A preliminary mechanistic exploration of the effect of leptin on the docetaxel sensitivity of MDA-MB-231 triple-negative breast cancer cells
Mol Clin Oncol. 2024 Feb 1;20(3):24. doi: 10.3892/mco.2024.2722. eCollection 2024 Mar.ABSTRACTBreast cancer is a common tumor encountered in women, and triple-negative breast cancer (TNBC) has an extremely poor prognosis. The effect of leptin on the docetaxel sensitivity of MDA-MB-231 TNBC cells has not been investigated. The present study aimed to clarify the effect of leptin and M2 tumor-associated macrophages (TAMs) on the chemosensitivity of TNBC cell lines and its possible mechanisms. In the present study, the apoptosis of the MDA-MB-231 cell line was detected at 0, 24, 48 and 72 h using a Cell Counting Kit-8 assay to...
Source: Clinical Breast Cancer - February 27, 2024 Category: Cancer & Oncology Authors: Simeng Gao Sijuan Ding Zhaohui Tang Source Type: research
A preliminary mechanistic exploration of the effect of leptin on the docetaxel sensitivity of MDA-MB-231 triple-negative breast cancer cells
Mol Clin Oncol. 2024 Feb 1;20(3):24. doi: 10.3892/mco.2024.2722. eCollection 2024 Mar.ABSTRACTBreast cancer is a common tumor encountered in women, and triple-negative breast cancer (TNBC) has an extremely poor prognosis. The effect of leptin on the docetaxel sensitivity of MDA-MB-231 TNBC cells has not been investigated. The present study aimed to clarify the effect of leptin and M2 tumor-associated macrophages (TAMs) on the chemosensitivity of TNBC cell lines and its possible mechanisms. In the present study, the apoptosis of the MDA-MB-231 cell line was detected at 0, 24, 48 and 72 h using a Cell Counting Kit-8 assay to...
Source: Clinical Genitourinary Cancer - February 27, 2024 Category: Cancer & Oncology Authors: Simeng Gao Sijuan Ding Zhaohui Tang Source Type: research
Equivalent prognosis with no lymph node metastasis to pathological complete remission in patients with localized advanced esophageal cancer after neoadjuvant triplet chemotherapy with docetaxel, cisplatin, and 5-fluorouracil followed by curative surgery: a single-center retrospective cohort study
CONCLUSIONS: The prognosis of the ypT+N0 group after NAC with DCF followed by surgery was similar to that of pathological complete remission. Grouping patients according to pathological lymph node status is a reasonable predictor of prognosis.PMID:38410613 | PMC:PMC10894374 | DOI:10.21037/jtd-23-1484 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - February 27, 2024 Category: Respiratory Medicine Authors: Takashi Chinen Hironori Yamaguchi Hideyuki Ohzawa Shiro Matsumoto Kentaro Kurashina Shin Saito Yoshinori Hosoya Hirofumi Fujii Joji Kitayama Naohiro Sata Source Type: research
