Warning Signs in the Era of Unruptured Intracranial Aneurysms: Report on 2 Cases of Fatal Aneurysmal Hemorrhage
Conclusion: These cases suggested that treatment should be started as soon as possible, when a UIA is diagnosed based on a short-term period of severe headaches or when a UIA is observed and then severe headaches appear. There is no straightforward guideline for treatment timing in these patients. However, in this era of UIAs, the significance of sentinel headaches should be reevaluated. Given the incidence of headaches in the general population and the very low risk of aneurysm rupture, there may be a tendency to neglect the role of headache as a possible warning sign.Cerebrovasc Dis Extra 2021;11:77 –80 (Source: Ce...
Source: Cerebrovascular Diseases Extra - July 20, 2021 Category: Neurology Source Type: research

Endovascular Treatment in Acute Ischemic Stroke Adoption and Practice: A Single-Center Indonesian Experience
Indonesia is facing increasing stroke prevalence in the past 5 years. Ischemic stroke imposes economic and productivity burden if it is not addressed properly. Endovascular treatment studies are conducted in developed countries where facilities and cost do not count in therapy consideration if it is indicated. Developing countries like Indonesia should work hard to provide the best hyperacute stroke care with protocol deviation and limitation. This is the first review on endovascular treatment practice in a top single-center hospital in Indonesia. Further improvement is needed to catch up with state-of-the-art hyperacute i...
Source: Cerebrovascular Diseases Extra - July 20, 2021 Category: Neurology Source Type: research

Stroke Burden and Stroke Services in Bangladesh
Cerebrovasc Dis Extra 2021;11:69 –71 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - July 9, 2021 Category: Neurology Source Type: research

Superb Microvascular Imaging Ultrasound for Cervical Carotid Artery Stenosis for Prediction of the Development of Microembolic Signals on Transcranial Doppler during Carotid Exposure in Endarterectomy
Conclusion: Preoperative cervical carotid artery SMI ultrasound predicts the development of MES on TCD during exposure of the carotid arteries in CEA.Cerebrovasc Dis Extra 2021;11:61 –68 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - May 25, 2021 Category: Neurology Source Type: research

Cerebral Venous Thrombosis Associated with COVID-19 Infection: An Observational, Multicenter Study
Conclusion: COVID-19-related CVT is more common among males at older ages when compared to previously reported non-COVID-19-related CVT cases. CVT should be suspected in COVID-19 patients presenting with headache or seizures. Mortality is high, but functional neurological outcome is good among survivors.Cerebrovasc Dis Extra 2021;11:55 –60 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - May 11, 2021 Category: Neurology Source Type: research

Stroke Burden and Services in the Philippines
Cerebrovasc Dis Extra 2021;11:52 –54 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - May 11, 2021 Category: Neurology Source Type: research

Burden of Stroke in Myanmar
Myanmar is home to over 51 million people. The age- and sex-standardized mortality rate due to stroke is 165.4/100,000, while the rate of age- and sex-standardized disability-adjusted life years lost due to stroke is 2971.3/100,000. The prevalence of stroke among adults aged 40 –99 years is 1.5%. Stroke is the leading cause of morbidity and mortality and comprises 20% of the neurological workload. There are only 10 stroke units in the whole country. Doctors are aware of the importance of hypertension in stroke prevention and the need for physiotherapy after stroke, but, until recently and in rural areas, they also te...
Source: Cerebrovascular Diseases Extra - May 10, 2021 Category: Neurology Source Type: research

Stroke in Sri Lanka: How Can We Minimise the Burden?
The burden of stroke in Sri Lanka is high and steadily increasing. Accurate estimation of the burden is hampered by a paucity of epidemiological data. More neurologists, stroke units, facilities for modern treatments and multi-disciplinary rehabilitation services are urgently needed. Essential drugs for risk factor control and secondary prevention are available in many hospitals. Aggressive preventive strategies and promoting stroke awareness are the best ways to minimise the stroke burden in Sri Lanka.Cerebrovasc Dis Extra 2021;11:46 –48 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - April 28, 2021 Category: Neurology Source Type: research

Management of Patients with Cranial Dural Arteriovenous Fistula and Secondary Parkinson & apos;s Syndrome: Comment
Cerebrovasc Dis Extra 2021;11:45 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - April 12, 2021 Category: Neurology Source Type: research

Ten Years of < b > < i > Cerebrovascular Diseases EXTRA < /i > < /b >
Cerebrovasc Dis Extra 2021;11:44 –44 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - March 26, 2021 Category: Neurology Source Type: research

Using Ultrasound and Inflammation to Improve Prediction of Ischemic Stroke: A Secondary Analysis of the Multi-Ethnic Study of Atherosclerosis
Conclusions: In a multiethnic cohort of patients without cerebrovascular disease at baseline, we found that CD, CS, and IL-6 helped predict the occurrence of primary ischemic stroke. Future research could evaluate if these basic ultrasound and serum measurements have implications for primary prevention efforts or clinical trial inclusion criteria.Cerebrovasc Dis Extra 2021;11:37 –43 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - February 18, 2021 Category: Neurology Source Type: research

Identification of Biomarkers in Patients with Thrombotic Thrombocytopenic Purpura Presenting with Large and Small Ischemic Stroke
Conclusions: iTTP patients can present with large ischemic strokes and are usually younger. Further research should be performed in assessing different etiologies of iTTP-associated stroke based on neutrophil extracellular trap formation biomarkers (e.g., histone markers) seen in small ischemic stroke.Cerebrovasc Dis Extra 2021;11:29 –36 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - February 18, 2021 Category: Neurology Source Type: research

Detection of Major Cardioembolic Sources in Real-World Patients with Ischemic Stroke or Transient Ischemic Attack of Undetermined Cause
Conclusion: Detecting a major CES is essential because appropriate treatment lowers the risk of recurrent stroke. Nonetheless, in this real-world study that aimed at routine use of TTE and ambulatory rhythm monitoring in patients with ischemic stroke or TIA of undetermined cause, the prevalence of major CES was low. Most patients with major CES on TTE already had an indication for referral to a cardiologist, suggesting that major CES might also have been identified with a much more selective use of TTE.Cerebrovasc Dis Extra 2021;11:22 –28 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - February 1, 2021 Category: Neurology Source Type: research

Intracerebral Hemorrhage Recurrence in Patients with and without Cerebral Amyloid Angiopathy
Conclusions: This study confirms a higher ICH recurrence risk in patients with CAA-related ICH and suggests that age, disseminated cSS, and burden of EPVS in the centrum semiovale are associated with ICH recurrence.Cerebrovasc Dis Extra 2021;11:15 –21 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - January 27, 2021 Category: Neurology Source Type: research

Residual Stroke Risk in Patients with Atrial Fibrillation Treated with Non-Vitamin K Oral Anticoagulants: An 8-Year Retrospective Cohort Study
Conclusions: Stroke developed in NVAF patients despite being on NOACs, with the majority being female, older, and hypertensive. Surprisingly, in general they had reasonable lipid and diabetic control.Cerebrovasc Dis Extra 2021;11:9 –14 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - January 18, 2021 Category: Neurology Source Type: research

Role of Favorable Perfusion Imaging in Predicting the Outcome of Patients with Acute Ischemic Stroke due to Large Vessel Occlusion Undergoing Effective Thrombectomy: A Single-Center Study
Conclusions: In our small-sized and retrospective study, the presence of ischemic penumbra was associated with a better clinical outcome in patients with AIS due to LVO after MT. In the future, a larger and controlled study with similar criteria of enrollment is needed to further validate the role of CTP in patient selection for MT, regardless of the time from the onset of symptoms.Cerebrovasc Dis Extra 2021;11:1 –8 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - January 15, 2021 Category: Neurology Source Type: research

Red Blood Cell Distribution Width as a 5-Year Prognostic Marker in Patients Submitted to Carotid Endarterectomy
Conclusion: RDW is a widely available and low-cost marker that independently predicts long-term mortality, MACE, and MI after CEA. This biomarker could prove useful in assessing which patients would likely benefit from CEA in the long term.Cerebrovasc Dis Extra 2020;10:181 –192 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - December 16, 2020 Category: Neurology Source Type: research

High Prevalence of Deep Venous Thrombosis in Non-Severe COVID-19 Patients Hospitalized for a Neurovascular Disease
Conclusion: Despite thromboprophylaxis, systematic bedside DUS showed a high prevalence (38.5%) of asymptomatic DVT in non-severe COVID-19 patients suffering from a neurovascular disease. In the absence of a reliable marker of DVT, we suggest that this non-invasive investigation could be an interesting tool to monitor peripheral venous thrombotic complications in such patients.Cerebrovasc Dis Extra 2020;10:174 –180 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - December 7, 2020 Category: Neurology Source Type: research

Use of the Cardiovascular Polypill in Secondary Prevention of Cerebrovascular Disease: A Real-Life Tertiary Hospital Cohort Study of 104 Patients
Conclusion: In our experience, the cardiovascular polypill achieved a higher reduction in SBP levels and was well tolerated. Adherence was similar to that found in the previous literature, which is remarkable given the real-life setting of our study.Cerebrovasc Dis Extra 2020;10:166 –173 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - November 11, 2020 Category: Neurology Source Type: research

Impact of a Stay-at-Home Order on Stroke Admission, Subtype, and Metrics during the COVID-19 Pandemic
Conclusions: There was a trend of decreasing AIS admissions during the COVID-19 pandemic. There was also a significantly increased number of AIS patients with LVO who received MT, especially those with COVID-19. We conclude that cytokine storm resulting from SARS-CoV-2 infection might play a role in AIS patients with COVID-19.Cerebrovasc Dis Extra 2020;10:159 –165 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - November 9, 2020 Category: Neurology Source Type: research

Treatment with Delipid Extracorporeal Lipoprotein Filter from Plasma after Intravenous Thrombolysis for Acute Ischemic Stroke: A Single-Center Experience
Conclusions: DELP following intravenous thrombolysis should be safe, and is associated with neurological function improvement, possibly through multiple neuroprotective mechanisms. Prospective trials are needed.Cerebrovasc Dis Extra 2020;10:148 –158 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - October 22, 2020 Category: Neurology Source Type: research

Anemia Predicts Poor Clinical Outcome in Mechanical Thrombectomy Patients with Fair or Good Collateral Circulation
Conclusions: Low hemoglobin on admission predicts poor clinical outcome in mechanical thrombectomy patients with fair or good collateral circulation.Cerebrovasc Dis Extra 2020;10:139 –147 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - October 22, 2020 Category: Neurology Source Type: research

The Challenging Clinical Management of Patients with Cranial Dural Arteriovenous Fistula and Secondary Parkinson ’s Syndrome: Pathophysiology and Treatment Options
Cranial dural arteriovenous fistula (cDAVF) may rarely lead to parkinsonism and rapid cognitive decline. Dysfunction of the extrapyramidal system and the thalamus, due to venous congestion of the Galenic system with subsequent parenchymal edema, is likely to represent an important pathophysiological mechanism. Here, we report a case of a 57-year-old man with a cDAVF of the straight sinus (Borden type III; DES-Zurich bridging vein shunt [BVS] type with direct, exclusive, and strained leptomeningeal venous drainage [LVD]) and subsequent edema of both thalami, the internal capsule, the hippocampi, the pallidum, and the mesenc...
Source: Cerebrovascular Diseases Extra - October 22, 2020 Category: Neurology Source Type: research

Prevalence and Risk Factors of Silent Brain Infarction in Patients with Aortic Stenosis
Conclusion: These findings indicate that AS is associated with a high prevalence of SBI, and that the CHA2DS2-VASc score and eGFR are useful for risk stratification.Cerebrovasc Dis Extra 2020;10:116 –123 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - October 8, 2020 Category: Neurology Source Type: research

Occurrence of Cerebrovascular Diseases Decreased after the Great East Japan Earthquake and Tsunami of 2011
Conclusions: The occurrence of CVDs in the flooded coastal areas did not increase in the year of the Great East Japan Earthquake and Tsunami; furthermore, it decreased for men according to the severity of flood damage in the subsequent years; this can be attributed to supportive activities for the tsunami victims and the migration of the population.Cerebrovasc Dis Extra 2020;10:105 –115 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - October 8, 2020 Category: Neurology Source Type: research

Readmissions for Depression and Suicide Attempt following Stroke and Myocardial Infarction
Conclusions: IS was associated with greater hazard of readmission due to depression compared to MI. Patients with a history of depression, smoking, and alcoholism were more likely to be readmitted with depression, while advanced age and discharge home were protective. It is unclear to what extent differences in type of ischemic tissue damage and disability contribute, and further investigation is warranted.Cerebrovasc Dis Extra 2020;10:94 –104 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - August 27, 2020 Category: Neurology Source Type: research

Endovascular Treatment of Intracranial Dural Arteriovenous Fistulas: A German Single-Center Experience
Conclusion: Endovascular treatment of intracranial DAVFs is feasible, safe, and effective with high rates of CO. In more than half of the patients, the DAVF was completely occluded after a single procedure. However, in tentorial DAVFs, multiple sessions were more often required.Cerebrovasc Dis Extra 2020;10:84 –93 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - August 26, 2020 Category: Neurology Source Type: research

Cortical and Internal Watershed Infarcts Might Be Key Signs for Predicting Neurological Deterioration in Patients with Internal Carotid Artery Occlusion with Mild Symptoms
Conclusion: In patients with mildly symptomatic ICA occlusion, CWIs and IWIs might be key signs for predicting neurological deterioration after hospitalization.Cerebrovasc Dis Extra 2020;10:76 –83 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - July 29, 2020 Category: Neurology Source Type: research

Measurement of Intraoperative Graft Flow Predicts Radiological Hyperperfusion during Bypass Surgery in Patients with Moyamoya Disease
Conclusions: Measuring intraoperative graft flow during bypass surgery may be an effective means of predicting hyperperfusion and could serve to facilitate early therapeutic intervention such as strict blood pressure control.Cerebrovasc Dis Extra 2020;10:66 –75 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - July 29, 2020 Category: Neurology Source Type: research

High White Blood Cell Count Is a Risk Factor for Contrast-Induced Nephropathy following Mechanical Thrombectomy for Acute Ischemic Stroke
Conclusions: This study found that CIN occurred in 8.8% of patients with AIS following mechanical thrombectomy. High WBC count was associated with an increased risk of CIN and may be helpful for predicting CIN.Cerebrovasc Dis Extra 2020;10:59 –65 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - July 1, 2020 Category: Neurology Source Type: research

Efficacy and Safety of Endovascular Treatment in Acute Tandem Carotid Occlusions: Analysis of a Single-Center Cohort
Conclusions: Our results suggest that endovascular treatment with emergent carotid stenting and intracranial thrombectomy in patients with acute stroke due to tandem occlusions is an effective and safe procedure.Cerebrovasc Dis Extra 2020;10:50 –58 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - June 24, 2020 Category: Neurology Source Type: research

Rates and Determinants for the Use of Anticoagulation Treatment before Stroke in Patients with Known Atrial Fibrillation
Conclusions: Only 21.9% of the patients hospitalized for a stroke or TIA with known AF before the event were adequately treated according to recent treatment guidelines. It is important to improve medical information about the risk of AF and the efficacy of anticoagulants in stroke prevention.Cerebrovasc Dis Extra 2020;10:44 –49 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - May 6, 2020 Category: Neurology Source Type: research

The Hyperdense Middle Cerebral Artery Sign in Drip-and-Ship Models of Acute Stroke Management
Conclusion: When clinical data are provided, detection of HMCAS on thinly sliced NCCT could be enough to decide on transfer for thrombectomy in drip-and-ship models of acute stroke management, especially in situations where CTA is less available and referral centers for thrombectomy fewer and further apart.Cerebrovasc Dis Extra 2020;10:36 –43 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - April 28, 2020 Category: Neurology Source Type: research

Does Intravenous Thrombolysis Influence the Time of Recanalization and Success of Mechanical Thrombectomy during the Acute Phase of Cerebral Infarction?
Conclusions: There was no difference in terms of procedure times in patients treated by IVT and MT vs. patients treated by MT alone either in the full cohort or in the successful revascularization subgroup. The data from the successful revascularization subgroup may be useful for studying revascularization times, provided that data from procedures that were stopped prematurely by the operator due to the length of time since symptom onset is removed.Cerebrovasc Dis Extra 2020;10:28 –35 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - April 28, 2020 Category: Neurology Source Type: research

Cognitive Impairment Correlates Linearly with Mean Flow Velocity by Transcranial Doppler below a Definable Threshold
Conclusions: In high-grade, asymptomatic carotid artery stenosis, cognitive impairment correlated linearly with lower flow in the hemisphere fed by the occluded internal carotid artery, but only below a threshold of MFV = 45 cm/s. Identifying a hemodynamic threshold for cognitive decline using a simple, noninvasive method may influence revascularization decision-making in otherwise “asymptomatic” carotid disease.Cerebrovasc Dis Extra 2020;10:21 –27 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - April 14, 2020 Category: Neurology Source Type: research

Biomarkers Associated with Atrial Fibrillation in Patients with Ischemic Stroke: A Pilot Study from the NOR-FIB Study
Conclusions: Our results demonstrate an association between inflammation and AF and that multiple proteins alone and in combination may potentially be used as indicators of AF in CS and TIA patients. However, further studies including larger samples sizes are needed to support these findings. In the ongoing NOR-FIB study, we plan further biomarker assessments in patients with CS and TIA undergoing long-term cardiac rhythm monitoring with insertable cardiac monitors.Cerebrovasc Dis Extra 2020;10:11 –20 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - February 6, 2020 Category: Neurology Source Type: research

Weather Fluctuations May Have an Impact on Stroke Occurrence in a Society: A Population-Based Cohort Study
Conclusions: Meteorological effects on the frequency of ambulance transportation due to stroke were studied. A lower temperature and radical humidity change were identified as risk factors for ambulance transportation due to stroke, and a decrease in temperature was also associated. We speculate on the possibilities of using meteorological data to optimize the assignment of limited medical resources in medical economics.Cerebrovasc Dis Extra 2020;10:1 –10 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - February 5, 2020 Category: Neurology Source Type: research

Comparison of ABC Methods with Computerized Estimates of Intracerebral Hemorrhage Volume: The INTERACT2 Study
Conclusions: Overall, ABC/2 performs better than mABC/2 in estimating ICH volume. The largest discrepancies were evidenced against automated software for irregular-shaped and large ICH with SAH, but the clinical significance of this is uncertain.Cerebrovasc Dis Extra 2019;9:148 –154 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - December 13, 2019 Category: Neurology Source Type: research

Prevalence of and Risk Factors for Cerebral Microbleeds in Moyamoya Disease and Syndrome in the American Population
Conclusions: CMB are less prevalent in MMD/MMS in the USA than in Asia. An older age at diagnosis and male gender were associated with CMB. The presence of CMB was not associated with an increased risk of a subsequent ischemic or hemorrhagic stroke.Cerebrovasc Dis Extra 2019;9:139 –147 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - December 12, 2019 Category: Neurology Source Type: research

“Weekend Effect” on 30-Day Readmissions among Stroke Survivors: An Analysis of the National Readmission Database
Conclusions: We found no association between weekend admission and 30-day readmissions, providing indirect evidence of homogeneity in the quality of care delivered during week day and weekend admissions.Cerebrovasc Dis Extra 2019;9:66 –71 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - June 24, 2019 Category: Neurology Source Type: research

Microbleeds after Carotid Artery Stenting: Small Embolism May Induce Cerebral Microbleeds
Conclusions: We found that new cerebral microbleeds developed after CAS and that these might be associated with new ischemic lesions, mostly in the territory of the treated carotid artery. We speculate that these microbleeds result from the deoxygenation of hemoglobin in the embolus or, alternatively, small hemorrhagic transformation of ischemic lesions.Cerebrovasc Dis Extra 2019;9:57 –65 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - June 14, 2019 Category: Neurology Source Type: research

Stent Retriever Thrombectomy Potentially Increases the Recanalization Rate, Improves Clinical Outcome, and Decreases Mortality in Acute Basilar Occlusion: A Systematic Review and Meta-Analysis
Conclusions: The data from this meta-analysis suggest a possible superiority of SRT over IVT, pending positive results of randomized controlled trials. According to international recommendations, patients with BAO should preferentially be treated with SRT; if no contraindications exist, IVT should not be withheld.Cerebrovasc Dis Extra 2019;9:46 –56 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - June 5, 2019 Category: Neurology Source Type: research

Cardiac Magnetic Resonance Imaging in Patients with Acute Ischemic Stroke and Elevated Troponin: A TRoponin ELevation in Acute Ischemic Stroke (TRELAS) Sub-Study
Conclusions: The TRELAS sub-study indicates that noninvasive cardiac MRI may provide helpful information to identify stroke patients with or without acute coronary syndrome. Our findings might help to select stroke patients in urgent need of coronary angiography.Cerebrovasc Dis Extra 2019;9:19 –24 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - May 5, 2019 Category: Neurology Source Type: research

Increased Plasma VEGF Levels in Patients with Cerebral Large Artery Disease Are Associated with Cerebral Microbleeds
Conclusions: In patients with CLAD, elevated plasma VEGF might be associated with CMBs, especially those located in the cortex and/or at the gray-white junction.Cerebrovasc Dis Extra 2019;9:25 –30 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - May 5, 2019 Category: Neurology Source Type: research

Nonsteroidal Anti-Inflammatory Drugs: A Potential Pharmacological Treatment for Intracranial Aneurysm
Background: Saccular intracranial aneurysms (IAs) are outpouchings of the vessel wall of intracranial arteries. Rupture of IAs results in subarachnoid hemorrhage which is associated with high morbidity and mortality. Surgical interventions, such as clipping and coiling, have associated risks. Currently, there are no proven pharmacological treatments to prevent the growth or rupture of IAs. Infiltration of proinflammatory cytokines in response to increased wall sheer stress is a hallmark of IA. Nonsteroidal anti-inflammatory drugs (NSAIDs) are being investigated as potential therapeutic agents for reduction in growth and/or...
Source: Cerebrovascular Diseases Extra - May 5, 2019 Category: Neurology Source Type: research

Circulating Microparticles in Patients with Symptomatic Carotid Disease Are Related to Embolic Plaque Activity and Recent Cerebral Ischaemia
Conclusions: PMP and EMP were associated with stroke and recent cerebrovascular events (DWI+) but only PMP were also associated with ongoing (MES+) thrombo-embolic activity suggesting a differential biomarker potential for EMP to index cerebral ischaemia while PMP may predict on-going thrombo-embolic activity.Cerebrovasc Dis Extra 2019;9:9 –18 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - April 3, 2019 Category: Neurology Source Type: research

Health Economic Evaluations of Digital Health Interventions for Secondary Prevention in Stroke Patients: A Systematic Review
Background: In the first 5 years after their stroke, about a quarter of patients will suffer from a recurrent stroke. Digital health interventions facilitating interactions between a caregiver and a patient from a distance are a promising approach to improve patient adherence to lifestyle changes proposed by secondary prevention guidelines. Many of these interventions are not implemented in daily practice, even though efficacy has been shown. One of the reasons can be the lack of clear economic incentives for implementation. We propose to map all health economic evidence regarding digital health interventions for secondary...
Source: Cerebrovascular Diseases Extra - January 13, 2019 Category: Neurology Source Type: research

Transient Ischaemic Attack Rarely Precedes Stroke in a Cohort with Low Proportions of Large Artery Atherosclerosis: A Population-Based Study
Conclusion: In our population-based cohort, rates of TIA preceding ischaemic stroke were much lower than previously reported, probably reflective of effective secondary prevention (active TIA clinics) and primary prevention (limiting LAA prevalence). In our population, further enhancements in TIA care will be of limited yield.Cerebrovasc Dis Extra 2018;8:101 –105 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - August 23, 2018 Category: Neurology Source Type: research

A Novel Intraoperative Laser Light Imaging System to Simultaneously Visualize Visible Light and Near-Infrared Fluorescence for Indocyanine Green Videoangiography
Conclusions: Using the present setup, we can observe the color operative field and enhanced blood flow using ICG in real time. This setup could facilitate various cerebrovascular surgeries.Cerebrovasc Dis Extra 2018;8:96 –100 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - July 27, 2018 Category: Neurology Source Type: research

Effect of Exercise on Physical Recovery of People with Locked-In Syndrome after Stroke: What Do We Know from the Current Evidence? A Systematic Review
Conclusion: Studies indicate a positive trend of effect of exercise for physical recovery of people with LIS after stroke including the improvement of muscle strength, tone, walking ability, and activity in daily living. Mixed physical exercises were used. The effects were not significant. No adverse event has been reported. The quality of the existing evidence is relatively low since the papers were either case series or case studies. Further studies are needed on exercise types and dosages for better prescriptions for people with LIS after stroke. This may help to extend their lives with better control of the complicatio...
Source: Cerebrovascular Diseases Extra - July 13, 2018 Category: Neurology Source Type: research