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Condition: Hemorrhagic Stroke
Therapy: Thrombolytic Therapy

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Total 340 results found since Jan 2013.

Intravenous thrombolytic therapy for ischemic stroke via telemedicine compared with bedside treatment in an experienced stroke unit
Conclusions This study demonstrates that the telestroke system, Virtuall, is as safe and effective in initiating rt-PA treatment as bedside evaluation in an experienced stroke unit, despite a longer intra-hospital time.
Source: European Research in Telemedicine - December 1, 2015 Category: Information Technology Source Type: research

Analysis on the correlation factors for hemorrhagic transformation after intravenous thrombolytic therapy.
CONCLUSIONS: Intravenous thrombolysis hemorrhagic transformation associated with these factors including the vessel wall, blood composition and biochemical markers. PMID: 25855925 [PubMed - indexed for MEDLINE]
Source: Pharmacological Reviews - November 20, 2015 Category: Drugs & Pharmacology Authors: Zhang PL, Wang YX, Chen Y, Zhang CH, Li CH, Dong Z, Zhang SS, Tong YF, Li YQ, Tong XG, Wang JH Tags: Eur Rev Med Pharmacol Sci Source Type: research

Safety of tirofiban for patients with acute ischemic stroke in routine clinical practice.
Authors: Zhu YQ, Zhang YJ, Ruan HL, Liu Q, Zhan Q, Li Q Abstract The aim of the present study was to investigate the safety of tirofiban alone and in combination with various treatments in acute ischemic stroke (AIS). A total of 120 patients with AIS were included in the study, and these patients were divided into three treatment groups: Group A (tirofiban alone, n=68), group B (tirofiban plus thrombolytic therapy, n=26), and group C (tirofiban as a 'bridging therapy', n=26). Risk factors, stroke severity, initial imaging, treatment regimens, complications and long-term outcomes were analyzed. In total, eight patie...
Source: Experimental and Therapeutic Medicine - November 18, 2015 Category: Journals (General) Tags: Exp Ther Med Source Type: research

Cerebral hemorrhage following thrombolytic therapy for stroke: Are neutrophils really neutral?
An ideal biomarker can accurately predict disease risk stratification. The longstanding link between inflammatory responses and atherosclerotic disease and vascular events suggests great promise for inflammatory measures as biomarkers in stroke and other vascular disease. Recent studies across multiple areas and disciplines have suggested that leukocytes, as an inflammatory marker, and specifically neutrophils, may hold promise in predicting poor outcomes in various cardiovascular diseases (e.g., heart failure, acute coronary syndromes, stable coronary artery disease), including stroke, as well as in neoplasms, infections,...
Source: Neurology - October 19, 2015 Category: Neurology Authors: Roever, L., Levine, S. R. Tags: All Cerebrovascular disease/Stroke, All epidemiology, Prevalence studies, Risk factors in epidemiology, Intracerebral hemorrhage EDITORIALS Source Type: research

Functional Outcome of Hemorrhagic Transformation after Thrombolysis for Ischemic Stroke: A Prospective Study
Conclusion: HT after thrombolysis is very frequent on SWI, but the initial stroke severity is an important predictor to assess the role of HT for patient outcome.Cerebrovasc Dis Extra 2015;5:103-106
Source: Cerebrovascular Diseases Extra - October 9, 2015 Category: Neurology Source Type: research

Thrombolytic therapy for pulmonary embolism.
CONCLUSIONS: There is low quality evidence that thrombolytics reduce death following acute pulmonary embolism compared with heparin. Furthermore, thrombolytic therapies included in the review were heterogeneous. Thrombolytic therapy may be helpful in reducing the recurrence of pulmonary emboli but may cause more major and minor haemorrhagic events and stroke. More high quality double blind RCTs assessing safety and cost-effectiveness are required. PMID: 26419832 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - September 30, 2015 Category: Journals (General) Authors: Hao Q, Dong BR, Yue J, Wu T, Liu GJ Tags: Cochrane Database Syst Rev Source Type: research

Validation of Stroke and Thrombolytic Therapy in Korean National Health Insurance Claim Data.
CONCLUSIONS: Discharge with hemorrhagic stroke and use of thrombolytic therapy were identified with high reliability in administrative discharge data. A substantial level of agreement was also obtained for IS, despite variation between the algorithms and data sets. PMID: 26365022 [PubMed - as supplied by publisher]
Source: Journal of Clinical Neurology - September 15, 2015 Category: Neurology Tags: J Clin Neurol Source Type: research

Thrombosis: Novel nanomedical concepts of diagnosis and treatment.
Abstract Intravascular thrombosis, a critical pathophysiological feature of many cardiovascular disorders, leads to the formation of life-threatening obstructive blood clots within the vessels. Rapid recanalization of occluded vessels is essential for the patients' outcome, but the currently available systemic fibrinolytic therapy is associated with low efficacy and tremendous side effects. Additionally, many patients are ineligible for systemic thrombolytic therapy, either due to delayed admission to the hospital after symptom onset, or because of recent surgery, or bleeding. In order to improve the treatment eff...
Source: World Journal of Cardiology - August 26, 2015 Category: Cardiology Authors: Cicha I Tags: World J Cardiol Source Type: research

Prognostic Significance of Short-Term Blood Pressure Variability in Acute Stroke: Systematic Review Clinical Sciences
Conclusions— This systematic review and meta-analysis suggest that greater systolic BPV, measured early from ischemic stroke or intracerebral hemorrhage onset, is associated with poor longer-term functional outcome. Future prospective studies should investigate how best to measure and define BPV in acute stroke, as well as to determine its prognostic significance.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Manning, L. S., Rothwell, P. M., Potter, J. F., Robinson, T. G. Tags: Cerebrovascular disease/stroke, Acute Cerebral Hemorrhage, Acute Cerebral Infarction, Acute Stroke Syndromes Clinical Sciences Source Type: research

Bryostatin extends tPA time window to 6 h following middle cerebral artery occlusion in aged female rats.
Abstract Blood-brain barrier (BBB) disruption and hemorrhagic transformation (HT) following ischemic /reperfusion injury contributes to post-stroke morbidity and mortality. Bryostatin, a potent protein kinase C (PKC) modulator, has shown promise in treating neurological injury. In the present study, we tested the hypothesis that administration of bryostatin would reduce BBB disruption and HT following acute ischemic stroke; thus, prolonging the time window for administering recombinant tissue plasminogen activator (r-tPA). Acute cerebral ischemia was produced by reversible occlusion of the right middle cerebral ar...
Source: European Journal of Pharmacology - July 16, 2015 Category: Drugs & Pharmacology Authors: Tan Z, Lucke-Wold BP, Logsdon AF, Turner RC, Tan C, Li X, Hongpaison J, Alkon DL, Simpkins JW, Rosen CL, Huber JD Tags: Eur J Pharmacol Source Type: research

Lack Of Tafi Increases Brain Damage And Microparticle Generation After Thrombolytic Therapy In Ischemic Stroke
Thrombin-activatable fibrinolysis inhibitor (TAFI) plays an important role in coagulation and fibrinolysis. Whereas TAFI deficiency may lead to a haemorrhagic tendency, data from TAFI knockout mice (TAFI−/−) are controversial and no differences have been reported in these animals after ischemic stroke. There are also no data regarding the role of circulating microparticles (MPs) in TAFI−/−.
Source: Thrombosis Research - June 10, 2015 Category: Hematology Authors: Orbe J, Alexandru N, Roncal C, Belzunce M, Bibiot P, Rodriguez JA, Meijers JCM, Georgescu A, Paramo JA Source Type: research

Role of perfusion imaging in acute stroke.
Authors: Sillanpää N Abstract Imaging has a central role in the diagnosis and classification of acute stroke, the triage of patients to different treatment approaches and the prediction of the clinical outcome and the risk of hemorrhagic complications. A multimodal imaging protocol that includes a perfusion study allows diagnostics beyond anatomical findings by enabling the characterization of the ischemic brain tissue and the cerebral hemodynamic state. This information potentially leads to more accurate clinical decision making with the intention to select the right patients for different revascularization ther...
Source: Panminerva Medica - June 4, 2015 Category: Journals (General) Tags: Panminerva Med Source Type: research

Improved performance of new prenotification criteria for acute stroke patients
Conclusion The accuracy of the new prehospital stroke criteria has higher PPV and specificity compared to previous CPSS validation studies.
Source: Journal of the Formosan Medical Association - May 13, 2015 Category: Journals (General) Source Type: research

Safety and efficacy of desmoteplase given 3–9 h after ischaemic stroke in patients with occlusion or high-grade stenosis in major cerebral arteries (DIAS-3): a double-blind, randomised, placebo-controlled phase 3 trial
Publication date: Available online 30 April 2015 Source:The Lancet Neurology Author(s): Gregory W Albers , Rüdiger von Kummer , Thomas Truelsen , Jens-Kristian S Jensen , Gabriela M Ravn , Bjørn A Grønning , Hugues Chabriat , Ku-Chou Chang , Antonio E Davalos , Gary A Ford , James Grotta , Markku Kaste , Lee H Schwamm , Ashfaq Shuaib Background Current treatment of ischaemic stroke with thrombolytic therapy is restricted to 3–4·5 h after symptom onset. We aimed to assess the safety and efficacy of desmoteplase, a fibrin-dependent plasminogen activator, given between 3 h and 9 h after symptom onset in patients with ...
Source: The Lancet Neurology - May 1, 2015 Category: Neurology Source Type: research

Improved performance of new prenotification criteria for acute stroke patients.
CONCLUSION: The accuracy of the new prehospital stroke criteria has higher PPV and specificity compared to previous CPSS validation studies. PMID: 25886861 [PubMed - as supplied by publisher]
Source: J Formos Med Assoc - April 15, 2015 Category: Journals (General) Authors: Hsieh MJ, Tang SC, Ko PC, Chiang WC, Tsai LK, Chang AM, Wang AY, Yeh SJ, Huang KY, Jeng JS, Ma MH Tags: J Formos Med Assoc Source Type: research