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Therapy: Stem Cell Therapy
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Total 2351 results found since Jan 2013.
Electroacupuncture and human iPSC-derived small extracellular vesicles regulate the gut microbiota in ischemic stroke via the brain-gut axis
Electroacupuncture (EA) and induced pluripotent stem cell (iPSC)-derived small extracellular vesicles (iPSC-EVs) have substantial beneficial effects on ischemic stroke. However, the detailed mechanisms remain unclear. Here, we explored the mechanisms underlying the regulation of EA and iPSC-EVs in the microbiome-gut-brain axis (MGBA) after ischemic stroke. Ischemic stroke mice (C57BL/6) were subjected to middle cerebral artery occlusion (MCAO) or Sham surgery. EA and iPSC-EVs treatments significantly improved neurological function and neuronal and intestinal tract injury, downregulated the levels of IL-17 expression and up...
Source: Frontiers in Immunology - January 20, 2023 Category: Allergy & Immunology Source Type: research
Modulatory effects of mesenchymal stem cells on microglia in ischemic stroke
Ischemic stroke accounts for 70–80% of all stroke cases. Immunity plays an important role in the pathophysiology of ischemic stroke. Microglia are the first line of defense in the central nervous system. Microglial functions are largely dependent on their pro-inflammatory (M1-like) or anti-inflammatory (M2-like) phenotype. Modulating neuroinflammation via targeting microglia polarization toward anti-inflammatory phenotype might be a novel treatment for ischemic stroke. Mesenchymal stem cells (MSC) and MSC-derived extracellular vesicles (MSC-EVs) have been demonstrated to modulate microglia activation and phenotype polari...
Source: Frontiers in Neurology - January 18, 2023 Category: Neurology Source Type: research
Self-assembled DNA nanocages promote cell migration & amp; differentiation of human umbilical vein endothelial cells
Chembiochem. 2023 Jan 16. doi: 10.1002/cbic.202200634. Online ahead of print.ABSTRACTDNA nanocages have been explored for capabilities to influence cellular behavior and its functions. Recent times have seen the development of new emergent functionalities of DNA nanodevices as class of biomaterials with immense capacity to interface with biological systems and having vast potential in disease diagnosis and therapeutics. Being chemically robust and biocompatible in nature, DNA nanocages have been surface modified and structurally fine-tuned to find emerging applications in the field of stem cell therapy and tissue regenerat...
Source: Chembiochem - January 16, 2023 Category: Biochemistry Authors: Anjali Rajwar Gada Payal Vaswani Ramesh Singh Dhiraj Devidas Bhatia Source Type: research
Bone marrow mesenchymal stem cell-derived exosomal lncRNA KLF3-AS1 stabilizes Sirt1 protein to improve cerebral ischemia/reperfusion injury via miR-206/USP22 axis
CONCLUSION: BMSC-Exos KLF3-AS1 promoted the Sirt1 deubiquitinating to ameliorate cerebral I/R-induced inflammatory injury via KLF3-AS1/miR-206/USP22 network.PMID:36627572 | DOI:10.1186/s10020-022-00595-1
Source: Molecular Medicine - January 10, 2023 Category: Molecular Biology Authors: Xiaowei Xie Yu Cao Liangping Dai Dingzhou Zhou Source Type: research
Stem cells alleviate OGD/R mediated stress response in PC12 cells following a co-culture: modulation of the apoptotic cascade through BDNF-TrkB signaling
Cell Stress Chaperones. 2023 Jan 9. doi: 10.1007/s12192-022-01319-4. Online ahead of print.ABSTRACTApoptosis mediated by endoplasmic reticulum (ER) stress plays a crucial role in several neurovascular disorders, including ischemia/reperfusion injury (I/R injury). Previous in vitro and in vivo studies have suggested that following I/R injury, ER stress is vital for mediating CCAT-enhancer-binding protein homologous protein (CHOP) and caspase-12-dependent apoptosis. However, its modulation in the presence of stem cells and the underlying mechanism of cytoprotection remains elusive. In vivo studies from our lab have reported ...
Source: Cell Stress and Chaperones - January 9, 2023 Category: Cytology Authors: Harpreet Kaur Deepaneeta Sarmah Aishika Datta Anupom Borah Dileep R Yavagal Pallab Bhattacharya Source Type: research
Exosome therapies improve outcome in rodents with ischemic stroke; Meta-analysis
This study systematically evaluated the efficacy of exosome therapy in ischemic stroke based on preclinical studies in rodent models.METHODS: We reviewed existing literature on exosome therapy in rodent stroke models from various databases, and reviewed the interventional measures, and outcome measures systematically, with changes in the infarct volume and functional scores as outcome parameters. Seventeen homogeneous studies were found qualitatively acceptable for meta-analysis. The study used software RevMan 5.3 to conduct the meta-analysis (PROSPERO Register Number: CRD42022314138) RESULTS: Compared to placebo, exosomes...
Source: Brain Research - January 2, 2023 Category: Neurology Authors: Simy Grace Cherian Sunil K Narayan Murugesan Arumugam Source Type: research
GSE208008 Effects of extracellular vehicles secreted from human-induced pluripotent stem cell-derived mesenchymal stem cells on the functional recovery of an ischemic stroke mouse model
Contributors : Xianwei Su ; Gang LuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the the expression profile and potential pathways involved in celluar ischemic stroke model, we established murine HT22 cell lines with oxygen-glucose deprivation/reoxygenation (OGD/R) in vitro
Source: GEO: Gene Expression Omnibus - December 31, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Neuroprotective Effects of Conditioned Medium of Mesenchymal Stem Cells (MSC-CM) as a Therapy for Ischemic Stroke Recovery: A Systematic Review
Neurochem Res. 2022 Dec 30. doi: 10.1007/s11064-022-03848-x. Online ahead of print.ABSTRACTIt has been reported that the therapeutic potential of stem cells is mainly mediated by their paracrine factors. In order to identify the effects of conditioned medium of mesenchymal stem cells (MSC-CM) against stroke, a systematic review was conducted. We searched PubMed, Scopus, and ISI Web of Science databases for all available articles relevant to the effects of MSC-CM against the middle cerebral artery occlusion (MCAO) model of ischemic stroke until August 2022. The quality of the included studies was evaluated using The STAIR s...
Source: Neurochemical Research - December 29, 2022 Category: Neuroscience Authors: Mahin Behzadifard Nahid Aboutaleb Mojtaba Dolatshahi Maryam Khorramizadeh Hamzeh Mirshekari Jahangiri Zeynab Kord Donya Nazarinia Source Type: research
Functional roles of mesenchymal stem cell-derived exosomes in ischemic stroke treatment
Curr Stem Cell Res Ther. 2022 Dec 22. doi: 10.2174/1574888X18666221222123818. Online ahead of print.ABSTRACTStroke is a life-threatening disease and one of the leading causes of death and physical disability worldwide. Currently, no drugs on the market promote neural recovery after stroke insult, and spontaneous remodeling processes are limited to induce recovery in the ischemic regions. Therefore, promoting a cell-based therapy has been needed to elevate the endogenous recovery process. Mesenchymal stem cells (MSCs) have been regarded as candidate cell sources for therapeutic purposes of ischemic stroke, and their therape...
Source: Current Stem Cell Research and Therapy - December 25, 2022 Category: Stem Cells Authors: Maryam Farzaneh Seyed Esmaeil Khoshnam Source Type: research
