Filtered By:
Drug: Lortab
This page shows you your search results in order of date. This is page number 7.
Order by Relevance | Date
Total 4663 results found since Jan 2013.
Layer-by-layer reinforced-mediated sustained-release nanoantioxidants for long-lasting prevention against drug-induced liver injury
Colloids Surf B Biointerfaces. 2023 Aug 1;230:113489. doi: 10.1016/j.colsurfb.2023.113489. Online ahead of print.ABSTRACTDrug-induced liver injury (DILI) is a commonly encountered and diagnostically complex etiology of acute liver failure, characterized by early indications of hepatic oxidative stress. The most economical approach for DILI treatment is effective and durable oxidative stress prevention. Herein, we propose a long-lasting nanoantioxidant called PDA-Zn-BAI NPs characterized by sustained-release of baicalein (a natural antioxidant) for the long-lasting prevention of DILI. It is constructed using dopamine as an ...
Source: Colloids and Surfaces - August 14, 2023 Category: Biotechnology Authors: Peng Tang Huiyin Wu Mengru Wang Yongpeng Wang Ruihan Zhang Xingjie Zhang Xiaoli Li Bin Liang Weilie Xiao Source Type: research
Plastic nanoparticles cause proteome stress and aggregation by compromising cellular protein homeostasis ex vivo and in vivo
Ecotoxicol Environ Saf. 2023 Aug 10;262:115347. doi: 10.1016/j.ecoenv.2023.115347. Online ahead of print.ABSTRACTDecomposition of plastic materials into minuscule particles and their long-term uptake pose increasing concerns on environmental sustainability and biosafety. Besides common cell viability and cytotoxicity evaluations, how plastic nanoparticles interfere with different stress response pathways and affect cellular fitness has been less explored. Here, we provided the first piece of evidence to demonstrate plastic nanoparticles potentially can deteriorate proteome stability, compromise cellular protein homeostasis...
Source: Ecotoxicology and Environmental Safety - August 12, 2023 Category: Environmental Health Authors: Biao Jing Wang Wan Bo Hu Wenhan Jin Zhenduo Zhang Congcong Peng Mengdie Wang Jintai Deng Xuepeng Dong Yu Liu Zhenming Gao Source Type: research
Primary human hepatocytes-laden scaffolds for the treatment of acute liver failure
Biomater Adv. 2023 Aug 5;153:213576. doi: 10.1016/j.bioadv.2023.213576. Online ahead of print.ABSTRACTCell-based liver therapies based on retrieving and steadying failed metabolic function(s) for acute and chronic diseases could be a valuable substitute for liver transplants, even though they are limited by the low engraftment capability and reduced functional quality of primary human hepatocytes (PHH). In this paper we propose the use of gelatin-hyaluronic acid (Gel-HA) scaffolds seeded with PHH for the treatment of liver failure. We first optimized the composition using Gel-HA hydrogels, looking for the mechanical proper...
Source: Adv Data - August 11, 2023 Category: Epidemiology Authors: Julio Rodriguez-Fernandez Emma Garcia-Legler Estela Villanueva-Badenas M Teresa Donato Jos é Luis Gomez-Ribelles Manuel Salmeron-Sanchez Gloria Gallego-Ferrer Laia Tolosa Source Type: research
Solar photo-Fenton optimization at neutral pH for microcontaminant removal at pilot plant scale
Environ Sci Pollut Res Int. 2023 Aug 11. doi: 10.1007/s11356-023-28988-7. Online ahead of print.ABSTRACTThe increasing occurrence of micropollutants in natural water bodies has medium to long-term effects on both aquatic life and human health. The aim of this study is to optimize the degradation of two pharmaceutical pollutants of emerging concern: amoxicillin and acetaminophen in aqueous solution at laboratory and pilot scale, by solar photo-Fenton process carried out at neutral pH using ethylenediamine-N,N'-disuccinic acid (EDDS) as a complexing agent to maintain iron in solution. The initial concentration of each compou...
Source: Environmental Science and Pollution Research International - August 11, 2023 Category: Environmental Health Authors: Mercedes Hinojosa Isabel Oller Jos é María Quiroga Sixto Malato Agata Egea-Corbacho Asunci ón Acevedo-Merino Source Type: research
Primary human hepatocytes-laden scaffolds for the treatment of acute liver failure
Biomater Adv. 2023 Aug 5;153:213576. doi: 10.1016/j.bioadv.2023.213576. Online ahead of print.ABSTRACTCell-based liver therapies based on retrieving and steadying failed metabolic function(s) for acute and chronic diseases could be a valuable substitute for liver transplants, even though they are limited by the low engraftment capability and reduced functional quality of primary human hepatocytes (PHH). In this paper we propose the use of gelatin-hyaluronic acid (Gel-HA) scaffolds seeded with PHH for the treatment of liver failure. We first optimized the composition using Gel-HA hydrogels, looking for the mechanical proper...
Source: Adv Data - August 11, 2023 Category: Epidemiology Authors: Julio Rodriguez-Fernandez Emma Garcia-Legler Estela Villanueva-Badenas M Teresa Donato Jos é Luis Gomez-Ribelles Manuel Salmeron-Sanchez Gloria Gallego-Ferrer Laia Tolosa Source Type: research
Solar photo-Fenton optimization at neutral pH for microcontaminant removal at pilot plant scale
Environ Sci Pollut Res Int. 2023 Aug 11. doi: 10.1007/s11356-023-28988-7. Online ahead of print.ABSTRACTThe increasing occurrence of micropollutants in natural water bodies has medium to long-term effects on both aquatic life and human health. The aim of this study is to optimize the degradation of two pharmaceutical pollutants of emerging concern: amoxicillin and acetaminophen in aqueous solution at laboratory and pilot scale, by solar photo-Fenton process carried out at neutral pH using ethylenediamine-N,N'-disuccinic acid (EDDS) as a complexing agent to maintain iron in solution. The initial concentration of each compou...
Source: Environmental Science and Pollution Research International - August 11, 2023 Category: Environmental Health Authors: Mercedes Hinojosa Isabel Oller Jos é María Quiroga Sixto Malato Agata Egea-Corbacho Asunci ón Acevedo-Merino Source Type: research
Proliferation of Monocytes and Macrophages in Homeostasis, Infection, Injury and Disease
J Leukoc Biol. 2023 Aug 9:qiad093. doi: 10.1093/jleuko/qiad093. Online ahead of print.ABSTRACTMonocytes (Mo) and macrophages (Mϕ) play important roles in the function of tissues, organs, and systems of all animals, during homeostasis, infection, injury and disease. For decades, conventional wisdom has dictated that Mo and Mϕ are end-stage cells that do not proliferate and that Mϕ accumulation in tissues is the result of infiltration of Mo from the blood and subsequent differentiation to Mϕ. However, reports from the early 1900s to the present describe evidence of Mo and Mϕ proliferation in different tissues and contex...
Source: Journal of Leukocyte Biology - August 9, 2023 Category: Hematology Authors: Jingbo Pang Timothy J Koh Source Type: research
Salidroside ameliorates acetaminophen-induced acute liver injury through the inhibition of endoplasmic reticulum stress-mediated ferroptosis by activating the AMPK/SIRT1 pathway
In this study, male C57BL/6 J mice were intraperitoneally (i.p.) injected APAP (500 mg/kg) to induce an ALI model. Salidroside was i.p. injected at a dose of 100 mg/kg 2 h prior to APAP administration. Mice were sacrificed 12 h after APAP injection and the liver and serum of the mice were obtained for histological and biochemistry analysis. AML12 cells were used in in vitro assays. The results indicated that salidroside mitigated glutathione degradation via inhibiting cation transport regulator homolog 1 (CHAC1) to attenuate ferroptosis, and simultaneously suppressing PERK-eIF2α-ATF4 axis-mediated ER stress, thus alleviat...
Source: Ecotoxicology and Environmental Safety - August 9, 2023 Category: Environmental Health Authors: Jun Xu Luying Zhao Xiangting Zhang Kanglei Ying Ruoru Zhou Weimin Cai Xiao Wu Haoran Jiang Qian Xu Dan Miao Yuan Zeng Fujun Yu Source Type: research
Proliferation of Monocytes and Macrophages in Homeostasis, Infection, Injury and Disease
J Leukoc Biol. 2023 Aug 9:qiad093. doi: 10.1093/jleuko/qiad093. Online ahead of print.ABSTRACTMonocytes (Mo) and macrophages (Mϕ) play important roles in the function of tissues, organs, and systems of all animals, during homeostasis, infection, injury and disease. For decades, conventional wisdom has dictated that Mo and Mϕ are end-stage cells that do not proliferate and that Mϕ accumulation in tissues is the result of infiltration of Mo from the blood and subsequent differentiation to Mϕ. However, reports from the early 1900s to the present describe evidence of Mo and Mϕ proliferation in different tissues and contex...
Source: Journal of Leukocyte Biology - August 9, 2023 Category: Hematology Authors: Jingbo Pang Timothy J Koh Source Type: research
Salidroside ameliorates acetaminophen-induced acute liver injury through the inhibition of endoplasmic reticulum stress-mediated ferroptosis by activating the AMPK/SIRT1 pathway
In this study, male C57BL/6 J mice were intraperitoneally (i.p.) injected APAP (500 mg/kg) to induce an ALI model. Salidroside was i.p. injected at a dose of 100 mg/kg 2 h prior to APAP administration. Mice were sacrificed 12 h after APAP injection and the liver and serum of the mice were obtained for histological and biochemistry analysis. AML12 cells were used in in vitro assays. The results indicated that salidroside mitigated glutathione degradation via inhibiting cation transport regulator homolog 1 (CHAC1) to attenuate ferroptosis, and simultaneously suppressing PERK-eIF2α-ATF4 axis-mediated ER stress, thus alleviat...
Source: Ecotoxicology and Environmental Safety - August 9, 2023 Category: Environmental Health Authors: Jun Xu Luying Zhao Xiangting Zhang Kanglei Ying Ruoru Zhou Weimin Cai Xiao Wu Haoran Jiang Qian Xu Dan Miao Yuan Zeng Fujun Yu Source Type: research
Proliferation of Monocytes and Macrophages in Homeostasis, Infection, Injury and Disease
J Leukoc Biol. 2023 Aug 9:qiad093. doi: 10.1093/jleuko/qiad093. Online ahead of print.ABSTRACTMonocytes (Mo) and macrophages (Mϕ) play important roles in the function of tissues, organs, and systems of all animals, during homeostasis, infection, injury and disease. For decades, conventional wisdom has dictated that Mo and Mϕ are end-stage cells that do not proliferate and that Mϕ accumulation in tissues is the result of infiltration of Mo from the blood and subsequent differentiation to Mϕ. However, reports from the early 1900s to the present describe evidence of Mo and Mϕ proliferation in different tissues and contex...
Source: Journal of Leukocyte Biology - August 9, 2023 Category: Hematology Authors: Jingbo Pang Timothy J Koh Source Type: research
Occurrence and risk assessment of pharmaceuticals in hospital wastewater in Costa Rica
Chemosphere. 2023 Aug 5:139746. doi: 10.1016/j.chemosphere.2023.139746. Online ahead of print.ABSTRACTThis work aims to determine the occurrence, hazard and prioritization of pharmaceuticals from hospital wastewater in Costa Rica through the monitoring of 70 compounds and assessing their environmental risk through a hazard quotient approach (HQ). Moreover, the quantification of selected antibiotic resistance genes (ARGs) was conducted for the first time in this matrix in this geographical location. Thirty-four pharmaceuticals were detected, being caffeine, 1,7-dimethylxanthine, acetaminophen, ibuprofen, naproxen, ciproflox...
Source: Chemosphere - August 7, 2023 Category: Chemistry Authors: Carlos E Rodr íguez-Rodríguez Didier Ram írez-Morales Mario Masis-Mora Jos é R Montiel-Mora Claudio Soto-Garita Emanuel Araya-Valverde Juan Carlos Cambronero-Heinrichs Alexandre S ànchez-Melsió Susana Brice ño-Guevara Michael Mendez-Rivera Jos é L Source Type: research
