Cancers, Vol. 16, Pages 935: Clinical Benefit from Docetaxel +/ & minus; Ramucirumab Is Not Associated with Mutation Status in Metastatic Non-Small-Cell Lung Cancer Patients Who Progressed on Platinum Doublets and Immunotherapy
In conclusion, in patients with metastatic NSCLC who have progressed on platinum doublets and ICIs, the clinical benefit from docetaxel +/− ramucirumab is not associated with the cancer gene mutation status. Platinum/taxane-based regimens may offer a superior clinical benefit over docetaxel +/− ramucirumab in this patient population. (Source: Cancers)
Source: Cancers - February 26, 2024 Category: Cancer & Oncology Authors: Kang Qin Kaiwen Wang Shenduo Li Lingzhi Hong Priyadharshini Padmakumar Rinsurongkawong Waree Shawna M. Hubert Xiuning Le Natalie Vokes Kunal Rai Ara Vaporciyan Don L. Gibbons John V. Heymach J. Jack Lee Scott E. Woodman Caroline Chung David A. Jaffray Meh Tags: Article Source Type: research
BCG and Alternative Therapies to BCG Therapy for Non-Muscle-Invasive Bladder Cancer
Curr Oncol. 2024 Feb 16;31(2):1063-1078. doi: 10.3390/curroncol31020079.ABSTRACTBladder cancer is a heterogeneous disease. Treatment decisions are mostly decided based on disease stage (non-muscle invasive or muscle invasive). Patients with muscle-invasive disease will be offered a radical treatment combined with systemic therapy, while in those with non-muscle-invasive disease, an attempt to resect the tumor endoscopically will usually be followed by different intravesical instillations. The goal of intravesical therapy is to decrease the recurrence and/or progression of the tumor. In the current landscape of bladder canc...
Source: Current Oncology - February 23, 2024 Category: Cancer & Oncology Authors: Sarah Lidagoster Reuben Ben-David Benjamin De Leon John P Sfakianos Source Type: research
Anticancer Effect by Combined Treatment of < em > Artemisia annua < /em > L. Polyphenols and Docetaxel in DU145 Prostate Cancer Cells and HCT116 Colorectal Cancer Cells
In this study, we examined how the anticancer effect of DTX is regulated by polyphenols extracted from Korean Artemisia annua L. (pKAL) in DU145 prostate cancer cells (mutant p53) and HCT116 colorectal cancer cells (wild-type p53). Here, we show that the anticancer effect of DTX was enhanced more significantly by pKAL in HCT116 cells than in DU145 cells via phase-contrast microscopy, CCK-8 assay, Western blot, and flow cytometric analysis of annexin V/propidium iodide-stained cells. Notably, mutant p53 was slightly downregulated by single treatment of pKAL or DTX in DU145 cells, whereas wild-type p53 was significantly upre...
Source: Current Issues in Molecular Biology - February 23, 2024 Category: Molecular Biology Authors: Eun Joo Jung Hye Jung Kim Sung Chul Shin Gon Sup Kim Jin-Myung Jung Soon Chan Hong Ky Hyun Chung Choong Won Kim Won Sup Lee Source Type: research
Anticancer Effect by Combined Treatment of < em > Artemisia annua < /em > L. Polyphenols and Docetaxel in DU145 Prostate Cancer Cells and HCT116 Colorectal Cancer Cells
In this study, we examined how the anticancer effect of DTX is regulated by polyphenols extracted from Korean Artemisia annua L. (pKAL) in DU145 prostate cancer cells (mutant p53) and HCT116 colorectal cancer cells (wild-type p53). Here, we show that the anticancer effect of DTX was enhanced more significantly by pKAL in HCT116 cells than in DU145 cells via phase-contrast microscopy, CCK-8 assay, Western blot, and flow cytometric analysis of annexin V/propidium iodide-stained cells. Notably, mutant p53 was slightly downregulated by single treatment of pKAL or DTX in DU145 cells, whereas wild-type p53 was significantly upre...
Source: Mol Biol Cell - February 23, 2024 Category: Molecular Biology Authors: Eun Joo Jung Hye Jung Kim Sung Chul Shin Gon Sup Kim Jin-Myung Jung Soon Chan Hong Ky Hyun Chung Choong Won Kim Won Sup Lee Source Type: research
BCG and Alternative Therapies to BCG Therapy for Non-Muscle-Invasive Bladder Cancer
Curr Oncol. 2024 Feb 16;31(2):1063-1078. doi: 10.3390/curroncol31020079.ABSTRACTBladder cancer is a heterogeneous disease. Treatment decisions are mostly decided based on disease stage (non-muscle invasive or muscle invasive). Patients with muscle-invasive disease will be offered a radical treatment combined with systemic therapy, while in those with non-muscle-invasive disease, an attempt to resect the tumor endoscopically will usually be followed by different intravesical instillations. The goal of intravesical therapy is to decrease the recurrence and/or progression of the tumor. In the current landscape of bladder canc...
Source: Current Oncology - February 23, 2024 Category: Cancer & Oncology Authors: Sarah Lidagoster Reuben Ben-David Benjamin De Leon John P Sfakianos Source Type: research
Anticancer Effect by Combined Treatment of < em > Artemisia annua < /em > L. Polyphenols and Docetaxel in DU145 Prostate Cancer Cells and HCT116 Colorectal Cancer Cells
In this study, we examined how the anticancer effect of DTX is regulated by polyphenols extracted from Korean Artemisia annua L. (pKAL) in DU145 prostate cancer cells (mutant p53) and HCT116 colorectal cancer cells (wild-type p53). Here, we show that the anticancer effect of DTX was enhanced more significantly by pKAL in HCT116 cells than in DU145 cells via phase-contrast microscopy, CCK-8 assay, Western blot, and flow cytometric analysis of annexin V/propidium iodide-stained cells. Notably, mutant p53 was slightly downregulated by single treatment of pKAL or DTX in DU145 cells, whereas wild-type p53 was significantly upre...
Source: Current Issues in Molecular Biology - February 23, 2024 Category: Molecular Biology Authors: Eun Joo Jung Hye Jung Kim Sung Chul Shin Gon Sup Kim Jin-Myung Jung Soon Chan Hong Ky Hyun Chung Choong Won Kim Won Sup Lee Source Type: research
BCG and Alternative Therapies to BCG Therapy for Non-Muscle-Invasive Bladder Cancer
Curr Oncol. 2024 Feb 16;31(2):1063-1078. doi: 10.3390/curroncol31020079.ABSTRACTBladder cancer is a heterogeneous disease. Treatment decisions are mostly decided based on disease stage (non-muscle invasive or muscle invasive). Patients with muscle-invasive disease will be offered a radical treatment combined with systemic therapy, while in those with non-muscle-invasive disease, an attempt to resect the tumor endoscopically will usually be followed by different intravesical instillations. The goal of intravesical therapy is to decrease the recurrence and/or progression of the tumor. In the current landscape of bladder canc...
Source: Current Oncology - February 23, 2024 Category: Cancer & Oncology Authors: Sarah Lidagoster Reuben Ben-David Benjamin De Leon John P Sfakianos Source Type: research
Anticancer Effect by Combined Treatment of < em > Artemisia annua < /em > L. Polyphenols and Docetaxel in DU145 Prostate Cancer Cells and HCT116 Colorectal Cancer Cells
In this study, we examined how the anticancer effect of DTX is regulated by polyphenols extracted from Korean Artemisia annua L. (pKAL) in DU145 prostate cancer cells (mutant p53) and HCT116 colorectal cancer cells (wild-type p53). Here, we show that the anticancer effect of DTX was enhanced more significantly by pKAL in HCT116 cells than in DU145 cells via phase-contrast microscopy, CCK-8 assay, Western blot, and flow cytometric analysis of annexin V/propidium iodide-stained cells. Notably, mutant p53 was slightly downregulated by single treatment of pKAL or DTX in DU145 cells, whereas wild-type p53 was significantly upre...
Source: Current Issues in Molecular Biology - February 23, 2024 Category: Molecular Biology Authors: Eun Joo Jung Hye Jung Kim Sung Chul Shin Gon Sup Kim Jin-Myung Jung Soon Chan Hong Ky Hyun Chung Choong Won Kim Won Sup Lee Source Type: research
BCG and Alternative Therapies to BCG Therapy for Non-Muscle-Invasive Bladder Cancer
Curr Oncol. 2024 Feb 16;31(2):1063-1078. doi: 10.3390/curroncol31020079.ABSTRACTBladder cancer is a heterogeneous disease. Treatment decisions are mostly decided based on disease stage (non-muscle invasive or muscle invasive). Patients with muscle-invasive disease will be offered a radical treatment combined with systemic therapy, while in those with non-muscle-invasive disease, an attempt to resect the tumor endoscopically will usually be followed by different intravesical instillations. The goal of intravesical therapy is to decrease the recurrence and/or progression of the tumor. In the current landscape of bladder canc...
Source: Current Oncology - February 23, 2024 Category: Cancer & Oncology Authors: Sarah Lidagoster Reuben Ben-David Benjamin De Leon John P Sfakianos Source Type: research
Anticancer Effect by Combined Treatment of < em > Artemisia annua < /em > L. Polyphenols and Docetaxel in DU145 Prostate Cancer Cells and HCT116 Colorectal Cancer Cells
In this study, we examined how the anticancer effect of DTX is regulated by polyphenols extracted from Korean Artemisia annua L. (pKAL) in DU145 prostate cancer cells (mutant p53) and HCT116 colorectal cancer cells (wild-type p53). Here, we show that the anticancer effect of DTX was enhanced more significantly by pKAL in HCT116 cells than in DU145 cells via phase-contrast microscopy, CCK-8 assay, Western blot, and flow cytometric analysis of annexin V/propidium iodide-stained cells. Notably, mutant p53 was slightly downregulated by single treatment of pKAL or DTX in DU145 cells, whereas wild-type p53 was significantly upre...
Source: Current Issues in Molecular Biology - February 23, 2024 Category: Molecular Biology Authors: Eun Joo Jung Hye Jung Kim Sung Chul Shin Gon Sup Kim Jin-Myung Jung Soon Chan Hong Ky Hyun Chung Choong Won Kim Won Sup Lee Source Type: research
BCG and Alternative Therapies to BCG Therapy for Non-Muscle-Invasive Bladder Cancer
Curr Oncol. 2024 Feb 16;31(2):1063-1078. doi: 10.3390/curroncol31020079.ABSTRACTBladder cancer is a heterogeneous disease. Treatment decisions are mostly decided based on disease stage (non-muscle invasive or muscle invasive). Patients with muscle-invasive disease will be offered a radical treatment combined with systemic therapy, while in those with non-muscle-invasive disease, an attempt to resect the tumor endoscopically will usually be followed by different intravesical instillations. The goal of intravesical therapy is to decrease the recurrence and/or progression of the tumor. In the current landscape of bladder canc...
Source: Current Oncology - February 23, 2024 Category: Cancer & Oncology Authors: Sarah Lidagoster Reuben Ben-David Benjamin De Leon John P Sfakianos Source Type: research
Anticancer Effect by Combined Treatment of < em > Artemisia annua < /em > L. Polyphenols and Docetaxel in DU145 Prostate Cancer Cells and HCT116 Colorectal Cancer Cells
In this study, we examined how the anticancer effect of DTX is regulated by polyphenols extracted from Korean Artemisia annua L. (pKAL) in DU145 prostate cancer cells (mutant p53) and HCT116 colorectal cancer cells (wild-type p53). Here, we show that the anticancer effect of DTX was enhanced more significantly by pKAL in HCT116 cells than in DU145 cells via phase-contrast microscopy, CCK-8 assay, Western blot, and flow cytometric analysis of annexin V/propidium iodide-stained cells. Notably, mutant p53 was slightly downregulated by single treatment of pKAL or DTX in DU145 cells, whereas wild-type p53 was significantly upre...
Source: Current Issues in Molecular Biology - February 23, 2024 Category: Molecular Biology Authors: Eun Joo Jung Hye Jung Kim Sung Chul Shin Gon Sup Kim Jin-Myung Jung Soon Chan Hong Ky Hyun Chung Choong Won Kim Won Sup Lee Source Type: research
BCG and Alternative Therapies to BCG Therapy for Non-Muscle-Invasive Bladder Cancer
Curr Oncol. 2024 Feb 16;31(2):1063-1078. doi: 10.3390/curroncol31020079.ABSTRACTBladder cancer is a heterogeneous disease. Treatment decisions are mostly decided based on disease stage (non-muscle invasive or muscle invasive). Patients with muscle-invasive disease will be offered a radical treatment combined with systemic therapy, while in those with non-muscle-invasive disease, an attempt to resect the tumor endoscopically will usually be followed by different intravesical instillations. The goal of intravesical therapy is to decrease the recurrence and/or progression of the tumor. In the current landscape of bladder canc...
Source: Current Oncology - February 23, 2024 Category: Cancer & Oncology Authors: Sarah Lidagoster Reuben Ben-David Benjamin De Leon John P Sfakianos Source Type: research
Anticancer Effect by Combined Treatment of < em > Artemisia annua < /em > L. Polyphenols and Docetaxel in DU145 Prostate Cancer Cells and HCT116 Colorectal Cancer Cells
In this study, we examined how the anticancer effect of DTX is regulated by polyphenols extracted from Korean Artemisia annua L. (pKAL) in DU145 prostate cancer cells (mutant p53) and HCT116 colorectal cancer cells (wild-type p53). Here, we show that the anticancer effect of DTX was enhanced more significantly by pKAL in HCT116 cells than in DU145 cells via phase-contrast microscopy, CCK-8 assay, Western blot, and flow cytometric analysis of annexin V/propidium iodide-stained cells. Notably, mutant p53 was slightly downregulated by single treatment of pKAL or DTX in DU145 cells, whereas wild-type p53 was significantly upre...
Source: Current Issues in Molecular Biology - February 23, 2024 Category: Molecular Biology Authors: Eun Joo Jung Hye Jung Kim Sung Chul Shin Gon Sup Kim Jin-Myung Jung Soon Chan Hong Ky Hyun Chung Choong Won Kim Won Sup Lee Source Type: research
