Accuracy of a Glycerol Dehydrogenase Assay for Ethylene Glycol Detection
CONCLUSIONS: The GDH assay provides a sensitive and specific method for the detection and quantification of EG that is comparable to a GC-based method. More widespread use of this rapid, inexpensive assay could improve the care of patients with suspected toxic alcohol exposure. Further study is needed to evaluate the test performance in real-time patient treatment decisions.PMID:37695470 | DOI:10.1007/s13181-023-00967-x (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - September 11, 2023 Category: Toxicology Authors: Ari B Filip Christopher W Farnsworth Michael E Mullins Bridgit O Crews Jeffrey A Kraut Source Type: research
Accuracy of a Glycerol Dehydrogenase Assay for Ethylene Glycol Detection
CONCLUSIONS: The GDH assay provides a sensitive and specific method for the detection and quantification of EG that is comparable to a GC-based method. More widespread use of this rapid, inexpensive assay could improve the care of patients with suspected toxic alcohol exposure. Further study is needed to evaluate the test performance in real-time patient treatment decisions.PMID:37695470 | DOI:10.1007/s13181-023-00967-x (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - September 11, 2023 Category: Toxicology Authors: Ari B Filip Christopher W Farnsworth Michael E Mullins Bridgit O Crews Jeffrey A Kraut Source Type: research
Accuracy of a Glycerol Dehydrogenase Assay for Ethylene Glycol Detection
CONCLUSIONS: The GDH assay provides a sensitive and specific method for the detection and quantification of EG that is comparable to a GC-based method. More widespread use of this rapid, inexpensive assay could improve the care of patients with suspected toxic alcohol exposure. Further study is needed to evaluate the test performance in real-time patient treatment decisions.PMID:37695470 | DOI:10.1007/s13181-023-00967-x (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - September 11, 2023 Category: Toxicology Authors: Ari B Filip Christopher W Farnsworth Michael E Mullins Bridgit O Crews Jeffrey A Kraut Source Type: research
Accuracy of a Glycerol Dehydrogenase Assay for Ethylene Glycol Detection
CONCLUSIONS: The GDH assay provides a sensitive and specific method for the detection and quantification of EG that is comparable to a GC-based method. More widespread use of this rapid, inexpensive assay could improve the care of patients with suspected toxic alcohol exposure. Further study is needed to evaluate the test performance in real-time patient treatment decisions.PMID:37695470 | DOI:10.1007/s13181-023-00967-x (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - September 11, 2023 Category: Toxicology Authors: Ari B Filip Christopher W Farnsworth Michael E Mullins Bridgit O Crews Jeffrey A Kraut Source Type: research
Accuracy of a Glycerol Dehydrogenase Assay for Ethylene Glycol Detection
CONCLUSIONS: The GDH assay provides a sensitive and specific method for the detection and quantification of EG that is comparable to a GC-based method. More widespread use of this rapid, inexpensive assay could improve the care of patients with suspected toxic alcohol exposure. Further study is needed to evaluate the test performance in real-time patient treatment decisions.PMID:37695470 | DOI:10.1007/s13181-023-00967-x (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - September 11, 2023 Category: Toxicology Authors: Ari B Filip Christopher W Farnsworth Michael E Mullins Bridgit O Crews Jeffrey A Kraut Source Type: research
Accuracy of a Glycerol Dehydrogenase Assay for Ethylene Glycol Detection
CONCLUSIONS: The GDH assay provides a sensitive and specific method for the detection and quantification of EG that is comparable to a GC-based method. More widespread use of this rapid, inexpensive assay could improve the care of patients with suspected toxic alcohol exposure. Further study is needed to evaluate the test performance in real-time patient treatment decisions.PMID:37695470 | DOI:10.1007/s13181-023-00967-x (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - September 11, 2023 Category: Toxicology Authors: Ari B Filip Christopher W Farnsworth Michael E Mullins Bridgit O Crews Jeffrey A Kraut Source Type: research
Accuracy of a Glycerol Dehydrogenase Assay for Ethylene Glycol Detection
CONCLUSIONS: The GDH assay provides a sensitive and specific method for the detection and quantification of EG that is comparable to a GC-based method. More widespread use of this rapid, inexpensive assay could improve the care of patients with suspected toxic alcohol exposure. Further study is needed to evaluate the test performance in real-time patient treatment decisions.PMID:37695470 | DOI:10.1007/s13181-023-00967-x (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - September 11, 2023 Category: Toxicology Authors: Ari B Filip Christopher W Farnsworth Michael E Mullins Bridgit O Crews Jeffrey A Kraut Source Type: research
Accuracy of a Glycerol Dehydrogenase Assay for Ethylene Glycol Detection
CONCLUSIONS: The GDH assay provides a sensitive and specific method for the detection and quantification of EG that is comparable to a GC-based method. More widespread use of this rapid, inexpensive assay could improve the care of patients with suspected toxic alcohol exposure. Further study is needed to evaluate the test performance in real-time patient treatment decisions.PMID:37695470 | DOI:10.1007/s13181-023-00967-x (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - September 11, 2023 Category: Toxicology Authors: Ari B Filip Christopher W Farnsworth Michael E Mullins Bridgit O Crews Jeffrey A Kraut Source Type: research
Accuracy of a Glycerol Dehydrogenase Assay for Ethylene Glycol Detection
CONCLUSIONS: The GDH assay provides a sensitive and specific method for the detection and quantification of EG that is comparable to a GC-based method. More widespread use of this rapid, inexpensive assay could improve the care of patients with suspected toxic alcohol exposure. Further study is needed to evaluate the test performance in real-time patient treatment decisions.PMID:37695470 | DOI:10.1007/s13181-023-00967-x (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - September 11, 2023 Category: Toxicology Authors: Ari B Filip Christopher W Farnsworth Michael E Mullins Bridgit O Crews Jeffrey A Kraut Source Type: research
Chronic Doxepin Toxicity Masquerading as Epilepsy in a 10-Year-Old Boy
We present a case of chronic doxepin toxicity mimicking epilepsy in a child attributable to three potential factors: supratherapeutic dosing, pharmacogenomic variability, and drug-drug interactions.CASE REPORT: A 10-year-old boy with insomnia, diagnosed with epilepsy 6 months prior, presented to an emergency department with confusion, ataxia, and increasing seizure frequency. He was prescribed doxepin for insomnia and four antiepileptics for seizures. After admission, he had two seizures and remained confused. EKGs showed QRS prolongation, suggesting doxepin toxicity. Doxepin-nordoxepin combined serum concentration was 141...
Source: Journal of Medical Toxicology - September 8, 2023 Category: Toxicology Authors: James D Whitledge C James Watson Michele M Burns Source Type: research
Chronic Doxepin Toxicity Masquerading as Epilepsy in a 10-Year-Old Boy
We present a case of chronic doxepin toxicity mimicking epilepsy in a child attributable to three potential factors: supratherapeutic dosing, pharmacogenomic variability, and drug-drug interactions.CASE REPORT: A 10-year-old boy with insomnia, diagnosed with epilepsy 6 months prior, presented to an emergency department with confusion, ataxia, and increasing seizure frequency. He was prescribed doxepin for insomnia and four antiepileptics for seizures. After admission, he had two seizures and remained confused. EKGs showed QRS prolongation, suggesting doxepin toxicity. Doxepin-nordoxepin combined serum concentration was 141...
Source: Journal of Medical Toxicology - September 8, 2023 Category: Toxicology Authors: James D Whitledge C James Watson Michele M Burns Source Type: research
Chronic Doxepin Toxicity Masquerading as Epilepsy in a 10-Year-Old Boy
We present a case of chronic doxepin toxicity mimicking epilepsy in a child attributable to three potential factors: supratherapeutic dosing, pharmacogenomic variability, and drug-drug interactions.CASE REPORT: A 10-year-old boy with insomnia, diagnosed with epilepsy 6 months prior, presented to an emergency department with confusion, ataxia, and increasing seizure frequency. He was prescribed doxepin for insomnia and four antiepileptics for seizures. After admission, he had two seizures and remained confused. EKGs showed QRS prolongation, suggesting doxepin toxicity. Doxepin-nordoxepin combined serum concentration was 141...
Source: Journal of Medical Toxicology - September 8, 2023 Category: Toxicology Authors: James D Whitledge C James Watson Michele M Burns Source Type: research
Assessing Platelet Mitochondrial Dysfunction in a Murine Model of Acute Acetaminophen Toxicity
CONCLUSIONS: Platelet oxygen consumption as a measure of mitochondrial function may be useful as a biomarker of hepatic APAP toxicity in the setting of moderate to severe overdose. Treatment with 4-MP decreases hepatic necrosis and may mitigate the harmful effects of APAP on platelet mitochondrial function detected via POC.PMID:37644341 | DOI:10.1007/s13181-023-00964-0 (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - August 29, 2023 Category: Toxicology Authors: Carolyn Fox Michael L Ekaney Michael Runyon Hieu M Nguyen Philip J Turk Iain H McKillop Christine M Murphy Source Type: research
The Toxicology Investigators Consortium 2022 Annual Report
J Med Toxicol. 2023 Aug 29. doi: 10.1007/s13181-023-00962-2. Online ahead of print.ABSTRACTSince 2010, medical toxicology physicians from the American College of Medical Toxicology (ACMT) Toxicology Investigators Consortium (ToxIC) have provided reports on their in-hospital and clinic patient consultations to a national case registry, known as the ToxIC Core Registry. De-identified patient data entered into the registry includes patient demographics, reason for medical toxicology evaluation, exposure agents, clinical signs and symptoms, treatments and antidotes administered, and mortality. This thirteenth annual report pro...
Source: Journal of Medical Toxicology - August 29, 2023 Category: Toxicology Authors: Alexandra M Amaducci Sharan L Campleman Shao Li Dana L Karshenas Meghan B Spyres Lynn A Farrugia A Min Kang Rachel E Culbreth Paul M Wax Jeffrey Brent Kim Aldy Toxicology Investigators Consortium Study Group Source Type: research
Assessing Platelet Mitochondrial Dysfunction in a Murine Model of Acute Acetaminophen Toxicity
CONCLUSIONS: Platelet oxygen consumption as a measure of mitochondrial function may be useful as a biomarker of hepatic APAP toxicity in the setting of moderate to severe overdose. Treatment with 4-MP decreases hepatic necrosis and may mitigate the harmful effects of APAP on platelet mitochondrial function detected via POC.PMID:37644341 | DOI:10.1007/s13181-023-00964-0 (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - August 29, 2023 Category: Toxicology Authors: Carolyn Fox Michael L Ekaney Michael Runyon Hieu M Nguyen Philip J Turk Iain H McKillop Christine M Murphy Source Type: research
