Anticancer Effect by Combined Treatment of < em > Artemisia annua < /em > L. Polyphenols and Docetaxel in DU145 Prostate Cancer Cells and HCT116 Colorectal Cancer Cells
In this study, we examined how the anticancer effect of DTX is regulated by polyphenols extracted from Korean Artemisia annua L. (pKAL) in DU145 prostate cancer cells (mutant p53) and HCT116 colorectal cancer cells (wild-type p53). Here, we show that the anticancer effect of DTX was enhanced more significantly by pKAL in HCT116 cells than in DU145 cells via phase-contrast microscopy, CCK-8 assay, Western blot, and flow cytometric analysis of annexin V/propidium iodide-stained cells. Notably, mutant p53 was slightly downregulated by single treatment of pKAL or DTX in DU145 cells, whereas wild-type p53 was significantly upre...
Source: Current Issues in Molecular Biology - February 23, 2024 Category: Molecular Biology Authors: Eun Joo Jung Hye Jung Kim Sung Chul Shin Gon Sup Kim Jin-Myung Jung Soon Chan Hong Ky Hyun Chung Choong Won Kim Won Sup Lee Source Type: research
BCG and Alternative Therapies to BCG Therapy for Non-Muscle-Invasive Bladder Cancer
Curr Oncol. 2024 Feb 16;31(2):1063-1078. doi: 10.3390/curroncol31020079.ABSTRACTBladder cancer is a heterogeneous disease. Treatment decisions are mostly decided based on disease stage (non-muscle invasive or muscle invasive). Patients with muscle-invasive disease will be offered a radical treatment combined with systemic therapy, while in those with non-muscle-invasive disease, an attempt to resect the tumor endoscopically will usually be followed by different intravesical instillations. The goal of intravesical therapy is to decrease the recurrence and/or progression of the tumor. In the current landscape of bladder canc...
Source: Current Oncology - February 23, 2024 Category: Cancer & Oncology Authors: Sarah Lidagoster Reuben Ben-David Benjamin De Leon John P Sfakianos Source Type: research
Anticancer Effect by Combined Treatment of < em > Artemisia annua < /em > L. Polyphenols and Docetaxel in DU145 Prostate Cancer Cells and HCT116 Colorectal Cancer Cells
In this study, we examined how the anticancer effect of DTX is regulated by polyphenols extracted from Korean Artemisia annua L. (pKAL) in DU145 prostate cancer cells (mutant p53) and HCT116 colorectal cancer cells (wild-type p53). Here, we show that the anticancer effect of DTX was enhanced more significantly by pKAL in HCT116 cells than in DU145 cells via phase-contrast microscopy, CCK-8 assay, Western blot, and flow cytometric analysis of annexin V/propidium iodide-stained cells. Notably, mutant p53 was slightly downregulated by single treatment of pKAL or DTX in DU145 cells, whereas wild-type p53 was significantly upre...
Source: Current Issues in Molecular Biology - February 23, 2024 Category: Molecular Biology Authors: Eun Joo Jung Hye Jung Kim Sung Chul Shin Gon Sup Kim Jin-Myung Jung Soon Chan Hong Ky Hyun Chung Choong Won Kim Won Sup Lee Source Type: research
BCG and Alternative Therapies to BCG Therapy for Non-Muscle-Invasive Bladder Cancer
Curr Oncol. 2024 Feb 16;31(2):1063-1078. doi: 10.3390/curroncol31020079.ABSTRACTBladder cancer is a heterogeneous disease. Treatment decisions are mostly decided based on disease stage (non-muscle invasive or muscle invasive). Patients with muscle-invasive disease will be offered a radical treatment combined with systemic therapy, while in those with non-muscle-invasive disease, an attempt to resect the tumor endoscopically will usually be followed by different intravesical instillations. The goal of intravesical therapy is to decrease the recurrence and/or progression of the tumor. In the current landscape of bladder canc...
Source: Current Oncology - February 23, 2024 Category: Cancer & Oncology Authors: Sarah Lidagoster Reuben Ben-David Benjamin De Leon John P Sfakianos Source Type: research
Anticancer Effect by Combined Treatment of < em > Artemisia annua < /em > L. Polyphenols and Docetaxel in DU145 Prostate Cancer Cells and HCT116 Colorectal Cancer Cells
In this study, we examined how the anticancer effect of DTX is regulated by polyphenols extracted from Korean Artemisia annua L. (pKAL) in DU145 prostate cancer cells (mutant p53) and HCT116 colorectal cancer cells (wild-type p53). Here, we show that the anticancer effect of DTX was enhanced more significantly by pKAL in HCT116 cells than in DU145 cells via phase-contrast microscopy, CCK-8 assay, Western blot, and flow cytometric analysis of annexin V/propidium iodide-stained cells. Notably, mutant p53 was slightly downregulated by single treatment of pKAL or DTX in DU145 cells, whereas wild-type p53 was significantly upre...
Source: Current Issues in Molecular Biology - February 23, 2024 Category: Molecular Biology Authors: Eun Joo Jung Hye Jung Kim Sung Chul Shin Gon Sup Kim Jin-Myung Jung Soon Chan Hong Ky Hyun Chung Choong Won Kim Won Sup Lee Source Type: research
