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Therapy: Stem Cell Therapy
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Total 2351 results found since Jan 2013.
Neuroprotection of Stem Cells Against Ischemic Brain Injury: From Bench to Clinic
Transl Stroke Res. 2023 Jul 7. doi: 10.1007/s12975-023-01163-3. Online ahead of print.ABSTRACTNeurological injuries can have numerous debilitating effects on functional status including sensorimotor deficits, cognitive impairment, and behavioral symptoms. Despite the disease burden, treatment options remain limited. Current pharmacological interventions are targeted at symptom management but are ineffective in reversing ischemic brain damage. Stem cell therapy for ischemic brain injury has shown promising preclinical and clinical results and has attracted attention as a potential therapeutic option. Various stem cell sourc...
Source: Cell Research - July 6, 2023 Category: Cytology Authors: Xiao Liu Xiaofeng Jia Source Type: research
Chronic myeloid leukemia, tyrosine kinase inhibitors and cardiovascular system
CONCLUSIONS: The current CML treatment target is a cure that leads to normal age and gender-adjusted survival with a "normal" quality of life. Cardiovascular disorders are one of the major obstacles to reaching this target in CML patients. The treatment choices for CML patients must include a cardiovascular perspective.PMID:37401285 | DOI:10.26355/eurrev_202306_32786
Source: European Review for Medical and Pharmacological Sciences - July 4, 2023 Category: Drugs & Pharmacology Authors: U Y Malkan I C Haznedaroglu Source Type: research
Transmembrane Stem Factor Nanodiscs Enhanced Revascularization in a Hind Limb Ischemia Model in Diabetic, Hyperlipidemic Rabbits
Res Sq. 2023 Jun 16:rs.3.rs-2997323. doi: 10.21203/rs.3.rs-2997323/v1. Preprint.ABSTRACTTherapies to revascularize ischemic tissue have long been a goal for the treatment of vascular disease and other disorders. Therapies using stem cell factor (SCF), also known as a c-Kit ligand, had great promise for treating ischemia for myocardial infarct and stroke, however clinical development for SCF was stopped due to toxic side effects including mast cell activation in patients. We recently developed a novel therapy using a transmembrane form of SCF (tmSCF) delivered in lipid nanodiscs. In previous studies, we demonstrated tmSCF n...
Source: Cell Research - July 3, 2023 Category: Cytology Authors: Eri Takematsu Miles Massidda Gretchen Howe Julia Goldman Patricia Felli Lei Mei Gregory Callahan Andrew Sligar Richard Smalling Aaron Baker Source Type: research
Fertility preservation in women with sickle cell disease prior to curative therapy with stem cell transplant: a case series
Sickle cell disease (SCD) is an inherited hemoglobinopathy affecting approximately 100,000 Americans (1). Due to the pathognomonic sickling of red blood cells, individuals with SCD are at risk of venous thromboembolism, hemolytic anemia, stroke, pain crises, infection and end organ damage (2). Hematopoietic stem cell transplant (HSCT), while curative, can also lead to gonadal dysfunction and thereby ovarian insufficiency due to the associated myeloablative and radiative conditioning regimens (3).
Source: Fertility and Sterility - July 1, 2023 Category: Reproduction Medicine Authors: M. Yamasaki, P. Lindner, A. Decherney, T. Spitzer Source Type: research
Bone marrow mesenchymal stem cell-derived exosomal miR-193b-5p reduces pyroptosis after ischemic stroke by targeting AIM2
Ischemic stroke is a frequently occurring cerebrovascular disease (CVD) linked to high mortality, disability, and incidence rates, and the second factor causing global mortality41,3. There are two common sources of embolism in ischamic strokes: large artery atherosclerosis and small artery atherosclerosis. Ischemic stroke can be treated clinically with thrombolytic therapy4. Although ischemic stroke is treatable, post-cerebral ischemia blood reperfusion frequently induces inflammation, oxidative stress (OS) or additional unfavorable events that may exacerbate brain injury20,24.
Source: Journal of Stroke and Cerebrovascular Diseases - June 30, 2023 Category: Neurology Authors: Yingju Wang, Hongping Chen, Xuehui Fan, Chen Xu, Meng Li, Hongxue Sun, Jihe Song, Feihong Jia, Wan Wei, Fangchao Jiang, Guozhong Li, Di Zhong Source Type: research
