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Protective Effects of Apamin on Acetaminophen-Induced Hepatotoxicity in Mice
Curr Issues Mol Biol. 2023 May 17;45(5):4389-4399. doi: 10.3390/cimb45050279.ABSTRACTAcetaminophen (APAP) overdose can cause severe liver damage, but therapeutic options are limited. Apamin is a natural peptide present in bee venom and has antioxidant and anti-inflammatory properties. Accumulating evidence suggests that apamin has favorable actions in rodent models of inflammatory disorders. Here, we examined the effect of apamin on APAP-evoked hepatotoxicity. Intraperitoneal administration of apamin (0.1 mg/kg) alleviated histological abnormalities and reduced serum levels of liver enzymes in mice injected with APAP. Apam...
Source: Current Issues in Molecular Biology - May 26, 2023 Category: Molecular Biology Authors: Hyo-Jeong Jang Jaechan Leem Gyun Moo Kim Source Type: research
