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Therapy: Stem Cell Therapy
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Total 2351 results found since Jan 2013.
Clinical Ageing
Subcell Biochem. 2023;103:437-458. doi: 10.1007/978-3-031-26576-1_16.ABSTRACTAgeing is generally characterised by the declining ability to respond to stress, increasing homeostatic imbalance, and increased risk of ageing-associated diseases . Mechanistically, the lifelong accumulation of a wide range of molecular and cellular impairments leads to organismal senescence. The aging population poses a severe medical concern due to the burden it places on healthcare systems and the general public as well as the prevalence of diseases and impairments associated with old age. In this chapter, we discuss organ failure during agein...
Source: Sub-Cellular Biochemistry - April 29, 2023 Category: Biochemistry Authors: Roxana Surugiu Daiana Burdusel Mihai-Andrei Ruscu Andreea Cercel Dirk M Hermann Israel Fernandez Cadenas Aurel Popa-Wagner Source Type: research
Stem Cell Therapy for Ischemic Brain Injury: Early Intranasal Delivery after Cardiac Arrest
Transl Stroke Res. 2023 Apr 4. doi: 10.1007/s12975-023-01150-8. Online ahead of print.ABSTRACTGlobal ischemic brain injury is the leading cause of mortality and long-term disability in patients resuscitated from cardiac arrest. Hypothermia and neuroprotective agents are two strategies partially improve neurological outcomes following resuscitation. However, the therapeutic effects of these treatments are inconsistently reported. Stem cell therapy has emerged as a promising protective strategy due to its potential for proliferation and differentiation into functional neural cells. This editorial reviews the current status o...
Source: Cell Research - April 4, 2023 Category: Cytology Authors: Xiao Liu Xiaofeng Jia Source Type: research
Therapeutic potential of stem cell extracellular vesicles for ischemic stroke in preclinical rodent models: a meta-analysis
CONCLUSION: The present meta-analysis confirmed that SC-EV therapy could improve neuron function and reduce infarct volume in a preclinical rodent ischemic stroke model, providing helpful clues for human clinical trials on SC-EVs.PMID:37013588 | DOI:10.1186/s13287-023-03270-2
Source: Cell Research - April 4, 2023 Category: Cytology Authors: Jing Zhao Huiyin Deng Chengfeng Xun Chunli Chen Zhiping Hu Lite Ge Zheng Jiang Source Type: research
Stem Cell Therapy for Ischemic Brain Injury: Early Intranasal Delivery after Cardiac Arrest
AbstractGlobal ischemic brain injury is the leading cause of mortality and long-term disability in patients resuscitated from cardiac arrest. Hypothermia and neuroprotective agents are two strategies partially improve neurological outcomes following resuscitation. However, the therapeutic effects of these treatments are inconsistently reported. Stem cell therapy has emerged as a promising pr otective strategy due to its potential for proliferation and differentiation into functional neural cells. This editorial reviews the current status of stem cell therapy via the intranasal route in primates and clinical studies, alo...
Source: Translational Stroke Research - April 4, 2023 Category: Neurology Source Type: research
Evidence of clinical efficacy and pharmacological mechanism of N-butylphthalide in the treatment of delayed encephalopathy after acute carbon monoxide poisoning
CONCLUSION: The NMA screened for regimens with better efficacy for each outcome indicator in order to provide a reference for clinical treatment. NBP can stably bind ALB, ESR1, EGFR, HSP90AA1, and other targets, and may play a role in neuroprotection for patients with DEACMP by modulating Lipid and atherosclerosis, IL-17 signaling pathway, MAPK signaling pathway, FoxO signaling pathway, PI3K/AKT signaling pathway.PMID:37006490 | PMC:PMC10060646 | DOI:10.3389/fneur.2023.1119871
Source: Atherosclerosis - April 3, 2023 Category: Cardiology Authors: Huiping Song Aochun Yue Xudong Zhou Wei Han Qin Li Source Type: research
Combined Application of Human Amniotic Membrane Mesenchymal Stem Cells and a Modified PGS-co-PCL Film in an Experimental Model of Myocardial Ischemia-Reperfusion Injury
Appl Biochem Biotechnol. 2023 Apr 3. doi: 10.1007/s12010-023-04446-5. Online ahead of print.ABSTRACTAccording to the World Health Organization (WHO), about 3.9 million people die annually of ischemic heart disease (IHD). Several clinical trials have shown that stem cell therapy is a promising therapeutic approach to IHD. Human amniotic membrane mesenchymal stem cells (hAMSCs) positively affect the repair of myocardial ischemia-reperfusion (MI/R) injury by stimulating endogenous repair mechanisms. The differentiated hAMSCs with and without modified PGS-co-PCL film were applied in the myocardium. MI/R injury was induced by l...
Source: Applied Biochemistry and Biotechnology - April 3, 2023 Category: Biochemistry Authors: Nastaran Bahrami Mahsa Ale-Ebrahim Yasin Asadi Nooshin Barikrow Ali Salimi Fatemeh Roholah Source Type: research
Remote ischemic postconditioning ameliorates stroke injury via the SDF-1 α/CXCR4 signaling axis in rats
Brain Res Bull. 2023 Mar 27:S0361-9230(23)00064-3. doi: 10.1016/j.brainresbull.2023.03.011. Online ahead of print.ABSTRACTRemote Ischemic Postconditioning (RIPostC) has become a research hotspot due to its protective effect on the brain in clinical studies related to ischemic stroke. The purpose of this study is to investigate the protective effect of RIPostC after ischemic stroke in rats. The middle cerebral artery occlusion/reperfusion (MCAO/R) model was established by the wire embolization method. RIPostC was obtained by inducing temporary ischemia in the hind limbs of rats. First, based on the results of short-term beh...
Source: Brain Research Bulletin - March 29, 2023 Category: Neurology Authors: Guannan Jiang Xiang Li Meirong Liu Haiying Li Haitao Shen Juan Liao Wanchun You Qi Fang Gang Chen Source Type: research
