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Drug: Lortab
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Total 4663 results found since Jan 2013.
The effects of subtoxic dose of acetaminophen combined with exercise on the liver of rats
Physiol Res. 2023 Jul 14;72(3):383-392.ABSTRACTRegular physical exercise is beneficial to the body. Acute exercise causes oxidant stress in many tissues including the liver by creating an unbalanced status between oxidant and antioxidant levels. Analgesic drugs are commonly consumed to reduce the pain after exercise. Acetaminophen (APAP), commonly used as an over-the-counter analgesic, can cause hepatotoxicity. The aim of this study was to investigate the effect and underlying mechanisms of APAP at subtoxic dose, which is given after the acute and exhaustive exercise on the rat livers. Male Wistar rats weighing 200-250 g w...
Source: Physiological Research - July 14, 2023 Category: Physiology Authors: I Aksu M Kiray C Gencoglu A Tas O Acikgoz Source Type: research
Rectus sheath catheters reduce opiate use in pancreaticoduodenectomy: a pre- and postintervention cohort study
CONCLUSION: The use of RSCs was associated with significant reductions in postoperative opiate consumption. Given the ease of placement and management, with minimal complications, RSCs should be incorporated into a course of postoperative multimodal analgesia. A large scale randomized controlled trial should be conducted to further investigate these findings.PMID:37442583 | DOI:10.1503/cjs.006922
Source: Canadian Journal of Surgery - July 13, 2023 Category: Surgery Authors: Patrick L C Tapley Martin Van der Vyver Natalie G Coburn Julie Hallet Calvin Law Rachel Roke Paul J Karanicolas Source Type: research
Cu < sub > 3 < /sub > (hexaamino triphenylhexane) < sub > 2 < /sub > /reduced graphene oxide composites with boosting electron-transfer properties for acetaminophen electrocatalytic degradation
In this study, a novel composite of Cu3(hexaamino triphenylhexane)2 [Cu3(HITP)2] and reduced graphene oxide (RGO) was synthesized to construct electron-transfer pathways between the two layers. Benefiting from the connection formed through RGO-O-N-Cu, the electron transfer from RGO to Cu3(HITP)2 was accelerated. The resettled charge distribution led the C atoms in the RGO layer, and the Cu and C atoms in Cu3(HITP)2 layer acted as the main surface active sites. O2•-, 1O2, and reactive chlorine were then triggered to boost the degradation of acetaminophen. The source of O2•- and 1O2 was more likely from surface oxygen gr...
Source: Chemosphere - July 13, 2023 Category: Chemistry Authors: Qian Zhang Yan Ling Yang Die Guo Jun-Ming Hong Source Type: research
Rectus sheath catheters reduce opiate use in pancreaticoduodenectomy: a pre- and postintervention cohort study
CONCLUSION: The use of RSCs was associated with significant reductions in postoperative opiate consumption. Given the ease of placement and management, with minimal complications, RSCs should be incorporated into a course of postoperative multimodal analgesia. A large scale randomized controlled trial should be conducted to further investigate these findings.PMID:37442583 | DOI:10.1503/cjs.006922
Source: Canadian Journal of Surgery - July 13, 2023 Category: Surgery Authors: Patrick L C Tapley Martin Van der Vyver Natalie G Coburn Julie Hallet Calvin Law Rachel Roke Paul J Karanicolas Source Type: research
Cu < sub > 3 < /sub > (hexaamino triphenylhexane) < sub > 2 < /sub > /reduced graphene oxide composites with boosting electron-transfer properties for acetaminophen electrocatalytic degradation
In this study, a novel composite of Cu3(hexaamino triphenylhexane)2 [Cu3(HITP)2] and reduced graphene oxide (RGO) was synthesized to construct electron-transfer pathways between the two layers. Benefiting from the connection formed through RGO-O-N-Cu, the electron transfer from RGO to Cu3(HITP)2 was accelerated. The resettled charge distribution led the C atoms in the RGO layer, and the Cu and C atoms in Cu3(HITP)2 layer acted as the main surface active sites. O2•-, 1O2, and reactive chlorine were then triggered to boost the degradation of acetaminophen. The source of O2•- and 1O2 was more likely from surface oxygen gr...
Source: Chemosphere - July 13, 2023 Category: Chemistry Authors: Qian Zhang Yan Ling Yang Die Guo Jun-Ming Hong Source Type: research
Development of a lung-liver in vitro coculture model for inhalation-like toxicity assessment
Toxicol In Vitro. 2023 Jul 10:105641. doi: 10.1016/j.tiv.2023.105641. Online ahead of print.ABSTRACTAnimal models are considered prime study models for inhalation-like toxicity assessment. However, in light of animal experimentation reduction (3Rs), we developed and investigated an alternative in vitro method to study systemic-like responses to inhalation-like exposures. A coculture platform was established to emulate inter-organ crosstalks between a pulmonary barrier, which constitutes the route of entry of inhaled compounds, and the liver, which plays a major role in xenobiotic metabolism. Both compartments (Calu-3 inser...
Source: Toxicology in Vitro - July 12, 2023 Category: Toxicology Authors: Sabrina Madiedo-Podvrsan Louise Sebillet Thomas Martinez Salimata Bacari Fengping Zhu Marie Cattelin Eric Leclerc Franck Merlier Rachid Jellali Ghislaine Lacroix Muriel Vayssade Source Type: research
