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Total 4663 results found since Jan 2013.
Assessing Platelet Mitochondrial Dysfunction in a Murine Model of Acute Acetaminophen Toxicity
CONCLUSIONS: Platelet oxygen consumption as a measure of mitochondrial function may be useful as a biomarker of hepatic APAP toxicity in the setting of moderate to severe overdose. Treatment with 4-MP decreases hepatic necrosis and may mitigate the harmful effects of APAP on platelet mitochondrial function detected via POC.PMID:37644341 | DOI:10.1007/s13181-023-00964-0
Source: Journal of Medical Toxicology - August 29, 2023 Category: Toxicology Authors: Carolyn Fox Michael L Ekaney Michael Runyon Hieu M Nguyen Philip J Turk Iain H McKillop Christine M Murphy Source Type: research
Cysteine conjugates of acetaminophen and p-aminophenol are potent inducers of cellular impairment in human proximal tubular kidney HK-2 cells
Arch Toxicol. 2023 Aug 28. doi: 10.1007/s00204-023-03569-2. Online ahead of print.ABSTRACTAcetaminophen (APAP) belong among the most used analgesics and antipyretics. It is structurally derived from p-aminophenol (PAP), a potent inducer of kidney toxicity. Both compounds can be metabolized to oxidation products and conjugated with glutathione. The glutathione-conjugates can be cleaved to provide cysteine conjugates considered as generally nontoxic. The aim of the present report was to synthesize and to purify both APAP- and PAP-cysteine conjugates and, as the first study at all, to evaluate their biological effects in huma...
Source: Archives of Toxicology - August 28, 2023 Category: Toxicology Authors: Tomas Rousar Jiri Handl Jan Capek Pavlina Nyvltova Erika Rousarova Miroslav Kubat Lenka Smid Jana Vanova David Malinak Kamil Musilek Petr Cesla Source Type: research
Remediation of fomesafen contaminated soil by Bacillus sp. Za: Degradation pathway, community structure and bioenhanced remediation
In this study, Bacillus sp. Za was utilized to degrade fomesafen residues in black and yellow brown soils. Fomesafen's degradation rate by strain Za in black soil reached 74.4%, and in yellow brown soil was 69.2% within 30 days. Twelve intermediate metabolites of fomesafen were identified in different soils, with nine metabolites present in black soil and eight found in yellow brown soil. Subsequently, the degradation pathway of fomesafen within these two soils was inferred. The dynamic change process of soil bacterial community structure in the degradation of fomesafen by strain Za was analyzed. The results showed that st...
Source: Environmental Pollution - August 27, 2023 Category: Environmental Health Authors: Guoqiang Zhao Jing Zhou Yanning Tian Qifeng Chen Dongmei Mao Jianchun Zhu Xing Huang Source Type: research
Effects of prenatal acetaminophen exposure at different stages, doses and courses on articular cartilage of offspring mice
This study provides an experimental basis for assessing fetal developmental toxicity and standardizing the clinical use of acetaminophen during pregnancy.PMID:37633638 | DOI:10.1016/j.fct.2023.114003
Source: Food and Chemical Toxicology - August 26, 2023 Category: Food Science Authors: Fan Zhang Liang Liu Hui Wang Liaobin Chen Source Type: research
Systematic study of the synergistic and kinetics effects on the removal of contaminants of emerging concern from water by ultrasound in the presence of diverse oxidants
Environ Sci Pollut Res Int. 2023 Aug 26. doi: 10.1007/s11356-023-29189-y. Online ahead of print.ABSTRACTThe enhancement of the ultrasound system by adding diverse oxidants to remove a model contaminant (acetaminophen, ACE) in water was investigated. Different parameters were evaluated to study their effect on both the degradation kinetics and the synergy of the combination. The variables studied were the ultrasonic frequency (575, 858, and 1135 kHz), type of oxidant (hydrogen peroxide, sodium peroxydisulfate (or persulfate, PDS), and potassium peroxymonosulfate (PMS)), ACE concentration (4, 8, and 40 µM), and oxidant conc...
Source: Environmental Science and Pollution Research International - August 26, 2023 Category: Environmental Health Authors: Sandra E Estrada-Fl órez Efra ím A Serna-Galvis Judy Lee Ricardo A Torres-Palma Source Type: research
Acute hepatitis of unknown etiology in an adult female: A case report
CONCLUSION: Idiopathic hepatitis makes treatment challenging. It can leave patients feeling confused and unfulfilled. Thus, educating the patient thoroughly for shared decision-making and management becomes essential.PMID:37621598 | PMC:PMC10445075 | DOI:10.12998/wjcc.v11.i22.5288
Source: Herpes - August 25, 2023 Category: Infectious Diseases Authors: Lucinda Dass Alexandra Marie Malabanan Pacia Mahgol Hamidi Source Type: research
JNJ-10450232 (NTM-006), A novel non-opioid with structural similarities to acetaminophen, produces relatively long-lasting analgesia after a single dose in patients undergoing 3rd molar extraction
Regul Toxicol Pharmacol. 2023 Aug 23:105480. doi: 10.1016/j.yrtph.2023.105480. Online ahead of print.ABSTRACTJNJ-10450232 (NTM-006) is a non-opioid, non-NSAID analgesic and antipyretic compound with structural similarity to acetaminophen. Preclinical models show comparable analgesia relative to acetaminophen and no evidence of hepatotoxicity associated with overdose. Moreover, it was safe and generally well tolerated in a First-in-Human Study. This single-dose, single-center, inpatient, randomized, double-blind study in moderate-to-severe acute pain following third molar extraction compared efficacy and safety of 250 mg an...
Source: Regulatory Toxicology and Pharmacology : RTP - August 25, 2023 Category: Toxicology Authors: Cathy K Gelotte Amy M Vakil Brenda A Zimmerman Peter Zannikos Rajesh Mishra Gary Eichenbaum Edwin K Kuffner Christopher M Flores Source Type: research
