Psychosocial experiences in youth with Tourette syndrome: a systematic review and meta-synthesis
AbstractSuffering from Tourette syndrome (TS) disrupts the daily lives and interpersonal relationships of patients. The psychosocial experiences of young people with TS are not yet clear. The aim of the systematic review is to identify and synthesize the psychosocial experiences of young people with TS. A meta-synthesis was conducted. PubMed, EMBASE, Cumulative Index to Nursing and Allied Health Literature, Web of Science, and Chinese Electronic Periodical Services databases were searched for articles published from their inception to February 2023. This review followed the Joanna Briggs Institute ’s Guidelines for Syste...
Source: European Child and Adolescent Psychiatry - December 21, 2023 Category: Psychiatry Source Type: research
Smart dual imprinted Origami 3D-ePAD for selective and simultaneous analysis of vanillylmandelic acid and 5-hydroxyindole-3-acetic acid carcinoid cancer biomarkers using graphene quantum dots coated with dual molecularly imprinted polymers
Talanta. 2023 Dec 7;269:125512. doi: 10.1016/j.talanta.2023.125512. Online ahead of print.ABSTRACTMeasuring the levels of the biomarkers vanillylmandelic acid (VMA) and 5-Hydroxyindole-3-acetic acid (5-HIAA) is a valuable tool for clinical diagnosis not only of neuroblastoma or carcinoid syndrome, but also of essential hypertension, depression, migraine, and Tourette's syndrome. Herein, we explore using graphene quantum dots (GQDs) coated with molecularly imprinted polymer (MIP) as novel dual-imprinted sensors for selective and simultaneous determination of VMA and 5-HIAA in urine and plasma samples. The dual-MIP was succe...
Source: Talanta - December 13, 2023 Category: Chemistry Authors: Kanpitcha Somnet Supansa Chimjarn Surasak Wanram Purim Jarujamrus Duangjai Nacapricha Peter A Lieberzeit Maliwan Amatatongchai Source Type: research
Smart dual imprinted Origami 3D-ePAD for selective and simultaneous analysis of vanillylmandelic acid and 5-hydroxyindole-3-acetic acid carcinoid cancer biomarkers using graphene quantum dots coated with dual molecularly imprinted polymers
Talanta. 2023 Dec 7;269:125512. doi: 10.1016/j.talanta.2023.125512. Online ahead of print.ABSTRACTMeasuring the levels of the biomarkers vanillylmandelic acid (VMA) and 5-Hydroxyindole-3-acetic acid (5-HIAA) is a valuable tool for clinical diagnosis not only of neuroblastoma or carcinoid syndrome, but also of essential hypertension, depression, migraine, and Tourette's syndrome. Herein, we explore using graphene quantum dots (GQDs) coated with molecularly imprinted polymer (MIP) as novel dual-imprinted sensors for selective and simultaneous determination of VMA and 5-HIAA in urine and plasma samples. The dual-MIP was succe...
Source: Talanta - December 13, 2023 Category: Chemistry Authors: Kanpitcha Somnet Supansa Chimjarn Surasak Wanram Purim Jarujamrus Duangjai Nacapricha Peter A Lieberzeit Maliwan Amatatongchai Source Type: research
Prevalence of depression and anxiety in patients with Tourette syndrome; 1997 to 2022: a systematic review and meta-analysis
Tourette Syndrome (TS) is a disorder in which the patient has a history of multiple motor and vocal tics. Depression and anxiety are common in these patients. The results of the studies show different prevalen... (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - December 1, 2023 Category: Pediatrics Authors: Parvin Abbasi, Sepideh Tanhaie and Mohsen Kazeminia Tags: Review Source Type: research
Prevalence of depression and anxiety in patients with Tourette syndrome; 1997 to 2022: a systematic review and meta-analysis
AbstractTourette Syndrome (TS) is a disorder in which the patient has a history of multiple motor and vocal tics. Depression and anxiety are common in these patients. The results of the studies show different prevalence of these disorders in patients with TS. So, the objective of the present study was to liken the prevalence of depression and anxiety in patients with TS by systematic review and meta-analysis. The present study was conducted according to PRISMA guidelines during 1997 –2022. The articles were obtained from Scopus, Embase, PubMed, Web of Science (WoS) and Google Scholar databases. I2 was used to investigate...
Source: Italian Journal of Pediatrics - December 1, 2023 Category: Pediatrics Source Type: research
Obsessive –Compulsive Disorder and Tourette’s Disorder Symptom Presentations: Differential Diagnosis and Treatment Considerations
AbstractPurpose of ReviewThis review summarizes the shared and distinct clinical features of obsessive-compulsive disorder Tourette ’s disorder (TD), and their comorbidity, in addition to state of the literature on differential diagnosis of these disorders, and best-practice treatment guidelines for their comorbid presentation.Recent FindingsOCD and TD are each marked by recurrent behaviors and maintained via alleviation of adverse internal processes. They also share clinical features, comorbidities, and etiology, complicating diagnosis. Differential diagnosis draws on consideration of the nature of repetitive behaviors...
Source: Current Developmental Disorders Reports - November 29, 2023 Category: Child Development Source Type: research
New | phs001423.v4.p2 | Tourette International Collaborative Genetics (TIC Genetics) Study - NJCTS and NIMH
Tourette International Collaborative Genetics (TIC Genetics) Study - NJCTS and NIMH (study page |release notes) (Source: dbGaP, the database of Genotypes and Phenotypes)
Source: dbGaP, the database of Genotypes and Phenotypes - November 21, 2023 Category: Genetics & Stem Cells Tags: StudyRelease Source Type: research
Psychosocial stress in children with Tourette syndrome and chronic tic disorder
This study aimed to understand the longitudinal relationship between psychosocial stress with tic exacerbation in children with Tourette syndrome (TS) and chronic tic disorder. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - November 14, 2023 Category: Perinatology & Neonatology Authors: Chiew Yin Tan, Nan-Chang Chiu, Yi-Hong Zeng, Jia-Yun Huang, Ruu-Fen Tzang, Hui-Ju Chen, Yi-Jie Lin, Fang-Ju Sun, Che-Sheng Ho Source Type: research
Prevalence, comorbidities, and profiles of neurodevelopmental disorders according to the DSM-5-TR in children aged 6 years old in a European region
ConclusionIn disadvantaged contexts, there was a higher prevalence of NDDs and comorbidities, unless the disorder was extreme, in which case only the NDD manifestations were presented. A significant proportion of the sample had not been previously diagnosed (88.6%); therefore, early detection programs are recommended to identify warning signs and develop policies that help and support the most disadvantaged sectors of the population. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - November 10, 2023 Category: Psychiatry Source Type: research
Elevated phospholipids and acylcarnitines C4 and C5 in cerebrospinal fluid distinguish viral CNS infections from autoimmune neuroinflammation
CONCLUSIONS: Changes in CNS metabolism differ substantially between viral CNS infections and autoimmune neuroinflammation and reveal CSF metabolites as pathophysiologically relevant diagnostic biomarkers for the differentiation between the two conditions. In viral CNS infections, the observed higher concentrations of free phospholipids are consistent with disruption of host cell membranes, whereas the elevated short-chain acylcarnitines likely reflect compromised mitochondrial homeostasis and energy generation.PMID:37919735 | DOI:10.1186/s12967-023-04637-y (Source: Herpes)
Source: Herpes - November 3, 2023 Category: Infectious Diseases Authors: Amani Al-Mekhlafi Fakhar H Waqas Maike Krueger Frank Klawonn Manas K Akmatov Kirsten M üller-Vahl Corinna Trebst Thomas Skripuletz Martin Stangel Kurt-Wolfram S ühs Frank Pessler Source Type: research
Elevated phospholipids and acylcarnitines C4 and C5 in cerebrospinal fluid distinguish viral CNS infections from autoimmune neuroinflammation
CONCLUSIONS: Changes in CNS metabolism differ substantially between viral CNS infections and autoimmune neuroinflammation and reveal CSF metabolites as pathophysiologically relevant diagnostic biomarkers for the differentiation between the two conditions. In viral CNS infections, the observed higher concentrations of free phospholipids are consistent with disruption of host cell membranes, whereas the elevated short-chain acylcarnitines likely reflect compromised mitochondrial homeostasis and energy generation.PMID:37919735 | PMC:PMC10621113 | DOI:10.1186/s12967-023-04637-y (Source: Herpes)
Source: Herpes - November 3, 2023 Category: Infectious Diseases Authors: Amani Al-Mekhlafi Fakhar H Waqas Maike Krueger Frank Klawonn Manas K Akmatov Kirsten M üller-Vahl Corinna Trebst Thomas Skripuletz Martin Stangel Kurt-Wolfram S ühs Frank Pessler Source Type: research
Elevated phospholipids and acylcarnitines C4 and C5 in cerebrospinal fluid distinguish viral CNS infections from autoimmune neuroinflammation
CONCLUSIONS: Changes in CNS metabolism differ substantially between viral CNS infections and autoimmune neuroinflammation and reveal CSF metabolites as pathophysiologically relevant diagnostic biomarkers for the differentiation between the two conditions. In viral CNS infections, the observed higher concentrations of free phospholipids are consistent with disruption of host cell membranes, whereas the elevated short-chain acylcarnitines likely reflect compromised mitochondrial homeostasis and energy generation.PMID:37919735 | PMC:PMC10621113 | DOI:10.1186/s12967-023-04637-y (Source: Herpes)
Source: Herpes - November 3, 2023 Category: Infectious Diseases Authors: Amani Al-Mekhlafi Fakhar H Waqas Maike Krueger Frank Klawonn Manas K Akmatov Kirsten M üller-Vahl Corinna Trebst Thomas Skripuletz Martin Stangel Kurt-Wolfram S ühs Frank Pessler Source Type: research
Alterations in the topological organization of the default-mode network in Tourette syndrome
The exact pathophysiology of TS is still elusive. Previous studies have identified default mode networks (DMN) abnormalities in patients with TS. However, these literatures investigated the neural activity dur... (Source: BMC Neurology)
Source: BMC Neurology - October 30, 2023 Category: Neurology Authors: Yue Yang, Hua Yang, Chunmei Yu, Fang Ni, Tao Yu and Rong Luo Tags: Research Source Type: research
The microstructural change of the brain and its clinical severity association in pediatric Tourette syndrome patients
ConclusionTreatment-na ïve pediatric GTS patients demonstrated increased connectivity within the CSTC circuit as per diffusion spectrum imaging, indicating possible CSTC circuit dysregulation. This finding could also suggest a compensatory change. It thus underscores the necessity of further investigation into the fundam ental pathological changes in GTS. Nevertheless, the observed altered connectivity in GTS patients might serve as a potential target for therapeutic intervention. (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - October 25, 2023 Category: Neurology Source Type: research
