Aortic valve perivascular adipose tissue computed tomography attenuation in patients with aortic stenosis
Conclusions
CT-derived aortic valve perivascular adipose tissue attenuation is not associated with AS disease severity, activity or progression suggesting that it has no value in the investigation and management of patients with AS. (Source: Heart)
Source: Heart - April 15, 2024 Category: Cardiology Authors: Botezatu, S. B., Yu, X., Meah, M. N., Williams, M. C., Dey, D., Newby, D. E., Tzolos, E., Dweck, M. R. Tags: Valvular heart disease Source Type: research
Protective effects of sodium butyrate on fluorosis in rats by regulating bone homeostasis and serum metabolism
In this study, a rat model of fluorosis induced by 100 mg/L sodium fluoride was used to investigate the impact of NaB on bone homeostasis and serum metabolomics. It was found that NaB significantly reduced the levels of bone resorption markers CTX-Ⅰ and TRACP-5B in fluorosis rats. Moreover, NaB increased calcium and magnesium levels in bone, while decreasing phosphorus levels. In addition, NaB improved various bone microstructure parameters, including bone mineral density (BMD), trabecular thickness (Tb. Th), trabecular bone separation (Tb. SP), and structural model index (SMI) in the femur. Notably, NaB intervention als...
Source: Ecotoxicology and Environmental Safety - April 6, 2024 Category: Environmental Health Authors: Ying Li Fengmei Yang Jie Liu Mengqi Jiang Ye Yu Qingyi Zhou Lu Sun Zhuo Zhang Lin Zhou Source Type: research
Protective effects of sodium butyrate on fluorosis in rats by regulating bone homeostasis and serum metabolism
In this study, a rat model of fluorosis induced by 100 mg/L sodium fluoride was used to investigate the impact of NaB on bone homeostasis and serum metabolomics. It was found that NaB significantly reduced the levels of bone resorption markers CTX-Ⅰ and TRACP-5B in fluorosis rats. Moreover, NaB increased calcium and magnesium levels in bone, while decreasing phosphorus levels. In addition, NaB improved various bone microstructure parameters, including bone mineral density (BMD), trabecular thickness (Tb. Th), trabecular bone separation (Tb. SP), and structural model index (SMI) in the femur. Notably, NaB intervention als...
Source: Ecotoxicology and Environmental Safety - April 6, 2024 Category: Environmental Health Authors: Ying Li Fengmei Yang Jie Liu Mengqi Jiang Ye Yu Qingyi Zhou Lu Sun Zhuo Zhang Lin Zhou Source Type: research
Rutin mitigates fluoride-induced nephrotoxicity by inhibiting ROS-mediated lysosomal membrane permeabilization and the GSDME-HMGB1 axis involved in pyroptosis and inflammation
In conclusion, our findings suggest that NaF induces renal damage through ROS-mediated activation of LMP and the GSDME/HMGB1 axis, leading to pyroptosis and inflammation. Rutin, a natural antioxidative and anti-inflammatory dietary supplement, offers a novel approach to prevent and treat fluoride-induced nephrotoxicity.PMID:38479315 | DOI:10.1016/j.ecoenv.2024.116195 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - March 13, 2024 Category: Environmental Health Authors: Yue Ma Panpan Xu Hengrui Xing Yue Zhang Tingting Li Xueman Ding Li Liu Qiang Niu Source Type: research
Role of (18)F-sodium fluoride positron emission tomography in imaging atherosclerosis
J Nucl Cardiol. 2024 Mar 11:101845. doi: 10.1016/j.nuclcard.2024.101845. Online ahead of print.ABSTRACTAtherosclerosis involving vascular beds across the human body remains the leading cause of death worldwide. Coronary and peripheral artery disease which are almost universally a result of atherosclerotic plaque can manifest clinically as myocardial infarctions, ischemic stroke or acute lower limb ischemia. Beyond imaging myocardial perfusion and blood flow nuclear imaging has the potential to depict the activity of the processes which are directly implicated in the atherosclerotic plaque progression and rupture. Out of se...
Source: Atherosclerosis - March 13, 2024 Category: Cardiology Authors: Jacek Kwiecinski Source Type: research
Rosuvastatin effect on atherosclerotic plaque metabolism: A subclinical atherosclerosis imaging study with (18)F-NaF PET-CT
CONCLUSION: In a single-centre non-randomized clinical trial of high CV risk individuals with subclinical atherosclerosis, the maximum atherosclerotic plaque 18F-NaF uptake was significantly reduced after six months of high-intensity statin.PMID:38480058 | DOI:10.1016/j.atherosclerosis.2024.117481 (Source: Atherosclerosis)
Source: Atherosclerosis - March 13, 2024 Category: Cardiology Authors: Manuel Oliveira-Santos Jo ão Borges-Rosa Rodolfo Silva Lu ís Paixão Cl áudio Espírito Santo Antero Abrunhosa Miguel Castelo-Branco Piotr J Slomka Lino Gon çalves Maria Jo ão Ferreira Source Type: research
Rutin mitigates fluoride-induced nephrotoxicity by inhibiting ROS-mediated lysosomal membrane permeabilization and the GSDME-HMGB1 axis involved in pyroptosis and inflammation
In conclusion, our findings suggest that NaF induces renal damage through ROS-mediated activation of LMP and the GSDME/HMGB1 axis, leading to pyroptosis and inflammation. Rutin, a natural antioxidative and anti-inflammatory dietary supplement, offers a novel approach to prevent and treat fluoride-induced nephrotoxicity.PMID:38479315 | DOI:10.1016/j.ecoenv.2024.116195 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - March 13, 2024 Category: Environmental Health Authors: Yue Ma Panpan Xu Hengrui Xing Yue Zhang Tingting Li Xueman Ding Li Liu Qiang Niu Source Type: research
Rutin mitigates fluoride-induced nephrotoxicity by inhibiting ROS-mediated lysosomal membrane permeabilization and the GSDME-HMGB1 axis involved in pyroptosis and inflammation
In conclusion, our findings suggest that NaF induces renal damage through ROS-mediated activation of LMP and the GSDME/HMGB1 axis, leading to pyroptosis and inflammation. Rutin, a natural antioxidative and anti-inflammatory dietary supplement, offers a novel approach to prevent and treat fluoride-induced nephrotoxicity.PMID:38479315 | DOI:10.1016/j.ecoenv.2024.116195 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - March 13, 2024 Category: Environmental Health Authors: Yue Ma Panpan Xu Hengrui Xing Yue Zhang Tingting Li Xueman Ding Li Liu Qiang Niu Source Type: research
Serial PET imaging to evaluate medical therapies: Is it ready for prime time?
In the current issue of Atherosclerosis, Oliveira-Santos and colleagues reported on the serial use of PET-CT imaging with sodium fluoride to evaluate the effect of rosuvastatin on atherosclerotic plaque progression [1]. Serial imaging of atherosclerotic disease has been widely employed over the course of the last three decades to characterize the factors that influence the natural history of the disease. When embedded within clinical trials of medical therapies, plaque imaging has provided important mechanistic insights into the potential impact of medical therapies on both the burden and composition of atherosclerosis. (S...
Source: Atherosclerosis - March 13, 2024 Category: Cardiology Authors: Stephen J. Nicholls Tags: Editorial Source Type: research
Rosuvastatin effect on atherosclerotic plaque metabolism: A subclinical atherosclerosis imaging study with 18F –NaF PET-CT
Atherosclerotic plaque fluorine-18 sodium fluoride (18F –NaF) uptake on positron emission tomography with computed tomography (PET-CT) identifies active microcalcification and has been shown to correlate with clinical instability in patients with cardiovascular (CV) disease. Statin therapy promotes coronary macrocalcification over time. Our aim was to investigate rosuvastatin effect on atheroma 18F–NaF uptake. (Source: Atherosclerosis)
Source: Atherosclerosis - February 28, 2024 Category: Cardiology Authors: Manuel Oliveira-Santos, Jo ão Borges-Rosa, Rodolfo Silva, Luís Paixão, Cláudio Espírito Santo, Antero Abrunhosa, Miguel Castelo-Branco, Lino Gonçalves, Maria João Ferreira, Piotr J. Slomka Source Type: research
The effect of nano silver fluoride, self-assembling peptide and sodium fluoride varnish on salivary cariogenic bacteria: a randomized controlled clinical trial
ConclusionIn general, the antimicrobial effect of P11-4 and NSF on salivaryS. mutans andLactobacilli was not significantly different from NaF varnish. P11-4 induced greater reduction more quickly than the two other agents and NSF antibacterial effect was lost after one month.Clinical relevanceNSF varnish and P11-4 have antimicrobial activity that does not significantly differ from NaF by 3 months. P11-4 has the greatest antibacterial effect after one month with sustained effect till 3 months. The antibacterial effect of NSF lasts for one month. NaF remains effective till 3 months.Trial RegistrationThis trial was prospectiv...
Source: Clinical Oral Investigations - February 23, 2024 Category: Dentistry Source Type: research
Fluoride promotes the secretion of inflammatory factors in microglia through NLRP3/Caspase-1/GSDMD pathway
In conclusion, our results suggested that NLRP3/Caspase-1/GSDMD-mediated classical pyroptosis pathway was involved in fluoride-induced BV2 microglia damage.PMID:38367109 | DOI:10.1007/s11356-024-32443-6 (Source: Cell Research)
Source: Cell Research - February 17, 2024 Category: Cytology Authors: Qiuyi Zhang Tao Li Ruili Shi Ruifang Qi Xiaoqiong Hao Baohui Ma Source Type: research
Fluoride promotes the secretion of inflammatory factors in microglia through NLRP3/Caspase-1/GSDMD pathway
In conclusion, our results suggested that NLRP3/Caspase-1/GSDMD-mediated classical pyroptosis pathway was involved in fluoride-induced BV2 microglia damage.PMID:38367109 | DOI:10.1007/s11356-024-32443-6 (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - February 17, 2024 Category: Environmental Health Authors: Qiuyi Zhang Tao Li Ruili Shi Ruifang Qi Xiaoqiong Hao Baohui Ma Source Type: research
Interactions and effects of a stannous-containing sodium fluoride dentifrice on oral pathogens and the oral microbiome
Numerous studies have investigated the effects of stannous ions on specific microbes and their efficacy in reducing dental plaque. Nonetheless, our understanding of their impact on the oral microbiome is still a subject of ongoing exploration. Therefore, this study sought to evaluate the effects of a stannous-containing sodium fluoride dentifrice in comparison to a zinc-containing sodium fluoride dentifrice and a control group on intact, healthy oral biofilms. Utilizing the novel 2bRAD-M approach for species-resolved metagenomics, and FISH/CLSM with probes targeting periodontal and caries associated species alongside Sn2+ ...
Source: Frontiers in Microbiology - February 15, 2024 Category: Microbiology Source Type: research
Quantification of Skeletal Muscle Perfusion in Peripheral Artery Disease Using < sup > 18 < /sup > F-Sodium Fluoride Positron Emission Tomography Imaging
CONCLUSIONS: 18F-NaF PET imaging quantifies perfusion deficits that correspond to clinical stages of PAD and represents a novel perfusion imaging strategy that could be partnered with atherosclerosis-targeted 18F-NaF PET imaging using a single radioisotope injection.REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03622359.PMID:38353265 | DOI:10.1161/JAHA.123.031823 (Source: Atherosclerosis)
Source: Atherosclerosis - February 14, 2024 Category: Cardiology Authors: Ting-Heng Chou Mahboubeh Nabavinia Nguyen K Tram Eleanor T Rimmerman Surina Patel Kumudha Narayana Musini Susan Natalie Eisert Tatiana Wolfe Molly K Wynveen Yuichi Matsuzaki Takahiro Kitsuka Ryuma Iwaki Sarah A Janse Adam J Bobbey Christopher K Breuer Lau Source Type: research
