Genetic Signatures for Distinguishing Chemo-Sensitive from Chemo-Resistant Responders in Prostate Cancer Patients
This study delves into the expression of drug resistance-associated genes, ABCB1 and CYP1B1, in cancer cells. Employing bioinformatics, we explored the molecular pathways and cascades linked to drug resistance following upregulation of these genes. Samples were obtained from archived prostate cancer patient specimens through pre-treatment biopsies of two categories: good vs. poor responders, with cDNAs synthesized from isolated RNAs subjected to qPCR analysis. The results revealed increased ABCB1 and CYP1B1 expression in tumor samples of the poor responders. Gene enrichment and network analysis associated ABCB1 with ABC tr...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Lemohang Gumenku Mamello Sekhoacha Beynon Abrahams Samson Mashele Aubrey Shoko Ochuko L Erukainure Source Type: research
Genetic Signatures for Distinguishing Chemo-Sensitive from Chemo-Resistant Responders in Prostate Cancer Patients
This study delves into the expression of drug resistance-associated genes, ABCB1 and CYP1B1, in cancer cells. Employing bioinformatics, we explored the molecular pathways and cascades linked to drug resistance following upregulation of these genes. Samples were obtained from archived prostate cancer patient specimens through pre-treatment biopsies of two categories: good vs. poor responders, with cDNAs synthesized from isolated RNAs subjected to qPCR analysis. The results revealed increased ABCB1 and CYP1B1 expression in tumor samples of the poor responders. Gene enrichment and network analysis associated ABCB1 with ABC tr...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Lemohang Gumenku Mamello Sekhoacha Beynon Abrahams Samson Mashele Aubrey Shoko Ochuko L Erukainure Source Type: research
Genetic Signatures for Distinguishing Chemo-Sensitive from Chemo-Resistant Responders in Prostate Cancer Patients
This study delves into the expression of drug resistance-associated genes, ABCB1 and CYP1B1, in cancer cells. Employing bioinformatics, we explored the molecular pathways and cascades linked to drug resistance following upregulation of these genes. Samples were obtained from archived prostate cancer patient specimens through pre-treatment biopsies of two categories: good vs. poor responders, with cDNAs synthesized from isolated RNAs subjected to qPCR analysis. The results revealed increased ABCB1 and CYP1B1 expression in tumor samples of the poor responders. Gene enrichment and network analysis associated ABCB1 with ABC tr...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Lemohang Gumenku Mamello Sekhoacha Beynon Abrahams Samson Mashele Aubrey Shoko Ochuko L Erukainure Source Type: research
Genetic Signatures for Distinguishing Chemo-Sensitive from Chemo-Resistant Responders in Prostate Cancer Patients
This study delves into the expression of drug resistance-associated genes, ABCB1 and CYP1B1, in cancer cells. Employing bioinformatics, we explored the molecular pathways and cascades linked to drug resistance following upregulation of these genes. Samples were obtained from archived prostate cancer patient specimens through pre-treatment biopsies of two categories: good vs. poor responders, with cDNAs synthesized from isolated RNAs subjected to qPCR analysis. The results revealed increased ABCB1 and CYP1B1 expression in tumor samples of the poor responders. Gene enrichment and network analysis associated ABCB1 with ABC tr...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Lemohang Gumenku Mamello Sekhoacha Beynon Abrahams Samson Mashele Aubrey Shoko Ochuko L Erukainure Source Type: research
Genetic Signatures for Distinguishing Chemo-Sensitive from Chemo-Resistant Responders in Prostate Cancer Patients
This study delves into the expression of drug resistance-associated genes, ABCB1 and CYP1B1, in cancer cells. Employing bioinformatics, we explored the molecular pathways and cascades linked to drug resistance following upregulation of these genes. Samples were obtained from archived prostate cancer patient specimens through pre-treatment biopsies of two categories: good vs. poor responders, with cDNAs synthesized from isolated RNAs subjected to qPCR analysis. The results revealed increased ABCB1 and CYP1B1 expression in tumor samples of the poor responders. Gene enrichment and network analysis associated ABCB1 with ABC tr...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Lemohang Gumenku Mamello Sekhoacha Beynon Abrahams Samson Mashele Aubrey Shoko Ochuko L Erukainure Source Type: research
Genetic Signatures for Distinguishing Chemo-Sensitive from Chemo-Resistant Responders in Prostate Cancer Patients
This study delves into the expression of drug resistance-associated genes, ABCB1 and CYP1B1, in cancer cells. Employing bioinformatics, we explored the molecular pathways and cascades linked to drug resistance following upregulation of these genes. Samples were obtained from archived prostate cancer patient specimens through pre-treatment biopsies of two categories: good vs. poor responders, with cDNAs synthesized from isolated RNAs subjected to qPCR analysis. The results revealed increased ABCB1 and CYP1B1 expression in tumor samples of the poor responders. Gene enrichment and network analysis associated ABCB1 with ABC tr...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Lemohang Gumenku Mamello Sekhoacha Beynon Abrahams Samson Mashele Aubrey Shoko Ochuko L Erukainure Source Type: research
Hypersensitivity Reactions to Taxanes: A Multicenter Study for Outcomes and Safety of Rapid Drug Desensitization
CONCLUSIONS: Our experience demonstrates a 100% success rate in completing the 255 RDDs for taxanes, affirming the safety and efficacy of the RDD within the study population.PMID:38528382 | DOI:10.4168/aair.2024.16.2.142 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 26, 2024 Category: Allergy & Immunology Authors: Makbule Seda Bayrak Durmaz Done Gulcin Unutmaz Meryem Demir Ozlem Goksel Adile Berna Dursun Sevim Bavbek Source Type: research
Influence of Neoadjuvant Immunotherapy-Chemotherapy on Perioperative Outcomes in Locally Advanced Esophageal Adenocarcinoma
CONCLUSION: The addition of immunotherapy to neoadjuvant chemotherapy for locally advanced esophageal adenocarcinoma does not appear to alter perioperative short-term outcomes significantly after esophagectomy.PMID:38530527 | DOI:10.1245/s10434-024-15186-z (Source: Ann Oncol)
Source: Ann Oncol - March 26, 2024 Category: Cancer & Oncology Authors: Yehonatan Nevo James Tankel Hedi Zhao Jaime Ramirez Jonathan Cools-Lartigue Carmen Muller Thierry Alcindor Lorenzo Ferri Source Type: research
Hypersensitivity Reactions to Taxanes: A Multicenter Study for Outcomes and Safety of Rapid Drug Desensitization
CONCLUSIONS: Our experience demonstrates a 100% success rate in completing the 255 RDDs for taxanes, affirming the safety and efficacy of the RDD within the study population.PMID:38528382 | DOI:10.4168/aair.2024.16.2.142 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 26, 2024 Category: Allergy & Immunology Authors: Makbule Seda Bayrak Durmaz Done Gulcin Unutmaz Meryem Demir Ozlem Goksel Adile Berna Dursun Sevim Bavbek Source Type: research
Hypersensitivity Reactions to Taxanes: A Multicenter Study for Outcomes and Safety of Rapid Drug Desensitization
CONCLUSIONS: Our experience demonstrates a 100% success rate in completing the 255 RDDs for taxanes, affirming the safety and efficacy of the RDD within the study population.PMID:38528382 | PMC:PMC10973638 | DOI:10.4168/aair.2024.16.2.142 (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 26, 2024 Category: Allergy & Immunology Authors: Makbule Seda Bayrak Durmaz Done Gulcin Unutmaz Meryem Demir Ozlem Goksel Adile Berna Dursun Sevim Bavbek Source Type: research
