of print.ABSTRACTCortico-striatal neurocircuits mediate goal-directed and habitual actions which are necessary for adaptive behaviour. It has recently been proposed that some of the core symptoms of autism spectrum disorder (ASD) and Gilles de la Tourette syndrome (GTS), such as tics and other repetitive behaviours, may emerge because of imbalances in these neurocircuits. We have recently developed a model of ASD and GTS by knocking down Immp2l, a mitochondrial gene frequently associated with these disorders. The current study sought to determ...
Source: Brain Research - August 4, 2023 Category: Neurology Authors: Beatrice K Leung Sam Merlin Adam K Walker Adam J Lawther George Paxinos Valsamma Eapen Raymond Clarke Bernard W Balleine Teri M Furlong Source Type: research
Convergent imaging-transcriptomic evidence for disturbed iron homeostasis in Gilles de la Tourette syndrome
Neurobiol Dis. 2023 Aug 1:106252. doi: 10.1016/j.nbd.2023.106252. Online ahead of print.ABSTRACTGilles de la Tourette syndrome (GTS) is a neuropsychiatric movement disorder with reported abnormalities in various neurotransmitter systems. Considering the integral role of iron in neurotransmitter synthesis and transport, it is hypothesized that iron exhibits a role in GTS pathophysiology. As a surrogate measure of brain iron, quantitative susceptibility mapping (QSM) was performed in 28 patients with GTS and 26 matched controls. Significant susceptibility reductions in the patients, consistent with reduced local iron content...
Source: Neurobiology of Disease - August 3, 2023 Category: Neurology Authors: Ahmad Seif Kanaan Dongmei Yu Riccardo Metere Andreas Sch äfer Torsten Schlumm Berkin Bilgic Alfred Anwander Carol A Mathews Jeremiah M Scharf Kirsten M üller-Vahl Harald E M öller Source Type: research
Convergent imaging-transcriptomic evidence for disturbed iron homeostasis in Gilles de la Tourette syndrome
Neurobiol Dis. 2023 Aug 1:106252. doi: 10.1016/j.nbd.2023.106252. Online ahead of print.ABSTRACTGilles de la Tourette syndrome (GTS) is a neuropsychiatric movement disorder with reported abnormalities in various neurotransmitter systems. Considering the integral role of iron in neurotransmitter synthesis and transport, it is hypothesized that iron exhibits a role in GTS pathophysiology. As a surrogate measure of brain iron, quantitative susceptibility mapping (QSM) was performed in 28 patients with GTS and 26 matched controls. Significant susceptibility reductions in the patients, consistent with reduced local iron content...
Source: Neurobiology of Disease - August 3, 2023 Category: Neurology Authors: Ahmad Seif Kanaan Dongmei Yu Riccardo Metere Andreas Sch äfer Torsten Schlumm Berkin Bilgic Alfred Anwander Carol A Mathews Jeremiah M Scharf Kirsten M üller-Vahl Harald E M öller Source Type: research
EEG findings in Gilles de la Tourette syndrome
Background:Patients with Gilles de la Tourette Syndrome (GTS) have an 18-fold increased risk of epilepsy. On the other hand, first presentation of tic disorder may mimic epilepsy, especially focal seizures. Epileptiform discharges found on EEG in patients with tic disorders may lead to the unnecessary introduction of antiepileptic medications. The aim of this work was to show the incidence and characteristics of EEG abnormalities in patients with diagnosed GTS who do not have epilepsy as a comorbidity. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - August 1, 2023 Category: Neurology Authors: C. Rajczewska-Oleszkiewicz, J. Kaczy ńska, P. Janik Source Type: research
Klazomania in Gilles de la Tourette syndrome
Background:Klazomania is defined as compulsive, paroxysmal, loud shouting and usually recognized as a vocal tic. However, there is no systematic studies on klazomania in GTS. We aimed to assess if clinical associations of klazomania include tic-related variables, or whether its occurrence is associated rather with co-morbid psychiatric disorders. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - August 1, 2023 Category: Neurology Authors: J. Kaczy ńska, P. Janik Source Type: research
Heat-induced tic reduction in Gilles de la Tourette syndrome
Background:Patients with Gilles de la Tourette syndrome (GTS) may exhibit decrements or increments of tics with heat. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - August 1, 2023 Category: Neurology Authors: A. Durbin, J. Brasic Source Type: research
Tourette Syndrome and Obsessive-Compulsive Disorder: A Comprehensive Review of Structural Alterations and Neurological Mechanisms
Behav Brain Res. 2023 Jul 29:114606. doi: 10.1016/j.bbr.2023.114606. Online ahead of print.ABSTRACTCurrently, it is possible to study the pathogenesis of Tourette's syndrome (TS) in more detail, due to more advanced methods of neuroimaging. However, medical and surgical treatment options are limited by a lack of understanding of the nature of the disorder and its relationship to some psychiatric disorders, the most common of which is obsessive-compulsive disorder (OCD). It is believed that the origin of chronic tic disorders is based on an imbalance of excitatory and inhibitory influences in the Cortico-Striato-Thalamo-Cor...
Source: Behavioural Brain Research - July 31, 2023 Category: Neurology Authors: Anna D Shitova Tatyana S Zharikova Olga N Kovaleva Anastasia M Luchina Arthur S Aktemirov Anna V Olsufieva Mikhail Y Sinelnikov Andr é Pontes-Silva Yury O Zharikov Source Type: research
Tourette Syndrome and Obsessive-Compulsive Disorder: A Comprehensive Review of Structural Alterations and Neurological Mechanisms
Behav Brain Res. 2023 Jul 29:114606. doi: 10.1016/j.bbr.2023.114606. Online ahead of print.ABSTRACTCurrently, it is possible to study the pathogenesis of Tourette's syndrome (TS) in more detail, due to more advanced methods of neuroimaging. However, medical and surgical treatment options are limited by a lack of understanding of the nature of the disorder and its relationship to some psychiatric disorders, the most common of which is obsessive-compulsive disorder (OCD). It is believed that the origin of chronic tic disorders is based on an imbalance of excitatory and inhibitory influences in the Cortico-Striato-Thalamo-Cor...
Source: Brain Research - July 31, 2023 Category: Neurology Authors: Anna D Shitova Tatyana S Zharikova Olga N Kovaleva Anastasia M Luchina Arthur S Aktemirov Anna V Olsufieva Mikhail Y Sinelnikov Andr é Pontes-Silva Yury O Zharikov Source Type: research
