Exosome therapies improve outcome in rodents with ischemic stroke; Meta-analysis

This study systematically evaluated the efficacy of exosome therapy in ischemic stroke based on preclinical studies in rodent models.METHODS: We reviewed existing literature on exosome therapy in rodent stroke models from various databases, and reviewed the interventional measures, and outcome measures systematically, with changes in the infarct volume and functional scores as outcome parameters. Seventeen homogeneous studies were found qualitatively acceptable for meta-analysis. The study used software RevMan 5.3 to conduct the meta-analysis (PROSPERO Register Number: CRD42022314138) RESULTS: Compared to placebo, exosomes treated ischemic stroke models showed significantly reduced brain infarct volume and improved functional recovery on days 7 and 28. Though there are no safety concerns reported in any preclinical studies, there is insufficient data to make robust conclusions on the therapy's safety.INTERPRETATION: Therapy with subcellular exosomes is a promising treatment to be explored in further animal ischemic stroke models to arrive at robust conclusions on its safety. It must precede Phase I and II-Human randomized clinical trials to establish the safety and proof of concept study on the efficacy of exosome therapy in ischemic stroke.PMID:36592803 | DOI:10.1016/j.brainres.2022.148228

Source: Brain Research - January 2, 2023 Category: Neurology Authors: Simy Grace Cherian Sunil K Narayan Murugesan Arumugam Source Type: research