Filtered By:
Drug: Lortab
This page shows you your search results in order of date. This is page number 9.
Order by Relevance | Date
Total 4663 results found since Jan 2013.
Patient, operative and pain management factors influencing inpatient compared with surgical day care mastectomy procedures at a community hospital
CONCLUSION: We found no significant differences in surgical outcomes between inpatients and those with same-day discharge after mastectomy procedures. These findings add to the growing body of evidence that surgical day care mastectomy procedures are safe in the community setting.PMID:37500104 | DOI:10.1503/cjs.010422
Source: Canadian Journal of Surgery - July 27, 2023 Category: Surgery Authors: Colin Davey Leo Chen Hamish Hwang Source Type: research
Dose-dependent effects of acetaminophen and ibuprofen on mitochondrial respiration of human platelets
In conclusion, platelets from healthy donors represents a population of cells easily available, which can be routinely used in studies assessing mitochondrial drug toxicity. Whether these results can be recapitulated in patients treated with these medications is worth further investigation as potential peripheral biomarker of drug overdose.PMID:37486451 | DOI:10.1007/s11010-023-04814-z
Source: Molecular and Cellular Biochemistry - July 24, 2023 Category: Biochemistry Authors: Alina Maria Be ţiu Rodica Lighezan Vlad Florian Avram Danina Mirela Muntean Eskil Elm ér Lucian Petrescu Source Type: research
Excessive N-acetylcysteine exaggerates glutathione redox homeostasis and apoptosis during acetaminophen exposure in Huh-7 human hepatoma cells
Biochem Biophys Res Commun. 2023 Jul 20;676:66-72. doi: 10.1016/j.bbrc.2023.07.023. Online ahead of print.ABSTRACTAcetaminophen (APAP) hepatotoxicity is one of the biggest drawbacks of this relatively safe and widely used drug. In addition to its hepatotoxicity, APAP also cause comparable levels of toxicity on human hepatoma cells. Here we show activation of the intrinsic caspase-9/3 pathway of apoptosis followed by gasdermin E (GSDME) cleavage and subsequent ballooning in APAP (10 mM, 72 h)-treated Huh-7 human hepatocarcinoma cells. N-acetylcysteine (NAC), an antioxidant currently used as an antidote for APAP overdose, do...
Source: Biochemical and Biophysical Research communications - July 24, 2023 Category: Biochemistry Authors: Toshihiko Aki Hiroki Tanaka Takeshi Funakoshi Kana Unuma Koichi Uemura Source Type: research
Dose-dependent effects of acetaminophen and ibuprofen on mitochondrial respiration of human platelets
In conclusion, platelets from healthy donors represents a population of cells easily available, which can be routinely used in studies assessing mitochondrial drug toxicity. Whether these results can be recapitulated in patients treated with these medications is worth further investigation as potential peripheral biomarker of drug overdose.PMID:37486451 | DOI:10.1007/s11010-023-04814-z
Source: Molecular Medicine - July 24, 2023 Category: Molecular Biology Authors: Alina Maria Be ţiu Rodica Lighezan Vlad Florian Avram Danina Mirela Muntean Eskil Elm ér Lucian Petrescu Source Type: research
Excessive N-acetylcysteine exaggerates glutathione redox homeostasis and apoptosis during acetaminophen exposure in Huh-7 human hepatoma cells
Biochem Biophys Res Commun. 2023 Jul 20;676:66-72. doi: 10.1016/j.bbrc.2023.07.023. Online ahead of print.ABSTRACTAcetaminophen (APAP) hepatotoxicity is one of the biggest drawbacks of this relatively safe and widely used drug. In addition to its hepatotoxicity, APAP also cause comparable levels of toxicity on human hepatoma cells. Here we show activation of the intrinsic caspase-9/3 pathway of apoptosis followed by gasdermin E (GSDME) cleavage and subsequent ballooning in APAP (10 mM, 72 h)-treated Huh-7 human hepatocarcinoma cells. N-acetylcysteine (NAC), an antioxidant currently used as an antidote for APAP overdose, do...
Source: Biochemical and Biophysical Research communications - July 24, 2023 Category: Biochemistry Authors: Toshihiko Aki Hiroki Tanaka Takeshi Funakoshi Kana Unuma Koichi Uemura Source Type: research
Pharmacokinetics of multiple oral doses of acetaminophen in equine neonates
Am J Vet Res. 2023 Jul 25:1-8. doi: 10.2460/ajvr.23.04.0079. Online ahead of print.ABSTRACTOBJECTIVE: To determine the pharmacokinetics and clinical safety of acetaminophen after oral administration of 40 mg/kg q 12 hours or 60 mg/kg q 24 hours for 14 days.ANIMALS: 12 healthy light-breed neonatal foals.PROCEDURES: 6 foals received acetaminophen at 40 mg/kg q 12 hours and 6 foals received 60 mg/kg q 24 hours for 14 days. The study dates were January 31 to April 15, 2023. Physical examinations were performed daily. Plasma disposition of acetaminophen was determined after the first, mid-point drug administration. Hematology a...
Source: American Journal of Veterinary Research - July 22, 2023 Category: Veterinary Research Authors: Cosette Faivre David M Wong Nicolas F Villarino Michael Court Jenifer R Gold Source Type: research
Synthesis of highly efficient novel two-step spatial 2D photocatalyst material WS < sub > 2 < /sub > /ZnIn < sub > 2 < /sub > S < sub > 4 < /sub > for degradation of various toxic pollutants
Environ Res. 2023 Jul 20:116715. doi: 10.1016/j.envres.2023.116715. Online ahead of print.ABSTRACTIn this article, we report the synthesis, characterization of novel biofriendly 2D/2D heterostructure of WS21/ZnIn2S42 material in which 2D WS2 nanosheets are uniformly distributed spatially onto the spherically arranged 2D leaves of ZnIn2S4. We then studied the in-depth photocatalytic degradation activity of this novel nanocomposite and its pristine component materials on cationic dye: malachite green, anionic dye: congo red and reduction of heavy metal: chromium(VI) and the degradation efficiency of composite material was al...
Source: Environmental Research - July 22, 2023 Category: Environmental Health Authors: Waseem Ashraf Syed Hasan Parvez Manika Khanuja Source Type: research
Pharmacokinetics of multiple oral doses of acetaminophen in equine neonates
Am J Vet Res. 2023 Jul 25:1-8. doi: 10.2460/ajvr.23.04.0079. Online ahead of print.ABSTRACTOBJECTIVE: To determine the pharmacokinetics and clinical safety of acetaminophen after oral administration of 40 mg/kg q 12 hours or 60 mg/kg q 24 hours for 14 days.ANIMALS: 12 healthy light-breed neonatal foals.PROCEDURES: 6 foals received acetaminophen at 40 mg/kg q 12 hours and 6 foals received 60 mg/kg q 24 hours for 14 days. The study dates were January 31 to April 15, 2023. Physical examinations were performed daily. Plasma disposition of acetaminophen was determined after the first, mid-point drug administration. Hematology a...
Source: American Journal of Veterinary Research - July 22, 2023 Category: Veterinary Research Authors: Cosette Faivre David M Wong Nicolas F Villarino Michael Court Jenifer R Gold Source Type: research
First evidence of environmental bioaccumulation of pharmaceuticals on adult native anurans (Rhinella arenarum) from Argentina
Environ Pollut. 2023 Jul 20:122231. doi: 10.1016/j.envpol.2023.122231. Online ahead of print.ABSTRACTThe presence of pharmaceutically active compounds (PhACs) in surface water is well known, whereas their natural occurrence in biota is much less explored. The aim of this work was to evaluate the bioaccumulation of PhACs in adult toads of the neotropical species Rhinella arenarum. Three sites were selected in Buenos Aires (Argentina): a reference site (Site 1), a site with direct discharge from a secondary wastewater treatment plant (WWTP) (Site 2) and a site 300 m downstream of the WWTP discharge (Site 3). Surface water sa...
Source: Environmental Pollution - July 22, 2023 Category: Environmental Health Authors: C Salgado Costa F Bahl G S Natale T M Mac Loughlin D J G Marino A Venturino S Rodriguez-Mozaz L H M L M Santos Source Type: research
The effects of subtoxic dose of acetaminophen combined with exercise on the liver of rats
Physiol Res. 2023 Jul 14;72(3):383-392.ABSTRACTRegular physical exercise is beneficial to the body. Acute exercise causes oxidant stress in many tissues including the liver by creating an unbalanced status between oxidant and antioxidant levels. Analgesic drugs are commonly consumed to reduce the pain after exercise. Acetaminophen (APAP), commonly used as an over-the-counter analgesic, can cause hepatotoxicity. The aim of this study was to investigate the effect and underlying mechanisms of APAP at subtoxic dose, which is given after the acute and exhaustive exercise on the rat livers. Male Wistar rats weighing 200-250 g w...
Source: Physiological Research - July 14, 2023 Category: Physiology Authors: I Aksu M Kiray C Gencoglu A Tas O Acikgoz Source Type: research
