Comparison of Induction Cisplatin, Docetaxel, and 5-Fluorouracil to An Induction Platinum Doublet Regimen for Locally Advanced Human Papillomavirus-Associated Oropharyngeal Cancer

Management of locoregionally advanced (LA) human papillomavirus-positive oropharyngeal squamous cell carcinoma (HPV(+)OPSCC) often entails induction chemotherapy (IC) followed by definitive chemoradiation. The standard IC regimen for head and neck cancer, docetaxel, cisplatin, and 5-fluorouracil (TPF), has a high rate of toxicity. Due to the chemosensitivity of HPV(+)OPSCC, platinum-taxane doublets are often used as IC with less toxicity. No study to date has compared TPF to a platinum-taxane doublet IC regimen.

Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: A. Ganti, P.W. McGarrah, H. Fuentes Bayne, C. Fazer-Posorske, D.J. Ma, S.C. Lester, D.M. Routman, M.A. Neben-Wittich, M.E. Gamez, J.M. Wilson, D.L. Price, E.J. Moore, K.K. Tasche, K.M. Van Abel, L.X. Yin, N.R. Foster, K. Price Tags: 105 Source Type: research