In Reply to "Hydroxychloroquine Overdose: What Are the Exact Roles of Diazepam and Potassium Infusion?"
In Reply to "Hydroxychloroquine Overdose: What Are the Exact Roles of Diazepam and Potassium Infusion?" J Med Toxicol. 2020 Sep 14;: Authors: Chai PR, Ferro EG, Kirshenbaum JM, Hayes BD, Culbreth SE, Boyer EW, Erickson TB PMID: 32926301 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - September 14, 2020 Category: Toxicology Authors: Chai PR, Ferro EG, Kirshenbaum JM, Hayes BD, Culbreth SE, Boyer EW, Erickson TB Tags: J Med Toxicol Source Type: research

Hydroxychloroquine Overdose: What Are the Exact Roles of Diazepam and Potassium Infusion?
chi A PMID: 32926302 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - September 14, 2020 Category: Toxicology Authors: Mégarbane B, Schicchi A Tags: J Med Toxicol Source Type: research

Transitioning to Virtual: ACMT's 2020 Annual Scientific Meeting.
Abstract The American College of Medical Toxicology (ACMT) 2020 Annual Scientific Meeting (ASM) was scheduled to be held in New York City, March 12-15, 2020, and had the largest conference registration in the history of ACMT's ASM. In the week prior to the conference, the severity of the COVID-19 pandemic in New York City and the USA was becoming apparent. On the first day of the conference, organizers canceled the live portion of the meeting and converted the conference into an entirely virtual meeting. We discuss the challenges of holding a virtual conference, future directions for online meetings, and why our c...
Source: Journal of Medical Toxicology - August 24, 2020 Category: Toxicology Authors: Kopec KT, Stolbach A Tags: J Med Toxicol Source Type: research

A Case Report of a Severe, Unusually Delayed Anaphylactoid Reaction to Intravenous N-Acetylcysteine During Treatment of Acute Acetaminophen Toxicity in an Adolescent.
This report presents the case of an adolescent with a delayed, life-threatening anaphylactoid reaction 24.5 hours after starting NAC, where discontinuing NAC could have resulted in fulminant hepatic failure (FHF) and death. CASE REPORT: A 17-year-old previously healthy female presented with nausea, vomiting, and abdominal pain 10 hours after an acute acetaminophen ingestion. Her 11-hour serum acetaminophen concentration was above the treatment line (149 μg/mL), and she had elevated transaminases (AST = 202 U/L, ALT = 284 U/L). She was treated with intravenous NAC...
Source: Journal of Medical Toxicology - August 21, 2020 Category: Toxicology Authors: Epperson LC, Weiss ST, Cao DJ Tags: J Med Toxicol Source Type: research

Negligible Oleandrin Content of Hot Dogs Cooked on Nerium oleander Skewers.
CONCLUSION: Hot dogs cooked on Nerium oleander skewers contain a negligible amount of oleandrin with respect to that sufficient to cause human poisoning. Reports of poisonings occurring in this manner are most likely the result of an urban myth. PMID: 32803693 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - August 14, 2020 Category: Toxicology Authors: Suchard J, Greb A Tags: J Med Toxicol Source Type: research

Epidemiology, Clinical Features, and Management of Texas Coral Snake (Micrurus tener) Envenomations Reported to the North American Snakebite Registry.
CONCLUSIONS: Envenomations from M. tener in Southeast Texas are characterized by painful paresthesias. Mild swelling and erythema are common. Neurotoxicity necessitating antivenom or mechanical ventilation did not occur. PMID: 32803694 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - August 14, 2020 Category: Toxicology Authors: Greene S, Ruha AM, Campleman S, Brent J, Wax P, ToxIC Snakebite Study Group Tags: J Med Toxicol Source Type: research

Swipe Right: a Comparison of Accuracy of Plant Identification Apps for Toxic Plants.
CONCLUSION: A plant identification app may be a useful tool to assist healthcare providers and the public in identifying toxic plants. PMID: 32794048 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - August 13, 2020 Category: Toxicology Authors: Otter J, Mayer S, Tomaszewski CA Tags: J Med Toxicol Source Type: research

A Pharmacokinetic Analysis of Hemodialysis for Metformin-Associated Lactic Acidosis.
CONCLUSION: We report a case of MALA likely secondary to AKI and severe volume depletion. The patient improved with supportive care, sodium bicarbonate, and hemodialysis. Analysis of whole blood, serum, urine, and dialysate concentrations showed limited efficacy of hemodialysis in the removal of metformin from blood, contrary to previously published data. Despite evidence of acute kidney injury, a relatively large amount of metformin was eliminated in the urine while the patient was undergoing hemodialysis. These data suggest that clinical improvement is likely due to factors besides removal of metformin. PMID: 327895...
Source: Journal of Medical Toxicology - August 12, 2020 Category: Toxicology Authors: Harding SA, Biary R, Hoffman RS, Su MK, Howland MA Tags: J Med Toxicol Source Type: research

Short-Term Graft Failure of Organs Procured from Drug-Related Deaths Compared with Other Causes of Death.
CONCLUSIONS: The proportion of graft failures in the drug-related deaths (DDD) group was equal to or less than those from other causes of death on short-term follow-up. Drug-related death does not appear to be a contraindication for organ procurement despite increased risk features for infectious disease transmission. PMID: 32789584 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - August 12, 2020 Category: Toxicology Authors: Kim T, Chhabra N, Weech DM, Leikin JB Tags: J Med Toxicol Source Type: research

ACMT Position Statement: Caring for Patients with Opioid Use Disorder during Coronavirus Disease Pandemic.
PMID: 32748068 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - August 3, 2020 Category: Toxicology Authors: Stolbach A, Mazer-Amirshahi M, Schwarz ES, Juurlink D, Wiegand TJ, Nelson LS Tags: J Med Toxicol Source Type: research

Antidotal Sodium Bicarbonate Therapy: Delayed QTc Prolongation and Cardiovascular Events.
Abstract BACKGROUND: Sodium bicarbonate therapy (SBT) is currently indicated for the management of a variety of acute drug poisonings. However, SBT effects on serum potassium concentrations may lead to delayed QTc prolongation (DQTP), and subsequent risk of adverse cardiovascular events (ACVE), including death. Emergency department (ED)-based studies evaluating associations between SBT and ACVE are limited; thus, we aimed to investigate the association between antidotal SBT, ECG changes, and ACVE. METHODS: This was a secondary data analysis of a consecutive cohort of ED patients with acute drug overdose over ...
Source: Journal of Medical Toxicology - July 31, 2020 Category: Toxicology Authors: Shastry S, Ellis J, Loo G, Vedanthan R, Richardson LD, Manini AF Tags: J Med Toxicol Source Type: research

Prevalence of Acute Hypersensitivity Reactions in Pediatric Patients Receiving Crotalidae Polyvalent Immune Fab.
CONCLUSION: Acute hypersensitivity reactions to CPIF did not occur in this cohort. Such reactions are rare with the use of CPIF in pediatric patients. PMID: 32710249 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - July 24, 2020 Category: Toxicology Authors: Corbett B, Otter J, Masom CP, Clark RF Tags: J Med Toxicol Source Type: research

Persistent Hyperinsulinemia Following High-Dose Insulin Therapy: A Case Report.
CONCLUSION: The kinetics of insulin following discontinuation of high-dose insulin therapy are largely unknown, but supraphysiologic insulin levels persist for some time following therapy; this may allow for simple discontinuation rather than titration of insulin at the end of therapy. Dextrose replacement is frequently needed; although the duration is often difficult to predict, prolonged infusions may not be necessary. PMID: 32656624 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - July 11, 2020 Category: Toxicology Authors: Corcoran JN, Jacoby KJ, Olives TD, Bangh SA, Cole JB Tags: J Med Toxicol Source Type: research

First-Line Vasopressor and Mortality Rates in ED Patients with Acute Drug Overdose.
CONCLUSIONS: In ED patients with undifferentiated drug overdose and circulatory shock, the first-line vasopressor is associated with in-hospital mortality. First-line push-dose phenylephrine was associated with the lowest odds of in-hospital mortality. Future randomized studies are warranted for validation. PMID: 32656625 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - July 11, 2020 Category: Toxicology Authors: Clifford C, Sethi M, Cox D, Manini AF Tags: J Med Toxicol Source Type: research

Opioid Overdose Deaths with Buprenorphine Detected in Postmortem Toxicology: a Retrospective Analysis.
CONCLUSION: Decedents with buprenorphine detected on toxicology testing commonly had documented polysubstance use. Although data are limited, buprenorphine may provide some risk mitigation against full agonist opioid overdose including fentanyl. Further work should explore the use of postmortem concentrations of buprenorphine, norbuprenorphine, and other opioid metabolites to determine the role of buprenorphine in fatal overdose pharmacology. PMID: 32648229 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - July 9, 2020 Category: Toxicology Authors: Wightman RS, Perrone J, Scagos R, Krieger M, Nelson LS, Marshall BDL Tags: J Med Toxicol Source Type: research

Clinical Pharmacists: Essential During a Poison Outbreak.
PMID: 32638283 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - July 7, 2020 Category: Toxicology Authors: Routsolias JC, Gimbar RP, Zell-Kanter M Tags: J Med Toxicol Source Type: research

ACMT Position Statement: Medication Administration and Safety During the Response to COVID-19 Pandemic.
PMID: 32617893 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - July 3, 2020 Category: Toxicology Authors: Farmer BM, Cole JB, Olives TD, Farrell NM, Rao R, Nelson LS, Mazer-Amirshahi M, Stolbach AI Tags: J Med Toxicol Source Type: research

ACMT Position Statement: Limiting Harms of Vaping and E-cigarette Use.
PMID: 32601813 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - June 29, 2020 Category: Toxicology Authors: Mazer-Amirshahi M, Garlich FM, Calello DP, Stolbach AI Tags: J Med Toxicol Source Type: research

Acute Elemental Mercury Poisoning Masquerading as Fever and Rash.
Abstract This is a case series of 3 children from a single family who developed symptomatic elemental mercury poisoning requiring hospitalization and chelation. The mercury exposure primarily occurred in the home but the mercury was also tracked to one of their schools requiring environmental cleanup at both the home and school. The clinical assessment and management, as well as public health investigation and response, are discussed. There are many lessons learned in this difficult, often delayed, diagnosis. Early recognition of this environmental toxic exposure is essential. Communication between the clinicians ...
Source: Journal of Medical Toxicology - June 22, 2020 Category: Toxicology Authors: Young AC, Wax PM, Feng SY, Kleinschmidt KC, Ordonez JE Tags: J Med Toxicol Source Type: research

Characteristics of Transgender Patient Cases Managed by a Toxicologist: an Analysis of the Toxicology Investigator's Consortium (ToxIC) Registry: January 2017-June 2019.
CONCLUSION: Among transgender patients in the ToxIC registry, the most common primary reason for the encounter was intentional use of a pharmaceutical drug intended for self-harm. In this small cohort, there were some age and transition differences in prevalence. These findings may inform poisoning prevention practices as well as sex- and gender-based management of patients in this vulnerable population. PMID: 32557176 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - June 17, 2020 Category: Toxicology Authors: Surmaitis RM, Greenberg MR, Ebeling-Koning NE, Grenz PM, McWhirter CR, Careyva BA, Sabino JN, Cook MD, Cannon RD, Koons AL, Katz KD, Kincaid H, Laubach LT, Beauchamp GA, toxicology investigator’s consortium (ToxIC) Tags: J Med Toxicol Source Type: research

Intentional Hydroxychloroquine Overdose Treated with High-Dose Diazepam: an Increasing Concern in the COVID-19 Pandemic.
DISCUSSION: Hydroxychloroquine toxicity is rare but projected to increase in frequency given its selection as a potential modality to treat COVID-19 disease. It is important for clinicians to recognize the unique effects of hydroxychloroquine poisoning and initiate appropriate emergency maneuvers to improve the outcomes in these patients. PMID: 32514696 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - June 8, 2020 Category: Toxicology Authors: Chai PR, Ferro EG, Kirshenbaum JM, Hayes BD, Culbreth SE, Boyer EW, Erickson TB Tags: J Med Toxicol Source Type: research

The Importance of Continuing Medical Education During the COVID-19 Pandemic: the Global Educational Toxicology Uniting Project (GETUP).
PMID: 32500282 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - June 4, 2020 Category: Toxicology Authors: Wong A, Vohra R, Kopec K, Brooke N, Stolbach A Tags: J Med Toxicol Source Type: research

ACMT Position Statement: Off-Label Prescribing during COVID-19 Pandemic.
PMID: 32500283 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - June 4, 2020 Category: Toxicology Authors: Stolbach AI, Mazer-Amirshahi M, Marino R, Nelson LS, Sugarman J Tags: J Med Toxicol Source Type: research

Medical Toxicology Education and Global Health: It is Still a World of Limited Resources in Low- and Middle-Income Countries.
PMID: 32495115 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - June 3, 2020 Category: Toxicology Authors: Neumann NR, Thompson TM Tags: J Med Toxicol Source Type: research

Effect of Methylene Blue on a Porcine Model of Amlodipine Toxicity.
CONCLUSION: In this porcine model of amlodipine toxicity, methylene blue did not improve survival time compared with norepinephrine. Whether methylene blue is beneficial in combatting distributive shock in amlodipine toxicity remains unclear and requires further study. PMID: 32495116 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - June 3, 2020 Category: Toxicology Authors: LeRoy JM, Boley SP, Corcoran JN, Engebretsen KM, Stellpflug SJ Tags: J Med Toxicol Source Type: research

Sex Differences in Pediatric Poisonings by Age Group: a Toxicology Investigators' Consortium (ToxIC) Analysis (2010-2016).
Abstract OBJECTIVE: To review pediatric poisonings evaluated at the bedside by medical toxicologists and reported in the ToxIC registry, by sex and age group. METHODS: Pediatric poisoning cases age ≤18 years, reported between January 2010 and December 2016, were reviewed. Descriptive statistics were used to describe study variables by age group and sex. RESULTS: A total of 12,699 cases were analyzed. There were 7517 females and 5182 males. Those
Source: Journal of Medical Toxicology - June 2, 2020 Category: Toxicology Authors: Beauchamp GA, Carey JL, Cook MD, Cannon RD, Katz KD, Yoon J, Kincaid H, Ely BJ, Pollack E, Mazzaccaro RJ, Greenberg MR, Toxicology Investigators Consortium (ToxIC) Tags: J Med Toxicol Source Type: research

Opioid-Associated Hearing Loss: A 20-Year Review from the New Jersey Poison Center.
CONCLUSION: Opioid-associated ototoxicity was most commonly associated with heroin exposure and appeared independent of hypoxic events. Further investigation that clarifies the risk factors and long-term outcomes is needed. PMID: 32468345 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - May 28, 2020 Category: Toxicology Authors: Mozeika AM, Ruck BE, Nelson LS, Calello DP Tags: J Med Toxicol Source Type: research

The Landscape of Prescription Drug Shortages During the COVID-19 Pandemic.
PMID: 32458230 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - May 27, 2020 Category: Toxicology Authors: Fox ER, Stolbach AI, Mazer-Amirshahi M Tags: J Med Toxicol Source Type: research

ACMT Position Statement: Medication Shortages During Coronavirus Disease Pandemic.
PMID: 32418120 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - May 16, 2020 Category: Toxicology Authors: Mazer-Amirshahi M, Fox ER, Farmer BM, Stolbach AI Tags: J Med Toxicol Source Type: research

When It Comes to Snakebites, Kids Are Little Adults: a Comparison of Adults and Children with Rattlesnake Bites.
CONCLUSION: While adult and pediatric patients have some differences in envenomation characteristics and laboratory parameters, adults and pediatric patients had similar rates of systemic toxicity, severity, length of stay, and late hematologic toxicity. PMID: 32394223 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - May 11, 2020 Category: Toxicology Authors: Levine M, Ruha AM, Wolk B, Caravati M, Brent J, Campleman S, Wax P, ToxIC North American Snakebite Study Group Tags: J Med Toxicol Source Type: research

Endotracheal Intubation in the Pharmaceutical-Poisoned Patient: a Narrative Review of the Literature.
CONCLUSIONS: ETI is a key component of the supportive care provided to the patient poisoned by a pharmaceutical agent. Clinicians should be aware of the spectrum of toxicities that can necessitate intubation, as well as airway management nuances that are specific to various poisoning presentations. PMID: 32394224 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - May 11, 2020 Category: Toxicology Authors: Burket GA, Horowitz BZ, Hendrickson RG, Beauchamp GA Tags: J Med Toxicol Source Type: research

Medical Toxicology and COVID-19: Our Role in a Pandemic.
PMID: 32356251 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - April 30, 2020 Category: Toxicology Authors: Neumann NR, Chai PR, Wood DM, Greller HA, Mycyk MB Tags: J Med Toxicol Source Type: research

COVID-19: Therapeutics and Their Toxicities.
Abstract SARS-CoV-2 is a novel coronavirus that emerged in 2019 and is causing the COVID-19 pandemic. There is no current standard of care. Clinicians need to be mindful of the toxicity of a wide variety of possibly unfamiliar substances being tested or repurposed to treat COVID-19. The United States Food and Drug Administration (FDA) has provided emergency authorization for the use of chloroquine and hydroxychloroquine. These two medications may precipitate ventricular dysrhythmias, necessitating cardiac and electrolyte monitoring, and in severe cases, treatment with epinephrine and high-doses of diazepam. Recomb...
Source: Journal of Medical Toxicology - April 30, 2020 Category: Toxicology Authors: Chary MA, Barbuto AF, Izadmehr S, Hayes BD, Burns MM Tags: J Med Toxicol Source Type: research

Review of Health Consequences of Electronic Cigarettes and the Outbreak of Electronic Cigarette, or Vaping, Product Use-Associated Lung Injury.
Abstract Electronic cigarettes (e-cigarettes) are battery-operated devices to insufflate nicotine or other psychoactive e-liquid aerosols. Despite initial claims of e-cigarettes as a nicotine-cessation device, aggressive marketing of e-cigarettes has led to an explosion in adolescents' and young adults' use over the last few years. Coupled with a lack of adequate investigation and regulation of e-cigarettes, the USA is facing an outbreak of e-cigarette, or vaping, product use-associated lung injury (EVALI) starting in mid-2019. While little long-term health hazard data are available, the components and constituent...
Source: Journal of Medical Toxicology - April 16, 2020 Category: Toxicology Authors: Cao DJ, Aldy K, Hsu S, McGetrick M, Verbeck G, De Silva I, Feng SY Tags: J Med Toxicol Source Type: research

ACMT Position Statement on Prescription Drug Shortages.
PMID: 32297150 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - April 15, 2020 Category: Toxicology Authors: Mazer-Amirshahi M, Fox ER, Nelson LS, Smith SW, Stolbach AI Tags: J Med Toxicol Source Type: research

Lithium Toxicity from the Addition of an ACE Inhibitor with an Unexpected Type I Brugada Pattern ECG: Case Files of the Medical Toxicology Fellowship at the University of California, San Diego.
PMID: 32297151 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - April 15, 2020 Category: Toxicology Authors: Schneir A, Masom CP Tags: J Med Toxicol Source Type: research

Understanding Naloxone Uptake from an Emergency Department Distribution Program Using a Low-Energy Bluetooth Real-time Location System.
CONCLUSIONS: Based on acquired BLE signals, 80% of dispensed naloxone kits left the hospital campus. Use of RTLS to passively geolocate naloxone rescue kits is feasible, but detection can be adversely affected by technological errors. PWUD are amenable to transient monitoring technologies but identified barriers to implementation. PMID: 32253630 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - April 6, 2020 Category: Toxicology Authors: Lai JT, Chapman BP, Carreiro SP, Babu KM, Boyer EW, Chai PR Tags: J Med Toxicol Source Type: research

Efficacy of Intravenous Hydroxocobalamin for Treatment of Sodium Methanethiolate Exposure in a Swine Model (Sus scrofa) of Severe Methanethiol Toxicity.
CONCLUSIONS: In our model of intravenous methanethiolate poisoning, IV HOC administration resulted in a transient improvement in vital signs and prolonged time to death; however, it did not improve survival. PMID: 32239422 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - April 1, 2020 Category: Toxicology Authors: Maddry JK, Paredes RM, Rebeles J, Olson G, Castaneda M, Canellis K, Ng PC, Bebarta VS Tags: J Med Toxicol Source Type: research

In Reply:  More Questions than Answers in Metformin-Associated Lactic Acidosis (MALA).
In Reply: More Questions than Answers in Metformin-Associated Lactic Acidosis (MALA). J Med Toxicol. 2020 Mar 31;: Authors: Blumenberg A, Benabbas R, Sinert R, Jeng A, Wiener SW PMID: 32236797 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - March 31, 2020 Category: Toxicology Authors: Blumenberg A, Benabbas R, Sinert R, Jeng A, Wiener SW Tags: J Med Toxicol Source Type: research

The Effect of Residual Confoundingon Mortality in Metformin-Associated Lactic Acidosis.
PMID: 32219673 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - March 26, 2020 Category: Toxicology Authors: Wang JJ, Hoffman RS Tags: J Med Toxicol Source Type: research

The Role and Promise of Artificial Intelligence in Medical Toxicology.
Abstract Artificial intelligence (AI) refers to machines or software that process information and interact with the world as understanding beings. Examples of AI in medicine include the automated reading of chest X-rays and the detection of heart dysrhythmias from wearables. A key promise of AI is its potential to apply logical reasoning at the scale of data too vast for the human mind to comprehend. This scaling up of logical reasoning may allow clinicians to bring the entire breadth of current medical knowledge to bear on each patient in real time. It may also unearth otherwise unreachable knowledge in the attem...
Source: Journal of Medical Toxicology - March 25, 2020 Category: Toxicology Authors: Chary MA, Manini AF, Boyer EW, Burns M Tags: J Med Toxicol Source Type: research

E-Cigarette, or Vaping, Product Use Associated Lung Injury (EVALI) with Acute Respiratory Failure in Three Adolescent Patients: a Clinical Timeline, Treatment, and Product Analysis.
DISCUSSION: EVALI is a recent public health concern without a known etiology which can cause life-threatening lung injury in patients without prior lung pathology. We hope these cases will highlight the importance of return precautions in adolescents with vague respiratory symptoms and provide a cautionary tale to providers while they counsel patients regarding the use of these products. PMID: 32193828 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - March 19, 2020 Category: Toxicology Authors: Billa R, Tigges C, Vijayakumar N, Radke J, Pedati C, Weiner R, McCabe D Tags: J Med Toxicol Source Type: research

JMT Peer Reviewers 2019: Thank you from the Editorial Board.
PMID: 32193829 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - March 19, 2020 Category: Toxicology Authors: Mycyk MB Tags: J Med Toxicol Source Type: research

Nicotine Content from Cigarettes Submerged in Soda.
CONCLUSIONS: The mean concentration of nicotine measured over the course of 6 hours from one immersed cigarette can be potentially toxic especially to children. Nicotine concentrations are positively correlated with the number of cigarettes and time of immersion. PMID: 32180139 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - March 16, 2020 Category: Toxicology Authors: Ershad M, Beld J, Mostafa A, Dela Cruz M, Vearrier D, Greenberg MI Tags: J Med Toxicol Source Type: research

In Response to Borgsteede et al. About Bupropion and Serotonin Toxicity.
PMID: 32125682 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - March 3, 2020 Category: Toxicology Authors: Murray BP, Carpenter J, Moran TP, Calello DP, Kazzi Z Tags: J Med Toxicol Source Type: research

Tweetchats, Disseminating Information, and Sparking Further Scientific Discussion with Social Media.
Discussion with Social Media. J Med Toxicol. 2020 Feb 24;: Authors: Chary MA, Chai PR PMID: 32096006 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - February 24, 2020 Category: Toxicology Authors: Chary MA, Chai PR Tags: J Med Toxicol Source Type: research

Media Reports of Unintentional Opioid Exposure of Public Safety First Responders in North America.
PMID: 32096007 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - February 24, 2020 Category: Toxicology Authors: Herman PA, Brenner DS, Dandorf S, Kemp S, Kroll B, Trebach J, Hsieh YH, Stolbach AI Tags: J Med Toxicol Source Type: research

ACMT 2020 Annual Scientific Meeting Abstracts - New York, NY.
Authors: PMID: 32086766 [PubMed] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - February 21, 2020 Category: Toxicology Tags: J Med Toxicol Source Type: research

No Causal Relation Between Bupropion in Therapeutic Dose and Serotonin Toxicity.
PMID: 32086767 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - February 21, 2020 Category: Toxicology Authors: Borgsteede SD, Birkenhager TK, Zaal RJ, Alsma J Tags: J Med Toxicol Source Type: research

Use of a Porcine Model to Evaluate the Risks and Benefits of Vasopressors in Propranolol Poisoning.
Abstract INTRODUCTION: Vasopressors are a commonly used treatment in beta-blocker poisoning despite evidence they may be ineffective or harmful. The primary objective of the present study is to use previously collected data from two prior studies (high-dose insulin (HDI) versus vasopressin + epinephrine and a placebo-controlled HDI study) to compare survival between vasopressin + epinephrine and placebo. Secondary outcomes included a comparison with HDI as well as comparisons with hemodynamic parameters, including mean arterial pressure (MAP), cardiac output (CO), heart rate (HR), and systemic vascular resistance ...
Source: Journal of Medical Toxicology - January 24, 2020 Category: Toxicology Authors: Cole JB, Corcoran JN, Engebretsen KM, Stellpflug SJ Tags: J Med Toxicol Source Type: research