Elevated MMP1 Expression in Carcinoma-Associated Fibroblasts of Breast Cancer Contributes to Tumor Progression and Unfavorable Prognosis
CONCLUSION: The results indicated that MMP1 expression in CAFs may participate in the malignant phenotype and unfavorable prognosis of breast cancer.PMID:38514057 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Chunfang Xi Zhendi Song Qingyu Cui Ye Zhao Kaifu Li Hua Kang Source Type: research
Elevated MMP1 Expression in Carcinoma-Associated Fibroblasts of Breast Cancer Contributes to Tumor Progression and Unfavorable Prognosis
CONCLUSION: The results indicated that MMP1 expression in CAFs may participate in the malignant phenotype and unfavorable prognosis of breast cancer.PMID:38514057 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Chunfang Xi Zhendi Song Qingyu Cui Ye Zhao Kaifu Li Hua Kang Source Type: research
Elevated MMP1 Expression in Carcinoma-Associated Fibroblasts of Breast Cancer Contributes to Tumor Progression and Unfavorable Prognosis
CONCLUSION: The results indicated that MMP1 expression in CAFs may participate in the malignant phenotype and unfavorable prognosis of breast cancer.PMID:38514057 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Chunfang Xi Zhendi Song Qingyu Cui Ye Zhao Kaifu Li Hua Kang Source Type: research
Elevated MMP1 Expression in Carcinoma-Associated Fibroblasts of Breast Cancer Contributes to Tumor Progression and Unfavorable Prognosis
CONCLUSION: The results indicated that MMP1 expression in CAFs may participate in the malignant phenotype and unfavorable prognosis of breast cancer.PMID:38514057 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Chunfang Xi Zhendi Song Qingyu Cui Ye Zhao Kaifu Li Hua Kang Source Type: research
Elevated MMP1 Expression in Carcinoma-Associated Fibroblasts of Breast Cancer Contributes to Tumor Progression and Unfavorable Prognosis
CONCLUSION: The results indicated that MMP1 expression in CAFs may participate in the malignant phenotype and unfavorable prognosis of breast cancer.PMID:38514057 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Chunfang Xi Zhendi Song Qingyu Cui Ye Zhao Kaifu Li Hua Kang Source Type: research
TMEM120B strengthens breast cancer cell stemness and accelerates chemotherapy resistance via beta1-integrin/FAK-TAZ-mTOR signaling axis by binding to MYH9
CONCLUSIONS: Our study reveals that TMEM120B bound to and stabilized MYH9 by preventing its degradation. This interaction activated the β1-integrin/FAK-TAZ-mTOR signaling axis, maintaining stemness and accelerating chemotherapy resistance.PMID:38504374 | DOI:10.1186/s13058-024-01802-z (Source: Cell Research)
Source: Cell Research - March 20, 2024 Category: Cytology Authors: Ran Hu Yu Cao Yuanyuan Wang Tingting Zhao Kaibo Yang Mingwei Fan Mengyao Guan Yuekang Hou Jiao Ying Xiaowen Ma Ning Deng Xun Sun Yong Zhang Xiupeng Zhang Source Type: research
A new copper(II) complex containing long-chain aliphatic hydrazide and 1,10-phenanthroline upregulates ADP hydrolysis in triple-negative breast cancer cells
J Inorg Biochem. 2024 Mar 16;255:112524. doi: 10.1016/j.jinorgbio.2024.112524. Online ahead of print.ABSTRACTCopper can be opportunely complexed to modulate oncogenic pathways, being a promising strategy for cancer treatment. Herein, three new copper(II) complexes containing long-chain aliphatic hydrazides and 1,10-phenanthroline (1,10-phen), namely, [Cu(octh)(1,10-phen)(H2O)](NO3)21, [Cu(dech)(1,10-phen)(H2O)](NO3)22 and [Cu(dodh)(1,10-phen)(H2O)](NO3)2.H2O 3 (where octh = octanoic hydrazide, dech = decanoic hydrazide, dodh = dodecanoic hydrazide) were successfully prepared and characterized by several physical-chemical m...
Source: Journal of Inorganic Biochemistry - March 20, 2024 Category: Biochemistry Authors: Helen Soares Valen ça Ferreira Luana Munique Sousa Ramos Fernanda Cardoso Silva Daniel Lima Alves Gabriele de Menezes Pereira Pedro Henrique de Oliveira Santiago Angelina Maria de Almeida Javier Ellena Pedro Paulo Corbi Carolina Gon çalves Oliveira Maur Source Type: research
A new copper(II) complex containing long-chain aliphatic hydrazide and 1,10-phenanthroline upregulates ADP hydrolysis in triple-negative breast cancer cells
J Inorg Biochem. 2024 Mar 16;255:112524. doi: 10.1016/j.jinorgbio.2024.112524. Online ahead of print.ABSTRACTCopper can be opportunely complexed to modulate oncogenic pathways, being a promising strategy for cancer treatment. Herein, three new copper(II) complexes containing long-chain aliphatic hydrazides and 1,10-phenanthroline (1,10-phen), namely, [Cu(octh)(1,10-phen)(H2O)](NO3)21, [Cu(dech)(1,10-phen)(H2O)](NO3)22 and [Cu(dodh)(1,10-phen)(H2O)](NO3)2.H2O 3 (where octh = octanoic hydrazide, dech = decanoic hydrazide, dodh = dodecanoic hydrazide) were successfully prepared and characterized by several physical-chemical m...
Source: Journal of Inorganic Biochemistry - March 20, 2024 Category: Biochemistry Authors: Helen Soares Valen ça Ferreira Luana Munique Sousa Ramos Fernanda Cardoso Silva Daniel Lima Alves Gabriele de Menezes Pereira Pedro Henrique de Oliveira Santiago Angelina Maria de Almeida Javier Ellena Pedro Paulo Corbi Carolina Gon çalves Oliveira Maur Source Type: research
A new copper(II) complex containing long-chain aliphatic hydrazide and 1,10-phenanthroline upregulates ADP hydrolysis in triple-negative breast cancer cells
J Inorg Biochem. 2024 Mar 16;255:112524. doi: 10.1016/j.jinorgbio.2024.112524. Online ahead of print.ABSTRACTCopper can be opportunely complexed to modulate oncogenic pathways, being a promising strategy for cancer treatment. Herein, three new copper(II) complexes containing long-chain aliphatic hydrazides and 1,10-phenanthroline (1,10-phen), namely, [Cu(octh)(1,10-phen)(H2O)](NO3)21, [Cu(dech)(1,10-phen)(H2O)](NO3)22 and [Cu(dodh)(1,10-phen)(H2O)](NO3)2.H2O 3 (where octh = octanoic hydrazide, dech = decanoic hydrazide, dodh = dodecanoic hydrazide) were successfully prepared and characterized by several physical-chemical m...
Source: Journal of Inorganic Biochemistry - March 20, 2024 Category: Biochemistry Authors: Helen Soares Valen ça Ferreira Luana Munique Sousa Ramos Fernanda Cardoso Silva Daniel Lima Alves Gabriele de Menezes Pereira Pedro Henrique de Oliveira Santiago Angelina Maria de Almeida Javier Ellena Pedro Paulo Corbi Carolina Gon çalves Oliveira Maur Source Type: research
A new copper(II) complex containing long-chain aliphatic hydrazide and 1,10-phenanthroline upregulates ADP hydrolysis in triple-negative breast cancer cells
J Inorg Biochem. 2024 Mar 16;255:112524. doi: 10.1016/j.jinorgbio.2024.112524. Online ahead of print.ABSTRACTCopper can be opportunely complexed to modulate oncogenic pathways, being a promising strategy for cancer treatment. Herein, three new copper(II) complexes containing long-chain aliphatic hydrazides and 1,10-phenanthroline (1,10-phen), namely, [Cu(octh)(1,10-phen)(H2O)](NO3)21, [Cu(dech)(1,10-phen)(H2O)](NO3)22 and [Cu(dodh)(1,10-phen)(H2O)](NO3)2.H2O 3 (where octh = octanoic hydrazide, dech = decanoic hydrazide, dodh = dodecanoic hydrazide) were successfully prepared and characterized by several physical-chemical m...
Source: Journal of Inorganic Biochemistry - March 20, 2024 Category: Biochemistry Authors: Helen Soares Valen ça Ferreira Luana Munique Sousa Ramos Fernanda Cardoso Silva Daniel Lima Alves Gabriele de Menezes Pereira Pedro Henrique de Oliveira Santiago Angelina Maria de Almeida Javier Ellena Pedro Paulo Corbi Carolina Gon çalves Oliveira Maur Source Type: research
Retraction Note: Effect of pantoprazole to enhance activity of docetaxel against human tumour xenografts by inhibiting autophagy
British Journal of Cancer, Published online: 20 March 2024; doi:10.1038/s41416-024-02660-4Retraction Note: Effect of pantoprazole to enhance activity of docetaxel against human tumour xenografts by inhibiting autophagy (Source: British Journal of Cancer)
Source: British Journal of Cancer - March 20, 2024 Category: Cancer & Oncology Authors: Q. Tan A. M. Joshua J. K. Saggar M. Yu M. Wang N. Kanga J. Y. Zhang X. Chen B. G. Wouters I. F. Tannock Source Type: research
Neoadjuvant Chemotherapy Alone or Combined with EGFR-Directed Targeted Therapy or Anti-PD-1 Immunotherapy for Locally Advanced Lacrimal Sac and Nasolacrimal Duct Carcinomas
CONCLUSIONS: Neoadjuvant systemic therapy can shrink tumors in patients with locally advanced primary lacrimal sac/NLD carcinoma with orbital or skull base invasion.PMID:38500295 | DOI:10.1080/08820538.2024.2324057 (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - March 19, 2024 Category: Opthalmology Authors: Jeremy Goldfarb Janet Fan Luana Guimaraes de Sousa Neal Akhave Jeffrey Myers Ryan Goepfert Krish Manisundaram Jiawei Zhao Steven J Frank Amy Moreno Renata Ferrarotto Bita Esmaeli Source Type: research
Neoadjuvant chemohormonal therapy before radical prostatectomy in high-risk prostate cancer: a mini-review
Am J Clin Exp Urol. 2024 Feb 15;12(1):1-7. eCollection 2024.ABSTRACTHigh-risk localized prostate cancer (PCa) has the potential of recurrence and progression to a lethal phenotype, and neoadjuvant therapy followed by radical prostatectomy (RP) may be an option for these patients. Docetaxel has been recently shown to be an effective chemotherapeutic agent for high-volume metastatic hormone-sensitive PCa and metastatic castration-resistant PCa, and these increased efficacy create the impetus to assess the potential role of preoperative docetaxel in high-risk localized PCa. In this mini-review, we found that neoadjuvant chemo...
Source: Clinical Prostate Cancer - March 19, 2024 Category: Cancer & Oncology Authors: Junjie Fan Zhangdong Jiang Guojing Wang Dalin He Kaijie Wu Source Type: research
Neoadjuvant chemohormonal therapy before radical prostatectomy in high-risk prostate cancer: a mini-review
Am J Clin Exp Urol. 2024 Feb 15;12(1):1-7. eCollection 2024.ABSTRACTHigh-risk localized prostate cancer (PCa) has the potential of recurrence and progression to a lethal phenotype, and neoadjuvant therapy followed by radical prostatectomy (RP) may be an option for these patients. Docetaxel has been recently shown to be an effective chemotherapeutic agent for high-volume metastatic hormone-sensitive PCa and metastatic castration-resistant PCa, and these increased efficacy create the impetus to assess the potential role of preoperative docetaxel in high-risk localized PCa. In this mini-review, we found that neoadjuvant chemo...
Source: Clinical Prostate Cancer - March 19, 2024 Category: Cancer & Oncology Authors: Junjie Fan Zhangdong Jiang Guojing Wang Dalin He Kaijie Wu Source Type: research
Neoadjuvant Chemotherapy Alone or Combined with EGFR-Directed Targeted Therapy or Anti-PD-1 Immunotherapy for Locally Advanced Lacrimal Sac and Nasolacrimal Duct Carcinomas
CONCLUSIONS: Neoadjuvant systemic therapy can shrink tumors in patients with locally advanced primary lacrimal sac/NLD carcinoma with orbital or skull base invasion.PMID:38500295 | DOI:10.1080/08820538.2024.2324057 (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - March 19, 2024 Category: Opthalmology Authors: Jeremy Goldfarb Janet Fan Luana Guimaraes de Sousa Neal Akhave Jeffrey Myers Ryan Goepfert Krish Manisundaram Jiawei Zhao Steven J Frank Amy Moreno Renata Ferrarotto Bita Esmaeli Source Type: research
