212 Effect of QT Interval Prolongation on Ventricular Arrhythmias and Cardiac Arrest following Liver Transplantation and Derivation of a Points-Based Risk Index
Patients undergoing liver transplantation (LT) have a four-fold higher risk of periprocedural cardiac arrest and ventricular arrhythmias (CA/VA) compared with other noncardiac surgeries. We sought to assess whether prolonged corrected QT interval (QTc) is associated with an increased risk of CA/VA following LT. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - November 8, 2020 Category: Cardiology Authors: J. Ko, A. Koshy, H. Han, B. Cailes, A. Enayati, A. Testro, P. Gow, L. Weinberg, H. Lim, O. Farouque, A. Teh Source Type: research
Telomere dynamics from hatching to sexual maturity and maternal effects in the "multivariate egg" [RESEARCH ARTICLE]
F. Criscuolo, R. Torres, S. Zahn, and T. D. Williams Avian eggs contain a large number of molecules deposited by the mother that provide the embryo with energy but also potentially influence its development via the effects of maternally-derived hormones and antibodies: the avian egg is "multivariate". Multivariate effects on offspring phenotype were evaluated in a sister study on captive zebra finches, by simultaneously manipulating maternally derived antibodies after LPS-treatment of mothers and egg-treatment using yolk testosterone injection. LPS-treatment had a positive effect on body mass growth at 30 days after hatchi...
Source: Journal of Experimental Biology - November 2, 2020 Category: Biology Authors: Criscuolo, F., Torres, R., Zahn, S., Williams, T. D. Tags: RESEARCH ARTICLE Source Type: research
An Extraordinary Cause of Dyspnea and Weight Loss
Question: A 42-year-old male 10 years post liver –intestine transplantation was referred from a regional hospital to our institute with unintentional weight loss (15 kg over 6 months), progressive exertional dyspnea, and what was thought to be a loud pansystolic murmur. Past medical history is significant for short bowel syndrome with total pare nteral nutrition dependence complicated by intestinal failure associated liver disease, diminishing venous access, and a distant history of a right nephrectomy as a child. (Source: Gastroenterology)
Source: Gastroenterology - July 13, 2020 Category: Gastroenterology Authors: Timothy P. Hanrahan, Mark Goodwin, Adam Testro Tags: Electronic Clinical Challenges and Images in GI Source Type: research
Clinical Challenges and Images in GI: An extraordinary cause of dyspnoea and weight loss.
(Source: Gastroenterology)
Source: Gastroenterology - July 12, 2020 Category: Gastroenterology Authors: Timothy P. Hanrahan, Mark Goodwin, Adam Testro Source Type: research
Venous Thromboembolism in a Transgender Adolescent on Testosterone Therapy: A Case Report and Literature Review
The incidence of pediatric venous thromboembolism (VTE) has been increasing in the past few decades and can be associated with significant mortality and morbidity. There are known risk factors associated with VTE, including estrogen therapy. However, the relationship between testosterone and VTE remains unclear. Here, we present a 17-year-old female-to-male transgender patient without a history of inherited thrombophilia, who developed pulmonary embolism while receiving testosterone injections for gender dysphoria. Despite the limited data on testosterone and the risk of VTE, health care providers should counsel patients a...
Source: Journal of Pediatric Hematology Oncology - June 24, 2020 Category: Hematology Tags: Online Articles: Original Articles Source Type: research
Female-to-male transgender patient with idiopathic intracranial hypertention
A 15-year old female-to-male (FTM) transgender individual presented with new onset of daily headaches and pulsatile tinnitus. He started receiving gender-affirming hormonal therapy with regular testosterone injections at the dose of 75 mg per week six months before presentation. The body-mass index was 31, however, patient denied recent weight gain and stated that his weight remained unchanged after imitating therapy with testosterone injections. He had past medical history of anxiety and depression but was not using any medica tions other than testosterone injections and denied the use of over-the-counter vitamins or s...
Source: Journal of the Neurological Sciences - June 1, 2020 Category: Neurology Authors: Edward A. Margolin, Ryan H. Mason Tags: Letter to the Editor Source Type: research
Forebrain Transcriptional Response to Transient Changes in Circulating Androgens in a Cichlid Fish
It has been hypothesized that androgens respond to the social interactions as a way to adjust the behavior of individuals to the challenges of the social environment in an adaptive manner. Therefore, it is expected that transient changes in circulating androgen levels within physiological scope should impact the state of the brain network that regulates social behavior, which should translate into adaptive behavioral changes. Here, we examined the effect that a transient peak in androgen circulating levels, which mimics socially driven changes in androgen levels, has on the forebrain state, which harbors most nuclei of the...
Source: G3: Genes Genomes Genetics - May 31, 2020 Category: Genetics & Stem Cells Authors: Felix, A. S., Cardoso, S. D., Roleira, A., Oliveira, R. F. Tags: Investigations Source Type: research
[Expressions of HSP110 family members in the testes and epididymis of mice at different stages of development and their regulation by hormones].
CONCLUSIONS: The expression levels of HSP110 family are affected by developmental regulation, and the expressions of HSPA4 and HSPA4l are under the regulation by hormones.
PMID: 31640949 [PubMed - in process] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - September 29, 2019 Category: Universities & Medical Training Authors: Rong C, Du Z, Liu J, Wu X Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
Epidemiology and outcomes of acute liver failure in Australia.
CONCLUSION: Paracetamol toxicity is the most common aetiology of ALF in South-Eastern Australia with a rising incidence over 30 years. TFS has improved, however it remains low in non-paracetamol ALF.
PMID: 31388400 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - August 9, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research
Incidental hepatic steatosis in radiology reports: a survey of emergency department clinicians ’ perspectives and current practice
ConclusionOur survey highlights the importance of clear communication between radiologists and ED physicians when incidental findings are encountered. Radiologists play an important role in alerting ED physicians and clinicians who have access to patients ’ radiology reports to the presence of incidental findings including hepatic steatosis. (Source: Journal of Medical Imaging and Radiation Oncology)
Source: Journal of Medical Imaging and Radiation Oncology - August 4, 2019 Category: Radiology Authors: Numan Kutaiba,
Joe ‐Anthony Rotella,
Zaid Ardalan,
Adam Testro Tags: Medical Imaging —Original Article Source Type: research
Impaired Cardiac Reserve on Dobutamine Stress Echocardiography Predicts Development of Hepatorenal Syndrome
Background: The role of cardiac dysfunction in the genesis of hepatorenal syndrome (HRS) is poorly understood. We studied cardiovascular haemodynamics in HRS and assessed whether a diminished cardiac reserve with stress testing predicted the development of HRS. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - June 23, 2019 Category: Cardiology Authors: A. Koshy, B. Cailes, A. Testro, J. Ramchand, J. Sajeev, H. Han, P. Calafiore, E. Jones, P. Srivastava, H. Salehi, A. Teh, H. Lim, P. Gow, O. Farouque Tags: 013 Source Type: research
Beta Blocker Use Increases The Risk of Perioperative Cardiac Events in Liver Transplant Patients
Background: Recent evidence has linked beta blocker (BB) use with perioperative major adverse cardiovascular events (MACE) after non-cardiac surgery. BB are often used for treatment of portal hypertension in liver disease. We sought to determine whether BB use was associated with adverse perioperative outcomes in liver transplantation (LT). (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - June 23, 2019 Category: Cardiology Authors: B. Cailes, A. Koshy, J. Ko, H. Han, H. Lim, A. Teh, L. Weinberg, A. Testro, P. Gow, O. Farouque Tags: 354 Source Type: research
Cardiac Output in End-Stage Liver Disease Increases Proportional to the Degree of Liver Dysfunction
Background: End-stage liver disease is associated with significant systemic and haemodynamic alterations that affect cardiac function. Cirrhotic cardiomyopathy remains an ill-defined entity among cardiologists. Understanding the complex interplay between liver dysfunction and cardiac function can lead to a better understanding of the compensatory mechanisms of the heart in liver failure. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - June 23, 2019 Category: Cardiology Authors: A. Koshy, B. Cailes, P. Gow, A. Testro, H. Han, J. Sajeev, J. Ko, L. Weinberg, P. Srivastava, H. Lim, A. Teh, O. Farouque Tags: 358 Source Type: research
Existing Models to Assess Perioperative Cardiac Risk demonstrate poor predictive validity in patients undergoing liver transplantation
Background: Liver transplantation (LT) is associated with risk for perioperative cardiovascular events. Although guideline recommended risk scores are well validated in non-cardiac surgery, there is uncertainty regarding their utility in LT. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - June 23, 2019 Category: Cardiology Authors: B. Cailes, A. Koshy, J. Ko, H. Han, H. Lim, A. Teh, L. Weinberg, A. Testro, P. Gow, O. Farouque Tags: 382 Source Type: research
Hepatorenal Syndrome in Patients Undergoing Liver Transplantation is an Independent Risk Factor for Perioperative Cardiac Complications
Background: Hepatorenal syndrome (HRS) is a serious complication of cirrhosis associated with a poor survival in the absence of liver transplantation (LT). Although HRS confers higher risk of complications due to cirrhosis, it is unclear whether it leads to increased risk of perioperative major adverse cardiovascular events (MACE) following LT. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - June 23, 2019 Category: Cardiology Authors: B. Cailes, A. Koshy, J. Sajeev, H. Han, J. Ko, L. Weinberg, P. Gow, A. Testro, H. Lim, A. Teh, O. Farouque Tags: 390 Source Type: research
