Potential of telmisartan in the treatment of benign prostatic hyperplasia
This study was carried out to investigate the protective effect of telmisartan on testosterone induced‐BPH in rats. Fifty‐four male Wistar rats (200 ‐ 250g) were randomly divided into 9 groups (n =6) and orally treated for 28 consecutive days: group 1‐ vehicle normal, olive oil (10 ml/kg); group 2‐ BPH model control (10 ml/kg); groups 3‐5 ‐ telmisartan (5, 10 or 20 mg/kg, respectively); group 6‐ pioglitazone (20 mg/kg); group 7‐ celecoxib (20 mg/kg); group 8‐ combination of telmisartan (5 mg/kg) and pioglitazone (20 mg/kg); group 9‐ combination of telmisartan (5 mg/kg) and celecoxib (20 mg/kg). Animal...
Source: Fundamental and Clinical Pharmacology - July 21, 2017 Category: Drugs & Pharmacology Authors: Ismail Ogunbayode Ishola, Charles C. Anunobi, Kehinde Habeeb Tijani, Olasunmbo Afolayan, Victoria U. Udokwu Tags: Original Article Source Type: research
Early radiological intervention and haematology screening is associated with excellent outcomes in Budd Chiari syndrome
ConclusionThere is a high incidence of MPN in patients with primary BCS, including patients with normal peripheral blood counts at the time of diagnosis. Our approach of anticoagulation, aggressive and early radiological intervention aimed at rapid decompression of the congested liver resulted in excellent medium‐term outcomes. (Source: Internal Medicine Journal)
Source: Internal Medicine Journal - July 4, 2017 Category: Internal Medicine Authors: Allison Mo, Adam Testro, Janine French, Marcus Robertson, Peter Angus, Andrew Grigg Tags: Original Article Source Type: research
A novel immune function biomarker identifies patients at risk of clinical events early following liver transplantation
Conclusion: Low IFNγ suggesting over‐suppression is associated with infections, while high IFNγ indicating under‐suppression is associated with rejection. This assay offers the potential to allow individualisation and optimisation of immunosuppression that could fundamentally alter the way patients are managed following transplantation. This article is protected by copyright. All rights reserved. (Source: Liver Transplantation)
Source: Liver Transplantation - January 29, 2017 Category: Transplant Surgery Authors: Siddharth Sood, Craig Haifer, Lijia Yu, Julie Pavlovic, Leonid Churilov, Paul J. Gow, Robert M. Jones, Peter W. Angus, Kumar Visvanathan, Adam G. Testro Tags: Original Article Source Type: research
Comparison of Testosterone Replacement Therapy Medications in the Treatment of Hypogonadism
Testosterone replacement therapy (TRT) is 1 treatment option for men with hypogonadism. When TRT is prescribed, effectiveness, patient compliance, cost, and potential side effects should be considered and used to develop an individualized treatment plan. Depo-Testosterone (Pfizer Inc, New York, NY, USA) is the most cost-efficient TRT option and is only administered every 2 weeks, which may improve patient compliance, although the dose interval can be adjusted to once per week. Androderm is the most efficacious TRT medication, with up to 92% of patients reaching normal testosterone levels. (Source: The Journal for Nurse Practitioners)
Source: The Journal for Nurse Practitioners - January 26, 2017 Category: Nursing Authors: Karlen E. Luthy, Chris Williams, Donna S. Freeborn, Aaron Cook Tags: Continuing Education Source Type: research
Immune function biomarker QuantiFERON-monitor is associated with infection risk in cirrhotic patients.
CONCLUSION: QFM is lower in cirrhotics, allowing objective determinations of an individual's unique level of immune dysfunction. Low QFM was associated with increased susceptibility to infection.
PMID: 28050238 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - January 6, 2017 Category: Gastroenterology Tags: World J Hepatol Source Type: research
Dapoxetine attenuates testosterone-induced prostatic hyperplasia in rats by the regulation of inflammatory and apoptotic proteins.
In conclusion, the current study provides an evidence for the protective effects of dapoxetine against testosterone-induced BPH in rats. This can be attributed, at least in part, to decreasing AR expression, and the anti-proliferative, anti-inflammatory and pro-apoptotic activities of dapoxetine in BPH.
PMID: 27687055 [PubMed - as supplied by publisher] (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - September 25, 2016 Category: Toxicology Authors: Sayed RH, Saad MA, El-Sahar AE Tags: Toxicol Appl Pharmacol Source Type: research
Outpatient Terlipressin Infusion for the Treatment of Refractory Ascites
Peter W Angus (Source: The American Journal of Gastroenterology)
Source: The American Journal of Gastroenterology - June 29, 2016 Category: Gastroenterology Authors: Paul J GowZaid S ArdalanAbhinav VasudevanAdam G TestroBei YePeter W Angus Source Type: research
Protective potential of epigallocatechin-3-gallate against benign prostatic hyperplasia in metabolic syndrome rats
In this study, rat model of benign prostatic hyperplasia (BPH) accompanied with metabolic syndrome was induced by fed on high-fat diet for 12 weeks combined with testosterone injection (10mg/kg/d) from 9th to 12th weeks. EGCG was orally given from 9th to 12th weeks. Finally, the levels of glucose, total cholesterol, triglyceride, prostate weight, insulin-like growth factors (IGFs), inflammatory cytokines, antioxidant enzymes, and prostatic expression of IGF binding protein-3 (IGFBP-3) and peroxisome proliferator activated receptors (PPARs) were evaluated. It was found that EGCG significantly decreased the levels of glucose...
Source: Environmental Toxicology and Pharmacology - June 14, 2016 Category: Environmental Health Source Type: research
Intestinal Failure and Transplant: The Australian Experience (2009 to 2014)
A joint adult and pediatric intestinal transplant (ITx) program for Australia was developed in 2009 to provide life-saving ITx to patients with irreversible intestinal failure (IF). We aimed to analyze the outcomes of patients treated by our service over the past 5 years. (Source: Transplantation Proceedings)
Source: Transplantation Proceedings - February 29, 2016 Category: Transplant Surgery Authors: B. Chapman, P. De Cruz, R. Jones, W. Hardikar, A. Testro Tags: 14th International Small Bowel Transplant Symposium Source Type: research
Validation of an enzyme-immunoassay for the non-invasive monitoring of faecal testosterone metabolites in male cheetahs (Acinonyx jubatus).
Abstract
In mammals, the sex hormone testosterone is the major endocrine variable to objectify testicular activity and thus reproductive function in males. Testosterone is involved in the development and function of male reproductive physiology and sex-related behaviour. The development of a reliable androgen enzyme-immunoassay (EIA) to monitor faecal testosterone metabolites (fTM) is a powerful tool to non-invasively assess the gonadal status of males. We validated an epiandrosterone EIA for male cheetahs by performing a testosterone radiometabolism study followed by high-performance liquid chromatography...
Source: General and Comparative Endocrinology - January 29, 2016 Category: Endocrinology Authors: Pribbenow S, Wachter B, Ludwig C, Weigold A, Dehnhard M Tags: Gen Comp Endocrinol Source Type: research
Bipolar disorder, testosterone administration, and homicide: a case report.
CONCLUSION: Further studies of the role of testosterone in the neurobiology of violent and homicidal behavior may lead to improvements in the prevention of homicides.
PMID: 24527885 [PubMed - indexed for MEDLINE] (Source: International Journal of Psychiatry in Clinical Practice)
Source: International Journal of Psychiatry in Clinical Practice - December 25, 2015 Category: Psychiatry Tags: Int J Psychiatry Clin Pract Source Type: research
A Novel Mutation Causing 17-β-Hydroxysteroid Dehydrogenase Type 3 Deficiency in an Omani Child: First Case Report and Review of Literature.
Authors: Al-Sinani A, Mula-Abed WA, Al-Kindi M, Al-Kusaibi G, Al-Azkawi H, Nahavandi N
Abstract
This is the first case report in Oman and the Gulf region of a 17-β-hydroxysteroid dehydrogenase type 3 (17-β-HSD3) deficiency with a novel mutation in the HSD17B3 gene that has not been previously described in the medical literature. An Omani child was diagnosed with 17-β-HSD3 deficiency and was followed up for 11 years at the Pediatric Endocrinology Clinic, Royal Hospital, Oman. He presented at the age of six weeks with ambiguous genitalia, stretched penile and bilateral undescended testes. Ultrasound showe...
Source: Oman Medical Journal - December 12, 2015 Category: Middle East Health Tags: Oman Med J Source Type: research
Efficacy of outpatient continuous terlipressin infusions for hepatorenal syndrome
(Source: Hepatology)
Source: Hepatology - November 2, 2015 Category: Internal Medicine Authors: Abhinav Vasudevan, Zaid Ardalan, Paul Gow, Peter Angus, Adam Testro Tags: Correspondence Source Type: research
Misinterpretation of the Safety of Testosterone Dosage Forms
To the Editor Given recent warnings by the US Food and Drug Administration and Health Canada about the potential cardiovascular risk of testosterone administration, the effects of testosterone are of intense interest. Layton et al add to the ongoing conversation by using medical records to show higher rates of cardiovascular events in men using testosterone injections than in men using testosterone gels. Understandably, given the difficulties of comparing testosterone users with nonusers in an observational study exploiting administrative data, Layton et al have not yet provided the other key comparison listed in the abstr...
Source: JAMA Internal Medicine - November 1, 2015 Category: Internal Medicine Source Type: research
Reproductive endocrinology: Are intramuscular testosterone injections harmful?
Nature Reviews Endocrinology 11, 510 (2015).
doi:10.1038/nrendo.2015.111
Authors: Bradley D. Anawalt & William J. Bremner
Injectable testosterone esters and transdermal testosterone gels have generally been assumed to be equally safe and effective forms of testosterone-replacement therapy for male hypogonadism. Now, findings from a recent study suggest that transdermal testosterone gels are superior to injectable testosterone esters in terms of reducing cardiovascular events, all-cause hospitalizations and all-cause mortality. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - July 7, 2015 Category: Endocrinology Authors: Bradley D. AnawaltWilliam J. Bremner Tags: News and Views Source Type: research
