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Discovery of hepatoprotective activity components from Thymus quinquecostatus celak. by molecular networking, biological evaluation and molecular dynamics studies
In this study, combining molecular networking visualization and bioassay-guided fractionation strategies, a pair of novel skeleton diterpenoid enantiomers, (+)- and (-)-thymutatusone A [(+)- and (-)-1], along with one new and one known biogenetically related compounds (2-3) and 16 other known compounds (4-19), were identified from T. quinquecostatus. Their structures were exhaustively characterized by comprehensive spectroscopic data, X-ray diffraction analysis, and ECD calculations. Compounds (±)-1, (-)-1, and (+)-1, with a rare tricyclo [7.3.1.02,7] tridecane skeleton, exhibited potent hepatoprotective activity in HepG2...
Source: Bioorganic Chemistry - August 21, 2023 Category: Chemistry Authors: Xiangjian Zhong Ruolan Song Dongjie Shan Xueyang Ren Yuan Zheng Fang Lv Qingyue Deng Yingyu He Xianxian Li Ruiwen Li Li Yan Gaimei She Source Type: research
Graphene/metal-organic framework nano-sandwiches derived N, P-codoped porous carbon nanosheets as robust material for electrochemical analysis
Anal Chim Acta. 2023 Oct 9;1277:341675. doi: 10.1016/j.aca.2023.341675. Epub 2023 Jul 29.ABSTRACTConstruction of novel two-dimensional porous carbon nanosheets with superior electrochemical activity is of great challenge. Here, graphene/ZIF-8 nano-sandwiches derived N, P-codoped porous carbon nanosheets (N, P-codoped PCN) was easily obtained by sequential room temperature self-assembly and high-temperature carbonization method. Relative to the widely used physically exfoliated graphene nanosheets (GN) and graphene/ZIF-8 derived N-doped porous carbon nanosheets (N-doped PCN), N, P-codoped PCN displayed larger active surface...
Source: Analytica Chimica Acta - August 21, 2023 Category: Chemistry Authors: Shiyu Tang Caoling Li Lele Li Jingqi Huang Bin Wang Ruizheng Zhong Yong Tang Can Wu Kangbing Wu Source Type: research
Discovery of hepatoprotective activity components from Thymus quinquecostatus celak. by molecular networking, biological evaluation and molecular dynamics studies
In this study, combining molecular networking visualization and bioassay-guided fractionation strategies, a pair of novel skeleton diterpenoid enantiomers, (+)- and (-)-thymutatusone A [(+)- and (-)-1], along with one new and one known biogenetically related compounds (2-3) and 16 other known compounds (4-19), were identified from T. quinquecostatus. Their structures were exhaustively characterized by comprehensive spectroscopic data, X-ray diffraction analysis, and ECD calculations. Compounds (±)-1, (-)-1, and (+)-1, with a rare tricyclo [7.3.1.02,7] tridecane skeleton, exhibited potent hepatoprotective activity in HepG2...
Source: Bioorganic Chemistry - August 21, 2023 Category: Chemistry Authors: Xiangjian Zhong Ruolan Song Dongjie Shan Xueyang Ren Yuan Zheng Fang Lv Qingyue Deng Yingyu He Xianxian Li Ruiwen Li Li Yan Gaimei She Source Type: research
Graphene/metal-organic framework nano-sandwiches derived N, P-codoped porous carbon nanosheets as robust material for electrochemical analysis
Anal Chim Acta. 2023 Oct 9;1277:341675. doi: 10.1016/j.aca.2023.341675. Epub 2023 Jul 29.ABSTRACTConstruction of novel two-dimensional porous carbon nanosheets with superior electrochemical activity is of great challenge. Here, graphene/ZIF-8 nano-sandwiches derived N, P-codoped porous carbon nanosheets (N, P-codoped PCN) was easily obtained by sequential room temperature self-assembly and high-temperature carbonization method. Relative to the widely used physically exfoliated graphene nanosheets (GN) and graphene/ZIF-8 derived N-doped porous carbon nanosheets (N-doped PCN), N, P-codoped PCN displayed larger active surface...
Source: Analytica Chimica Acta - August 21, 2023 Category: Chemistry Authors: Shiyu Tang Caoling Li Lele Li Jingqi Huang Bin Wang Ruizheng Zhong Yong Tang Can Wu Kangbing Wu Source Type: research
Medication use in a cohort of adults with chronic intestinal failure: A prospective cross-sectional study
CONCLUSION: Polypharmacy was observed in most patients with chronic IF. Most medication was taken orally in formulations requiring disintegration, dissolution, and gastrointestinal absorption, which could be compromised in chronic IF.PMID:37604787 | DOI:10.1002/ncp.11065
Source: Nutrition in Clinical Practice - August 21, 2023 Category: Nutrition Authors: Barbara Deleenheer Nathalie Lauwers Isabel Spriet Peter Declercq Tim Vanuytsel Source Type: research
Graphene/metal-organic framework nano-sandwiches derived N, P-codoped porous carbon nanosheets as robust material for electrochemical analysis
Anal Chim Acta. 2023 Oct 9;1277:341675. doi: 10.1016/j.aca.2023.341675. Epub 2023 Jul 29.ABSTRACTConstruction of novel two-dimensional porous carbon nanosheets with superior electrochemical activity is of great challenge. Here, graphene/ZIF-8 nano-sandwiches derived N, P-codoped porous carbon nanosheets (N, P-codoped PCN) was easily obtained by sequential room temperature self-assembly and high-temperature carbonization method. Relative to the widely used physically exfoliated graphene nanosheets (GN) and graphene/ZIF-8 derived N-doped porous carbon nanosheets (N-doped PCN), N, P-codoped PCN displayed larger active surface...
Source: Analytica Chimica Acta - August 21, 2023 Category: Chemistry Authors: Shiyu Tang Caoling Li Lele Li Jingqi Huang Bin Wang Ruizheng Zhong Yong Tang Can Wu Kangbing Wu Source Type: research
Medication use in a cohort of adults with chronic intestinal failure: A prospective cross-sectional study
CONCLUSION: Polypharmacy was observed in most patients with chronic IF. Most medication was taken orally in formulations requiring disintegration, dissolution, and gastrointestinal absorption, which could be compromised in chronic IF.PMID:37604787 | DOI:10.1002/ncp.11065
Source: Nutrition in Clinical Practice - August 21, 2023 Category: Nutrition Authors: Barbara Deleenheer Nathalie Lauwers Isabel Spriet Peter Declercq Tim Vanuytsel Source Type: research
Graphene/metal-organic framework nano-sandwiches derived N, P-codoped porous carbon nanosheets as robust material for electrochemical analysis
Anal Chim Acta. 2023 Oct 9;1277:341675. doi: 10.1016/j.aca.2023.341675. Epub 2023 Jul 29.ABSTRACTConstruction of novel two-dimensional porous carbon nanosheets with superior electrochemical activity is of great challenge. Here, graphene/ZIF-8 nano-sandwiches derived N, P-codoped porous carbon nanosheets (N, P-codoped PCN) was easily obtained by sequential room temperature self-assembly and high-temperature carbonization method. Relative to the widely used physically exfoliated graphene nanosheets (GN) and graphene/ZIF-8 derived N-doped porous carbon nanosheets (N-doped PCN), N, P-codoped PCN displayed larger active surface...
Source: Analytica Chimica Acta - August 21, 2023 Category: Chemistry Authors: Shiyu Tang Caoling Li Lele Li Jingqi Huang Bin Wang Ruizheng Zhong Yong Tang Can Wu Kangbing Wu Source Type: research
Discovery of hepatoprotective activity components from Thymus quinquecostatus celak. by molecular networking, biological evaluation and molecular dynamics studies
In this study, combining molecular networking visualization and bioassay-guided fractionation strategies, a pair of novel skeleton diterpenoid enantiomers, (+)- and (-)-thymutatusone A [(+)- and (-)-1], along with one new and one known biogenetically related compounds (2-3) and 16 other known compounds (4-19), were identified from T. quinquecostatus. Their structures were exhaustively characterized by comprehensive spectroscopic data, X-ray diffraction analysis, and ECD calculations. Compounds (±)-1, (-)-1, and (+)-1, with a rare tricyclo [7.3.1.02,7] tridecane skeleton, exhibited potent hepatoprotective activity in HepG2...
Source: Bioorganic Chemistry - August 21, 2023 Category: Chemistry Authors: Xiangjian Zhong Ruolan Song Dongjie Shan Xueyang Ren Yuan Zheng Fang Lv Qingyue Deng Yingyu He Xianxian Li Ruiwen Li Li Yan Gaimei She Source Type: research
Medication use in a cohort of adults with chronic intestinal failure: A prospective cross-sectional study
CONCLUSION: Polypharmacy was observed in most patients with chronic IF. Most medication was taken orally in formulations requiring disintegration, dissolution, and gastrointestinal absorption, which could be compromised in chronic IF.PMID:37604787 | DOI:10.1002/ncp.11065
Source: Nutrition in Clinical Practice - August 21, 2023 Category: Nutrition Authors: Barbara Deleenheer Nathalie Lauwers Isabel Spriet Peter Declercq Tim Vanuytsel Source Type: research
