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Enterococcus casseliflavus regulates amino acid metabolism in edible insect Clanis bilineata tsingtauica: a functional metagenomics study
This study not only extends our knowledge of gut microbiome in soybean hawkmoths at the species level, but also provides an initial investigation of gene functionality in interaction with insect hosts. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - March 25, 2024 Category: Microbiology Source Type: research

Impaired neuronal macroautophagy in the prelimbic cortex contributes to comorbid anxiety-like behaviors in rats with chronic neuropathic pain
Autophagy. 2024 Mar 24:1-18. doi: 10.1080/15548627.2024.2330038. Online ahead of print.ABSTRACTA large proportion of patients with chronic pain experience co-morbid anxiety. The medial prefrontal cortex (mPFC) is proposed to underlie this comorbidity, but the molecular and neuronal mechanisms are not fully understood. Here, we reported that impaired neuronal macroautophagy in the prelimbic cortical (PrL) subregion of the mPFC paralleled the occurrence of anxiety-like behaviors in rats with chronic spared nerve injury (SNI). Intriguingly, such macroautophagy impairment was mainly observed in a FOS/c-Fos+ neuronal subpopulat...
Source: Autophagy - March 24, 2024 Category: Cytology Authors: Su Fu Haojie Sun Jiaxin Wang Shuaixin Gao Liu Zhu Kun Cui Shimeng Liu Xuetao Qi Rui Guan Xiaocen Fan Qingying Liu Wen Chen Li Su Shuang Cui Feifei Liao Fengyu Liu Catherine C L Wong Ming Yi You Wan Source Type: research

Efficient removal of tetracycline and Cu < sup > 2+ < /sup > by honeycomb derived magnetic carbon: Adsorption mechanism and advanced oxidation regeneration mechanism
This study discussed the application and regeneration methods of magnetic adsorbents in water treatment, offering new insights into environmental remediation using magnetic materials.PMID:38520810 | DOI:10.1016/j.ecoenv.2024.116225 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - March 23, 2024 Category: Environmental Health Authors: Rongfa Zhang Song Xia Wei Bao Wenxuan Li Jifei Hou Xuede Li Source Type: research

Effects of antibiotics on secondary metabolism and oxidative stress in oilseed rape seeds
In this study, typical tetracycline and sulfonamide antibiotics tetracycline (TC) and sulfamethoxazole (SMZ) were used to investigate the effects of antibiotics on rapeseed quality and oxidative stress at the level of secondary metabolism on the basis of examining the effects of the two drugs on the growth of soil-cultivated rapeseed seedlings. The results showed that both plant height and biomass of rapeseed seedlings were significantly suppressed and ROS were significantly induced in rapeseed by exposure to high concentrations (2.5 mg/kg) of TC and SMZ. Carotenoids, tocopherols, and SOD enzymes were involved in the oxida...
Source: Environmental Science and Pollution Research International - March 23, 2024 Category: Environmental Health Authors: Ke Li Mengting Zhao Shanshan Zhou Lili Niu Lu Zhao Dongmei Xu Source Type: research

Antibacterial activity of the antimicrobial peptide PMAP-36 in combination with tetracycline against porcine extraintestinal pathogenic Escherichia coli in vitro and in vivo
In this study, we investigated the antibacterial activity of porcine myeloid antimicrobial peptide 36 (PMAP-36) in combination with tetracycline against porcine ExPEC PCN033 both in vitro and in vivo. The minimum bactericidal concentrations (MBCs) of AMPs (PMAP-36 and PR-39) against the ExPEC strains PCN033 and RS218 were 10 μM and 5 μM, respectively. Results of the checkerboard assay and the time-kill assay showed that PMAP-36 and antibiotics (tetracycline and gentamicin) had synergistic bactericidal effects against PCN033. PMAP-36 and tetracycline in combination led to PCN033 cell wall shrinkage, as was shown by scanni...
Source: Cell Research - March 23, 2024 Category: Cytology Authors: Qi Tao Yi Lu Qian Liu Runqiu Chen Yating Xu Gang Li Xiaoxiang Hu Chao Ye Lianci Peng Rendong Fang Source Type: research

Molecules, Vol. 29, Pages 1444: Novel Enzyme-Assisted Recycle Amplification Strategy for Tetracycline Detection Based on Oxidized Single-Walled Carbon Nanohorns
In this study, oxidized single-walled carbon nanohorns (oxSWCNHs) were prepared using nitric acid oxidation and subsequently combined with 3&prime;6-carboxyfluorescein through charge transfer to prepare fluorescent probes. These oxSWCNHs were used to quench fluorogen signals at short distances and dissociate ssDNA using cryonase enzymes. We established a method for rapidly detecting tetracycline (TC) in complex samples based on the amplification of cryonase enzyme signals. After optimizing the experimental conditions, our method showed a detection limit of 5.05 ng/mL, with good specificity. This method was used to ...
Source: Molecules - March 23, 2024 Category: Chemistry Authors: Tingting Feng Shuzhu Yan Yu Huang Tags: Article Source Type: research

Prevalence of antibiotics, antibiotic resistance genes, and their associations in municipal wastewater treatment plants along the Yangtze River basin, China
Environ Pollut. 2024 Mar 20:123800. doi: 10.1016/j.envpol.2024.123800. Online ahead of print.ABSTRACTThe overuse and misuse of antibiotics have resulted in the pollution of antibiotics and antibiotic resistance genes (ARGs) in municipal wastewater treatment plants (WWTPs), posing threats to ecological security and human health. Thus, a comprehensive investigation was conducted to assess the occurrence, removal efficiency, and ecological risks of antibiotics, along with the diversity, abundance, and co-occurrence of ARGs, and their correlations in 13 WWTPs along the Yangtze River Basin. Among 35 target antibiotics, 23 antib...
Source: Environmental Pollution - March 22, 2024 Category: Environmental Health Authors: Yangyang Zhang Yifan Hu Xiuwen Li Linjun Gao Shuya Wang Shuyu Jia Peng Shi Aimin Li Source Type: research

Combined fabrication of zeolitic imidazolate framework-8 and lanthanide towards coordination polymers: A dual-signal fluorescent probe for sensing Cu < sup > 2+ < /sup > based on synergistic e ﬀect of aggregation-induced emission and antenna effect
Talanta. 2024 Mar 18;273:125941. doi: 10.1016/j.talanta.2024.125941. Online ahead of print.ABSTRACTCopper ion (Cu2+) detection remains an important task for monitoring water quality because of its specific toxicity. Herein, a new dual-signal fluorescent probe was developed by combining zeolitic imidazolate framework-8 (ZIF-8) and lanthanide for the detection of Cu2+ for the ﬁrst time. The lanthanide coordination polymer (guanosine monophosphate and Eu3+, GMP/Eu) was initially incorporated into ZIF-8 to yield ZIF-8/GMP/Eu nanomaterials with extremely weak single emission fluorescence at 618 nm. It was found that the resul...
Source: Talanta - March 22, 2024 Category: Chemistry Authors: Yanmei Si Yanli Li Jianli Guo Hua Wang Xinfang Wang Jia Fu Source Type: research

Assessing the potential for improved predictive capacity of antimicrobial resistance in outpatient Staphylococcus aureus isolates using seasonal and spatial antibiograms
ConclusionsStandard antibiograms are poor in predictingS. aureus susceptibility to antibiotics often chosen by clinicians, and seasonal and spatial antibiograms do not provide an improved tool in anticipating non-susceptibility. These findings suggest that further refinements to antibiograms may be necessary to improve their utility in informing choice of effective antibiotic therapy. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - March 22, 2024 Category: Infectious Diseases Source Type: research

Antibiotic ’s target site affects the potentiation of Lactiplantibacillus plantarum inhibition and inactivation by electroporation
DiscussionOur results indicate that electroporation potentiates inactivation of G+ bacteria to a larger extent for antibiotics that inhibit intracellular processes and require transport into the cytoplasm, and to a smaller extent for antibiotics that inhibit cell-wall synthesis. This is the inverse of the relation observed in G– bacteria, and can be explained by the difference in the envelope structure: in G– bacteria the outer membrane must be breached for wall-inhibiting antibiotics to access their target, whereas in G+ bacteria the wall is inherently accessible from the outside and permeabilization does not affect t...
Source: Frontiers in Microbiology - March 22, 2024 Category: Microbiology Source Type: research

Antibacterial activity of the antimicrobial peptide PMAP-36 in combination with tetracycline against porcine extraintestinal pathogenic Escherichia coli in vitro and in vivo
In this study, we investigated the antibacterial activity of porcine myeloid antimicrobial peptide 36 (PMAP-36) in combination with tetracycline against porcine ExPEC PCN033 both in vitro and in vivo. The minimum bactericidal concentrations (MBCs) of AMPs (PMAP-36 and PR-39) against the ExPEC strains PCN033 and RS218 were 10 μM and 5 μM, respectively. Results of the checkerboard assay and the time-kill assay showed that PMAP-36 and antibiotics (tetracycline and gentamicin) had synergistic bactericidal effects against PCN033. PMAP-36 and tetracycline in combination led to PCN033 cell wall shrinkage, as was shown by sca...
Source: Veterinary Research - March 22, 2024 Category: Veterinary Research Source Type: research