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Therapy: Stem Cell Therapy
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Total 2351 results found since Jan 2013.
Hypoxia-Preconditioned Bone Marrow Mesenchymal Stem Cells Improved Cerebral Collateral Circulation and Stroke Outcome in Mice
CONCLUSIONS: BMSCs increased collateral circulation and improved poststroke outcomes, through the upregulation of Rabep2. These effects were enhanced by hypoxic preconditioning.PMID:37226732 | DOI:10.1161/ATVBAHA.122.318559
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 25, 2023 Category: Cardiology Authors: Hao Tian Xinxuan Yang Jiahui Zhao Xiran Liu Xin Liu Yuan Cai Alexandra Wehbe Yuchuan Ding Shanping Yu Ling Wei Liping Liu Source Type: research
Danhong injection improves neurological function in rats with ischemic stroke by enhancing neurogenesis and activating BDNF/AKT/CREB signaling pathway
In this study, we aimed to determine the effect of DHI on long-term neurological function recovery after cerebral ischemia and explored the related mechanisms. Middle cerebral artery occlusion (MCAO) was used to establish an IS model in rats. The efficacy of DHI was assessed using neurological severity scores, behaviors, cerebral infarction volume and histopathology. Immunofluorescence staining was performed to assess hippocampal neurogenesis. An in vitro oxygen-glucose deprivation/reoxygenation (OGD/R) cell model was constructed and western-blot analyses were performed to verify the underlying mechanisms. Our results show...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 19, 2023 Category: Drugs & Pharmacology Authors: Lan Li Jie-Hong Yang Chang Li Hui-Fen Zhou Li Yu Xiao-Long Wu Yi-Hang Lu Yu He Hai-Tong Wan Source Type: research
Correction: Synergistic therapeutic effects of intracerebral transplantation of human modified bone marrow-derived stromal cells (SB623) and voluntary exercise with running wheel in a rat model of ischemic stroke
Stem Cell Res Ther. 2023 May 8;14(1):123. doi: 10.1186/s13287-023-03362-z.NO ABSTRACTPMID:37158966 | DOI:10.1186/s13287-023-03362-z
Source: Cell Research - May 9, 2023 Category: Cytology Authors: Satoru Yabuno Takao Yasuhara Takayuki Nagase Satoshi Kawauchi Chiaki Sugahara Yosuke Okazaki Kakeru Hosomoto Susumu Sasada Tatsuya Sasaki Naoki Tajiri Cesar V Borlongan Isao Date Source Type: research
Mitochondrial transplantation and immune response of human bone marrow mesenchymal stem cells for the Therapeutic of ischemic stroke
Curr Stem Cell Res Ther. 2023 May 5. doi: 10.2174/1574888X18666230505103407. Online ahead of print.ABSTRACTIschemic stroke is the leading cause of death and disability worldwide, with increasing incidence and mortality, imposing a significant social and economic burden on patients and their families. However, cerebral vascular occlusion leads to acute loss of neurons and destruction of synaptic structures. The limited treatment options cannot adequately address intra-neuronal mitochondrial dysfunction due to stroke. Therefore, stem cell-derived mitochondria transplantation plays an important role in neuronal protection and...
Source: Current Stem Cell Research and Therapy - May 8, 2023 Category: Stem Cells Authors: Yidong Liao Jiang Ming Wenxue Song Guangtang Chen Junshuan Cui Longcai He Zili Wang Xudong Wang Mingsong Xiong Hua Yang Kaya Xu Source Type: research
Rat BM-MSCs secretome alone and in combination with stiripentol and ISRIB, ameliorated microglial activation and apoptosis in experimental stroke
CONCLUSION: STP and trans ISRIB, alone and in combination with rat BM-MSCs secretome, might be considered as potential neuroprotective agents in the acute ischemic stroke (AIS) management.DATA AVAILABILITY STATEMENT: Data will be made available on reasonable request.PMID:37146724 | DOI:10.1016/j.bbr.2023.114471
Source: Brain Research - May 5, 2023 Category: Neurology Authors: Neha Dhir Ashish Jain Amit Raj Sharma Sunil Sharma Dhruv Mahendru Ajay Patial Deepti Malik Ajay Prakash Savita Verma Attri Shalmoli Bhattacharyya Bishan Das Radotra Bikash Medhi Source Type: research
Synergistic effects of electroacupuncture and bone marrow stromal cells transplantation therapy in ischemic stroke
CONCLUSIONS: Our results show that the combination treatment significantly improved restoration of neurological deficits in the animal stroke model. However, further studies are required to see if EA could promote the rapid differentiation of BMSC into neural stem cells in the short term.PMID:37140285 | DOI:10.26355/eurrev_202304_32106
Source: European Review for Medical and Pharmacological Sciences - May 4, 2023 Category: Drugs & Pharmacology Authors: Z Sun Y-Q Chen B-Y Ran Q Wu W Shen L-N Kan Source Type: research
Mesenchymal stem cell-derived exosomes in cardiovascular and cerebrovascular diseases: From mechanisms to therapy
Biomed Pharmacother. 2023 May 2;163:114817. doi: 10.1016/j.biopha.2023.114817. Online ahead of print.ABSTRACTCardiovascular and cerebrovascular diseases (CVDs) remain an intractable problem and have high morbidity and mortality worldwide, as well as substantial health and economic burdens, representing an urgent clinical need. In recent years, the focus of research has shifted from the use of mesenchymal stem cells (MSCs) for transplantation to the use of their secretory exosomes (MSC-exosomes) for the treatment of numerous CVDs, including atherosclerosis, myocardial infarction (MI), heart failure (HF), ischemia/reperfusio...
Source: Atherosclerosis - May 4, 2023 Category: Cardiology Authors: Yanhong Pan Weipeng Wu Xiaoxin Jiang Yunhong Liu Source Type: research
Synergistic effects of electroacupuncture and bone marrow stromal cells transplantation therapy in ischemic stroke
CONCLUSIONS: Our results show that the combination treatment significantly improved restoration of neurological deficits in the animal stroke model. However, further studies are required to see if EA could promote the rapid differentiation of BMSC into neural stem cells in the short term.PMID:37140285 | DOI:10.26355/eurrev_202304_32106
Source: Pharmacological Reviews - May 4, 2023 Category: Drugs & Pharmacology Authors: Z Sun Y-Q Chen B-Y Ran Q Wu W Shen L-N Kan Source Type: research
