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Total 4663 results found since Jan 2013.
Novel graphene electrochemical transistors incorporating zirconia inorganic molecular imprinted layer ：Design, construction and application for highly sensitive and selective detection of acetaminophen
Anal Chim Acta. 2023 Aug 15;1269:341405. doi: 10.1016/j.aca.2023.341405. Epub 2023 May 22.ABSTRACTOwing to their intrinsic amplifying effect together with chemical stability, graphene electrochemical transistor sensors (GECTs) are gaining momentum for sensing applications. However, the surface of GECTs for different detection substances must be modified with different recognition molecules, which was cumbersome and lack a universal method. Molecularly imprinted polymer (MIP) is a kind of polymer with specific recognition function for given molecules. Here, MIP and GECTs were combined to effectively solve the problem of wea...
Source: Analytica Chimica Acta - June 8, 2023 Category: Chemistry Authors: Nan Gao Junzi Pan Lei Wang Zhiwei Cai Gang Chang Yuxiang Wu Yunbin He Source Type: research
Leonurine alleviates acetaminophen-induced acute liver injury by regulating the PI3K/AKT signaling pathway in mice
In conclusion, Leo attenuated ALI, and reversed liver cell necrosis, the inflammatory response and oxidative stress-induced damage by regulating the PI3K/AKT signaling pathway.PMID:37267857 | DOI:10.1016/j.intimp.2023.110375
Source: International Immunopharmacology - June 2, 2023 Category: Allergy & Immunology Authors: Yajie Yu Shizhe Zhou Yan Wang Shuting Di Yingluo Wang Xin Huang Ying Chen Source Type: research
Titanate nanotubes as an efficient oral detoxifying agent against drug overdose: application in rat acetaminophen poisoning
Nanoscale Adv. 2023 Apr 25;5(11):2950-2962. doi: 10.1039/d2na00874b. eCollection 2023 May 30.ABSTRACTVoluntary drug intoxication is mainly due to drug overdose or the interaction of several drugs. Coma and its associated complications such as hypoventilation, aspiration pneumopathy, and heart rhythm disorders are the main hallmarks of drug intoxication. Conventional detoxification treatments, including gastric lavage or vomiting, administration of ipecac or activated charcoal (CH), and the use of antidotes, have proven to be inefficient and are generally associated with severe adverse effects. To overcome these limitations...
Source: Adv Data - June 1, 2023 Category: Epidemiology Authors: Abir Salek Mouna Selmi Leila Njim Polona Umek Philippe Mejanelle Fathi Moussa Wahiba Douki Karim Hosni Tarek Baati Source Type: research
Peli3 ablation ameliorates acetaminophen-induced liver injury through inhibition of GSK3 β phosphorylation and mitochondrial translocation
Exp Mol Med. 2023 Jun 1. doi: 10.1038/s12276-023-01009-w. Online ahead of print.ABSTRACTThe signaling pathways governing acetaminophen (APAP)-induced liver injury have been extensively studied. However, little is known about the ubiquitin-modifying enzymes needed for the regulation of APAP-induced liver injury. Here, we examined whether the Pellino3 protein, which has E3 ligase activity, is needed for APAP-induced liver injury and subsequently explored its molecular mechanism. Whole-body Peli3-/- knockout (KO) and adenovirus-mediated Peli3 knockdown (KD) mice showed reduced levels of centrilobular cell death, infiltration ...
Source: Molecular Medicine - May 31, 2023 Category: Molecular Biology Authors: Jaewon Lee Jihoon Ha Jun-Hyeong Kim Dongyeob Seo Minbeom Kim Yerin Lee Seong Shil Park Dahee Choi Jin Seok Park Young Jae Lee Siyoung Yang Kyung-Min Yang Su Myung Jung Suntaek Hong Seung-Hoi Koo Yong-Soo Bae Seong-Jin Kim Seok Hee Park Source Type: research
Pharmacokinetics and repeated dose 28-day oral toxicity studies of acetaminophen nanosuspension
In this study, an attempt was made to improve oral bioavailability and reduce the toxicity of acetaminophen using nanosuspension technology. The acetaminophen nanosuspensions (APAP-NSs) were prepared by a nano-precipitation method using polyvinyl alcohol and hydroxypropylmethylcellulose as stabilizers. The mean diameter of APAP-NSs was 124 ± 3.8 nm. The dissolution profile of APAP-NSs was significantly point-to-point higher than the coarse drug in simulated gastrointestinal fluids. The in vivo study revealed 1.6- and 2.8-fold increases in the AUC0-inf and Cmax of the drug, respectively, in APAP-NSs-receiving animals compa...
Source: Biomed Res - May 29, 2023 Category: Research Authors: Zahra Karami Sepideh Arbabi Bidgoli Mohammadreza Saghatchi Zanjani Peyman Arabshahi Taraneh Gazori Mehrdad Hamidi Source Type: research
Early treatment with N-acetylcysteine reduces hepatotoxicity in acute acetaminophen poisoning
We reported a case of a 15-year- old girl referred to our Emergency Department 3 hours after ingestion of 10 g of paracetamol for suicidal purposes. She promptly started the administration of intravenous N-acetylcysteine (NAC) and the patient was discharged after 5 days of hospitalization in good clinical condition and with neuropsychiatric follow-up. Our case shows that the timing of the intravenous NAC administration is considered the most important factor in the prevention of acetaminophen-induced hepatic failure, despite high serum levels after acetaminophen ingestion.PMID:37247196 | DOI:10.23750/abm.v94iS1.13714
Source: Acta Bio-Medica : Atenei Parmensis - May 29, 2023 Category: General Medicine Authors: Serena Ferretti Antonietta Curatola Antonio Chiaretti Benedetta Graglia Antonio Gatto Lavinia Capossela Valeria Pansini Source Type: research
Graphitic carbon nitride metal-free photocatalyst for the simultaneous removal of emerging pharmaceutical pollutants in wastewater
This study presents a promising approach for treating and mitigating pharmaceutical contaminants in wastewater.PMID:37245581 | DOI:10.1016/j.envres.2023.116246
Source: Environmental Research - May 28, 2023 Category: Environmental Health Authors: Thi Huong Pham Nguyen Minh Viet Pham Thi Thu Hoai Sung Hoon Jung Kim Taeyoung Source Type: research
