Low-testosterone center coming to Greater Cincinnati: EXCLUSIVE
Middle-age men in Northern Kentucky who hope to regain their youthful vitality might soon be able to get testosterone injections at a Low T Center without having to pop across the Ohio River.
Mike Sisk, the president of the rapidly expanding national chain that operates the Low T Center in Mason, tells me that he is “actively seeking locations … on the Kentucky side of Cincinnati.”
It would be the first Low T Center in the Bluegrass State. The one in Warren County, which opened in January… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - February 14, 2014 Category: Biotechnology Authors: Barrett J. Brunsman Source Type: research
long‐acting TESTOSTERONE injections for treatment of TESTOSTERONE DEFICIENCY AFTER BRACHYTHERAPY for prostate cancer
ConclusionsWith a median 31 months of follow‐up, long‐acting T injections in men with PCa treated with brachytherapy produced significant clinical benefits. There were no cases of rising serum PSA, PCa progression, or recurrence. (Source: BJU International)
Source: BJU International - February 12, 2014 Category: Urology & Nephrology Authors: Felipe G. Balbontin, Sergio A. Moreno, Enrique Bley, Rodrigo Chacon, Andres Silva, Abraham Morgentaler Tags: Sexual Medicine Source Type: research
Acute Hepatic Decompensation Precipitated by Pregnancy-Related Catabolic Stress: A Rare Mimic of Acute Liver Failure.
CONCLUSION:: This is an unusual presentation that reminds us of the importance of considering metabolic disorders during the catabolic stress of pregnancy.
PMID: 24413235 [PubMed - as supplied by publisher] (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - January 10, 2014 Category: OBGYN Authors: Sinclair M, Ket S, Testro A, Gow PJ, Angus PW Tags: Obstet Gynecol Source Type: research
Clinical Management of Youth with Gender Dysphoria in Vancouver
Conclusion: Treatment with gonadotropin-releasing hormone analog and/or cross-sex hormones, in collaboration with transgender-competent mental health professionals, is an intervention that appears to be appropriate in carefully selected youth with gender dysphoria. Long-term follow-up studies are needed to determine the safety of these treatments in this age group. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 9, 2013 Category: Pediatrics Authors: Karine Khatchadourian, Shazhan Amed, Daniel L. Metzger Tags: Original Articles Source Type: research
Cyclosporine and tacrolimus have inhibitory effects on toll‐like receptor signaling after liver transplantation
In conclusion, patients on calcineurin inhibitors had impaired inflammatory cytokine production in response to TLR2, TLR4, and TLR7/8 stimulation compared comparison with healthy controls. Importantly, TAC and CYA appear to have different effects on TLR signaling. Impaired TLR function has important repercussions for risk of infection, graft rejection, and disease recurrence after transplantation, and the different immunosuppressive profiles of CYA and TAC may guide the choice of therapy to improve disease outcomes. Liver Transpl 19:1099‐1107, 2013. © 2013 AASLD. (Source: Liver Transplantation)
Source: Liver Transplantation - September 24, 2013 Category: Transplant Surgery Authors: Jessica Howell, Rohit Sawhney, Adam Testro, Narelle Skinner, Paul Gow, Peter Angus, Dilip Ratnam, Kumar Visvanathan Tags: Original Article Source Type: research
Response
We thank Dr Lin for the helpful comments. EGD and capsule endoscopy (CE) identified the etiology in 62 of 83 patients (75%) in our cohort. Of the remaining patients, 2 of 21 (9.5%) had an underlying colorectal cancer, 1 of 21 patients (4.8%) were subsequently found to have gastric angiectasia, and 18 of 21 patients (85.7%) had no cause identified. However, EGD can be nondiagnostic in up to 25% of patients presenting with melena. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - September 20, 2013 Category: Gastroenterology Authors: Sujievvan Chandran, Adam Testro Tags: Letters to the Editor Source Type: research
Post–Liver Transplant Leptin Results in Resolution of Severe Recurrence of Lipodystrophy‐Associated Nonalcoholic Steatohepatitis
We describe the first case of a patient undergoing orthoptic liver transplantation for acquired generalized lipodystrophy‐related nonalcoholic steatohepatitis who developed severe recurrence of nonalcoholic fatty liver disease in the first few months posttransplant but responded rapidly to the administration of exogenous leptin. The beneficial effects of therapy were supported by histology along with magnetic resonance spectroscopy studies, which demonstrated that leptin therapy greatly reduced fat deposition in the liver. Leptin therapy may have a role to play in preventing patients with lipodystrophy developing end‐s...
Source: American Journal of Transplantation - September 5, 2013 Category: Transplant Surgery Authors: S. P. Casey, J. Lokan, A. Testro, S. Farquharson, A. Connelly, J. Proietto, P. W. Angus Tags: Case Report Source Type: research
Postliver Transplant Leptin Results in Resolution of Severe Recurrence of Lipodystrophy‐Associated Nonalcoholic Steatohepatitis
We describe the first case of a patient undergoing orthoptic liver transplantation for acquired generalized lipodystrophy‐related nonalcoholic steatohepatitis who developed severe recurrence of nonalcoholic fatty liver disease in the first few months posttransplant but responded rapidly to the administration of exogenous leptin. The beneficial effects of therapy were supported by histology along with magnetic resonance spectroscopy studies, which demonstrated that leptin therapy greatly reduced fat deposition in the liver. Leptin therapy may have a role to play in preventing patients with lipodystrophy developing end‐s...
Source: American Journal of Transplantation - September 5, 2013 Category: Transplant Surgery Authors: S. P. Casey, J. Lokan, A. Testro, S. Farquharson, A. Connelly, J. Proietto, P. W. Angus Tags: Case Report Source Type: research
Reduction of the Number of Neurones in the Caudal Mesenteric Ganglion Innervating the Ovary in Sexually Mature Gilts Following Testosterone Administration
The effect of testosterone on the morphological and chemical plasticity of the porcine caudal mesenteric ganglion (CaMG) ovary‐projecting neurones was investigated. To identify the neurones on day 3 of the oestrous cycle, the ovaries of both the control and experimental gilts were injected with Fast Blue retrograde neuronal tracer. From next day until day 20 of the anticipated second studied cycle, experimental gilts were injected with testosterone, whereas control gilts received oil. Testosterone injections increased testosterone (by approximately 3.5‐fold) and 17β‐oestradiol (by approximately 1.6‐fold) levels in...
Source: Journal of Neuroendocrinology - August 20, 2013 Category: Endocrinology Authors: B. Jana, L. Rytel, J. Czarzasta, J. Całka Tags: Original Article Source Type: research
Cyclosporine and tacrolimus have inhibitory effects on toll‐like receptor signalling after liver transplantation
In conclusion, patients on calcineurin inhibitors had impaired inflammatory cytokine production in response to TLR2, TLR4, and TLR7/8 stimulation in comparison with healthy controls. Importantly, TAC and CYA appear to have different effects on TLR signaling. Impaired TLR function after liver transplantation has important repercussions for risks of infection, graft rejection, and disease recurrence (eg, hepatitis C virus infection) after transplantation, and the different innate immunosuppressive profiles of CYA and TAC may be used to guide the choice of therapy to improve disease outcomes. Liver Transpl, 2013. © 2013 AASL...
Source: Liver Transplantation - July 25, 2013 Category: Transplant Surgery Authors: Jessica Howell, Rohit Sawhney, Adam Testro, Narelle Skinner, Paul Gow, Peter Angus, Dilip Ratnam, Kumar Visvanathan Tags: Original Article Source Type: research
Reduction of the number of neurons in the caudal mesenteric ganglion innervating the ovary in sexually mature gilts following testosterone administration
This article is protected by copyright. All rights reserved. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - June 14, 2013 Category: Endocrinology Authors: Barbara Jana, Liliana Rytel, Joanna Czarzasta, Jarosław Całka Tags: Original Article Source Type: research
Electronic estimations of renal function (eGFR) are inaccurate in solid-organ transplant recipients and can result in significant under-dosing of prophylactic valganciclovir.
Abstract
In a prospective study of solid-organ transplant recipients (n=22; 15 hepatic/7 renal) receiving valganciclovir for cytomegalovirus (CMV) prophylaxis, electronic estimation of glomerular filtration rate (eGFR) underestimated the true GFR (24 hr urine creatinine clearance) by >20% in 14/22 (63.6%). Its use was associated with inappropriate under-dosing of valganciclovir while the Cockroft-Gault equation was accurate in 21/22 (95.4%). Sub-therapeutic ganciclovir levels (≤0.6mg/L) were common 10/22 (45.4%); 7 severely deficient (<0.3mg/L).
PMID: 23733466 [PubMed - as supplied by publi...
Source: Antimicrobial Agents and Chemotherapy - June 3, 2013 Category: Microbiology Authors: Trevillyan J, Angus P, Shelton E, Whitlam J, Ierino F, Pavlovic J, Gregory D, Urbancic K, Torresi J, Testro A, Grayson M Tags: Antimicrob Agents Chemother Source Type: research
Clinical Reasoning: A 47-year-old man with progressive gait disturbance and stiffness in his legs
A 47-year-old man presented with a 5-year history of slowly progressive gait disorder with clumsiness and unsteadiness during walking, as well as stiffness and cramping pain in his legs. He also had erectile dysfunction and nocturia. He denied sensory deficits and other focal neurologic or systemic symptoms. He had a medical history of hypogonadism, diagnosed 1 year before the onset of the gait disorder, attributed to a bilateral orchiectomy due to a testicular tumor, performed elsewhere when he was 37. He was receiving IM testosterone injections every 3 weeks. His family medical history included pes cavus in his mother an...
Source: Neurology - May 20, 2013 Category: Neurology Authors: Fontes-Villalba, A., Palma, J.-A., Fernandez-Seara, M. A., Pastor, M. A., de Castro, P. Tags: MRI, PET, Endocrine, Leukodystrophies, Spastic paraplegia RESIDENT AND FELLOW SECTION Source Type: research
Risk stratification of upper GI bleeding with an esophageal capsule
Conclusion:
Although CE is not currently ready to be used as a triage tool, when duodenal visualization was achieved CE correlated well with EGD findings and identified 92% of patients who may have been managed as outpatients. (Clinical trial registration number: ACTRN 12609000580279.) (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - February 28, 2013 Category: Gastroenterology Authors: Sujievvan Chandran, Adam Testro, Paul Urquhart, Richard La Nauze, Sim Ong, Edward Shelton, Hamish Philpott, Siddarth Sood, Rhys Vaughan, William Kemp, Gregor Brown, Paul Froomes Tags: Clinical Endoscopy Source Type: research
To TOE or not to TOE? That is the question in patients with portal hypertension and varices
We read with interest your recently published review by Cardénas and Ginès on patients with cirrhosis, awaiting liver transplantation,1 with an emphasis on the high morbidity and mortality with variceal bleeding. Such patients may require a transoesophageal echocardiogram (TOE) to assess cardiorespiratory abnormalities potentially precluding a transplant, as well as for intraoperative haemodynamic monitoring and for investigation for endocarditis. However, the safety of performing a TOE in such patients is debated by clinicians due to the perceived risk of postprocedural bleeding.2 Three small studies have an...
Source: Gut - February 28, 2013 Category: Gastroenterology Authors: Leung, C., Yeoh, S. W., Lim, L. Y., Boyapati, R., Testro, A. G., Vaughan, R., Marion, K., Burrell, L. M., Angus, P. W. Tags: PostScript Source Type: research
