Intravesical sequential gemcitabine/docetaxel for non-muscle invasive bladder cancer: tips and tricks for better efficacy and tolerability
J Chemother. 2024 Mar 4:1-4. doi: 10.1080/1120009X.2024.2325765. Online ahead of print.NO ABSTRACTPMID:38439550 | DOI:10.1080/1120009X.2024.2325765 (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - March 5, 2024 Category: Cancer & Oncology Authors: Mohamad Abou Chakra Mohamad Moussa Michael A O'Donnell Source Type: research
Two Hematological Markers Predicting the Efficacy and Prognosis of Neoadjuvant Chemotherapy Using Lobaplatin Against Triple-Negative Breast Cancer
CONCLUSION: PLR and NLR could be used to predict the efficacy of neoadjuvant therapy with the taxane, anthracycline, and lobaplatin regimen for patients with TNBC, as patients who had lower PLR and NLR values had a higher tpCR rate and a better long-term prognosis.PMID:38431781 | DOI:10.1093/oncolo/oyae025 (Source: The Oncologist)
Source: The Oncologist - March 3, 2024 Category: Cancer & Oncology Authors: Cheng Wang Qiyun Shi Guozhi Zhang Xiujuan Wu Wenting Yan Andi Wan Siyi Xiong Long Yuan Hao Tian Dandan Ma Jun Jiang Xiaowei Qi Yi Zhang Source Type: research
Molecular classification reveals the sensitivity of lung adenocarcinoma to radiotherapy and immunotherapy: multi-omics clustering based on similarity network fusion
ConclusionsIn summary, this study identified a risk classifier based on multi-omics data that can guide treatment selection for LUAD patients. (Source: Cancer Immunology, Immunotherapy)
Source: Cancer Immunology, Immunotherapy - March 2, 2024 Category: Cancer & Oncology Source Type: research
Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway
CONCLUSION: Our findings identify an autocrine loop of IL-11/IL-11RA that confers docetaxel resistance through the JAK1/STAT4 pathway. The pSTAT4-CBP interaction serves as a critical enhancer of c-MYC transcriptional activity in prostate cancer cells. Targeting this signalling axis presents a potential therapeutic strategy to overcome docetaxel resistance in advanced prostate cancer.PMID:38429845 | DOI:10.1186/s13046-024-02962-8 (Source: Cell Research)
Source: Cell Research - March 1, 2024 Category: Cytology Authors: Bisheng Cheng Lingfeng Li Tianlong Luo Qiong Wang Yong Luo Shoumin Bai Kaiwen Li Yiming Lai Hai Huang Source Type: research
Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway
CONCLUSION: Our findings identify an autocrine loop of IL-11/IL-11RA that confers docetaxel resistance through the JAK1/STAT4 pathway. The pSTAT4-CBP interaction serves as a critical enhancer of c-MYC transcriptional activity in prostate cancer cells. Targeting this signalling axis presents a potential therapeutic strategy to overcome docetaxel resistance in advanced prostate cancer.PMID:38429845 | DOI:10.1186/s13046-024-02962-8 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - March 1, 2024 Category: Cancer & Oncology Authors: Bisheng Cheng Lingfeng Li Tianlong Luo Qiong Wang Yong Luo Shoumin Bai Kaiwen Li Yiming Lai Hai Huang Source Type: research
Comparison of efficacy and safety of 5-FU or capecitabine combined with cisplatin and docetaxel (mDCF and mDCX) as a first-line chemotherapy regimen in her 2-negative metastatic gastric cancer patients: A retrospective study
Medicine (Baltimore). 2024 Mar 1;103(9):e37259. doi: 10.1097/MD.0000000000037259.ABSTRACTThe prognosis of metastatic gastric cancer (GC) is poor, with a median survival time of less than a year. Capecitabine is a prodrug, metabolized by thymidine phosphorylase to its cytotoxic metabolite (5-FU). Few studies have compared capecitabine and 5-FU in mGC. In this retrospective study, we compared the efficacy and safety of modified DCF (mDCF) (docetaxel, cisplatin, and 5-FU) and modified DCX (mDCX) (docetaxel, cisplatin, and capecitabine) regimens for first-line treatment in patients with mGC. The study included 112 mGC patients...
Source: Cancer Control - March 1, 2024 Category: Cancer & Oncology Authors: Nebi Serkan Demirci Abdulmunir Azizy Nail Paksoy İzzet Doğan Senem Karabulut Latif Karahan Didem Tastekin Source Type: research
Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway
CONCLUSION: Our findings identify an autocrine loop of IL-11/IL-11RA that confers docetaxel resistance through the JAK1/STAT4 pathway. The pSTAT4-CBP interaction serves as a critical enhancer of c-MYC transcriptional activity in prostate cancer cells. Targeting this signalling axis presents a potential therapeutic strategy to overcome docetaxel resistance in advanced prostate cancer.PMID:38429845 | DOI:10.1186/s13046-024-02962-8 (Source: Cancer Control)
Source: Cancer Control - March 1, 2024 Category: Cancer & Oncology Authors: Bisheng Cheng Lingfeng Li Tianlong Luo Qiong Wang Yong Luo Shoumin Bai Kaiwen Li Yiming Lai Hai Huang Source Type: research
Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway
CONCLUSION: Our findings identify an autocrine loop of IL-11/IL-11RA that confers docetaxel resistance through the JAK1/STAT4 pathway. The pSTAT4-CBP interaction serves as a critical enhancer of c-MYC transcriptional activity in prostate cancer cells. Targeting this signalling axis presents a potential therapeutic strategy to overcome docetaxel resistance in advanced prostate cancer.PMID:38429845 | PMC:PMC10905933 | DOI:10.1186/s13046-024-02962-8 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - March 1, 2024 Category: Cancer & Oncology Authors: Bisheng Cheng Lingfeng Li Tianlong Luo Qiong Wang Yong Luo Shoumin Bai Kaiwen Li Yiming Lai Hai Huang Source Type: research
Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway
Docetaxel resistance represents a significant obstacle in the treatment of prostate cancer. The intricate interplay between cytokine signalling pathways and transcriptional control mechanisms in cancer cells c... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - March 1, 2024 Category: Cancer & Oncology Authors: Bisheng Cheng, Lingfeng Li, Tianlong Luo, Qiong Wang, Yong Luo, Shoumin Bai, Kaiwen Li, Yiming Lai and Hai Huang Tags: Research Source Type: research
Equivalent prognosis with no lymph node metastasis to pathological complete remission in patients with localized advanced esophageal cancer after neoadjuvant triplet chemotherapy with docetaxel, cisplatin, and 5-fluorouracil followed by curative surgery: a single-center retrospective cohort study
CONCLUSIONS: The prognosis of the ypT+N0 group after NAC with DCF followed by surgery was similar to that of pathological complete remission. Grouping patients according to pathological lymph node status is a reasonable predictor of prognosis.PMID:38410613 | PMC:PMC10894374 | DOI:10.21037/jtd-23-1484 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - February 27, 2024 Category: Respiratory Medicine Authors: Takashi Chinen Hironori Yamaguchi Hideyuki Ohzawa Shiro Matsumoto Kentaro Kurashina Shin Saito Yoshinori Hosoya Hirofumi Fujii Joji Kitayama Naohiro Sata Source Type: research
A preliminary mechanistic exploration of the effect of leptin on the docetaxel sensitivity of MDA-MB-231 triple-negative breast cancer cells
Mol Clin Oncol. 2024 Feb 1;20(3):24. doi: 10.3892/mco.2024.2722. eCollection 2024 Mar.ABSTRACTBreast cancer is a common tumor encountered in women, and triple-negative breast cancer (TNBC) has an extremely poor prognosis. The effect of leptin on the docetaxel sensitivity of MDA-MB-231 TNBC cells has not been investigated. The present study aimed to clarify the effect of leptin and M2 tumor-associated macrophages (TAMs) on the chemosensitivity of TNBC cell lines and its possible mechanisms. In the present study, the apoptosis of the MDA-MB-231 cell line was detected at 0, 24, 48 and 72 h using a Cell Counting Kit-8 assay to...
Source: Clinical Breast Cancer - February 27, 2024 Category: Cancer & Oncology Authors: Simeng Gao Sijuan Ding Zhaohui Tang Source Type: research
A preliminary mechanistic exploration of the effect of leptin on the docetaxel sensitivity of MDA-MB-231 triple-negative breast cancer cells
Mol Clin Oncol. 2024 Feb 1;20(3):24. doi: 10.3892/mco.2024.2722. eCollection 2024 Mar.ABSTRACTBreast cancer is a common tumor encountered in women, and triple-negative breast cancer (TNBC) has an extremely poor prognosis. The effect of leptin on the docetaxel sensitivity of MDA-MB-231 TNBC cells has not been investigated. The present study aimed to clarify the effect of leptin and M2 tumor-associated macrophages (TAMs) on the chemosensitivity of TNBC cell lines and its possible mechanisms. In the present study, the apoptosis of the MDA-MB-231 cell line was detected at 0, 24, 48 and 72 h using a Cell Counting Kit-8 assay to...
Source: Clinical Genitourinary Cancer - February 27, 2024 Category: Cancer & Oncology Authors: Simeng Gao Sijuan Ding Zhaohui Tang Source Type: research
Equivalent prognosis with no lymph node metastasis to pathological complete remission in patients with localized advanced esophageal cancer after neoadjuvant triplet chemotherapy with docetaxel, cisplatin, and 5-fluorouracil followed by curative surgery: a single-center retrospective cohort study
CONCLUSIONS: The prognosis of the ypT+N0 group after NAC with DCF followed by surgery was similar to that of pathological complete remission. Grouping patients according to pathological lymph node status is a reasonable predictor of prognosis.PMID:38410613 | PMC:PMC10894374 | DOI:10.21037/jtd-23-1484 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - February 27, 2024 Category: Respiratory Medicine Authors: Takashi Chinen Hironori Yamaguchi Hideyuki Ohzawa Shiro Matsumoto Kentaro Kurashina Shin Saito Yoshinori Hosoya Hirofumi Fujii Joji Kitayama Naohiro Sata Source Type: research
A preliminary mechanistic exploration of the effect of leptin on the docetaxel sensitivity of MDA-MB-231 triple-negative breast cancer cells
Mol Clin Oncol. 2024 Feb 1;20(3):24. doi: 10.3892/mco.2024.2722. eCollection 2024 Mar.ABSTRACTBreast cancer is a common tumor encountered in women, and triple-negative breast cancer (TNBC) has an extremely poor prognosis. The effect of leptin on the docetaxel sensitivity of MDA-MB-231 TNBC cells has not been investigated. The present study aimed to clarify the effect of leptin and M2 tumor-associated macrophages (TAMs) on the chemosensitivity of TNBC cell lines and its possible mechanisms. In the present study, the apoptosis of the MDA-MB-231 cell line was detected at 0, 24, 48 and 72 h using a Cell Counting Kit-8 assay to...
Source: Clinical Breast Cancer - February 27, 2024 Category: Cancer & Oncology Authors: Simeng Gao Sijuan Ding Zhaohui Tang Source Type: research
