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Therapy: Stem Cell Therapy

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Total 2351 results found since Jan 2013.

Functional reconstruction of the impaired cortex and motor function by hMGEOs transplantation in stroke
Biochem Biophys Res Commun. 2023 Jun 3;671:87-95. doi: 10.1016/j.bbrc.2023.06.010. Online ahead of print.ABSTRACTStroke is the leading cause of death and long-term disability worldwide. But treatments are not available to promote functional recovery, and efficient therapies need to be investigated. Stem cell-based therapies hold great promise as potential technologies to restore function in brain disorders. Loss of GABAergic interneurons after stroke may result in sensorimotor defects. Here, by transplanting human brain organoids resembling the MGE domain (human MGE organoids, hMGEOs) derived from human induced pluripotent...
Source: Cell Research - June 10, 2023 Category: Cytology Authors: Shi-Ying Cao Meng-Dan Tao Shu-Ning Lou Di Yang Yu-Hui Lin Hai-Yin Wu Lei Chang Chun-Xia Luo Yun Xu Yan Liu Dong-Ya Zhu Source Type: research

Mesenchymal stem cells (MSCs) and MSC ‐derived exosomes in animal models of central nervous system diseases: Targeting the NLRP3 inflammasome
AbstractThe NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome is a multimeric protein complex that is engaged in the innate immune system and plays a vital role in inflammatory reactions. Activation of the NLRP3 inflammasome and subsequent release of proinflammatory cytokines can be triggered by microbial infection or cellular injury. The NLRP3 inflammasome has been implicated in the pathogenesis of many disorders affecting the central nervous system (CNS), ranging from stroke, traumatic brain injury, and spinal cord injury to Alzheimer's disease, Parkinson's disease, epilepsy, multiple sclerosis, and ...
Source: IUBMB Life - June 7, 2023 Category: Research Authors: Shahrzad Nazari, Seyed Mahmoud Pourmand, Elahe Motevaseli, Gholamreza Hassanzadeh Tags: CRITICAL REVIEW Source Type: research

Temporal patterns and distribution of pyroptosis-related molecules and effects of human mesenchymal stem cells on pyroptosis following cerebral ischemia/reperfusion in rats
Pyroptosis is a new type of programmed cell death that has a strong proinflammatory effect. The present study investigated the dynamic changes of pyroptosis-related molecules and the effect of mesenchymal stem cells (MSCs) on pyroptosis following cerebral ischemia/reperfusion (I/R).
Source: Journal of Stroke and Cerebrovascular Diseases - May 31, 2023 Category: Neurology Authors: Kuang Pan, Qingxia Peng, Zejia Huang, Zhaofei Dong, Weijye Lin, Yidong Wang Source Type: research

Bone Marrow Mesenchymal Stem Cell-Derived Dermcidin-Containing Migrasomes enhance LC3-Associated Phagocytosis of Pulmonary Macrophages and Protect against Post-Stroke Pneumonia
Adv Sci (Weinh). 2023 May 28:e2206432. doi: 10.1002/advs.202206432. Online ahead of print.ABSTRACTPneumonia is one of the leading causes of death in patients with acute ischemic stroke (AIS). Antibiotics fail to improve prognosis of patients with post-stroke pneumonia, albeit suppressing infection, due to adverse impacts on the immune system. The current study reports that bone marrow mesenchymal stem cells (BM-MSC) downregulate bacterial load in the lungs of stroke mice models. RNA-sequencing of the lung from BM-MSC-treated stroke models indicates that BM-MSC modulates pulmonary macrophage activities after cerebral ischem...
Source: Adv Data - May 28, 2023 Category: Epidemiology Authors: Tiemei Li Xiaotao Su Pinglan Lu Xinmei Kang Mengyan Hu Chunyi Li Shisi Wang Danli Lu Shishi Shen Huipeng Huang Yuxin Liu Xiaohui Deng Wei Cai Lei Wei Zhengqi Lu Source Type: research

Bone Marrow Mesenchymal Stem Cell-Derived Exosomal KLF4 Alleviated Ischemic Stroke Through Inhibiting N6-Methyladenosine Modification Level of Drp1 by Targeting lncRNA-ZFAS1
AbstractIschemic stroke has  become a serious public health problem that causes high rates of death and disability. Bone marrow mesenchymal stem cell (BMSC)-derived exosomes have shown promising therapeutic results in IS, while the underlying mechanisms need further investigation. Cell and mice models were established through oxygen–glucose deprivation/reoxygenation (OGD/R) treatment and middle cerebral artery occlusion (MCAO)/reperfusion. Exosomes were isolated from BMSCs. Related gene and protein expression was measured by qRT-PCR, Western blotting, and immunofluorescence analysis. The biological functions of treate d...
Source: Molecular Neurobiology - May 28, 2023 Category: Neurology Source Type: research

From lift off to splash down: An update on Mayo Clinic stem cells in space
It's been six years since Mayo Clinic physician Abba Zubair, M.D., Ph.D., watched stem cells from his regenerative medicine laboratory blast into space as part of a research effort to see if zero gravity would help the cells multiply faster. Approximately 15 million people worldwide experience a stroke annually, according to the World Health Organization. Currently, stroke remains a top cause of death and disability in the world. Finding new therapies for stroke is important…
Source: Mayo Clinic Florida News - May 26, 2023 Category: Hospital Management Source Type: news

Hypoxia-Preconditioned Bone Marrow Mesenchymal Stem Cells Improved Cerebral Collateral Circulation and Stroke Outcome in Mice
CONCLUSIONS: BMSCs increased collateral circulation and improved poststroke outcomes, through the upregulation of Rabep2. These effects were enhanced by hypoxic preconditioning.PMID:37226732 | DOI:10.1161/ATVBAHA.122.318559
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 25, 2023 Category: Cardiology Authors: Hao Tian Xinxuan Yang Jiahui Zhao Xiran Liu Xin Liu Yuan Cai Alexandra Wehbe Yuchuan Ding Shanping Yu Ling Wei Liping Liu Source Type: research

Stem Cell Implants: Emerging Innovation for Stroke Recovery
J Neuro Oncol Res. 2023;3(1):3102. Epub 2023 Apr 30.ABSTRACTStroke is a debilitating neurovascular injury that those effects hundreds of thousands of Americans each year. Despite the high prevalence, disease morbidity and mortality, options for stroke intervention and rehabilitation are still limited. Stem cells have shown promise in stroke treatment due to their ability to self-renew and differentiate into different cell types. The primary sources of stem cells used today are bone marrow and fetal brain tissue, with mesenchymal stem cells, bone marrow stem cells and neural stem cells being particularly well-studied. By se...
Source: Cell Research - May 25, 2023 Category: Cytology Authors: Reid Colliander Kaitlyn Alleman Michael Diaz Med Jimenez Patrick King Pranav Mirpuri Christopher Cutler Brandon Lucke-Wold Source Type: research