Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway
CONCLUSION: Our findings identify an autocrine loop of IL-11/IL-11RA that confers docetaxel resistance through the JAK1/STAT4 pathway. The pSTAT4-CBP interaction serves as a critical enhancer of c-MYC transcriptional activity in prostate cancer cells. Targeting this signalling axis presents a potential therapeutic strategy to overcome docetaxel resistance in advanced prostate cancer.PMID:38429845 | DOI:10.1186/s13046-024-02962-8
Source: Cancer Control - Category: Cancer & Oncology Authors: Bisheng Cheng Lingfeng Li Tianlong Luo Qiong Wang Yong Luo Shoumin Bai Kaiwen Li Yiming Lai Hai Huang Source Type: research