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Specialty: Cardiology
Procedure: Transplants

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Total 261 results found since Jan 2013.

Cardiac complications in inherited mitochondrial diseases
In this study, we looked at molecular genetics of MIDs and cardiac manifestations in patients with mitochondrial dysfunction.
Source: Heart Failure Reviews - July 28, 2020 Category: Cardiology Source Type: research

Elevated plasma endocan and BOC in heart failure patients decrease after heart transplantation in association with improved hemodynamics
ConclusionOur results suggest that (i) plasma endocan in HF may reflect the state of pulmonary vascular congestion and PH-LHD, whereas (ii) plasma BOC may reflect the cardiac function and the hemodynamic overload  in HF. The exact role of these proteins and their clinical applicability as biomarkers in HF and PH-LHD ought to be investigated in larger cohorts.
Source: Heart and Vessels - July 9, 2020 Category: Cardiology Source Type: research

Biventricular imaging markers to predict outcomes in non ‐compaction cardiomyopathy: a machine learning study
ConclusionsOur findings show the importance of biventricular assessment to detect the severity of this cardiomyopathy and to plan for early clinical intervention. In addition, this study shows that even patients with normal LV function and negative late gadolinium enhancement had MACE. ML is a promising tool for analysing a large set of parameters to stratify and predict prognosis in LVNC patients.
Source: ESC Heart Failure - June 29, 2020 Category: Cardiology Authors: Camila Rocon, Mahdi Tabassian, Marcelo Dantas Tavares de Melo, Jose Arimateia Araujo Filho, Cesar Jos é Grupi, Jose Rodrigues Parga Filho, Edimar Alcides Bocchi, Jan D'hooge, Vera Maria Cury Salemi Tags: Original Research Article Source Type: research

A Novel Extracorporeal Continuous-Flow Ventricular Assist System for Patients With Advanced Heart Failure 　- Initial Clinical Experience.
CONCLUSIONS: This novel extracorporeal VAD system with a hydrodynamically levitated centrifugal pump can safely and successfully bridge patients with advanced heart failure to subsequent therapeutic stages. PMID: 32461539 [PubMed - as supplied by publisher]
Source: Circulation Journal - May 27, 2020 Category: Cardiology Authors: Seguchi O, Fujita T, Kitahata N, Iwasaki K, Kuroda K, Nakajima S, Watanabe T, Yanase M, Fukushima S, Tsukiya T, Katagiri N, Mizuno T, Takewa Y, Hamasaki T, Onda K, Hayashi T, Yamamoto H, Tatsumi E, Kobayashi J, Fukushima N Tags: Circ J Source Type: research

Prognostic significance of right ventricular hypertrophy and systolic function in Anderson –Fabry disease
ConclusionsRVH and RV systolic function show significant association with clinical events in AFD, but only proteinuria and left ventricular mass index emerged as independent predictors of outcome. Our findings suggest that RV involvement does not influence prognosis in AFD and confirm that renal involvement and left ventricular hypertrophy are the main determinant of major cardiac and non ‐cardiac events.
Source: ESC Heart Failure - May 19, 2020 Category: Cardiology Authors: Francesca Graziani, Rosa Lillo, Elena Panaioli, Maurizio Pieroni, Antonia Camporeale, Elena Verrecchia, Ludovico Luca Sicignano, Raffaele Manna, Antonella Lombardo, Gaetano Antonio Lanza, Filippo Crea Tags: Original Research Article Source Type: research

Risk assessment in PAH using quantitative CMR tricuspid regurgitation: relation to heart catheterization
ConclusionsA clear trend towards worse outcome with larger TRV or TR% was shown; however, the number of events was insufficient for significant outcome differences. Prognostic value of quantitative TR should be investigated in a larger multicentre cohort. Effective RV ejection fraction may be considered an improved measure of RV function in PAH.
Source: ESC Heart Failure - May 5, 2020 Category: Cardiology Authors: Erik Hedstr öm, Anna Bredfelt, Göran Rådegran, Håkan Arheden, Ellen Ostenfeld Tags: Original Research Article Source Type: research

Gut Microbiota-Derived Short-Chain Fatty Acids Promote Post-Stroke Recovery in Aged Mice.
Conclusions:This is the first study suggesting that the poor stroke recovery in aged mice can be reversed via "post-stroke bacteriotherapy" following the replenishment of youthful gut microbiome via modulation of immunologic, microbial and metabolomic profiles in the host. PMID: 32354259 [PubMed - as supplied by publisher]
Source: Circulation Research - April 30, 2020 Category: Cardiology Authors: Lee J, d'Aigle J, Atadja L, Quaicoe V, Honarpisheh P, Ganesh BP, Hassan A, Graf J, Petrosino JF, Putluri N, Zhu L, Durgan DJ, Bryan RM, McCullough LD, Venna VR Tags: Circ Res Source Type: research

Outcome of patients receiving a continuous flow left ventricular assist device - a retrospective single center study.
Conclusions. Survival rates were good, although one third of patients were bridged with temporary circulatory support. We report a high level of freedom from pump thrombosis, fatal stroke, and driveline infection. PMID: 32292078 [PubMed - as supplied by publisher]
Source: Scandinavian Cardiovascular Journal - April 16, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Outcome of mechanical circulatory support at the University Medical Centre Utrecht.
CONCLUSION: Not only short-term results but also 5‑year survival after cf-LVAD support demonstrate that MCS is a promising therapy as an extended bridge to heart transplantation. However, the incidence of several major complications still has to be addressed. PMID: 32096095 [PubMed - as supplied by publisher]
Source: Netherlands Heart Journal - February 23, 2020 Category: Cardiology Authors: Felix SEA, Ramjankhan FZ, Buijsrogge MP, Jacob KA, Asselbergs FW, Oerlemans MIF, Kirkels JH, van Laake LW, Oppelaar AMC, Suyker WJL, de Jonge N Tags: Neth Heart J Source Type: research

Status, Indications, and Use of Cardiac Replacement Therapy in the Era of Multimodal Mechanical Approaches to Circulatory Support: A Scoping Review
In conclusion, the Syncardia temporary TAH is a reasonable bridge-to-transplant option for selected patients with either biventricular failure or special anatomic conditions.RésuméLes auteurs décrivent l’utilisation, les indications et les résultats actuels du cœur artificiel total (CAT) temporaire Syncardia (Syncardia Systems, Tucson, AZ, États-Unis), le seul CAT actuellement approuvé comme stratégie de transition vers une transplantation au Canada, aux États-Unis et en Europe. Implanté chez plus de 1 700 patients dans le monde, le CAT temporaire Syncardia est la pompe la plus utilisée. À l’échelle mondia...
Source: Canadian Journal of Cardiology - February 7, 2020 Category: Cardiology Source Type: research

Prolargin and matrix metalloproteinase ‐2 in heart failure after heart transplantation and their association with haemodynamics
ConclusionsThe normalization pattern in HF patients of plasma prolargin and MMP ‐2 post‐HT towards controls' levels and their associations with improved haemodynamics indicate that prolargin and MMP‐2 may reflect, in part, the aberrant ECM remodelling involved in the pathophysiology of HF and associated PH. Their potential clinical use as biomarkers or targets for future therapy in HF and related PH remains to be investigated.
Source: ESC Heart Failure - December 18, 2019 Category: Cardiology Authors: Abdulla Ahmed, Salaheldin Ahmed, Mattias Arvidsson, Habib Bouzina, Jakob Lundgren, G öran Rådegran Tags: Original Research Article Source Type: research

Status, Indications and Use of Cardiac Replacement Therapy in the Era of Multimodal Mechanical Approaches to Circulatory Support: A Scoping Review
In conclusion, the SynCardia temporary TAH is a reasonable bridge-to-transplant option for selected patients with either biventricular failure or special anatomical conditions.
Source: Canadian Journal of Cardiology - November 30, 2019 Category: Cardiology Source Type: research

Current Role of the Total Artificial Heart in the Management of Advanced Heart Failure
AbstractThe total artificial heart (TAH) is a form of mechanical circulatory support that involves resection of the native ventricles followed by placement of a device that can restore total pulmonary and systemic flow. Given the increasing burden of congestive heart failure and cardiovascular disease, the number of people in need of cardiac replacement therapy will continue to grow. Despite aggressive efforts to expand the donor pool, the number of heart transplants in the United States (US) has plateaued at less than 3000 per year. In addition, there is increasing recognition of the long-term complications of current gen...
Source: Current Cardiology Reports - November 21, 2019 Category: Cardiology Source Type: research

Significance of Prior Stroke on Outcomes after LVAD-BTT
Strokes are a devastating complication following left ventricular assist device (LVAD). The purpose of this study was to determine if a cerebral vascular accident (CVA) prior to LVAD placement in a bridge-to-transplant population is associated with worse outcomes compared to those without a history of prior CVA.
Source: Journal of Cardiac Failure - July 31, 2019 Category: Cardiology Authors: Kimberly Hong, Michela Brambatti, Saige Smith, Enrico Ammirati, Eric Adler Tags: 392 Source Type: research

Bridging the Gap to LVAD Recovery and Explantation
Left ventricular assist device (LVAD) implantation continues to occur at an exceedingly high rate due to the donor and supply mismatch when it comes to heart transplantation. LVADs however do not come without risk and have high rates of significant bleeding, stroke, pump thrombosis and infection. Most of the clinical and research efforts thus far have been focused on LVAD insertion with the goal of destination therapy or as a bridge to transplant. The goal of bridge to recovery has often been underestimated despite multiple studies showing reverse remodeling of the myocardium.
Source: Journal of Cardiac Failure - July 31, 2019 Category: Cardiology Authors: Karlee K. Hoffman, Manreet Kanwar Tags: 361 Source Type: research