Constructing lactylation-related genes prognostic model to effectively predict the disease-free survival and treatment responsiveness in prostate cancer based on machine learning
Conclusion: The lactylation-related genes prognostic model can effectively predict the DFS and therapeutic responses in patients with PCa. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - March 19, 2024 Category: Genetics & Stem Cells Source Type: research
Oral docetaxel plus encequidar – A pharmacokinetic model and evaluation against IV docetaxel
Conclusion: The study demonstrates the benefits of MIDD using oDox + E as a mot ivating example. A population pharmacokinetic model was developed for the total and unbound concentration in plasma of docetaxel after administration of IV docetaxel and oDox + E. The model was used to simulate oDox + E dose regimens which were compared to the current standard of care IV doc etaxel regimen. A GO / NO-GO framework was applied to determine whether oDox + E should progress to the next phase of drug development and whether any conditions should apply. A two or three-dose regimen of oDox + E at 600 mg was able ...
Source: Journal of Pharmacokinetics and Pharmacodynamics - March 19, 2024 Category: Drugs & Pharmacology Source Type: research
Reversal of cisplatin resistance in oral squamous cell carcinoma by piperlongumine loaded smart nanoparticles through inhibition of Hippo-YAP signaling pathway
Transl Res. 2024 Mar 16:S1931-5244(24)00049-5. doi: 10.1016/j.trsl.2024.03.004. Online ahead of print.ABSTRACTCisplatin alone or in combination with 5FU and docetaxel is the preferred chemotherapy regimen for advanced-stage OSCC patients. However, its use has been linked to recurrence and metastasis due to the development of drug resistance. Therefore, sensitization of cancer cells to conventional chemotherapeutics can be an effective strategy to overcome drug resistance. Piperlongumine, an alkaloid, have shown anticancer properties and sensitizes numerous neoplasms, but its effect on OSCC has not been explored. However, l...
Source: Translational Research : the journal of laboratory and clinical medicine - March 18, 2024 Category: Laboratory Medicine Authors: Pratikshya Sa Priya Singh Sudhakar Panda Rajeeb K Swain Rupesh Dash Sanjeeb Kumar Sahoo Source Type: research
Reversal of cisplatin resistance in oral squamous cell carcinoma by piperlongumine loaded smart nanoparticles through inhibition of Hippo-YAP signaling pathway
Transl Res. 2024 Mar 16:S1931-5244(24)00049-5. doi: 10.1016/j.trsl.2024.03.004. Online ahead of print.ABSTRACTCisplatin alone or in combination with 5FU and docetaxel is the preferred chemotherapy regimen for advanced-stage OSCC patients. However, its use has been linked to recurrence and metastasis due to the development of drug resistance. Therefore, sensitization of cancer cells to conventional chemotherapeutics can be an effective strategy to overcome drug resistance. Piperlongumine, an alkaloid, have shown anticancer properties and sensitizes numerous neoplasms, but its effect on OSCC has not been explored. However, l...
Source: Translational Research : the journal of laboratory and clinical medicine - March 18, 2024 Category: Laboratory Medicine Authors: Pratikshya Sa Priya Singh Sudhakar Panda Rajeeb K Swain Rupesh Dash Sanjeeb Kumar Sahoo Source Type: research
Reversal of cisplatin resistance in oral squamous cell carcinoma by piperlongumine loaded smart nanoparticles through inhibition of Hippo-YAP signaling pathway
Transl Res. 2024 Mar 16:S1931-5244(24)00049-5. doi: 10.1016/j.trsl.2024.03.004. Online ahead of print.ABSTRACTCisplatin alone or in combination with 5FU and docetaxel is the preferred chemotherapy regimen for advanced-stage OSCC patients. However, its use has been linked to recurrence and metastasis due to the development of drug resistance. Therefore, sensitization of cancer cells to conventional chemotherapeutics can be an effective strategy to overcome drug resistance. Piperlongumine, an alkaloid, have shown anticancer properties and sensitizes numerous neoplasms, but its effect on OSCC has not been explored. However, l...
Source: Translational Research : the journal of laboratory and clinical medicine - March 18, 2024 Category: Laboratory Medicine Authors: Pratikshya Sa Priya Singh Sudhakar Panda Rajeeb K Swain Rupesh Dash Sanjeeb Kumar Sahoo Source Type: research
Reversal of cisplatin resistance in oral squamous cell carcinoma by piperlongumine loaded smart nanoparticles through inhibition of Hippo-YAP signaling pathway
Transl Res. 2024 Mar 16:S1931-5244(24)00049-5. doi: 10.1016/j.trsl.2024.03.004. Online ahead of print.ABSTRACTCisplatin alone or in combination with 5FU and docetaxel is the preferred chemotherapy regimen for advanced-stage OSCC patients. However, its use has been linked to recurrence and metastasis due to the development of drug resistance. Therefore, sensitization of cancer cells to conventional chemotherapeutics can be an effective strategy to overcome drug resistance. Piperlongumine, an alkaloid, have shown anticancer properties and sensitizes numerous neoplasms, but its effect on OSCC has not been explored. However, l...
Source: Translational Research : the journal of laboratory and clinical medicine - March 18, 2024 Category: Laboratory Medicine Authors: Pratikshya Sa Priya Singh Sudhakar Panda Rajeeb K Swain Rupesh Dash Sanjeeb Kumar Sahoo Source Type: research
Reversal of cisplatin resistance in oral squamous cell carcinoma by piperlongumine loaded smart nanoparticles through inhibition of Hippo-YAP signaling pathway
Transl Res. 2024 Mar 16:S1931-5244(24)00049-5. doi: 10.1016/j.trsl.2024.03.004. Online ahead of print.ABSTRACTCisplatin alone or in combination with 5FU and docetaxel is the preferred chemotherapy regimen for advanced-stage OSCC patients. However, its use has been linked to recurrence and metastasis due to the development of drug resistance. Therefore, sensitization of cancer cells to conventional chemotherapeutics can be an effective strategy to overcome drug resistance. Piperlongumine, an alkaloid, have shown anticancer properties and sensitizes numerous neoplasms, but its effect on OSCC has not been explored. However, l...
Source: Translational Research : the journal of laboratory and clinical medicine - March 18, 2024 Category: Laboratory Medicine Authors: Pratikshya Sa Priya Singh Sudhakar Panda Rajeeb K Swain Rupesh Dash Sanjeeb Kumar Sahoo Source Type: research
Anlotinib plus docetaxel vs. docetaxel alone for advanced non-small-cell lung cancer patients who failed first-line treatment: A multicenter, randomized phase II trial
Non-small-cell lung cancer (NSCLC) represents the predominant form (85 %-90 %) of malignant lung neoplasms [1]. In 2020, lung cancer accounted for 2,206,771 new cases globally, leading to 1,796,144 fatalities [2,3]. At the dawn of the 21st century, chemotherapy remained the cornerstone of NSCLC treatment. However, the emergence of immunotherapy has introduced a pl ethora of innovative strategies for NSCLC management [4,5]. Currently, platinum-based chemotherapy, either alone or in combination with immunotherapy, is the endorsed first-line treatment paradigm for NSCLC [1,6,7]. (Source: Lung Cancer)
Source: Lung Cancer - March 18, 2024 Category: Cancer & Oncology Authors: Xingxiang Pu, Zemin Xiao, Jia Li, Zhijun Wu, Zhongxia Ma, Jie Weng, Maoliang Xiao, Yanhua Chen, Yongqing Cao, Peiguo Cao, Qianzhi Wang, Yan Xu, Kang Li, Bolin Chen, Fang Xu, Liyu Liu, Yi Kong, Hui Zhang, Huaxin Duan, Lin Wu Tags: Research Paper Source Type: research
Reversal of cisplatin resistance in oral squamous cell carcinoma by piperlongumine loaded smart nanoparticles through inhibition of Hippo-YAP signaling pathway
Cisplatin alone or in combination with 5FU and docetaxel is the preferred chemotherapy regimen for advanced-stage OSCC patients. However, its use has been linked to recurrence and metastasis due to the development of drug resistance. Therefore, sensitization of cancer cells to conventional chemotherapeutics can be an effective strategy to overcome drug resistance. Piperlongumine, an alkaloid, have shown anticancer properties and sensitizes numerous neoplasms, but its effect on OSCC has not been explored. (Source: Translational Research)
Source: Translational Research - March 16, 2024 Category: Research Authors: Pratikshya Sa, Priya Singh, Sudhakar Panda, Rajeeb K. Swain, Rupesh Dash, Sanjeeb Kumar Sahoo Source Type: research
Modelling the Effectiveness of Tepotinib in Comparison to Standard-of-Care Treatments in Patients with Advanced Non-small Cell Lung Cancer (NSCLC) Harbouring METex14 Skipping in the UK
ConclusionsDespite the limitations of the evidence base, the numerous analyses conducted have consistently indicated positive outcomes for tepotinib versus the current standard of care. (Source: Targeted Oncology)
Source: Targeted Oncology - March 16, 2024 Category: Cancer & Oncology Source Type: research
Comparison of Induction Cisplatin, Docetaxel, and 5-Fluorouracil to An Induction Platinum Doublet Regimen for Locally Advanced Human Papillomavirus-Associated Oropharyngeal Cancer
Management of locoregionally advanced (LA) human papillomavirus-positive oropharyngeal squamous cell carcinoma (HPV(+)OPSCC) often entails induction chemotherapy (IC) followed by definitive chemoradiation. The standard IC regimen for head and neck cancer, docetaxel, cisplatin, and 5-fluorouracil (TPF), has a high rate of toxicity. Due to the chemosensitivity of HPV(+)OPSCC, platinum-taxane doublets are often used as IC with less toxicity. No study to date has compared TPF to a platinum-taxane doublet IC regimen. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: A. Ganti, P.W. McGarrah, H. Fuentes Bayne, C. Fazer-Posorske, D.J. Ma, S.C. Lester, D.M. Routman, M.A. Neben-Wittich, M.E. Gamez, J.M. Wilson, D.L. Price, E.J. Moore, K.K. Tasche, K.M. Van Abel, L.X. Yin, N.R. Foster, K. Price Tags: 105 Source Type: research
Randomized Phase 2 Trial of Stereotactic Body Radiation Therapy (SBRT) and Concurrent and Adjuvant Cetuximab vs Cetuximab and Docetaxel in Recurrent, Previously Irradiated Squamous Cell Carcinoma of the Head and Neck
The treatment of recurrent head and neck cancer presents a significant challenge in previously irradiated patients. Therapeutic options in this patient population tend to be limited and are often associated with severe toxicity and decreased efficacy compared with front line therapies. Stereotactic body radiation therapy (SBRT) is a salvage technique that provides highly conformal, ablative doses to tumor while minimizing exposure of the surrounding organs at risk. The precise role of concurrent systemic therapy with SBRT, though, remains unclear and is a topic of active investigation. (Source: International Journal of Rad...
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: C.T. Wilke, R.L. Ferris, J. Ohr, D.P. Zandberg, Z. Rahman, S. Kim, C. Snyderman, J.T. Johnson, S.A. Burton, A.C. Olson, D. Petro, S. Marks, L. Francis, D. Friedland, V. Gorantla, J. Mountz, H. Wang, D.E. Heron, D.A. Clump, H.D. Skinner Tags: 163 Source Type: research
Ductal, intraductal, and cribriform carcinoma of the prostate: Molecular characteristics and clinical management
Urol Oncol. 2024 Mar 13:S1078-1439(24)00053-X. doi: 10.1016/j.urolonc.2024.01.037. Online ahead of print.ABSTRACTProstatic acinar adenocarcinoma accounts for approximately 95% of prostate cancer (CaP) cases. The remaining 5% of histologic subtypes of CaP are known to be more aggressive and have recently garnered substantial attention. These histologic subtypes - namely, prostatic ductal adenocarcinoma (PDA), intraductal carcinoma of the prostate (IDC-P), and cribriform carcinoma of the prostate (CC-P) - typically exhibit distinct growth characteristics, genomic features, and unique oncologic outcomes. For example, PTEN mut...
Source: Urologic Oncology - March 14, 2024 Category: Urology & Nephrology Authors: Yibo Shi Hanzhang Wang Borivoj Golijanin Ali Amin Joanne Lee Mark Sikov Elias Hyams Gyan Pareek Benedito A Carneiro Anthony E Mega Galina G Lagos Lisha Wang Zhiping Wang Liang Cheng Source Type: research
