Atherosclerosis on CT coronary angiography and risk of long-term cardiovascular events post liver transplantation
CONCLUSION: The standardized CAD-RADS classification on CTCA predicted the occurrence of cardiovascular outcomes following LT, with a potential to increase utilization of preventive cardiovascular therapies.PMID:37432891 | DOI:10.1097/LVT.0000000000000215 (Source: Atherosclerosis)
Source: Atherosclerosis - July 11, 2023 Category: Cardiology Authors: Thalys Sampaio Rodrigues Anoop N Koshy Paul J Gow Laurence Weinberg Benjamin Cailes Adam Testro Gerard Smith Han S Lim Andrew W Teh Ruth P Lim Omar Farouque Source Type: research
Transcatheter Aortic Valve Implantation (TAVI) as a Bridge to Liver Transplantation: Experience From the Victorian Liver Transplant Unit
There are>250 liver transplants (LT) performed annually in Australia. Given the prohibitive risk of cardiac surgery in patients with end-stage liver disease, severe aortic stenosis (AS) has traditionally been a contraindication for LT. We sought to evaluate the feasibility of performing TAVI as a bridge to LT to facilitate LT eligibility. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - July 1, 2023 Category: Cardiology Authors: B. Cailes, A. Koshy, T. Rodrigues, A. Majumdar, M. Yudi, J. Yeoh, A. Testro, M. Horrigan, O. Farouque Source Type: research
Predictors and Outcomes of Statin Utilisation in Patients Undergoing Liver Transplantation
Statins are a mainstay in prevention and treatment of atherosclerosis. However, statins are largely underutilised in liver transplant (LT) candidates due to concerns regarding hepatotoxicity, despite previously demonstrated safety. We sought to assess the predictors and long-term outcomes of statin therapy in LT candidates. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - July 1, 2023 Category: Cardiology Authors: T. Sampaio Rodrigues, A. Koshy, B. Cailes, P. Gow, L. Weinberg, A. Testro, G. Smith, H. Lim, A. Teh, R. Lim, O. Farouque Source Type: research
Millet seed oil activates β–catenin signaling and promotes hair growth
This study investigates the potential of millet seed oil (MSO) in promoting the proliferation of hair follicle dermal papilla cells (HFDPC) and stimulating hair growth in animals with testosterone-dependent hair growth inhibition as part of a study on dietary treatments to improve hair growth. MSO-treated HFDPC significantly increased cell proliferation and phosphorylation of AKT, S6K1, and GSK3β proteins. This induces β-catenin, a downstream transcription factor, to translocate to the nucleus and increase the expression of factors related to cell growth. In a C57BL/6 mice model in which hair growth was inhibited by subc...
Source: Frontiers in Pharmacology - May 9, 2023 Category: Drugs & Pharmacology Source Type: research
Clinical and financial impacts of abnormal liver biochemistry after liver transplantation
After liver transplant (LT), many investigations are needed to evaluate abnormal liver function test (LFT), which has poor specificity for graft function and complication. A single center retrospective audit of a... (Source: BMC Research Notes)
Source: BMC Research Notes - January 27, 2023 Category: Research Authors: Dee Zhen Lim, Nicholas Low, Louise Jackett, Ronald Ma, Robert Jones, Adam Testro, Laurence Weinberg and Muralidharan Vijayaragavan Tags: Research Note Source Type: research
Expression with early postnatal peak and female-dominant sexual dimorphism of phospholipase D (PLD) 2 in submandibular gland ducts in situ of mice
AbstractIn the present study, expression and localization of PLD2 were examined in mouse submandibular glands in situ in comparison with those of PLD1 previously reported by the present authors. In immunoblots, PLD2-expression was high at postnatal 0 week (P0W) and P2W, and at P4W decreased considerably with the decrease of the male gland more marked, and at P8W it was undetectable in the male gland, but remained faint in the female. In the male gland at P8W after castration at P6W, PLD2-expression reappeared faintly. In the female glands with daily injections of testosterone started at P6W, at P8W the expression was und...
Source: Odontology - November 17, 2022 Category: Dentistry Source Type: research
Evaluating DNA recovery efficiency following bisulphite modification from plasma samples submitted for cell-free DNA methylation analysis
. (Source: Epigenetics)
Source: Epigenetics - June 28, 2022 Category: Genetics & Stem Cells Authors: Daniel RA Cox Boris Ka Leong Wong Eunice Lee Adam Testro Vijayaragavan Muralidharan Alexander Dobrovic Su Kah Goh Source Type: research
Androgens and spermatogenesis
Ann Endocrinol (Paris). 2022 Apr 27:S0003-4266(22)00057-9. doi: 10.1016/j.ando.2022.04.010. Online ahead of print.ABSTRACTMale infertility contributes to 50% of all cases of infertility. The main cause is low quality and quantity of sperm. In humans, spermatogenesis starts at the beginning of puberty and lasts lifelong. It is under the control of FSH and testicular androgens, and mainly testosterone (T), and therefore requires a normal gonadotroph axis, intratesticular T production by Leydig cells and functional androgen receptors (ARs) within testicular Sertoli cells. Various clinical cases illustrate the roles of T in hu...
Source: Annales d'Endocrinologie - April 30, 2022 Category: Endocrinology Authors: Sophie Christin-Maitre Jacques Young Source Type: research
Androgens and spermatogenesis
Ann Endocrinol (Paris). 2022 Apr 27:S0003-4266(22)00057-9. doi: 10.1016/j.ando.2022.04.010. Online ahead of print.ABSTRACTMale infertility contributes to 50% of all cases of infertility. The main cause is low quality and quantity of sperm. In humans, spermatogenesis starts at the beginning of puberty and lasts lifelong. It is under the control of FSH and testicular androgens, and mainly testosterone (T), and therefore requires a normal gonadotroph axis, intratesticular T production by Leydig cells and functional androgen receptors (ARs) within testicular Sertoli cells. Various clinical cases illustrate the roles of T in hu...
Source: Annales d'Endocrinologie - April 30, 2022 Category: Endocrinology Authors: Sophie Christin-Maitre Jacques Young Source Type: research
Androgens and spermatogenesis
Ann Endocrinol (Paris). 2022 Apr 27:S0003-4266(22)00057-9. doi: 10.1016/j.ando.2022.04.010. Online ahead of print.ABSTRACTMale infertility contributes to 50% of all cases of infertility. The main cause is low quality and quantity of sperm. In humans, spermatogenesis starts at the beginning of puberty and lasts lifelong. It is under the control of FSH and testicular androgens, and mainly testosterone (T), and therefore requires a normal gonadotroph axis, intratesticular T production by Leydig cells and functional androgen receptors (ARs) within testicular Sertoli cells. Various clinical cases illustrate the roles of T in hu...
Source: Annales d'Endocrinologie - April 30, 2022 Category: Endocrinology Authors: Sophie Christin-Maitre Jacques Young Source Type: research
Puberty induction with recombinant gonadotropin : what impact on future fertility?
Ann Endocrinol (Paris). 2022 Apr 15:S0003-4266(22)00056-7. doi: 10.1016/j.ando.2022.04.009. Online ahead of print.ABSTRACTCongenital hypogonadotropic hypogonadism (CHH) is a group of rare diseases characterized by inadequate secretion of the gonadotropins LH (luteinizing hormone) and FSH (follicle stimulating hormone) during the physiological activation periods of the gonadotropic axis. The disease? (anomaly) is present from fetal life and usually persists throughout life. Clinically, hypogonadotropic hypogonadism is associated with neonatal clinical signs (micropenis, cryptorchidism in boys in about half of the cases). Th...
Source: Annales d'Endocrinologie - April 18, 2022 Category: Endocrinology Authors: Anne Sophie Lambert Claire Bouvattier Source Type: research
Puberty induction with recombinant gonadotropin : what impact on future fertility?
Ann Endocrinol (Paris). 2022 Apr 15:S0003-4266(22)00056-7. doi: 10.1016/j.ando.2022.04.009. Online ahead of print.ABSTRACTCongenital hypogonadotropic hypogonadism (CHH) is a group of rare diseases characterized by inadequate secretion of the gonadotropins LH (luteinizing hormone) and FSH (follicle stimulating hormone) during the physiological activation periods of the gonadotropic axis. The disease? (anomaly) is present from fetal life and usually persists throughout life. Clinically, hypogonadotropic hypogonadism is associated with neonatal clinical signs (micropenis, cryptorchidism in boys in about half of the cases). Th...
Source: Annales d'Endocrinologie - April 18, 2022 Category: Endocrinology Authors: Anne Sophie Lambert Claire Bouvattier Source Type: research
Single-stage salvage urethroplasty for failed distal hypospadias: comparison of Mathieu and grafted tubularised incised plate repairs
ConclusionsSingle-stage salvage distal hypospadias repair was successful in 87.8% of patients. Both SM and SGTIP demonstrated acceptable results for salvage distal hypospadias repair. SM had better success and lower complications than SGTIP. SGTIP was associated with significantly higher post-operative UCF and meatal/neourethral stenosis. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - March 11, 2022 Category: Surgery Source Type: research
Unusual cause of branch retinal artery occlusion: polycythemia in a transgender man from unregulated testosterone use
Conclusion:
To the best of our knowledge, this is the first documented case of a trans man who developed branch retinal artery occlusion after self-administering supraphysiological doses of testosterone. In a young patient with no history of cardiovascular risk factors who develops retinal arterial occlusion, other causes such as hypercoagulable syndromes must be excluded. This case warns of the dangers of unregulated testosterone use, especially at supraphysiologic doses, and the risks of thrombotic events from secondary polycythemia. (Source: Retinal Cases and Brief Reports)
Source: Retinal Cases and Brief Reports - February 24, 2022 Category: Opthalmology Tags: Case Report Source Type: research
