Effects of fluoride on oxidative DNA damage, nitric oxide level, lipid peroxidation and cholinesterase enzyme activity in a rotenone-induced experimental Parkinson's model
CONCLUSIONS: Findings suggest that NaF and ROT may interact synergistically leading to oxidative damage and neuronal cell loss. As a result, we believe that exposure to pesticides in combination with NaF is one of the environmental factors that should not be ignored in the etiology of neurological diseases such as PD in populations in areas with endemic fluorosis.PMID:37699078 | DOI:10.1080/01616412.2023.2257452 (Source: Cell Research)
Source: Cell Research - September 12, 2023 Category: Cytology Authors: Yilmaz Kocak Gokhan Oto Zubeyir Huyut Hamit Hakan Alp Fikret Turkan Ezgi Onay Source Type: research
Effects of fluoride on oxidative DNA damage, nitric oxide level, lipid peroxidation and cholinesterase enzyme activity in a rotenone-induced experimental Parkinson's model
CONCLUSIONS: Findings suggest that NaF and ROT may interact synergistically leading to oxidative damage and neuronal cell loss. As a result, we believe that exposure to pesticides in combination with NaF is one of the environmental factors that should not be ignored in the etiology of neurological diseases such as PD in populations in areas with endemic fluorosis.PMID:37699078 | DOI:10.1080/01616412.2023.2257452 (Source: Neurological Research)
Source: Neurological Research - September 12, 2023 Category: Neurology Authors: Yilmaz Kocak Gokhan Oto Zubeyir Huyut Hamit Hakan Alp Fikret Turkan Ezgi Onay Source Type: research
Combined Effects of Fluoride and Dietary Seleno-L-Methionine at Environmentally Relevant Concentrations on Female Zebrafish (Danio rerio) Liver: Histopathological Damages, Oxidative Stress and Inflammation
In this study, female zebrafish (Danio rerio) were exposed to fluoride (80 mg/L sodium fluoride) and/or dietary selenomethionine (Se-Met) for 30, 60 and 90 days, the effects on the liver of zebrafish were investigated. The results indicated that an increase in fluoride burden, inhibited growth and impaired liver morphology were recorded after fluoride exposure. Furthermore, fluoride alone caused oxidative stress and inflammation in the liver, as reflected by the increase in ROS and MDA contents, the reduction of anti-oxidative enzymes, the altered immune related enzymes (ACP, AKP, LZM and MPO) and the expression of IL-6, I...
Source: Biological Trace Element Research - September 8, 2023 Category: Biology Authors: Xiulin Zhang Jinling Cao Jianjie Chen Guodong Wang Lijuan Li Xiaobing Wei Runxiao Zhang Source Type: research
Combined Effects of Fluoride and Dietary Seleno-L-Methionine at Environmentally Relevant Concentrations on Female Zebrafish (Danio rerio) Liver: Histopathological Damages, Oxidative Stress and Inflammation
In this study, female zebrafish (Danio rerio) were exposed to fluoride (80 mg/L sodium fluoride) and/or dietary selenomethionine (Se-Met) for 30, 60 and 90 days, the effects on the liver of zebrafish were investigated. The results indicated that an increase in fluoride burden, inhibited growth and impaired liver morphology were recorded after fluoride exposure. Furthermore, fluoride alone caused oxidative stress and inflammation in the liver, as reflected by the increase in ROS and MDA contents, the reduction of anti-oxidative enzymes, the altered immune related enzymes (ACP, AKP, LZM and MPO) and the expression of IL-6, I...
Source: Biological Trace Element Research - September 8, 2023 Category: Biology Authors: Xiulin Zhang Jinling Cao Jianjie Chen Guodong Wang Lijuan Li Xiaobing Wei Runxiao Zhang Source Type: research
Temporal Changes in Coronary 18F-Fluoride Plaque Uptake in Patients with Coronary Atherosclerosis
Conclusion: Coronary 18F-fluoride uptake is associated with the severity and progression of coronary artery disease but does not undergo a rapid dynamic change in patients with chronic or unstable coronary artery disease. This finding suggests that coronary 18F-fluoride uptake is a temporally stable marker of established and progressive disease. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 1, 2023 Category: Nuclear Medicine Authors: Daghem, M., Adamson, P. D., Wang, K.-L., Doris, M., Bing, R., van Beek, E. J. R., Forsyth, L., Williams, M. C., Tzolos, E., Dey, D., Slomka, P. J., Dweck, M. R., Newby, D. E., Moss, A. J. Tags: Clinical Investigations Source Type: research
A randomised trial of [ < sup > 18 < /sup > F]PSMA-1007-PET/CT versus NaF-PET/CT for staging primary prostate cancer: A trial protocol
BJUI Compass. 2023 May 12;4(5):513-522. doi: 10.1002/bco2.243. eCollection 2023 Sep.ABSTRACTBACKGROUND: Prostate-specific membrane antigen (PSMA)-positron emission tomography/contrast-enhanced computed tomography (PET/CT) is a sensitive imaging modality for prostate cancer (PCa). Due to lack of knowledge of the patient benefit, PSMA-PET/CT is not yet recommended in the European guidelines for staging and treatment planning of patients with newly diagnosed PCa. We will investigate the potential difference in progression-free survival (PFS) and quality of life (QoL) of using PSMA-PET/CT versus sodium fluoride (NaF)-PET/CT fo...
Source: Cancer Control - August 28, 2023 Category: Cancer & Oncology Authors: Karen Middelbo Buch-Olsen Mads Hvid Poulsen Steinbj ørn Hansen Mie Holm Vilstrup Jorun Holm S øren Hess Paw Christian Holdgaard Karsten Egbert Arnold Zieger S øren Sørensen Madsen Oke Gerke Kasper Tholstrup Pedersen Johan Hygum Dam Niels Langkj ær Lo Source Type: research
Early Events after Herpes Simplex Virus-Type 1 Entry Are Necessary for the Release of Gamma-Hydroxybutyrate upon Acute Infection
This study aims to shed light on the biochemical pathway and the stage within the viral life cycle responsible for the release of GHB in infected cells. UV-inactivation, acyclovir (ACV), and cycloheximide (CHX) treatments were used to inhibit HSV-1 replication at various stages. Vero cells treated with UV-inactivated HSV-1 significantly decreased GHB production. However, ACV or CHX treatments did not affect GHB production. We also showed that inhibition of glycolytic enzyme enolase by sodium fluoride (NaF) significantly reduces GHB production upon infection. This finding suggests that suppression of glycolytic activity neg...
Source: Herpes - August 26, 2023 Category: Infectious Diseases Authors: Faith O Osinaga Yu-Chih Chen Madan K Kharel Yan Waguespack Sichu Li Shaochung Victor Hsia Source Type: research
Early Events after Herpes Simplex Virus-Type 1 Entry Are Necessary for the Release of Gamma-Hydroxybutyrate upon Acute Infection
This study aims to shed light on the biochemical pathway and the stage within the viral life cycle responsible for the release of GHB in infected cells. UV-inactivation, acyclovir (ACV), and cycloheximide (CHX) treatments were used to inhibit HSV-1 replication at various stages. Vero cells treated with UV-inactivated HSV-1 significantly decreased GHB production. However, ACV or CHX treatments did not affect GHB production. We also showed that inhibition of glycolytic enzyme enolase by sodium fluoride (NaF) significantly reduces GHB production upon infection. This finding suggests that suppression of glycolytic activity neg...
Source: Herpes - August 26, 2023 Category: Infectious Diseases Authors: Faith O Osinaga Yu-Chih Chen Madan K Kharel Yan Waguespack Sichu Li Shaochung Victor Hsia Source Type: research
Comparative evaluation of four treatments for postorthodontic white spot lesions: a randomized controlled trial
ConclusionsThis study shows that after 1-year follow-up, the use of fluoride toothpaste, with or without the use of fluoride varnish or CPP-ACP, can reduce the area of WSLs. While resin infiltration can immediately improve dental aesthetics and continuously improved in 12 months, resin infiltration group showed much better results than other groups.Trial registrationClinical Trials Registration Number: ChiCTR2000032516.Clinical significanceThe use of fluoride toothpaste, with or without adjunctive use of fluoride varnish and CPP-ACP, can reduce the area of WSLs, while resin infiltration treatment has additional effect a...
Source: Clinical Oral Investigations - August 21, 2023 Category: Dentistry Source Type: research
Temporal Changes in Coronary < sup > 18 < /sup > F-Fluoride Plaque Uptake in Patients with Coronary Atherosclerosis
Conclusion: Coronary 18F-fluoride uptake is associated with the severity and progression of coronary artery disease but does not undergo a rapid dynamic change in patients with chronic or unstable coronary artery disease. This finding suggests that coronary 18F-fluoride uptake is a temporally stable marker of established and progressive disease.PMID:37591540 | DOI:10.2967/jnumed.122.264331 (Source: Atherosclerosis)
Source: Atherosclerosis - August 17, 2023 Category: Cardiology Authors: Marwa Daghem Philip D Adamson Kang-Ling Wang Mhairi Doris Rong Bing Edwin J R van Beek Laura Forsyth Michelle C Williams Evangelos Tzolos Damini Dey Piotr J Slomka Marc R Dweck David E Newby Alastair J Moss Source Type: research
Proteomics Sequencing Reveals the Role of TGF- β Signaling Pathway in the Peripheral Blood of Offspring Rats Exposed to Fluoride
In conclusion, long-term NaF intake may cause inflammatory response in the peripheral blood of rats by upregulating TGF-β signaling pathway, in which RhoA may play a key role.PMID:37582921 | DOI:10.1007/s12011-023-03805-x (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - August 15, 2023 Category: Biology Authors: Fang-Fang Yu Shui-Yuan Yu Lei-Zhen Duan Shuo Yang Xiang-Bo Hou Yu-Hui Du Ming-Hui Gao Juan Zuo Lei Sun Xiao-Li Fu Zhi-Yuan Li Hui Huang Guo-Yu Zhou Dao-Li Jia Rui-Qin Chen Yue Ba Source Type: research
Proteomics Sequencing Reveals the Role of TGF- β Signaling Pathway in the Peripheral Blood of Offspring Rats Exposed to Fluoride
In conclusion, long-term NaF intake may cause inflammatory response in the peripheral blood of rats by upregulating TGF-β signaling pathway, in which RhoA may play a key role.PMID:37582921 | DOI:10.1007/s12011-023-03805-x (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - August 15, 2023 Category: Biology Authors: Fang-Fang Yu Shui-Yuan Yu Lei-Zhen Duan Shuo Yang Xiang-Bo Hou Yu-Hui Du Ming-Hui Gao Juan Zuo Lei Sun Xiao-Li Fu Zhi-Yuan Li Hui Huang Guo-Yu Zhou Dao-Li Jia Rui-Qin Chen Yue Ba Source Type: research
Proteomics Sequencing Reveals the Role of TGF- β Signaling Pathway in the Peripheral Blood of Offspring Rats Exposed to Fluoride
In conclusion, long-term NaF intake may cause inflammatory response in the peripheral blood of rats by upregulating TGF-β signaling pathway, in which RhoA may play a key role.PMID:37582921 | DOI:10.1007/s12011-023-03805-x (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - August 15, 2023 Category: Biology Authors: Fang-Fang Yu Shui-Yuan Yu Lei-Zhen Duan Shuo Yang Xiang-Bo Hou Yu-Hui Du Ming-Hui Gao Juan Zuo Lei Sun Xiao-Li Fu Zhi-Yuan Li Hui Huang Guo-Yu Zhou Dao-Li Jia Rui-Qin Chen Yue Ba Source Type: research
Positron emission tomography in the diagnosis and follow-up of transthyretin amyloid cardiomyopathy patients: A systematic review
CONCLUSION: [11C]PIB, Na[18F]F and [18F]FBP can be used to diagnose cardiac amyloidosis, although [18F]FBP may not be suitable for the distinction of different types of amyloid cardiomyopathy. No studies on PET in the follow-up of ATTR amyloidosis patients were found. Future research should focus on the use of these PET tracers in the follow-up of ATTR amyloidosis patients.PMID:37561144 | DOI:10.1007/s00259-023-06381-3 (Source: Molecular Medicine)
Source: Molecular Medicine - August 10, 2023 Category: Molecular Biology Authors: H S A Tingen A Tubben J H A van 't Oever E M Pastoor P P A van Zon H L A Nienhuis P van der Meer R H J A Slart Source Type: research
Positron emission tomography in the diagnosis and follow-up of transthyretin amyloid cardiomyopathy patients: A systematic review
CONCLUSION: [11C]PIB, Na[18F]F and [18F]FBP can be used to diagnose cardiac amyloidosis, although [18F]FBP may not be suitable for the distinction of different types of amyloid cardiomyopathy. No studies on PET in the follow-up of ATTR amyloidosis patients were found. Future research should focus on the use of these PET tracers in the follow-up of ATTR amyloidosis patients.PMID:37561144 | DOI:10.1007/s00259-023-06381-3 (Source: Molecular Medicine)
Source: Molecular Medicine - August 10, 2023 Category: Molecular Biology Authors: H S A Tingen A Tubben J H A van 't Oever E M Pastoor P P A van Zon H L A Nienhuis P van der Meer R H J A Slart Source Type: research
